Preparation of cyclobutanes with four different substituents is rare and often arduous. Here a cocrystallisation strategy enables the intermolecular [2+2] cross-photoreaction of non-symmetrical stilbene derivatives to obtain chiral tetrasubstituted cyclobutanes with up to four different substituents in quantitative yield.
- Michael A. Sinnwell
- Ryan H. Groeneman
- Leonard R. MacGillivray
