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Korean scientist did not clone a human embryo but did clone a dog.

The study used snMultiome-seq to map gene expression and chromatin accessibility in human central amygdala cells from people with and without AUD. Here, the authors show that inhibitory neurons are most affected, with KLF16-driven regulatory changes and AUD-risk variants disrupting gene activity.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

In this multicenter phase 1 trial of patients with advanced solid tumors resistant to anti-PD-1 therapy, treatment with the anti-latent TGFβ1 antibody linavonkibart with or without pembrolizumab was safe, and encouraging clinical response rates were associated with T cell infiltration and immune activation.

Research in the tropics is unevenly distributed across regions and biomes. Here, the authors find that moist broadleaf forests account for 73% of all tropical citations but cover 29% of the land area, while drier, climate-vulnerable areas with fewer trees remain under-sampled and under-cited.

The authors present DNA-Diffusion, a generative AI framework that designs synthetic regulatory elements with tunable cell-type specificity. Experimental validation demonstrates their ability to reactivate AXIN2 expression, a leukemia-protective gene, in its native genomic context.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

To reach terabit density in random access memory devices, the select switching and storage components need to be improved. Here, the authors fabricate a fully stackable switching device based on chalcogenides, which reaches an exceptional performance following reactive nitrogen and nitrogen plasma treatments.

PU.1^low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunotherapeutic approaches for treatment.

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A ‘private’ visit by China's science and technology minister, to meet senior academics and industrialists in Taiwan appears to have helped pave the way for enhanced scientific and technological collaboration between two long-standing political rivals.

Asia seeks to capitalize on home-grown expertise.

We present the complete 62,460,029-base-pair sequence of a human Y chromosome from the HG002 genome (T2T-Y) that corrects multiple errors in GRCh38-Y and adds over 30 million base pairs of sequence to the reference.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Parity induces an accumulation of CD8⁺ T cells, including cells with a tissue-resident-memory-like phenotype within human normal breast tissue, offering long-term protection against triple-negative breast cancer.

A biologically informed, interpretable deep learning model has been developed to evaluate molecular drivers of resistance to cancer treatment, predict clinical outcomes and guide hypotheses on disease progression.

Reactive capture bypasses CO₂ regeneration, enabling efficient CO production but with low Faradaic efficiency. The authors report a Ni–N₃ molecular catalyst that resists amino acid adsorption and promotes efficient CO production in amino-acid systems.

Observational constraints, along with a better understanding of climate model behaviour, suggest that the projected weakening of the Atlantic meridional overturning circulation in the twenty-first century will be less severe than previously anticipated.

Controlling the alignment of bands at oxide interfaces is crucial for developing them into useful devices. By inserting charges into the interface to generate dipoles, Yajima et al. show tuning of the band alignment between SrRuO₃/Nb:SrTiO₃by 1.7 eV.

A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.

An atomic stencilling method based on the co-adsorption of iodide and 2-naphthalenethiol on gold is described, yielding more than 20 different types of nanoparticle with masked and painted regions and patchy particle morphologies not reported previously.

The nature of interfacial reconstructions at polar interfaces between transition metal oxides is known to be complex and difficult to characterize. Here, the authors quantify the atomic-scale charge distribution for manganite–titanate interfaces, spanning the manganite metal–insulator transition.

Magnetic reconnection has long been implicated in the acceleration of electrons to relativistic speeds in the Earth’s magnetosphere. Satellite observations and simulations indicate it is just part of the story, the rest of which involves a second process known as betatron acceleration.

Calcium-permeable AMPA receptors are identified to have a role in maintaining low feature selectivity in a specific population of inhibitory interneurons, and this function is conserved across ferrets, rodents, marmosets and humans.

The authors demonstrate strain-induced morphotropic phase boundary-like nanodomains in lead-free NaNbO₃ thin films, enabling multi-state switching and large enhancements in dielectric susceptibility and tunability over a broad frequency range.

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Unconventional unidirectional magnetoresistance observed in the heterostructures of a topological semimetal (WTe₂) and a magnetic insulator (Cr₂Ge₂Te₆) enables the electrical read-out of the magnetic states of a perpendicularly polarized magnet through longitudinal resistance measurements.

BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to provide evidence of variant pathogenicity.

This large meta-analysis of 11 GWAS identified 7 genetic loci associated with strabismus, esotropia and exotropia. Mendelian randomisation provided genetic evidence of the causal link between maternal smoking to increased strabismus risk in offspring.

Meta-analyses in up to 1.3 million individuals identify 87 rare-variant associations with blood pressure traits. On average, rare variants exhibit effects ~8 times larger than the mean effects of common variants and implicate candidate causal genes at associated regions.

A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.

Association analyses in over 1 million individuals identify 535 new loci influencing blood pressure traits. The results provide new insights into blood pressure regulation and highlight shared genetic architecture between blood pressure and lifestyle exposures.

The genetics and clinical consequences of resting heart rate (RHR) remain incompletely understood. Here, the authors discover new genetic variants associated with RHR and find that higher genetically predicted RHR decreases risk of atrial fibrillation and ischemic stroke.

Robust superconductivity is demonstrated in La₂PrNi₂O₇ thin films on a SrLaAlO₄ substrate.