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Delamination and cracking hinder the durability of air electrodes in ceramic cells. Here, the authors introduce oxide wedging at particle interfaces to enhance mechanical robustness and thermal compatibility, significantly improving electrode longevity.

The authors experimentally demonstrate the coexistence of superconductivity and ferroelectricity at LaAlO₃/KTaO₃ interfaces. The superconducting transition temperature is enhanced due to ferroelectric polarization-induced reduction in dielectric constant, which narrows the interfacial potential well, confining carriers closer to the interface.

Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding.

LRBA deficiency is associated with autoimmune disease and CTLA4 loss; this study identifies LRBA as a negative regulator of antitumor immunity and introduces LC427 as a promising small-molecule inhibitor of the CTLA4-LRBA interaction for cancer immunotherapy.

High-throughput chemical ligand discovery is challenged by false positives. Here, authors introduce a scalable enantioselective affinity-selection mass spectrometry approach for proteome-wide ligand discovery with high sensitivity and selectivity

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

The safety profile of proton pump inhibitor (PPI) use remains controversial. Here, the authors show that PPI use is associated with an increased risk of 15 leading global diseases, with absolute risks increasing with baseline risks, highlighting the need for personalized PPI use strategies.

Absorption in one-port passive systems is known to be bound by causality constraints. Here, authors study reflection and transmission of a two-port system to introduce a generalized causality constraint based on duality symmetry. Experimentally, the broadened bandwidth of their meta-absorbers shows the untapped absorption potential of broadband acoustic metamaterials.

Tools to identify who will develop Crohn’s disease in the future are limited. Here, the authors develop and validate a proteomics-based model that predicts disease onset up to 16 years before clinical diagnosis.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

The rapid preparation of highly crystalline covalent organic framework membranes is challenging. Here, the authors show a reverse-phase microemulsion interfacial polymerization to rapidly prepare large-area covalent organic framework membranes in tens of seconds applied to protein desalination.

Gut microbiota influence bone health, but the genetic and metabolic mechanisms are unclear. Here, the authors show that specific bifidobacterial taxa causally reduce bone mineral density, partly via n-3 fatty acid metabolism, highlighting host-microbe interactions with potential therapeutic implications.

The authors demonstrate that a cell’s external environment can physically control its genes. Osmotic pressure alters intranuclear crowding, shifting the equilibrium of proteins binding to dCas9-SunTag complex and thereby regulating gene expression.

The pathogenicity and transmissibility of SARS-CoV-2 in golden (Syrian) hamsters resemble features of COVID-19 in human patients, suggesting that these hamsters could be used to model this disease.

Vector-stimuli-responsive magnetorheological fibrous materials can be mass-produced, which can be assembled into yarns and woven into a variety of fabrics with actuation and stiffening abilities.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Influenza A infection results in γδ T cell influx and production of IL-17 in the lungs. Here, the authors show that this effect is primed by CD1-restricted ligands that are released by infected cells and presented by B1a cells in the lungs.

Data heterogeneity presents a challenge in distributed artificial intelligence (AI) for medical imaging across diverse clinical settings. Here, the authors develop HeteroSync Learning, a privacy-preserving distributed learning framework that mitigates data heterogeneity and outperforms classical, state-of-the-art, and foundation models.

In this work, authors present their goal-directed subgroup identification (GD-SI) framework, reconciling biological heterogeneity with clinical actionability, and offering a scalable infrastructure for precision trial design and personalized sepsis management.

Achieving selective and precise modification of macromolecules under biocompatible conditions (such as aqueous solutions, mild temperatures, and neutral pH) remains a significant technical challenge. Here, the authors develop a photoinduced coupling reaction based on N-hydroxy naphthalimide esters, which is effective in biologically relevant conditions.

The authors provide evidence of the secretion of mitochondrial components in extracellular vesicles dependent on GPRC5A as a pathway of mitochondrial quality control in AEC2s, which is essential for lung homeostasis maintenance.

In a large, partially prospective cohort of patients with molecularly profiled and clinically annotated meningioma, the extent of surgical resection and radiotherapy (RT) response correlate with molecular classification, which can be used in a molecular model to predict clinical outcomes in response to RT.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

This study presents an approach to enhancing the local field of avalanche photodetectors by integrating the lightning-rod effect with localized surface plasmon excitations.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

The anti-leprosy drug clofazimine inhibits coronavirus replication in several cell models and shows potent antiviral activity against SARS-CoV-2 infection in a hamster model, particularly when used in combination with remdesivir.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

A Dirac quantum spin liquid phase is predicted to have a continuum of fractionalized spinon excitations with a Dirac cone dispersion. A spin continuum consistent with this picture has now been observed in neutron scattering measurements.

Rechargeable zinc batteries are hindered by sluggish ion transport and unstable interfaces. Here, the authors design a zwitterionic gel-ligand-channel where molecular crowding promotes ion liberation, enabling fast ion migration and interfacial kinetics even at −60 °C.

Al/CuO/V₂C nanocomposites, created via a novel self-assembly method, show enhanced energy release and safety. Structure varies with V₂C amounts, enabling tunable performance and complete Al oxidation, ideal for microinitiator applications.

Previous ophthalmic foundation models have struggled to generalize effectively to diverse and rare fundus diseases, restricting their clinical applicability. Here, the authors introduce a vision-language foundation model that demonstrates superior performance in diagnosing both common and rare fundus conditions.

Organic crystal-based materials have potential in optoelectronic materials, but construction of lossless interfaces is challenging. Here, the authors report the growth of organic parallel grouping crystals without grain boundaries, by a solution viscosity-induced binuclear co-growth strategy.

Polyamide membranes are often fabricated using interfacial polymerization methods, though these methods can compromise membrane structure and performance. Here the authors design a polymerization method using ionic liquid and a doctor blading method to optimize membrane fabrication.

Developing efficient non-precious catalysts is key to advancing water electrolysis. Here, the authors report a microbial vulcanization strategy that co-dopes cobalt hydroxide with sulfur and organic molecules to optimize O–O coupling and accelerate the electrocatalytic oxygen evolution reaction.

Zero-field mobility has been an unreliable indicator to predict thick-film organic solar cell performance. Here, authors reveal that critical length is a decisive factor governing thick-film device performance and achieve maximum efficiency of 19.0% in 300-nm thick-film D18:L8-BO:BTP-eC9 devices.

Polyploidy and subsequent post-polyploid diploidization (PPD) contribute to evolutionary success of plant species. Here, using 11 genomes from all nine subfamilies of Malvaceae as an example, the authors provide evidence to support the “polyploidy for survival and PPD for success” hypothesis.

Maintaining facial warmth and humidity while ensuring adequate oxygen intake in cold environments is challenging for facial masks. Here, the authors design a MetaMask that recovers heat and moisture from exhaled air to warm inhaled air to 26.2 °C in a − 20 °C environment, while maintaining sufficient oxygen levels.

High-performance electrolytes are urgently required in the development of reversible lithium-metal batteries that offer high energy densities. Now, a versatile liquefied gaseous electrolyte is demonstrated with inherent safety, temperature resilience, high recyclability, and promising electrochemical properties.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.