Search

Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Combining generative AI and one round of wet lab evolution generates high-affinity RNA aptamers.

A single-cell epigenomic atlas of human immune cells highlights cell-type-specific features associated with genetic or environmental exposures.

WNT-signaling activation is a promising strategy for adult tissue and organ rejuvenation. The authors report an efficient approach to generate exosomes carrying WNTs and RSPONDINs family ligands that can achieve strong activation of the pathway to regenerate diseased and aged livers.

Achieving versatile, tunable, real-time topological photonic system is challenging. Now this is accomplished by designing superlattices of WS₂ and a polymer embedded in a microcavity.

R9AP is a key receptor for entry of Epstein–Barr virus into human epithelial and B cells, and interacts directly with the viral glycoprotein gH/gL complex to mediate virus–host membrane fusion.

Using genetically engineered models, Genovese and colleagues study patterns of convergent evolution in renal cancer, and pinpoint dysregulation of interferon signaling as a means of adaptation to chromosomal instability in metastatic progression.

xTrimo protein general language model (xTrimoPGLM) is a unified pretraining framework and foundation model designed for various protein-related tasks, including protein understanding and generation or design.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

The genetic risk of clear cell renal cell carcinoma is complex and the genes related are unclear. Here, the authors propose a deep reinforcement based model to identify risk genes.

This genome-wide association study on persistent hepatitis B virus (HBV) infection among Chinese confirms previously associated genetic loci while discovering a novel protective locus at 8p21.3. The study also demonstrates the nearby gene INST10 suppresses HBV replication in vitro.

Whole-genome sequencing and association analysis of 270 Epstein–Barr virus (EBV) isolates from China identify two non-synonymous EBV variants within BALF2 that are strongly associated with the risk of nasopharyngeal carcinoma.

Two B3 domain transcription factors are important for the resetting of the vernalized state in the embryos of Arabidopsis by competing against repressive Polycomb partners and recruiting the scaffold protein FRIGIDA to establish an activate chromatin state at FLC.

Yi-Xin Zeng and colleagues performed a genome-wide association study for nasopharyngeal cancer in Southern Chinese. The authors report three new susceptibility loci for nasopharyngeal cancer.

Polygenic Risk Scores (PRS) show promise for facilitating cancer risk stratification. Here, the authors performed a large genome-wide association study and develop a PRS for nasopharyngeal carcinoma, which could improve risk stratification and personalized screening.

Jianjun Liu, Wei-Hua Jia, Adeline Seow, Dongxin Lin and colleagues report a genome-wide association study of B cell non-Hodgkin lymphoma in individuals of Chinese ancestry. They identify a new susceptibility locus on chromosome 3q27 in the intergenic region between BCL6 (B cell lymphoma protein 6) and LPP (lipoma preferred partner).

Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Here, the authors carry out a two-stage genome-wide association study for AMD and identify three new AMD risk loci, highlighting the shared and distinct genetic basis of the disease in East Asians and Europeans.

IgA nephropathy is a major cause of end-stage renal disease in China, occurring at a high frequency in Asian populations. Here Li and colleagues conduct a four-stage genome-wide association study in a Chinese population, identifying novel loci and variants associated with disease risk.

Nasopharyngeal carcinoma is a diverse cancer characterised by a heterogeneous microenvironment. Here, the authors use single cell sequencing to analyse the tumour microenvironment in 10 nasopharyngeal carcinoma tumours and identify different cell types including immune-suppressive T regulatory, tolerogenic dendritic, and exhausted CD8 T cells.

One-way quantum computing requires an entangled multiqubit system. So-called cluster states have been proposed to provide this resource, but they are difficult to generate. An alternative that uses the ground state of a one-dimensional chain of spins is now experimentally realized and used to construct a quantum logic gate.

Strain engineering is a promising method to manipulate properties of two-dimensional (2D) materials but slippage between material and substrate makes strain transfer inefficient. Here the authors overcome slipping effects by encapsulating a 2D material in a polymer substrate.

Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and an HLA class II locus of significance in high-risk populations. They reanalyze the strength of evidence for previously published risk loci.

RNA demethylase FTO promotes gastric cancer tumorigenesis and progression via the SP1-AURKB-ATM signaling pathway, shedding new light on the diagnoses and treatments for gastric cancer patients.

Duanqing Pei and colleagues show that BMP signaling to histone H3 lysine 9 methylation is a barrier to reprogramming somatic cells into induced pluripotent cells (iPSCs) and that its removal promotes the formation of fully reprogrammed iPSCs from pre-iPSCs. pre-iPSCs exhibit pluripotent properties but do not activate the core pluripotent network.

Single-dose antiviral drugs consisting of engineered viral receptor-binding domains display immediate and long-acting effects through dual mechanisms of rapid receptor blockade and adaptive immunity induction.

Ningli Wang, Tin Aung and colleagues report genome-wide association analyses for primary angle closure glaucoma, a major cause of blindness worldwide. They identify three loci newly associated with this disease.

Chiea Chuen Khor, Tin Aung and colleagues report the results of a large genome-wide association study of primary angle closure glaucoma. They identify five new susceptibility loci and provide insights into disease pathogenesis.

Jieruo Gu, Jianjun Liu and colleagues report the results of a genome-wide association study of ankylosing spondylitis in Han Chinese. They identify two new susceptibility loci for this inflammatory disease and confirm strong associations with variants in the HLA-B region.