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Replicating enzyme function with minimal components is a major challenge in abiotic mimicry. Here, the authors show that liquid gallium droplets act as tunable artificial nucleases, cleaving DNA with nucleotide bias via oxide-mediated adsorption and hydroxyl radical-assisted hydrolysis.

Chaotic frequency comb, possessing the key metrics of intrinsic random amplitude, phase, and frequency modulation of comb lines, emerges as a novel chaotic source in information processing. Here, the authors propose and theoretically demonstrate magnonic chaotic frequency combs based on ultra-strong magnon-magnon coupling mechanism.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Mechanical frequency combs are promising for precision measurements, sensing, and metrology blew Gigahertz. Here, authors introduce a magneto-mechanical frequency comb including its integer- and half-integer-harmonic combs via magnetostrictive effect with the teeth spacing that can be continuously tuned.

This work demonstrates that embedding MnCoGe particles within magnesium alloys transforms the irreversible thermal expansion into a self-compensating behavior, yielding zero thermal expansion from 25 to 150 °C while retaining high strength and ultralow density.

Xu et al. report that CDK10 drives immune evasion by reducing nucleic acid sensors-mediated innate immune response in tumor cells and that its inhibition improves response to immune-checkpoint blockade in preclinical cancer models.

Intramolecular proton relays are proposed to enhance oxygen evolution for heterogeneous (hydro)oxide electrocatalysts, but molecular-level evidence remains limited. Now it has been shown, using an aza-fused microporous polymer with Ni–Fe sites, that adjacent Ni³⁺–OH sites relay protons from Fe⁴⁺=O, accelerating the water nucleophilic attack pathway and achieving high turnover frequencies with pH-tunable kinetics.

The ZFTA–RELA fusion, an oncogene for ependymomas, promotes the production of itaconate, and its dependence on this metabolite represents a new therapeutic target for this cancer.

Xuejun Zhang, Jun Wang, Liangdan Sun, Lennart Hammarström and colleagues sequence the MHC region in 20,635 Han Chinese individuals. Their Han-MHC database allows identification of new susceptibility loci for psoriasis and could serve as a tool for investigating the role of the MHC region in other complex diseases.

Pervaporation is a promising technique for treating high-salinity water, although it requires high temperatures to operate efficiently. By contrast, a solar–vacuum dual-driven desalination system utilizing a photo-responsive covalent organic framework enables highly effective desalination at ambient temperatures and achieves exceptional salt removal and water flux.

Min Deng, Kai Wang and colleagues report genome-wide association analyses of amyotrophic lateral sclerosis in the Han Chinese population. They identify two new risk loci at 1q32 and 22p11.

A study finds that RUVBL2 is a conserved component of eukaryotic circadian clocks and suggests that slow ATPase activity, which was initially discovered in cyanobacteria, is a shared feature of eukaryotic clocks.

Single-atom catalysts commonly present a random distribution of the active metal centres. Now a series of Mg-rich intermetallic compounds is introduced to enable ordered dispersed active metals. Furthermore, a cascade process is demonstrated on Mg₂₉Pd_1.3Rh_2.7, where Pd sites catalyse the semihydrogenation of phenylacetylene with subsequent hydroformylation on Rh sites.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Proton-coupled electron transfer (PCET) process is very important for water oxidation catalysis. Here, the authors introduced uncoordinated carboxylate in the second-coordination-sphere of Ni-Fe coordination polymer catalyst as an internal base to promote the water oxidation kinetics by such PCET process.

Introduction of any interface will inevitably lead to a decrease in carrier mobility. Here, authors employ atomic layer deposition technology to construct composite phase interfaces, decoupling the interrelated thermoelectric parameters in n-type ZrNiSn materials.

The application of quantum computing to computational chemistry faces various experimental and theoretical challenges. Now, a quantum simulation on a noisy quantum device has achieved chemical accuracy for small H₂ and LiH molecules.

Poor availability and access to clean water is a fundamental sustainability challenge facing our society. Here the authors show that covalent organic framework membranes enable excellent performance in seawater desalination including high permeation flux and fouling resistance, providing a promising technological solution.

A scalable approach is provided for preparing and verifying intermediate-scale genuine entanglement on a 66-qubit superconducting quantum processor.

The mechanism of HIV-1 latency reversal remains unclear. The authors suggest that PRMT3 drives the reversal by enhancing chromatin accessibility to form a transcriptional hub containing TEAD4 and P-TEFb at the viral promoter.

In locusts, the aggregation pheromone 4-vinylanisole is derived from dietary phenylalanine, and its production is dependent on two 4-vinylphenol methyltransferases that are potential targets for locust pest control.

Psoriasis is a chronic inflammatory disease affecting up to 3% of the population. Here, Zuo et al.perform exome array analysis, identify single-nucleotide polymorphisms at 15 new loci, implicating several biological pathways in psoriasis risk and disease heritability.

Although psoriasis is a chronic disorder affecting approximately 2% of the population, little is known about the underlying genetic architecture. Here, the authors carry out exome sequencing in a large Han Chinese cohort of psoriasis patients and healthy controls, and identify three new genes that may increase risk of developing the disease.

Here the authors unveil the essential role of MCL-1 for adult hair follicle regeneration and inhibition of proliferation stress-induced apoptosis in mice. They also identify a P53/MCL-1/BAK axis balancing proliferation and death of activated hair follicle stem cells to ensure proper hair growth.

Genetic risk loci for tuberculosis (TB) have so far been identified in African and Russian populations. Here, the authors perform a three-stage GWAS for TB in Han Chinese populations and find two risk loci near ESRRB and TGM6 and further demonstrate that tgm6 protects mice from Mtb infection.

Symmetry breaking and chiral amplification are fundamental principles in chemistry and biology but the control of initial chiral bias remains a great challenge. Here the authors show that chiral microvortices can lead to a selection of initial chiral bias of supramolecular systems composed of achiral molecules.

Deep-strong coupling in hybrid magnonic systems is yet to be explored. Here, the authors unveil unconventional coupling properties in synthetic antiferromagnets. The systems’ high degree of freedom enables a near-realization of deep-strong coupling.

Lead halide perovskites excel in optical and electronic properties, drawing significant attention in solar fuel studies. Here, the authors report a stable FAPbBr₃ photoanode optimized for water oxidation to achieve a low onset potential and high applied bias photon-to-current efficiency.

Non-syndromic cleft lip with palate is a common birth defect of unknown aetiology. Here, the authors discover 14 new genes associated with this condition, and show genetic heterogeneity in this and other non-syndromic orofacial clefting disorders.

Zinc-finger nickases are programmable nucleases that can be used to generate site-specific single-strand breaks in DNA. Liu et al. use this technology to insert an antimicrobial gene into the endogenous beta-casein locus in cloned cows, with the aim of providing protection against mastitis.

Xuejun Zhang, Jun Wang and colleagues report the application of exome sequencing to a large collection of psoriasis cases and controls. They identify seven common and low-frequency nonsynonymous variants within known psoriasis susceptibility genes that are associated with psoriasis risk.

This Resource describes data, code and tools developed for the Human Reference Atlas and the Human BioMolecular Atlas Program for building and navigating a multiscale human atlas.

Qing Lan and colleagues report the results of a genome-wide association study of lung cancer in never-smoking women from Asia. They identify three new susceptibility loci and confirm three other previously reported associations.