Nature Search

Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990–2023: a Global Burden of Disease study

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Sooji Lee
Hayeon Lee
Dong Keon Yon
Research30 Mar 2026
Nature Medicine

P: 1-25
Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast

Filamentous fungi are a valuable source of natural therapeutic products such as antibiotics. Here the authors engineer monocellularS. cerevisiaeto perform complex secondary metabolism typical of multicellular fungi in order to demonstrate biosynthesis and secretion of bioactive penicillin.

Ali R. Awan
Benjamin A. Blount
Tom Ellis
ResearchOpen Access04 May 2017
Nature Communications

Volume: 8, P: 1-8
Small-molecule binding and sensing with a designed protein family

Computationally designing proteins with interfaces that bind small molecules has posed a long-standing challenge. Here, authors combine deep learning and physics-based approaches to design proteins that bind small molecules, and demonstrate their approach by designing a cortisol biosensor.

Gyu Rie Lee
Samuel J. Pellock
David Baker
ResearchOpen Access28 Mar 2026
Nature Communications

P: 1-12
Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells

Elevated extrinsic tissue-scale forces can drive pathological foreign-body responses to implants, mediated by the Rac2-mediated activation of a subpopulation of mechanoresponsive myeloid cells.

Jagannath Padmanabhan
Kellen Chen
Geoffrey C. Gurtner
ResearchOpen Access25 Sept 2023
Nature Biomedical Engineering

Volume: 7, P: 1419-1436
Investigating the analytical robustness of the social and behavioural sciences

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Balazs Aczel
Barnabas Szaszi
Brian A. Nosek
Research01 Apr 2026
Nature

Volume: 652, P: 135-142
Butcher, baker

David Jones
News & Views02 Jun 1994
Nature

Volume: 369, P: 362
Protection of telomeres 1b safeguards the Arabidopsis genome by regulating ROS homeostasis

The authors uncover a noncanonical role for Arabidopsis POT1b in maintaining genome stability through ROS regulation, establishing an unexpected connection between telomere biology and cellular oxidative stress.

Ji-Hee Min
Claudia Castillo-González
Dorothy E. Shippen
ResearchOpen Access10 Mar 2026
Nature Communications

P: 1-18
Native diversity buffers against severity of non-native tree invasions

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Camille S. Delavaux
Thomas W. Crowther
Daniel S. Maynard
ResearchOpen Access23 Aug 2023
Nature

Volume: 621, P: 773-781
Dominant clones leverage developmental epigenomic states to drive ependymoma

Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of such tumours despite ‘quiet’ genomes.

Alisha S. Kardian
Hua Sun
Stephen C. Mack
ResearchOpen Access25 Mar 2026
Nature

P: 1-11
3D model of amphioxus steroid receptor complexed with estradiol

Michael Baker
David Chang
ResearchOpen Access05 Jun 2009
Nature Precedings

P: 1
Functional rapidly folding proteins from simplified amino acid sequences

David S. Riddle
Jed V. Santiago
David Baker
Research01 Oct 1997
Nature Structural Biology

Volume: 4, P: 805-809
A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions

Genome-wide analysis coupled with long-read sequencing identifies a repeat expansion in GOLGA8A associated with high risk for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.

Wouter De Coster
Marleen Van den Broeck
Rosa Rademakers
ResearchOpen Access12 Mar 2026
Nature Genetics

P: 1-11
Impact of solvent forces and broken symmetry on the assembly of designed proteins at a liquid-solid interface

Manipulating chemical interactions is crucial in protein assembly. Here, the authors highlight the importance of accounting for solvent forces mediated by interfacial hydration structures when designing protein assemblies at liquid-crystal interfaces.

Sakshi Yadav Schmid
Benjamin Helfrecht
James J. De Yoreo
ResearchOpen Access13 Mar 2026
Nature Communications

Volume: 17, P: 1-9
Family imprint reveals basin-wide patterns of Amazon forest embolism resistance

The Amazon faces worsening droughts, yet little is known about large-scale variation in the physiological limits of Amazon trees. Here, the authors reveal family-level conservatism in embolism resistance and estimate that Brazilian and Guiana shield forests are more resistant than Western Amazonia forests.

Julia Valentim Tavares
Emanuel Gloor
David Galbraith
ResearchOpen Access26 Feb 2026
Nature Communications

Volume: 17, P: 1-12
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Macromolecular modeling and design in Rosetta: recent methods and frameworks

This Perspective reviews tools developed over the past five years in the macromolecular modeling, docking and design software Rosetta.

Julia Koehler Leman
Brian D. Weitzner
Richard Bonneau
Reviews01 Jun 2020
Nature Methods

Volume: 17, P: 665-680
Hunting and fox numbers in the United Kingdom

Nicholas J. Aebischer
Sandra E. Baker
Jonathan C. Reynolds
Research22 May 2003
Nature

Volume: 423, P: 400
Accelerating coral assisted evolution to keep pace with climate change

Ongoing and projected climate changes are bringing increased marine heatwave frequency and intensity, threatening the health and survival of coral reefs. This Roadmap outlines the potential for assisted evolution methods to increase thermal tolerance in corals and describes ways to accelerate research and development for enhancing coral adaptation rates.

Adriana Humanes
Line Bay
Juan C. Ortiz
Reviews30 Mar 2026
Nature Reviews Biodiversity

P: 1-16
A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial

A single intravenous dose of the psychedelic dimethyltryptamine, combined with psychological support, produces rapid and lasting reductions in depressive symptoms in adults with major depressive disorder.

David Erritzoe
Tommaso Barba
Ellen James
ResearchOpen Access16 Feb 2026
Nature Medicine

Volume: 32, P: 591-598
Genetically encoded assembly recorder temporally resolves cellular history

The fluorescence-based protein assembly platform GEMINI is able to record the history of individual cells by leveraging a computationally designed protein assembly as an intracellular memory device.

Yuqing Yan
Jiaxi Lu
Dingchang Lin
ResearchOpen Access03 Mar 2026
Nature

P: 1-11
Quests for low-degree mantle melts

Trevor J. Falloon
David H. Green
Chris G. Ballhaus
Research23 May 1996
Nature

Volume: 381, P: 285
Photoelectric Spectrophotometry of Planetary Nebulæ

DONALD A. MacRAE
JURGEN STOCK
Research27 Mar 1954
Nature

Volume: 173, P: 589-590
An antibody-drug conjugate designed through clone and isotype selection restricts the growth of CSPG4-expressing triple-negative breast cancer

Benjamina Esapa
Yi Liu
Sophia N. Karagiannis
ResearchOpen Access07 Mar 2026
npj Precision Oncology

P: 1-19
Childhood brain tumors instruct cranial hematopoiesis and immunotolerance

Antigen presentation in skull bone marrow by hematopoietic stem and progenitor cells induces myelopoiesis and generates CD4⁺ regulatory T cells in a mouse model of ependymoma, promoting immune tolerance. Treatment with anti-GM-CSF antibody has antitumor effects that are augmented by immunotherapy.

Elizabeth Cooper
David A. Posner
Richard J. Gilbertson
ResearchOpen Access03 Feb 2026
Nature Genetics

Volume: 58, P: 317-328
Improved protein binder design using β-pairing targeted RFdiffusion

This study demonstrates the capability of deep learning protein design models in generating functionally validated β-strand pairing interfaces, expanding the structural diversity of de novo binding proteins and accessible target surfaces.

Isaac Sappington
Martin Toul
David Baker
ResearchOpen Access10 Jan 2026
Nature Communications

Volume: 17, P: 1-15
Inference on inner galaxy structure via gravitational waves from supermassive binaries

The lowest-frequency gravitational wave background may be shaped by supermassive black hole binaries that scatter nearby stars or dark matter. In this case, the NANOGrav 15-year dataset favours dense galactic centres with 10⁶ solar masses per cubic parsec.

Yifan Chen
Matthias Daniel
Olivia Young
Research05 Feb 2026
Nature Astronomy

P: 1-10
Deepening and broadening knowledge after the PISA scientific event: bibliometric, semantic network, and expert analyses of scientization in education research

David P Baker
Abdul Basit Adeel
Yuan Chih Fu
ResearchOpen Access23 Feb 2026
Humanities and Social Sciences Communications

Volume: 13, P: 1-14
Rewiring of cortical glucose metabolism fuels human brain cancer growth

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources such as environmental amino acids, providing a potential therapeutic target.

Andrew J. Scott
Anjali Mittal
Daniel R. Wahl
ResearchOpen Access03 Sept 2025
Nature

Volume: 646, P: 413-422
Energy and physical resource impacts of quantum computing merit greater attention

Quantum computing research and development is growing worldwide; yet the energy and physical resource demands of future quantum-accelerated data centres are unknown. Planning for quantum computing requires strong collaboration between research communities across engineering, physics, environmental sciences, economics, policy, and energy systems and scenario modelling.

David L. McCollum
Soumendra Bhanja
Naushita Sharma
Comments & Opinion25 Mar 2026
Nature Reviews Clean Technology

P: 1-2
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Photochemically-enabled, post-translational production of C-terminal amides

C-terminal α-amidated peptides are attractive therapeutic targets, but preparative methods to access amidated pharmaceuticals are limited both on lab and manufacturing-scale. Here, the authors report a straightforward and scalable approach to the C-terminal α-amidation of peptides and proteins from cysteine-extended polypeptide precursors.

David Hymel
Felix Wojcik
Michael R. Harris
ResearchOpen Access30 Nov 2024
Nature Communications

Volume: 15, P: 1-8
Population genomics of domestic and wild yeasts

David Carter
Gianni Liti
Edward Louis
ResearchOpen Access20 Jun 2008
Nature Precedings

P: 1
Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies

Variants in the PSMC5 gene impair proteasome function and cellular homeostasis, altering brain development in children. This study reveals underlying molecular mechanisms contributing to this neurodevelopmental phenotype, and suggests therapeutic leads for neurodevelopmental proteasomopathies.

Sébastien Küry
Janelle E. Stanton
Elke Krüger
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-21
Molecular packing in collagen

DAVID J. S. HULMES
ANDREW MILLER
Research17 Sept 1981
Nature

Volume: 293, P: 239-240
A Variation in the Electrophoretic Pattern of Human Erythrocyte Carbonic Anhydrase

RONALD F. RIEDER
DAVID J. WEATHERALL
Research26 Sept 1964
Nature

Volume: 203, P: 1364-1366
3D model of lamprey estrogen receptor with estradiol and 15[alpha]-hydroxy-estradiol

Michael Baker
David Chang
Charlie Chandsawangbhuwana
ResearchOpen Access09 Jan 2009
Nature Precedings

P: 1
Functional integration of striatal allografts in a primate model of Huntington's disease

A. Lisa Kendall
F. David Rayment
Stephen B. Dunnett
Research01 Jun 1998
Nature Medicine

Volume: 4, P: 727-729
Explorer (Satellite 1958a) Over Africa

DAVID S. EVANS
Research26 Apr 1958
Nature

Volume: 181, P: 1173-1174
High-throughput methods leveraging robotics and computer vision for the development of therapeutic phage cocktails

In this work, authors present an automated, high-throughput platform that utilizes robotics and computer vision to enable creation of a therapeutic phage cocktail, LBP-EC01, effective against over 96% of tested Escherichia coli isolates from urinary tract infections.

Taylor J. R. Penke
Aeron Tynes Hammack
Paul Garofolo
ResearchOpen Access30 Jan 2026
Nature Communications

Volume: 17, P: 1-13
Atmospheric cellular convection

R. David Baker II
Gerald Schubert
Research01 Oct 1992
Nature

Volume: 359, P: 370
Regulation of mammalian cellular metabolism by endogenous cyanide production

Zuhra and Petrosino et al. report evidence that cyanide acts as a regulatory gasotransmitter in mammalian cells, where it is shown to affect cellular bioenergetics, most likely via protein S-cyanylation.

Karim Zuhra
Maria Petrosino
Csaba Szabo
ResearchOpen Access03 Mar 2025
Nature Metabolism

Volume: 7, P: 531-555
Pervasive increase in tree mortality across the Australian continent

Eight decades of forest plot monitoring show a pervasive increase in tree mortality across Australia’s forest biomes driven by climate change, jeopardizing their role as enduring carbon sinks.

Ruiling Lu
Laura J. Williams
Belinda E. Medlyn
Research06 Jan 2026
Nature Plants

Volume: 12, P: 62-73
An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12

Chen Keasar
Liam J. McGuffin
Silvia N. Crivelli
ResearchOpen Access02 Jul 2018
Scientific Reports

Volume: 8, P: 1-18
Glucose feeds the tricarboxylic acid cycle via excreted ethanol in fermenting yeast

Metabolic labeling experiments on fermenting yeast revealed that ethanol is oxidized to acetaldehyde and acetyl-CoA and is also a major source of NADH and NADPH, demonstrating that ethanol can be consumed as a TCA cycle and redox fuel.

Tianxia Xiao
Artem Khan
Joshua D. Rabinowitz
Research15 Aug 2022
Nature Chemical Biology

Volume: 18, P: 1380-1387
Electrical impedance tomography reveals ventilation and perfusion heterogeneity in infants with bronchopulmonary dysplasia

Katelyn G. Enzer
Nilton Barbosa Da Rosa Jr
Christopher D. Baker
Research24 Feb 2026
Journal of Perinatology

P: 1-8
Latitudinal variations in plankton δ¹³C: implications for CO₂ and productivity in past oceans

Greg H. Rau
Taro Takahashi
David J. Des Marais
Research12 Oct 1989
Nature

Volume: 341, P: 516-518
Important role of hydrogen bonds in the structurally polarized transition state for folding of the src SH3 domain

Viara P. Grantcharova
David S. Riddle
David Baker
Research01 Aug 1998
Nature Structural Biology

Volume: 5, P: 714-720
Effect of climate on traits of dominant and rare tree species in the world’s forests

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

Iris Hordijk
Lourens Poorter
Thomas W. Crowther
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-15
Ultraviolet photoabsorption by halocarbons 11 and 12 from electron impact measurements

RUSSELL H. HUEBNER
DAVID L. BUSHNELL JR
C. E. KUYATT
Research02 Oct 1975
Nature

Volume: 257, P: 376-378
Chemotherapy-induced adipo-lineage cell senescence drives bone loss

Chemotherapy induces bone loss that compromises skeletal health in cancer patients. Here, the authors show that chemotherapy-induced senescence in bone marrow adipo-lineage cells leads to bone loss and demonstrate that senolytic targeting of senescent cells preserves skeletal health during chemotherapy, providing a potential strategy to protect the skeleton in cancer therapy.

Ganesh Kumar Raut
Taylor Malachowski
Sheila A. Stewart
ResearchOpen Access30 Dec 2025
Nature Communications

Volume: 17, P: 1-20

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