Nature Search

Rejoining of X-ray Induced Breaks in the DNA of Leukaemia Cells

J. T. LETT
I. CALDWELL
P. ALEXANDER
Research20 May 1967
Nature

Volume: 214, P: 790-792
DNA Strand Breakage in Cells irradiated with X-rays

C. J. DEAN
M. G. ORMEROD
P. ALEXANDER
Research14 Jun 1969
Nature

Volume: 222, P: 1042-1044
Evolutionary characterization of lung cancer metastasis

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and the seeding patterns that underpin it.

Sonya Hessey
Abigail Bunkum
Mariam Jamal-Hanjani
ResearchOpen Access29 Apr 2026
Nature

Volume: 653, P: 911-922
Importance for Radio-Protection of the Reaction of Cells to Sulphydryl and Disulphide Compounds

Z. M. BACQ
PETER ALEXANDER
Research11 Jul 1964
Nature

Volume: 203, P: 162-164
Genome-wide association and population-tailored polygenic risk for Parkinson’s disease in Taiwan

Yung-Tsai Chu
Yu-An Su
Masharip Atadzhanov
ResearchOpen Access22 May 2026
npj Parkinson's Disease

P: 1-14
Progress of Cancer Research

P. ALEXANDER
I. HIEGER
A. L. LEVENE
Research24 Nov 1962
Nature

Volume: 196, P: 715-719
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

Volume: 32, P: 527-544
Possible Implication of Myristicin as a Psychotropic Substance

ALEXANDER T. SHULGIN
Research23 Apr 1966
Nature

Volume: 210, P: 380-384
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Plant uptake and leaching of dimethylnitrosamine

DEBORAH DEAN-RAYMOND
M. ALEXANDER
Research01 Jul 1976
Nature

Volume: 262, P: 394-396
Sensitization of Radio-resistant Bacteria to X-rays by lodoacetamide

C. J. DEAN
P. ALEXANDER
Research29 Dec 1962
Nature

Volume: 196, P: 1324-1326
Ancient genomes reveal a deep history of Treponema pallidum in the Americas

Analyses of five treponemal genomes representing ancient relatives of Treponema pallidum suggest that this pathogen originated in the Americas.

Rodrigo Barquera
T. Lesley Sitter
Kirsten I. Bos
ResearchOpen Access18 Dec 2024
Nature

Volume: 640, P: 186-193
Low-power integrated optical amplification through second-harmonic resonance

An integrated optical parametric amplifier on thin-film lithium niobate achieves more than 17 dB gain with less than 200 mW input power.

Devin J. Dean
Taewon Park
Amir H. Safavi-Naeini
Research28 Jan 2026
Nature

Volume: 649, P: 1159-1164
Failure to detect autologous antibodies in the remission sera of patients with AML: complications introduced by the presence of rheumatoid factor

S E James
C J Dean
P Alexander
Research01 Sept 1980
British Journal of Cancer

Volume: 42, P: 385-391
Demonstrability of the Photochemical Formation of Biradicals by Magnetic Methods

MAX BORN
ALEXANDER SCHÖNBERG
Research19 Aug 1950
Nature

Volume: 166, P: 307
Quantifying electronic band interactions in van der Waals materials using angle-resolved reflected-electron spectroscopy

Heterostructures of graphene and hexagonal boron nitride have great potential for high-mobility electronics, yet little is known about the electronic interaction between these two atomically thin materials. Here, the authors perform angle-resolved reflected-electron spectroscopy to unveil their interplay.

Johannes Jobst
Alexander J. H. van der Torren
Sense Jan van der Molen
ResearchOpen Access29 Nov 2016
Nature Communications

Volume: 7, P: 1-6
A novel, covalent broad-spectrum inhibitor targeting human coronavirus M^pro

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Jing Sun
Deheng Sun
Jincun Zhao
ResearchOpen Access15 May 2025
Nature Communications

Volume: 16, P: 1-20
Lunar magnetic anomalies and the Cayley Formation

DESIREE E. STUART-ALEXANDER
Research01 Feb 1975
Nature

Volume: 253, P: 658
Pattern-enhanced Resonant Soft X-ray Scattering for Operando monitoring of electrochemical solid-liquid interfaces

Understanding interfaces at sub-nanometer scales is vital for complex chemical reactions. Here, the authors advance Pattern-enhanced Resonant Soft X-ray Scattering, enabling efficient operando probing of chemical and structural dynamics at solid-liquid interfaces.

Haoyi Li
Kas Andrle
Cheng Wang
ResearchOpen Access21 Feb 2026
Nature Communications

Volume: 17, P: 1-11
Capillary flow experiments for thermodynamic and kinetic characterization of protein liquid-liquid phase separation

Methods to quantitatively study liquid-liquid phase separation (LLPS) of proteins are lacking. Here the authors report Capillary flow experiments (Capflex) for the quantification of key LLPS parameters; they study Ddx4, the RP3 peptide and the aberrant liquid-to-solid phase transition of α-synuclein.

Emil G. P. Stender
Soumik Ray
Alexander K. Buell
ResearchOpen Access15 Dec 2021
Nature Communications

Volume: 12, P: 1-18
Clinical genetic variation across Hispanic populations in the Mexican Biobank

Analyzing data of the Mexican Biobank project, a new study finds regional differences in clinically relevant genetic frequencies and presents MexVar, a publicly accessible resource designed to support ancestry-informed genetic testing.

Carmina Barberena-Jonas
Santiago G. Medina-Muñoz
Andrés Moreno-Estrada
ResearchOpen Access21 Jan 2026
Nature Medicine

Volume: 32, P: 725-735
Mapping of mutation causing Friedreich's ataxia to human chromosome 9

Susan Chamberlain
Jacqui Shaw
Robert Williamson
Research21 Jul 1988
Nature

Volume: 334, P: 248-250
Erythropoietin receptor on cDC1s dictates immune tolerance

The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.

Xiangyue Zhang
Christopher S. McGinnis
Edgar G. Engleman
Research10 Dec 2025
Nature

Volume: 650, P: 470-480
Striated Muscles of an Amber Insect

ALEXANDER PETRUNKEVITCH
Research04 May 1935
Nature

Volume: 135, P: 760-761
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
X-ray-diffraction and electrical-transport imaging of superconducting superhydride (La,Y)H₁₀

The authors report the synthesis of (La_0.9Y_0.1)H₁₀ superhydrides and their characterization using synchrotron-based, spatially resolved x-ray diffraction and electrical transport imaging. They reveal μm-scale structural inhomogeneity with coexisting cubic and hexagonal clathrate phases exhibiting distinct superconducting transition temperatures.

Abdul Haseeb Manayil Marathamkottil
Kui Wang
Russell J. Hemley
ResearchOpen Access18 Dec 2025
Nature Communications

Volume: 16, P: 1-9
Optimal Population Coding, Revisited

Philipp Berens
Alexander Ecker
Matthias Bethge
ResearchOpen Access07 Jan 2011
Nature Precedings

P: 1
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID

Li and colleagues describe a monocyte-specific transcriptional state along with a persistent elevation of inflammatory markers specifically found in individuals with long COVID who had mild-to-moderate disease during acute SARS-CoV-2 infection.

Saumya Kumar
Chaofan Li
Yang Li
ResearchOpen Access14 Jan 2026
Nature Immunology

Volume: 27, P: 200-212
Somatic evolution following cancer treatment in normal tissue

High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.

Oriol Pich
Sophia Ward
Nicholas McGranahan
ResearchOpen Access10 Dec 2025
Nature

Volume: 653, P: 900-910
High-Reynolds Microfluidic Sorting of Large Yeast Populations

Eliezer Keinan
Ayelet Chen Abraham
Yaakov Nahmias
ResearchOpen Access13 Sept 2018
Scientific Reports

Volume: 8, P: 1-12
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Effect of cyclosporin A on the growth and spontaneous metastasis of syngeneic animal tumours

S A Eccles
S E Heckford
P Alexander
Research01 Aug 1980
British Journal of Cancer

Volume: 42, P: 252-259
Random heteropolymers as enzyme mimics

Modulation of random heteropolymers results in globular polymer clusters with catalytic activity mimicking proteins.

Hao Yu
Marco Eres
Ting Xu
Research31 Dec 2025
Nature

Volume: 649, P: 83-90
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Francisco Gimeno-Valiente
Carla Castignani
Nnennaya Kanu
ResearchOpen Access10 Sept 2025
Nature Genetics

Volume: 57, P: 2226-2237
Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs

Alexander Yu. Rudensky
Paula Preston-Hurlburt,
Charles A. Janeway
Research01 Oct 1992
Nature

Volume: 359, P: 429-431
Transcriptional repression directed by the yeast α2 protein in vitro

Brenda M. Herschbach
Martha B. Arnaud
Alexander D. Johnson
Research28 Jul 1994
Nature

Volume: 370, P: 309-311
The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

ALT telomeres experience DNA damage that may drive recombination-based telomere elongation. Here, the authors reveal that FANCM plays a critical role in the suppression of ALT activity through its interaction with the BTR (BLM-TOP3A-RMI) complex.

Robert Lu
Julienne J. O’Rourke
Hilda A. Pickett
ResearchOpen Access28 May 2019
Nature Communications

Volume: 10, P: 1-14
Clinical and molecular response to tebentafusp in previously treated patients with metastatic uveal melanoma: a phase 2 trial

In a multicenter, single-arm, open-label phase 2 study of patients with previously treated metastatic uveal melanoma, treatment with tebentafusp, a soluble TCR bispecific (gp100xCD3) showed promising clinical activity with an acceptable safety profile.

Richard D. Carvajal
Marcus O. Butler
Takami Sato
ResearchOpen Access13 Oct 2022
Nature Medicine

Volume: 28, P: 2364-2373
A Biological Application of Röntgen Photography

ALEXANDER MEEK
Research07 May 1896
Nature

Volume: 54, P: 8
Genome-wide association study of copy number variations in Parkinson’s disease

Zied Landoulsi
Ashwin Ashok Kumar Sreelatha
Bart P. C. van de Warrenburg
ResearchOpen Access20 Apr 2026
npj Parkinson's Disease

P: 1-11
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent risk loci. Comparisons with other psychiatric disorders and candidate gene analyses provide new insights into major depressive disorder.

Naomi R. Wray
Stephan Ripke
Patrick F. Sullivan
Research26 Apr 2018
Nature Genetics

Volume: 50, P: 668-681
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Defects in enteric innervation and kidney development in mice lacking GDNF

José G. Pichel
Liya Shen
Heiner Westphal
Research04 Jul 1996
Nature

Volume: 382, P: 73-76
The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein

Engin Özkaynak
Daniel Finley
Alexander Varshavsky
Research13 Dec 1984
Nature

Volume: 312, P: 663-666
Introduction of Howland Award

Alexander Nadas
Research01 Dec 1978
Pediatric Research

Volume: 12, P: 1137-1138
Differential DNA methylation of vocal and facial anatomy genes in modern humans

How traits specific to modern humans have evolved is difficult to study. Here, Gokhman et al. compare measured and reconstructed DNA methylation maps of present-day humans, archaic humans and chimpanzees and find that genes that affect vocal tract and facial anatomy show methylation changes between archaic and modern humans.

David Gokhman
Malka Nissim-Rafinia
Liran Carmel
ResearchOpen Access04 Mar 2020
Nature Communications

Volume: 11, P: 1-21
Adaptations for stealth in the wing-like flippers of a large ichthyosaur

Analysis of a fossilized front flipper of the Jurassic ichthyosaur Temnodontosaurus that preserves details of soft tissue indicates the presence of a serrated trailing edge that would have reduced noise generated while swimming, enabling stealth hunting and hiding from predators.

Johan Lindgren
Dean R. Lomax
Dan-Eric Nilsson
ResearchOpen Access16 Jul 2025
Nature

Volume: 644, P: 976-983
Eugenics and the Genetics Society

Alex Aylward
Daniel J. Fairbanks
Gregory Radick
ReviewsOpen Access20 Apr 2026
Heredity

P: 1-12
Reflections on the pigments of life

Ahead of his 85th birthday, David Dolphin, Emeritus Professor at the University of British Columbia, discusses his career combining academia with industry in an effort to advance scientific studies and help millions of people.

Alexander Rosu-Finsen
David Dolphin
Comments & Opinion15 Jan 2025
Nature Reviews Chemistry

Volume: 9, P: 81-82
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer

Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating T cell fraction provides sex-dependent and prognostic insights in patients.

Robert Bentham
Thomas P. Jones
Nicholas McGranahan
ResearchOpen Access18 Feb 2025
Nature Genetics

Volume: 57, P: 694-705

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