Nature Search

Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990–2023: a Global Burden of Disease study

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Sooji Lee
Hayeon Lee
Dong Keon Yon
Research30 Mar 2026
Nature Medicine

P: 1-25
Radiofrequency cascade readout of coupled spin qubits

A dispersive sensing technique, termed the radiofrequency electron cascade, can perform singlet-triplet readout of two exchange-coupled electron spins in a natural silicon planar metal–oxide–semiconductor quantum-dot array.

Jacob F. Chittock-Wood
Ross C. C. Leon
M. Fernando Gonzalez-Zalba
ResearchOpen Access30 Mar 2026
Nature Electronics

Volume: 9, P: 314-323
Investigating the replicability of the social and behavioural sciences

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

Andrew H. Tyner
Anna Lou Abatayo
Timothy M. Errington
Research01 Apr 2026
Nature

Volume: 652, P: 143-150
Investigating the analytical robustness of the social and behavioural sciences

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Balazs Aczel
Barnabas Szaszi
Brian A. Nosek
Research01 Apr 2026
Nature

Volume: 652, P: 135-142
Retraction Note: Multisensory learning binds neurons into a cross-modal memory engram

Zeynep Okray
Pedro F. Jacob
Scott Waddell
Amendments and CorrectionsOpen Access25 Mar 2026
Nature

P: 1
A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia

Researchers show that a disease-causing Tau mutation disrupts the autophagy-lysosome pathway in human neurons, leading to Tau accumulation, and that enhancing autophagy can partially restore protein clearance.

Farzaneh S. Mirfakhar
Jacob A. Marsh
Celeste M. Karch
ResearchOpen Access31 Mar 2026
Nature Communications

Volume: 17, P: 1-21
Reproducibility and robustness of economics and political science research

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Abel Brodeur
Derek Mikola
Yaolang Zhong
Research01 Apr 2026
Nature

Volume: 652, P: 151-156
National identity predicts public health support during a global pandemic

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Jay J. Van Bavel
Aleksandra Cichocka
Paulo S. Boggio
ResearchOpen Access26 Jan 2022
Nature Communications

Volume: 13, P: 1-14
Magnetic resonance control of spin-correlated radical pair dynamics in vivo

Magnetic resonance control of spin-correlated radical pairs alters red fluorescent protein emission in transgenic Caenorhabditis elegans, demonstrating in vivo magnetic field modulation of biomolecular processes.

Shaun C. Burd
Nahal Bagheri
Mark Kasevich
Research18 Mar 2026
Nature

Volume: 651, P: 940-945
Empiric azithromycin alters the upper respiratory microbiome and resistome without anti-inflammatory benefit in COVID-19

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

Abigail Glascock
Cole Maguire
Charles R. Langelier
ResearchOpen Access16 Mar 2026
Nature Microbiology

P: 1-13
Deleterious coding variation associated with autism is shared across ancestries

Genetic analyses in more than 15,000 individuals from across the Americas, including individuals with autism and family members, define the genetic landscape of autism in Latin American populations and identify significant overlap with other ancestries.

Marina Natividad Avila
Seulgi Jung
Joseph D. Buxbaum
ResearchOpen Access30 Mar 2026
Nature Medicine

P: 1-11
Infective Ribonucleic Acid Component of Cells Infected by Encephalomyocarditis Virus

A. J. D. BELLETT
A. T. H. BURNESS
F. KINGSLEY SANDERS
Research01 Sept 1962
Nature

Volume: 195, P: 874
Functional dissection of complex trait variants at single-nucleotide resolution

Massively parallel reporter assays across five cell types identify thousands of causal, noncoding regulatory variants among 220,000 loci, revealing diverse regulatory mechanisms shaping complex traits and disease.

Layla Siraj
Rodrigo I. Castro
Ryan Tewhey
ResearchOpen Access25 Feb 2026
Nature

P: 1-11
Astronomical tuning of the Aptian stage and its implications for age recalibrations and paleoclimatic events

The Early Cretaceous Aptian stage represents an interval of major dramatic climate changes, but there is no consensus on its lower boundary age. Here, the authors present an astro-chronological framework that offers new age constraints on the onset and duration of Aptian ocean anoxic events and the ‘cold snap’, among other significant climatic events.

C. G. Leandro
J. F. Savian
R. I. F. Trindade
ResearchOpen Access26 May 2022
Nature Communications

Volume: 13, P: 1-12
Adult ADHD with comorbid major depression shows a distinguishable polygenic pattern and negative cognitive style

Thorsten M. Kranz
Rhiannon V. McNeill
Georg C. Ziegler
ResearchOpen Access04 Apr 2026
Translational Psychiatry

P: 1-9
Native protein nanolithography that can write, read and erase

Ali Tinazli
Jacob Piehler
Robert Tampé
Research18 Mar 2007
Nature Nanotechnology

Volume: 2, P: 220-225
Transfer of a Neomycin–Kanamycin Resistance Determinant by the F Factor of Escherichia coli K12

E. S. ANDERSON
JUNE N. MAYHEW
N. D. F. GRINDLEY
Research26 Apr 1969
Nature

Volume: 222, P: 349-351
Multidimensional profiling of heterogeneity in supratentorial ependymomas

Individual supratentorial ependymoma tumour subgroups have two distinct progenitor-like cell states—neuroepithelial-like and embryonic-like—that are reminiscent of early human brain development and diverge in the extent of their neuronal or ependymal differentiation.

Daeun Jeong
Sara G. Danielli
Mariella G. Filbin
ResearchOpen Access11 Mar 2026
Nature

P: 1-11
ERCC6L2 ensures repair fidelity for staggered-end DNA double-strand breaks

Structural features of DNA double-strand break (DSB) ends play key roles in determining DNA repair pathway usage and outcomes. Here, the authors identify ERCC6L2, a poorly characterized ATPase, as playing a minimal role in blunt end DSB repair but crucial for repair of staggered end DSBs.

Eric J. Aird
Almudena Serrano-Benitez
Stephen P. Jackson
ResearchOpen Access25 Feb 2026
Nature Communications

Volume: 17, P: 1-19
Acinetobacter baumannii’s lifestyle includes soil-dwelling colonization of decaying plant material and airborne spread

Little is known about the ecology and evolution of the nosocomial pathogen Acinetobacter baumannii outside the hospital. Here, Wilharm et al. show that the lifestyle of A. baumannii includes soil-dwelling and airborne dissemination, which helps to explain its adaptability and predisposition to establish within hospitals.

Gottfried Wilharm
Evelyn Skiebe
Leszek Jerzak
ResearchOpen Access10 Mar 2026
Nature Communications

Volume: 17, P: 1-19
An Unstable Intermediate Carrying Information from Genes to Ribosomes for Protein Synthesis

S. BRENNER
F. JACOB
M. MESELSON
Research13 May 1961
Nature

Volume: 190, P: 576-581
Representativeness of the Danish Blood Donor Study relative to the general population: a cross-sectional assessment

Jacob Træholt
Dorte Helenius
Sisse R. Ostrowski
ResearchOpen Access19 Mar 2026
Scientific Reports

P: 1-14
Broadly stable atmospheric CO₂ and CH₄ levels over the past 3 million years

Blue ice records from Antarctica are used to determine methane and carbon dioxide concentrations over the past 3 million years.

Julia Marks-Peterson
Sarah Shackleton
Edward Brook
Research18 Mar 2026
Nature

Volume: 651, P: 647-652
Global ocean heat content over the past 3 million years

Estimates of mean ocean temperature based on noble gas (Xe/Kr) measurements in shallow ice cores from the Allan Hills blue ice area, Antarctica, indicate enhanced cooling around the Plio-Pleistocene Transition and enhanced ice sheet growth around the time of the Mid-Pleistocene Transition.

Sarah Shackleton
Valens Hishamunda
John Higgins
Research18 Mar 2026
Nature

Volume: 651, P: 653-657
Inference on inner galaxy structure via gravitational waves from supermassive binaries

The lowest-frequency gravitational wave background may be shaped by supermassive black hole binaries that scatter nearby stars or dark matter. In this case, the NANOGrav 15-year dataset favours dense galactic centres with 10⁶ solar masses per cubic parsec.

Yifan Chen
Matthias Daniel
Olivia Young
Research05 Feb 2026
Nature Astronomy

P: 1-10
A Suggested Phenotypic Classification and Terminology for Enzyme Mutants in Micro-Organisms

J. F. COLLINS
J. MANDELSTAM
P. H. A. SNEATH
Research27 Nov 1965
Nature

Volume: 208, P: 841-843
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Both environmental factors and genetic factors influence human immunity. Albert and colleagues leverage data from the Milieu Intérieur Consortium to comprehensively describe the effects of lifestyle, environment and genetics on human innate and adaptive immunity.

Etienne Patin
Milena Hasan
Matthew L. Albert
Research23 Feb 2018
Nature Immunology

Volume: 19, P: 302-314
Selective Alterations of Mammalian Messenger-RNA Synthesis: Evidence for Differential Action of Hormones on Gene Transcription

CHEV KIDSON
K. S. KIRBY
Research08 Aug 1964
Nature

Volume: 203, P: 599-603
Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation

Population-based studies from Sweden with replication in Norway identify associations between host genetic variants and gut microbial composition and implicate short-chain fatty acid chemosensors as modulators of gut microbial richness.

Koen F. Dekkers
Kamalita Pertiwi
Tove Fall
ResearchOpen Access13 Feb 2026
Nature Genetics

Volume: 58, P: 540-549
Case-matched comparison of combined phacoemulsification with ab-interno trabeculectomy via Kahook dual blade and trabectome in a Caucasian population

David Kiessling
Hannah Bleiel
Alexandra Lappas
ResearchOpen Access13 Mar 2026
Scientific Reports

Volume: 16, P: 1-7
Prioritizing neglected food species in nutritional studies using expert-knowledge and explainable AI

Michelle Cristine Medeiros Jacob
Aline Martins de Carvalho
Ulysses Paulino Albuquerque
ResearchOpen Access02 Mar 2026
Scientific Reports

P: 1-14
Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid

P. BROOKES
P. D. LAWLEY
Research23 May 1964
Nature

Volume: 202, P: 781-784
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

Volume: 32, P: 527-544
Fracture Repair After Treatment with Deoxyribonucleic Acid from Fish

E. A. TONNA
E. P. CRONKITE
F. J. SANEN
Research14 Jul 1962
Nature

Volume: 195, P: 157-159
Human and mouse embryonal carcinoma cells in culture share an embryonic antigen (F9)

STUART HOLDEN
OLIVIER BERNARD
DOROTHEA BENNETT
Research08 Dec 1977
Nature

Volume: 270, P: 518-520
Seasonal Variation and Age of Radioactive Fall-Out

R. P. PARKER
J. O. CROOKALL
Research13 May 1961
Nature

Volume: 190, P: 574-576
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
A novel chronostratigraphic framework for the Aptian–Albian paleoclimate events

João M. F. Ramos
Jairo F. Savian
Ricardo I. F. Trindade
ResearchOpen Access20 Jan 2026
Scientific Reports

Volume: 16, P: 1-17
Mechanisms of Regulation of Hepatic Glycogen Synthesis

DONALD F. STEINER
Research01 Dec 1964
Nature

Volume: 204, P: 1171-1173
Role of Histones and other Proteins in Gene Control

J. A. V. BUTLER
Research01 Sept 1965
Nature

Volume: 207, P: 1041-1042
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Genetic modifiers of APOE-ε4-associated cognitive decline

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Alex G. Contreras
Skylar Walters
Timothy J. Hohman
ResearchOpen Access20 Feb 2026
Nature Communications

Volume: 17, P: 1-17
A Stellar magnesium to silicon ratio in the atmosphere of an exoplanet

Spectroscopic observations of the ultra-hot Jupiter WASP-189b reveal both volatile (H₂O, CO, OH) and refractory (Fe, Mg, Si) gas in its atmosphere. Here, the authors show that the abundance ratio of refractory species reflects that of the host star.

Jorge A. Sanchez
Peter C. B. Smith
Joost P. Wardenier
ResearchOpen Access18 Feb 2026
Nature Communications

Volume: 17, P: 1-9
Direct detection of cosmic-ray-excited H₂ in interstellar space

The famous nebula Barnard 68 has been used as a giant cosmic-ray detector: cosmic-ray-excited vibrational H₂ emission has been observed by JWST, giving a direct measurement of the CR ionization rate.

Shmuel Bialy
Amit Chemke
Ekaterina I. Makarenko
Research03 Feb 2026
Nature Astronomy

P: 1-8
Evaluating the environmental response of Rembrandt’s The Night Watch (1642) using water sorption experiments and diffusion modelling

Jorien R. Duivenvoorden
Esther van Duijn
Katrien Keune
ResearchOpen Access20 Mar 2026
npj Heritage Science

Volume: 14, P: 1-13
Coral microbiomes as reservoirs of unknown genomic and biosynthetic diversity

Reconstructing microbial genomes from 820 reef-building corals collected at 99 reefs across 32 islands throughout the Pacific Ocean highlights the importance of conserving coral reefs as vital reservoirs of molecular diversity.

Fabienne Wiederkehr
Lucas Paoli
Shinichi Sunagawa
ResearchOpen Access25 Feb 2026
Nature

P: 1-8
Anti-inflammatory therapy with low-dose IL-2 in acute coronary syndromes: a randomized phase 2 trial

In a randomized phase 2 trial in patients with acute coronary syndrome and high levels of the inflammation biomarker C-reactive protein, treatment with low-dose interleukin-2 increased the numbers of regulatory T cells and reduced arterial inflammation, compared to placebo.

Rouchelle S. Sriranjan-Rothwell
Tian X. Zhao
Leanne Masters
ResearchOpen Access08 Jan 2026
Nature Medicine

Volume: 32, P: 624-632
Genome-wide screen reveals dependence of break induced replication on several distinct checkpoints

Break-induced replication (BIR) repairs broken DNA but can also destabilize genomes. The authors identify 33 new genes controlling BIR completion, showing that spindle assembly and spindle positioning checkpoints coordinate repair, and that nuclear pore proteins regulate BIR at multiple steps.

Liping Liu
Rosemary S. Lee
Anna Malkova
ResearchOpen Access15 Dec 2025
Nature Communications

Volume: 17, P: 1-16
A Strong Suppressor Specific for UGA

J. F. SAMBROOK
D. P. FAN
S. BRENNER
Research14 Apr 1967
Nature

Volume: 214, P: 452-453

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