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A large fraction of aquatic bacteria remains uncultured. Here, the authors cultivated 627 strains of abundant freshwater bacteria from 14 European lakes, thus generating a collection that includes many previously uncultured, oligotrophic bacteria that may serve as model organisms.

Dimensional analysis is deriving predictive dimensionless variables for physical systems. Here, the authors introduce IT-π, an information-theoretic, model-free framework that identifies the dimensionless variables with the highest predictive power for the quantity of interest.

The authors describe the isolation and characterization of broadly cross-neutralizing monoclonal antibodies (mAbs) against diverse H5Nx viruses from individuals who received a monovalent H5N1 vaccine 15 years ago. They identify five mAbs that potently neutralized the majority of H5 clades and protected against lethal 2.3.4.4b H5N1 infection in mice.

Holliday junctions maintain chromosome synapsis to enable crossover assurance in budding yeast.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Familial startle disease is among the oddest of disorders. The demonstration of a mutation in the inhibitory glycine receptor points towards a cause of this and similar perturbations.

Separation of CO₂ from gas mixtures is a major application focus for porous materials. Now it has been shown that fluorinated non-porous crystalline materials can uptake CO₂ via mobile perfluoroalkyl regions, a process resembling the dissolution of CO₂ in perfluoroalkanes, while CH₄ uptake is hindered. In situ X-ray diffraction data provide insight into the sorption process.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Neural computations are envisioned as arising from either distinct function subpopulations or distributed collective dynamics. Dubreuil and Valente et al. examined recurrent neural networks trained on various cognitive tasks and found that a mixed-selective yet non-random subpopulation structure enabled flexible responding through gain-modulated latent dynamics.

Optical isolators, or optical diodes, allow electromagnetic radiation to travel in one direction but not the other. Here, the authors achieve unidirectional propagation of terahertz waves by taking advantage of the non-reciprocal nature of optical conductivity in magnetostatically biased graphene.

A new method to reconstruct ancestral genomes is used to estimate contigs of the last common ancestor of eukaryotes and to infer features such as the age of gene adjacencies and chromosome rearrangements.

The reasons for epistasis, wherein mutations interact non-additively, are often not fully understood. Now it is found that shifting the rate-limiting step from substrate binding to the chemical reaction step during the directed evolution of β-lactamase correlates with epistasis.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

In a prospective study including 2,300 pediatric and adult patients with liquid and solid tumors, RNA sequencing provided actionable molecular information in 87% of cases, with applications in diagnostics and therapy matching.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Green hydrogen production via water electrolysis requires a low-cost solution to provide efficient catalysts. Here, the authors report an industrially scalable method for synthesizing NiFe layered double hydroxide at room temperature and atmospheric pressure, enhancing alkaline electrolysis.

Studying quantum phase transitions at oxide interfaces provide a key to understand emergent two-dimensional (2D) superconductivity. Here, Chen et al. report comprehensive electronic phase diagram of the 2D electron system at the superconducting LaAlO₃/SrTiO₃ interface with independent control of carrier density and disorder.

Increased river incision and landscape erosion can be attributed to late Cenozoic cooling/changes in hydroclimate, according to cosmogenic isotope and luminescence ages of a sequence of bedrock terraces in the Yukon River basin.

Borna disease virus 1 replicates and transcribes its negative sense RNA genome in the nucleus of infected cells. Here, the authors present the cryoEM structures of the large polymerase protein in complex with the tetrameric phosphoprotein, revealing the structural features that govern its activity.

An ‘attoclock’ that measures the relative release time of electrons during double ionization is now presented. The technique enables investigation of the subtle differences between sequential and non-sequential ionization when elliptically polarized light is used to excite two electrons from argon atoms.

Efforts in predicting crystal structures from first principles have mainly focused on the bulk materials. A general approach based on a genetic algorithm is now proposed to simulate grain boundaries and heterophase interfaces in multicomponent systems. The efficiency of the approach is demonstrated in the case of grain boundaries in SrTiO₃.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Ionescu, Ankol et al. show that, in ALS mouse and iPSC models, TDP-43 aggregation at NMJs stems from aberrant axonal translation, normally repressed by muscle EV-derived miR126. Loss of miR126 in ALS increases TDP-43 buildup, impairs local synthesis and triggers degeneration.

Neoadjuvant immunochemotherapy against NSCLC has been tested in clinical trials. Here, the authors follow up longer-term survival and measure immune cell phenotype changes in a single-arm phase II clinical trial of neoadjuvant immunochemotherapy, indicating association of intratumoural TCR diversity and CD8 T cell positioning.

Drug resistance remains a major challenge in cancer treatment. Here, the authors identify Connexin43 as target that enhances BRAF/MEKi efficacy by interfering with DNA repair pathways, overcoming drug resistance. They develop an mRNA therapy that improves efficacy and sensitizes resistant cells.

Liquid biopsies enable minimally invasive applications for diagnosis and treatment monitoring. Here the authors analyse fragmentation patterns of circulating tumour DNA on multiple levels and develop a bioinformatic tool, LIQUORICE, to accurately detect and classify paediatric cancers with low mutational burden.

The influence of surface ponding on the interior of ice shelves is currently unknown. Here, the authors combine surface and borehole geophysics on the Larsen C Ice Shelf, Antarctica, with remote sensing and modelling and show how pond refreezing increases ice shelf density and temperature.

Magnetite provides a valuable record of the Earth's geomagnetic history. Here, Almeida et al. combine electron microscopy and energy-loss spectroscopy to study the effects of in situoxidation on the magnetization fidelity and crystalline phase of pseudo-single domain magnetite grains.

A theoretical framework describing the hydrodynamic interactions between a passive particle and an active medium in out-of-equilibrium systems predicts long-range Lévy flights for the diffusing particle driven by the density of the active component.

The enzyme ABHD18 is shown to have a key role in cardiolipin metabolism in mitochondria, offering a potential route for a small-molecule treatment of the rare genetic disease Barth syndrome.

Active control of optical fields at the nanoscale is difficult to achieve. Here, the authors fabricate an on-chip graphene NEMS suspended a few tens of nanometres above nitrogen vacancy centres and demonstrate electromechanical control of the photons emitted by electrostatic tuning of the graphene NEMS position.

Understanding who is being left behind, where and how is crucial to advancing the United Nations’ commitment to ‘leaving no one behind’. This study maps urban slums and wealth distribution across 32 sub-Saharan African countries, revealing a decreasing proportion of the population living in slums, yet a concerning rise in wealth inequality.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

ChReef is an optogenetic actuator for sustained optogenetic control of excitable cells in a variety of preclinical applications.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Analyses of the exposomes of populations across 40 countries found global disparities in healthy aging attributed to diverse biological, socioeconomic and political factors, with accelerated aging seen in populations from Egypt, South Africa, and Latin American and Caribbean regions.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Here, the authors describe the global distribution of crAssphage, its presence in Old-World and New-World primates, and its association with gut bacterial communities and dietary factors, providing insights into the origin, evolution and epidemiology of human gut crAssphage.