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Tau aggregates disrupt heterochromatin by sequestering H3K9me3, reactivating transposable elements. This generates Z-RNAs, activating ZBP1 to drive neuronal death. ZBP1 haploinsufficiency reverses cognitive decline in aged tau mice, offering a therapeutic target for tauopathies.

A reconstruction method based on Gaussian-apodized single-sideband electron ptychography removes artefacts to enable the high-fidelity identification of guest species in porous materials.

This study shows how mechanical stretch drives lipid metabolic reprogramming in human cavernous fibroblasts. The identified transition from fatty acids to gangliosides offers potential therapeutic targets for fibrosis-related diseases.

Cold tolerance at the booting stage is critical for the expansion of rice cultivation area. Here, the authors report that a CAMTA family transcription factor encoding gene CTB3 positively regulates japonica rice booting stage cold tolerance and its upstream and downstream interactors to fulfill the functionality.

Endocsymbiosis is known to fuel deep-sea life, while ectosymbiosis remains poorly understood. Analysing the genome of a cold-seep scallop, this study uncovers key adaptations to the deep sea and metabolic complementarity with chemosynthetic bacteria on its gill surface.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Electrosynthesis of amino acids is a transformative but challenging strategy. Here, the authors report a Sn catalyst in driving amino acid production at ampere-level current densities and reveal the role of catalyst dynamic reconstruction and microenvironment in controlling the reaction mechanism.

This study looks at Jiang Han Road in Wuhan, one of the most influential shopping streets in the city center, and examines the impacts of digitalization in the post-COVID era. It found a shift in the economic activity towards socialization in the digital space, and revealed key socioeconomic-spatial patterns fostering the adaptive capacity of the street.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Xue-Jun Zhang, Zhi-Rong Yao and colleagues report a genome-wide association study for atopic dermatitis in the Chinese Han population. They identified two new susceptibility loci at 5q22 and 20q13.

Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8⁺ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

Electric vehicles support decarbonization but raise critical material demand, which is often misestimated due to overlooked real-world and heterogeneous characteristics. Here, the authors use a bottom-up multi-dataset fusion approach to characterize segment mix, battery capacity, and battery chemistry across five passenger vehicle segments covering China’s 31 provinces and 29 EU countries.

How the brain organizes the retrieval of old and new memories remains unknown. Kim et al. identify a septo−entorhinal GABAergic pathway that controls flexible switching between episodic memories during memory retrieval to enable memory updating.

Solution processing of 2D/3D perovskite structures for solar cells offers limited control over layer formation. Lee et al. propose a dry approach, bringing the 2D and 3D perovskite layers into physical contact, to enhance the quality of the perovskite film.

Algal biomass declined while eukaryotic diversity increased and cyanobacterial diversity decreased after the 2000s as wetlands expanded, shown by reconstructing multi decadal algal communities using sedimentary ancient DNA and pigments from a glacier fed Tibetan alpine lake.

Genetic basis of the drought tolerance of upland rice is unclear. Here, the authors report the cloning of a COBRA-like protein encoding gene DROT1 and reveal that it is repressed by ERF3 and activated by ERF71 to help control the balance between growth and drought tolerance in upland rice.

The skin’s tanning response to sun exposure shows great interindividual variability. Here, Visconti et al. perform a genome-wide association study for ease of skin tanning and identify 20 genetic loci, ten of which had not previously been associated with pigmentation-related traits.

Our investigation highlights substantial heterogeneity in islet cell composition associated with hormone secretory traits, sex, reported race and ethnicity, genetically predicted ancestry, and genetic risk for type 2 diabetes (T2D).

Targeted degradation of proteins has therapeutic potential for a range of diseases. Here the authors report on an endosome-phagosome linking assembly for autophagic degradation of membrane and extracellular proteins, demonstrating degradation of a range of proteins of therapeutic interest.

Two-dimensional perovskite phases at the bottom interfaces of solar cells improve performance, but their formation is challenging. To address this, Zhao et al. graft the 2D perovskite-phase precursor onto a functionalized SnO₂ electrode substrate.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

The underlying strategies to tackle A-site inhomogeneity of Rb-alloyed wide bandgap perovskites remain under investigation. Here, authors incorporate a melamine additive as a phase uniformity regulator, achieving stabilized efficiency of 33.5% for two-terminal perovskite/silicon tandem solar cells.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Reversible solid oxide cells can be limited by the kinetics of the reactions occurring at the oxygen electrode. Here the authors show that compositing a Gd_0.3Ca_2.7Co_3.82Cu_0.18O_9−δ catalyst with a balanced oxygen-ion- and hole-conducting BaCe_1−xZr_xO₃-based material leads to enhancements in performance.

Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.

Cellist is a computationally efficient cell-segmentation method combining imaging and expression data from spatial transcriptomics across different technologies.

A set of hydroxy promoters physically mixed with cobalt oxides for syngas to light olefins conversion using Fischer–Tropsch synthesis is shown to boost catalyst performance as well as simplifying the process and increasing sustainability.

Zhu et al. have developed DeepFAN, a transformer-based deep learning model for diagnosis of incidental pulmonary nodules from computed tomography scans, and evaluated it for human–artificial intelligence collaboration in a multireader, multicase clinical trial.

High-nickel layered positive electrodes suffer from lattice oxygen loss and inherent lattice strain. Here, authors report a self-derived subtractive strategy to form a coherent spinel-phase shell with tunable thickness to confine active oxygen intermediates and suppresses interfacial side reactions.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Coating additive solutions onto wet perovskite films in situ enables flexible all-perovskite tandem solar cells with a certified power conversion efficiency of 23.0% for a module with an aperture area of 20.26 cm². The modules maintain 97% of their initial efficiency after 10,000 bending cycles with a 10 mm radius.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Persistent luminescence is promising for photodynamic therapy in deep-seated tumors, but the uncontrollability of light within the body complicates precise spatiotemporal regulation. Here, the authors report X-ray preactivated elimusertib-loaded tumor-targeted photodynamic nanoparticles with controllable “on-off-on” afterglow properties for the treatment of deep-seated tumors.

Stacking XA48-mediated effector-triggered immunity with XA21-mediated pattern-triggered immunity in Oryza sativa japonica reconstitutes the broad-spectrum resistance from wild rice.

Nongovernmental organizations play an important role in urban green space development. Analyzing a rich body of qualitative data, this study finds that Beijing nongovernmental organizations make a strategic choice: to promote procedural and recognitional justice but downplay distributional inequalities.

An artificial retina consisting of near-infrared-sensitive phototransistors and three-dimensional liquid metal electrodes can be adhered to the epiretinal surface to stimulate retinal ganglion cells, extending vision in mice with a retinal degenerative disease.

Imprinting by influenza viruses can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes.