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The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Density-dependent population regulation is widespread in animals. Here, the authors identify cathepsin B cysteine protease as a crowd-responding factor that induces increased genome mutagenesis, leading competitive growth in response to overpopulation.

Zhang et al. demonstrate that planthoppers secret an NLS-containing salivary effector, which redirects a histone deacetylase to the nucleus, thereby suppressing JA signaling and defense gene expression.

The authors introduce controlled compositional heterogeneity to broaden polarization vector distributions while preserving the antiferroelectric modulation in PbZrO₃-based ceramics. They reduce polarization hysteresis while maintaining high polarization strength.

Integrating single-cell multi-omics data remains challenging. Here, the authors benchmark 23 integration methods including foundation models across diverse datasets, revealing task-specific trade-offs and proposing an adaptation strategy that enhances foundation model performance.

Here authors present a method combining DFT calculations with experimental synthesis to address the challenges of slow recovery and limited recyclability in chemiresistive sensing MOFs.

AgBiS₂ nanocrystals show promise for thin, low-cost solar cells but are hindered by poor charge transport and limited infrared absorption. Yang et al. grow a molecular lead halide perovskite layer on the nanocrystals to passivate defects, improve transport, and enable highpower conversion efficiency.

Inner ear diseases are difficult to treat due to anatomical constraints. Here, the authors present a dual-segment continuum robot integrating navigation, endoscopy, and a force-sensing microneedle for atraumatic transcanal access to the round window membrane.

Flexible displays face challenges in power use, resolution, and durability. This work presents a flexible micro-LED display driven by HZO-based FeMFETs, achieving low power, high resolution, and strong mechanical reliability.

Integrating optical properties and conical structural design constructs a radiative cooling textile with self-sustaining spectral selectivity, enabling efficient directional sweat transport that mitigates sweat’s impact on its spectral performance.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Tight regulation of thymic T cell development is critical for immune homeostasis and leukemia prevention. Here, the authors identify USP10 as a MYC-induced deubiquitinase stabilizing SOX4 in early T cell development and T-cell acute lymphoblastic leukemia progression, while USP10 inhibition delays leukemogenesis in mice.

Rodents are frequently used as models of the human immune system, but not all immune functions are shared between the two evolutionary families. Here the authors provide evidence that the immune system of the tree shrew (Tupaia belangeri) is closer to humans than that of rodents and the single cell immune atlas they assemble support the wider employment of the tree shrew as immunological model.

The authors resolve 63 structurally diverse haplotype structures for the 22q11.2 deletion syndrome region. Deletion risk differs depending on structure; individuals of African ancestry are enriched for inverted repeats that predispose to inversion.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

FOXA1 is a master suppressor of prostate cancer tumorigenesis and lineage plasticity. Here, the authors discover that FOXA1 loss in mice drives basal-squamous de-differentiation and remodels the tumor microenvironment characterized by immunosuppressive myeloid cell accumulation and T-cell dysfunction.

Decoding skin gases can reveal a lot about our health. Here, the authors introduce a monolithic AI-powered wearable ring designed to non-invasively monitor dermal volatile-organic-compounds associated with diet-related metabolism.

Understanding the genetic factors that regulate panicle architecture is important for improving rice yields. In this study, Li et al. demonstrate that the gene PTB1is critical for regulating panicle seed setting rate and pollen tube growth.

Sedimentary organic carbon ages deviated from depositional ages, with falling terrestrial organic carbon fraction, suggesting energetic forcing reintroduced pre-aged organic carbon from offshore into coastal to inner-shelf areas, based on East China Sea coastal muddy sediment core analysis.

Nawsherwan et al. investigate sex disparities in young adults aged 20–40 with acute coronary syndrome in China. Results reveal that males receive more diagnostic care and treatment but have a higher risk of ST-elevation myocardial infarction, while females have a higher risk of unstable angina, highlighting the need for sex-specific approaches.

Radical C(sp³)–C(sp³) bond formation with stereocontrol is challenging. Now, photoredox catalysis and repurposed thiamine-dependent enzymes are combined to couple cinnamyl aldehydes with benzylic radicals, yielding enantioenriched carboxylic acids bearing one or even two stereocentres.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Functional and structural characterization of PtmA2 reveals that it is an unusual non-adenylating acyl-CoA ligase and part of a system wherein the canonical acyl-CoA ligase reaction is separated into two half-reactions performed by distinct enzymes.

Electrosynthesis of amino acids is a transformative but challenging strategy. Here, the authors report a Sn catalyst in driving amino acid production at ampere-level current densities and reveal the role of catalyst dynamic reconstruction and microenvironment in controlling the reaction mechanism.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

China’s natural forests became increasingly fragmented from 1990 to 2020, driven largely by expanding tree plantations and their interactions with logging, cropland change, and elevation, based on national mapping of structural and connectivity metrics.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Guang, He, et al. establish a multi-dimensional dengue risk assessment framework that combines hazard, human exposure, and social vulnerability under climate change and rapid urbanization. They find a northward expansion of high-risk areas and identify integrated climate adaptation and urban planning as key for prevention.

Standard of care CD19-targeting CAR-T therapy for Relapsed-Refractory Diffuse Large B Cell Lymphoma (r/r DLBCL) faces frequent resistance often driven by regulatory T cell (Treg) activation. This study identifies Timosaponin AIII (TAIII) as A2AR inhibitor for enhanced CAR-T activity while depleting CAR-Treg formation.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

You, Hu et al. discover a population of COTL1^high NK cells regulated by GITRL⁺ macrophages and demonstrate their functional importance in mediating anti-tumour immunity in cancer with impaired tumour-specific MHC-I expression.

This work demonstrates that embedding MnCoGe particles within magnesium alloys transforms the irreversible thermal expansion into a self-compensating behavior, yielding zero thermal expansion from 25 to 150 °C while retaining high strength and ultralow density.

Black hole (BH) masses can be estimated from tidal disruption events (TDEs). Here, the authors show that AT 2018cqh, a TDE, exhibits unusual X-ray characteristics consistent with a TDE scenario involving an intermediate-mass BH.