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Conventional rechargeable zinc-air batteries face slow kinetics and thermodynamic incompatibility. Here, the authors propose a dual-cathode zinc-ethylene glycol/air battery, enabling concurrent efficient electricity generation and electro-reforming of plastic wastes into high-value C2 chemicals.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Two-dimensional boridene supports neuromorphic optoelectronic computing through anomalous electrical anisotropy. Its low-temperature deposition supports back-end-of-line-compatible fabrication of twelve-inch wafer arrays.

Organo-electrocatalysts that can be used for both inorganic and organic conversions have been reported, ranging from laboratory-scale to large-scale reactions. This work demonstrates the application of a range of amide-based catalysts on electrodes to drive various reactions, including the chlorine evolution reaction and other chlorine-related organic transformations.

Sphingolipids mediate inflammation, although the role of lipid aldehyde 2-HD is poorly understood. Here, the authors show ALDH3B1 detoxifies 2-HD to protect retinal vasculature, with 2HD accumulation causing vascular abnormalities.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

The fabrication of conventional artificial chemoreceptors are difficult to scale up. Here a wafer scale cell-on-memristor chemoreceptive array is reported, allowing for self-powered biosensing and in situ spike encoding.

This study identifies parallel gut–brain pathways that fine-tune feeding. Distinct brainstem neurons and visceral afferents either sense esophageal stretch to regulate eating speed or detect gut nutrients to shape long-term food choices and satiety.

Rancid odors trigger retching and aversion. Here, authors show a nose-to-brain axis whereby such odors activate olfactory-piriform circuits that diverge to mediodorsal thalamic nucleus and nucleus accumbens to mediate retching-like behavior and aversion.

Achieving truly continuous and precise analog calculations using DNA neural networks is challenging. Here, the authors develop a fully analog DNA neural network system called CALCUL, that performs highly accurate weighted-sum operations and can be recycled.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

A wearable human–machine interface combines inertial and electromyography sensors with deep learning to robustly extract gesture signals and enable real-time robotic control under diverse motion artefacts in dynamic environments.

One strategy to address multidrug resistance in cancer is the development of modular methods to access bioactive scaffolds. Here, the authors report a Rh(III)-catalyzed carboxylic acid-directed C(sp²)−H allylation and apply it to the modular synthesis of (Z)-allylic macrolides which enhance antitumoral drug activity.

Heterostructures of indium gallium zinc oxide and tungsten diselenide can be used to create phototransistor arrays capable of three-dimensional morphology reconstruction, two-dimensional depth field mapping and multi-view coupling.

The authors realize a two-dimensional hybrid perovskite with robust multiaxial ferroelectricity and nonlinear optical response via molecular fluorination and lone pair expression of Ge²⁺, enabling prominent piezoelectric sensing in composite device

In the pre-synapse, vesicle fusion is a key process for neurotransmitter release in the nervous system. Here authors demonstrate under pathological condition, synaptotagmin1 with Zn²⁺ adopts an alternative mode to regulate spontaneous neurotransmitter release.

The synthesis of carbon dots with efficient solid-state emission is difficult, requiring harsh conditions. Here, the authors develop a mild molten-salt synthesis route and use machine learning to optimize the luminous efficiency of carbon dots.

Small molecule NIR-II fluorophores are of interest for a range of applications but can suffer from chemical and photostability issues. Here, the authors report on the development of an acceptor molecule with improved stability in alkaline conditions expanding the range of possible applications.

While the synthesis of hollow structures of transition metal oxides is well established, the related sulfide chemistry remains challenging. Here, the authors report the synthesis of nickel cobalt sulfide ball-in-ball hollow spheres, via anion exchange, and evaluate their pseudocapacitive behaviour.

This work achieves a flexible organic ferroelectric crystal with interesting plasticity by implementing fluorination on anion, making it a competitive candidate for flexible and wearable devices.

To make Mars colonization cheaper by reducing the heavy supplies needed from Earth, scientists have created a highly efficient recycling system that turns carbon dioxide and hydrogen into fresh water and rocket fuel (methane), and it works reliably even with the inconsistent solar power available on Mars.

Animals can fear specific objects with no previous experience. For example, naive mice are innately afraid of cats. Here the authors employed optogenet­ics and behavioral assays to determine the neural circuit mechanisms involved in mediating olfactory cue–induced innate fear in mice.

Serine is an important biomarker for skin healthcare. Here, the authors introduce a portable epidermal sensing system capable of direct sampling and in situ quantification of serine on the skin for personalized skin healthcare.

Drone flight safety is challenged in the landing phase, especially in windy conditions. Hao Xiong and colleagues propose a reinforcement learning-based trajectory planner to balance multiple landing-related objectives based on onboard wind sensory capability.

Wu and colleagues identify gene networks and transcription factors that control the differentiation of stem-like CD8+ CAR T cells into effector or exhausted CD8⁺ CAR T cells.

Li et al. identified GSH as a signaling molecule that triggers wound-induced systemic [Ca^2 +]_cyt transmission, activates JA biosynthesis, and regulates plant defense responses, highlighting the complex mechanisms of plant systemic defense signaling.

Undefined vacuole-like ultrastructures between epididymal cells have been observed. Here, the authors reveal that these structures contain organelle residues and protein aggregates that suggest a reservoir for protein recycling.

Lithium–sulphur batteries are a promising candidate for next-generation electrochemical energy storage. Here, the authors report a facile strategy for covalent stabilization of sulphur and its discharge products on amino-functionalized reduced graphene oxide, which enhances the cycling stability.

An echomyography system based on a single transducer can be integrated into a wearable patch and used to monitor breathing patterns and hand gestures.

Genetic, biochemical and high-resolution structural studies of chloroplast protein SOQ1 reveal the existence of a C-terminal lumenal domain with potential redox function and its essential role for suppressing photoprotection in plants.

Secondary phases or multi-step phase formation lead to poorly crystallized and defective kesterite films. Now Zhou et al. convert precursors into kesterite in a single step, using low partial pressure of selenium, and achieve solar cells with 13.8% certified efficiency.

Disulfiram is an FDA-approved drug for treating alcoholism. Wu and colleagues show that disulfiram can be repurposed to efficiently inhibit pyroptosis by specifically blocking gasdermin-mediated pore formation.

Characterization of full-length genome sequences from patients infected with a new coronavirus (2019-nCoV) shows that the sequences are nearly identical and indicates that the virus is related to a bat coronavirus.

In a prespecified interim analysis of the multicenter, randomized, phase 3 FLAMES trial, maintenance therapy with a PARP inhibitor in patients with ovarian cancer showed prolonged progression-free survival compared with placebo in all subgroups defined by BRCA or homologous recombination status.