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Cas9-based genome editing tools face challenges for efficient in vivo delivery due to their large size. Here, the authors present a set of compact genome-editing tools engineered from a CRISPR-associated IscB system which exhibit robust editing efficiency in human cells and mouse embryos.

Using time-resolved Coulomb-explosion imaging, the authors capture a 600 fs pseudorotation in the benzene cation, revealing coherent vibronic dynamics around a conical intersection and visualizing transient structural variations.

Universal femtosecond laser and spatial light modulation enable rapid fabrication of graphene-hybrid micro-supercapacitors on silicon. Simultaneous formation of ordered subwavelength electrode micro/nanostructures boosts processing efficiency and device performance.

Controlled doping of organic semiconductors is required to enhance charge injection in organic electronics, but the lack of suitable n-dopants with small ionization energy remains elusive. Here, the authors report air-stable metals that act as strong n-dopants in molecules with chelating ligands.

Antiferromagnets have negligible stray magnetic fields and are robust against magnetic perturbations, making them ideal for high-density magnetic memory. However, these features make electrically switching the Néel vector challenging. Here, Guo, Lin and coauthors demonstrate layer-dependent electrical switching of a van der Waals antiferromagnet.

Macrophage TP53-induced glycolysis and apoptosis regulator (TIGAR) is implicated in a range of immunopathology. Here the authors show TIGAR drives inflammation and sepsis via activation of TAK1 and that disruption of TIGAR-TAK1 interaction in a murine model of sepsis reduces immunopathology.

High-speed electrostatic micromotors with low energy consumption are attractive for small-scale electromechanical systems, but applications are limited by power supplies. Here the authors use a triboelectric nanogenerator for actuation of a high-speed micromotor by low-frequency mechanical stimuli.

Inspired by the regenerative capacity of deer antlers, Hao and colleagues report that antler blastema progenitor cell-derived extracellular vesicle treatment counteracts bone loss and epigenetic aging and is neuroprotective in mice and macaques.

The systematic ferroelectric domain control in ferroelectric CuInP₂S₆ systems has remained elusive. Herein, the authors report the efficient ferroelectric domain engineering under a unipolar electric field in CuIn₂S₆ system.

A new group of multi-principal-element alloys, designed through machine learning and extreme microstructural heterogeneities, achieve high strength (1.8-GPa yield strength) and ductility (25% uniform elongation) at room temperature.

Base editors lacking a deaminase improve thymine and cytosine conversion.

Whole-genome analysis of 103 Brucella melitensis isolates, compared to 850 global genomes, reveals a novel lineage in southwest China, with unique evolutionary patterns and geographic distribution that might contribute to pathogen evolution and spread.

Enhancing the toughness of hydrogels while maintaining biocompatibility is desirable for many biomedical applications. Here, Zhu et al. reports a strategy using peptide-based rigid nanorods for increased hydrogel toughness and compressive strength while preserving biocompatibility, demonstrating enhanced osteochondral repair and compatibility with additive manufacturing.

Prussian blue has been used as a photothermal agent for cancer therapy. Here the authors describe the production of Prussian blue nanoparticles from S. oneidensis MR-1 bacteria and show that a Prussian blue-based mitochondria-targeting nanoplatform potentiates response to immune checkpoint blockade.

A template-free magnetization strategy for inverse programming of hard-magnetic domains embedded in solvent-responsive hydrogel is reported using a photodosage-based printing method, achieving shape morphing into 3D curved surfaces under the actuation of a magnetic field.

A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

Modules of foldable crystalline silicon solar cells retain their power-conversion efficiency after being subjected to bending stress or exposure to air-flow simulations of a violent storm.

Aurora-A kinase is frequently over-expressed in tumours. Here, the authors show that it modulates the activity of lactate dehydrogenase B, resulting in enhanced glycolysis, bio-synthesis and tumour growth.

A study reports data from the first phase of the Chinese Pangenome Consortium including 116 de novo assemblies from 58 core samples representing 36 minority Chinese ethnic groups.

Nearly a century after dark matter was proposed, yet its nature remains elusive. Here, authors present their dark photon dark matter search results using two atomic magnetometer arrays 1700 km apart in large magnetic shields and offer the strongest terrestrial constraint in this mass range to date.

This study reveals that CYBDOM proteins promote drought tolerance by regenerating apoplastic ascorbic acid (AsA) and activating autophagy through interaction with RbohD, and link AsA redox, ROS and selective autophagy in plant stress responses

Orbital torque, arising from the orbital Hall effect, allows for the manipulation of magnetic order. Crucially, many light elements have large orbital Hall effects and therefore large orbital torques. Here, Zhang, Wei, Duan, Chen, and coauthors demonstrate efficient magnetization switching of Fe3GaTe2 using orbital torque.

TNS1, a focal adhesion protein that is upregulated during TGFβ -induced EMT, promotes metastasis of lung cancer via forming a positive feed-back loop with ZEB1, leading to ZEB1 upregulation by preventing its ubiquitin-proteasomal degradation.

Yang, Chen et al. present ModVAR, a multimodal tool that integrates DNA sequence, protein structure, and cancer omics to predict cancer driver variants. It performs strongly on validated benchmarks, flags potentially actionable variants supported by docking, and models changes in intrinsically disordered protein regions.

In this work, the authors report that citronellal stimulates skin renewal by promoting keratinocyte proliferation through the activation of TRPV3. Structural and functional analysis elucidate that essential oil ligands activate TRPV3 channels by competitively displacing endogenous lipids from the vanilloid site. These findings can help move skin healthcare forward.

Endothelial injury drives vascular diseases like atherosclerosis, but key regulators are unclear. Here, the authors show that endothelial major vault protein (MVP) acts as an intracellular regulator promoting Parkin-mediated mitophagy, thereby antagonizing vascular remodeling and suggesting its role as a potential therapeutic target.

To date the performance of molecular electronics compared to silicon limits their applications. Yang et al. develop the first mechano-optoelectronic switch based on mechanically controlled aggregation-induced emission of the self-assembled molecules, which can be reversibly switched at high speed.

Due to the polygenic nature of most diseases, simultaneous correction or introduction of single nucleotide variants is needed. Here, the authors demonstrated the feasibility of multiplex base editing for polygenes disease modeling in cynomolgus monkey embryos with high specificity.

Metabolic diseases are associated with chronic, low-grade inflammation. Here the authors show that major vault protein (MVP) suppresses NF-κB signalling in macrophages via an IRAK1–TRAF6 axis and that loss of MVP in myeloid cells exacerbates the inflammatory response in mice fed a high fat diet.

The structure of nanoparticles strongly influences their properties. Here, the authors use single crystal X-ray diffraction to resolve the crystal structures of Ag₁₃₆ and Ag₃₇₄nanoparticles, enabling the observation of local structure distortion and the lower size limit of surface plasmon resonance.

Innate lymphoid cells (ILC) have been shown to be involved in a range of inflammatory contexts but how their cellular lineage is regulated is not fully established. Here the authors show a role for circular RNA circTmem241 in the differentiation of ILC3 via initiation of Elk3 transcription.

Zhong et al. show that, in response to chimeric antigen receptor (CAR) T cell targeting, solid tumors increase the secretion of small extracellular vesicles carrying tumor antigens that are transferred to CAR T cells, resulting in fratricide and reduced antitumor activity.

A telomere-to-telomere genome assembly of allohexaploid bread wheat cv. Chinese Spring (CS-IAAS), along with transcriptomic and proteomic data, highlights wheat genome complexity and its structural and functional features.

The authors demonstrate a microfluidic spinning process for gradient aramid aerogels, with sheath and core layers of varied pore size, creating high thermal resistance at heat transfer interfaces, with radial thermal conductivity of 0.0228 W m⁻¹ K⁻¹

The hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.

Soft X-ray spectroscopy is a sensitive probe for electronic states in battery materials but has so far been mainly limited to ex situ work. Liu et al. develop in situ and operandosoft X-ray absorption spectroscopy, which leads to new findings of charge dynamics of lithium-ion battery cathodes.

Developing highly active and stable oxygen evolution electrocatalysts is crucial for enabling large-scale hydrogen production from seawater. Here, authors report a robust O₂-producing electrode for alkaline seawater, highlighting the critical role of distributed sites near the catalytic sites.

The CRISPR–Cas9-mediated generation of germline-transmissible mutations of SHANK3 in cynomolgus macaques (Macaca fascicularis) forms the basis of a non-human-primate model of autism spectrum disorder and Phelan–McDermid syndrome.

Despite the structural significance of boroxines in different classes of materials, their applicability in aqueous media is limited by their hydrolytic instability. Here, the authors discovered a water-stable boroxine structure with excellent pH stability and water-compatible dynamic covalent bonds.