Search

This study reports real-space, layer-resolved magnetic imaging of the van der Waals antiferromagnet (Fe,Co)₃GaTe₂ using SPLEEM, revealing A-type interlayer coupling, intrinsic chiral spin textures and enabling controlled writing of antiferromagnetic skyrmions.

Authors apply chiral engineering to tripeptide-drug conjugates (PDC), observing liquid-liquid phase separation for some PDCs with alternating L/D amino acids, while others form β-sheet-rich hydrogels. Chirality-controlled phase behavior offers a strategy to control phase transition and material properties in PDCs.

Here, the authors show that uridine enhances oocyte quality in aged mice by binding to PCBP1 to suppress ferroptosis and preserve mitochondrial function, suggesting a potential strategy to delay female reproductive aging.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Despite rapid development of model algorithms, more evidence is needed on the widespread clinical implementation of auto-segmentation tools. In this prospective, multicenter, observational trial, the authors find that AI-assisted delineation performs better than manual delineation while improving time efficiency and reducing performance metrics variability across centers and physicians with varying expertise.

In CRISPR/Cas12a systems, small RNA from pre-crRNA maturation is often overlooked. Here, authors show these fragments reconstitute with Cas12a to activate cleavage. They discover a crRNA activating Cas12a in a “delayed-switch” mode, resolving its incompatibility with nucleic acid amplification.

Cell-free systems hold potential for nucleic acid assays but are limited by the need for pre-amplification. Here the authors develop a cell-free diagnostic platform that detects viral RNA without pre-amplification demonstrating uses on six respiratory viruses in under 70 minutes with attomolar sensitivity.

Reducing dissipation when generating spin currents remains a central challenge in spintronics. Now, an artificial ferrimagnet is shown to produce spin current output and simultaneously lower magnetic damping.

Integrating spatial and single-cell data from 100 patients, the authors define conserved cellular communities and communications in glioblastoma, revealing distinct mesenchymal-like tumor subtypes and predominant neurogliomal synapses that shape tumor progression.

Perovskite solar modules suffer from reverse-bias instability. To address this, Wang et al. promote the assembly of self-assembled monolayers through hydrogen-bonding interactions with a polycarbazole template.

Selecting a coating adsorbent for solid-phase microextraction (SPME) with good compatibility for target molecules can be difficult, and testing methods for the vinyl acetate monomer, which is commonly used in the production of food contact materials, remain underexplored. Here, the authors propose an approach for assessing adsorption performance that combines dynamic vapor sorption and computational simulations, reporting ZIF-68 as an optimal coating material for the SPME testing of vinyl acetate and evaluating the monomer’s specific migration in several ethylene vinyl acetate copolymer materials.

Microplastics and nanoplastics were found at a higher level in brain tumour samples from living patients than in healthy human brain samples from cadavers, with a correlation between microplastic surface area and tumour proliferation.

Sepsis’s profound heterogeneity complicates prognosis and stratification. Here, the authors show that SepsisFormer and SMART, explainable AI models integrating coagulation–inflammation markers, enable outcome prediction, real-time risk assessment, and subgroup identification to guide sepsis therapy.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

DeepDrugDiscovery is an AI-powered screening platform incorporating ADMET and blood–brain barrier penetrability predictions to successfully identify mTOR-independent autophagy enhancers that can cross the blood–brain barrier for Alzheimer’s disease therapy.

Genomic data from snow carps reveal that the fusion of chromosomes initiates rediploidization following whole-genome duplication.

A biohybrid chiral hydrogel combining cell-membrane-coated nanoparticles with a D-chiral matrix reduces tumour stemness via biochemical and biophysical regulation, boosting radioimmunotherapy and preventing postoperative glioblastoma recurrence.

Primary alkyl amines are highly reactive in N-nucleophilic reactions with electrophiles but their α-C–H bonds are unreactive towards electrophiles due to their extremely low acidity. Combining 8-diazafluoren-9-one with an iridium catalyst, the authors demonstrate direct asymmetric α-C-H alkylation of unprotected primary alkyl amines with allylic carbonates.

This study shows that iron-bound organic carbon (Fe_R-OC) is generally persistent but can be remobilized during iron reduction and utilized by microbes in subseafloor sediments. This sedimentary Fe_R-OC pool may contribute to regulating Earth’s carbon cycle.

RNA editing influences gene regulation in cancer. Here, the authors show that EZH2 regulates RNA editing by ADAR1 through remodeling its interactome and nuclear transport, thereby promoting MDM2 expression and prostate cancer progression.

HfO₂-based ferroelectric materials are promising for non-volatile memory applications. Here, the authors demonstrate a highly enhanced ferroelectricity in Hf_0.5Zr_0.5O₂/Hf_0.9La_0.1O₂ multilayers, which approach the theoretical limit.

Age-related obesity is a major health issue with unclear causes. This work reveals that the enzyme GSNOR promotes obesity by reducing mitochondria in fat, leading to tissue “whitening” and identifying it as a potential therapeutic target.

Unique remodeling of elastin and collagen fibers in extracellular matrix along lung tumorigenesis is resolved with label-free multiphoton microscopy and a quantitative measure termed resemblance metric.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

This study shows that micro-level uncertainty in EV charging behaviour can amplify macrolevel load variability by up to 82.7%, with marked regional differences, underscoring the need for behaviour-aware strategies to maintain power system stability.

Electrocatalytic co-reduction of CO₂ and NO₃ ^- for urea synthesis is constrained by low efficiency. Here, the stable Cu^δ+ active sites, regulated by an analogous rectifying interface effect, not only enhanced the critical C-N coupling dynamics but also enabled high-performance urea synthesis.

Xu et al. report that inhibition of the F-box protein FBXL2 enhances HER2 expression, rendering HER2-negative breast cancer sensitive to the anti-HER2–drug conjugate trastuzumab deruxtecan.

Developing polymer composites which combine high strength, toughness, and impact resistance remains challenging. Here the authors propose a toughening strategy that integrates a trabecular interlock architecture with a stress-adaptive interface to enable efficient energy dissipation under mechanical loading.

The development of dental calculi involves bacteria in local mature biofilms converting the DNA in neutrophil extracellular traps from being degradable by the enzyme DNase I to being degradation resistant.

A new method is described that uses a periscope to generate high-speed, high-resolution projections of light fields, enabling sub-second volumetric 3D printing of millimetre-scale objects without rotating the sample.

In the phase III NAPOLI-3 trial, first-line treatment with NALIRIFOX was associated with improved overall survival compared to gemcitabine plus nab-paclitaxel in patients with metastatic pancreatic adenocarcinoma. Here the authors report the results of a randomized phase II trial comparing the two regimens, NALIRIFOX versus Gemcitabine plus Nab-Paclitaxel, in Chinese patients.

Anthropogenic nitrogen enrichment reduces symbiotic nitrogen fixation, but environmental factors alone cannot explain this response. This meta-analysis shows that integrating both environmental factors and plant performance traits improves the predictive accuracy of symbiotic nitrogen fixation responses by 42.7%.

Assessing the hepatotoxicity of a drug is critical in drug development. Here, the authors develop human multi-lineage liver organoids and identify imipramine as an inducer of indirect hepatotoxicity from a drug screen. The study offers insight into indirect hepatotoxicity and an in vitro platform for drug safety testing.

Alternative splicing greatly expands the transcriptomic and proteomic diversity in vertebrates. Here, the authors develop a machine-learning tool to identify functional splicing events during hematopoietic cell differentiation, revealing new regulators of hematopoiesis.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

PAN2-PAN3 complexes trim poly(A) tails of mRNAs. Here, the authors show that PAN2 associates with translation initiation factors and that germline-specific deletion of Pan2 in mice causes male infertility and compromises stability of key components of the translational machinery.

Protected areas (PAs) are central to China’s forest conservation strategy, yet their carbon storage effectiveness under different governance and management contexts remains uncertain. Here, authors show that stronger protection enables substantially greater forest carbon gains in China’s PAs, both now and in the future.

The generation of α-carbon radicals from alkoxyl radicals is challenging because 1,2-hydrogen atom transfer (HAT) is usually less favoured than 1,5-HAT. Here, the authors report a strategy to inhibit 1,5-HAT by introducing a silyl group into the α-position of alkoxyl radicals, enabling preparation of α-alkoxylimino alcohols and α-heteroaryl alcohols.

The mechanisms underlying oligodendrocyte precursor cells (OPCs) and neuron interactions remain unclear. Here, the authors show that chromatin remodeler BAF155 regulates OPC differentiation and myelination by coordinating synaptic genes for OPC neuron communication, contributing to autism-like behavioral deficits in mice