Using a combination of structural, biochemical and phylogenetic analyses, the authors reveal a common mode of action of WhiB-like (Wbl) family proteins found exclusively in Actinobacteria and actinobacteriophages, involving the binding to the primary sigma 70 factor via a previously unrecognized aromatic patch motif. These findings provide compelling evidence for a complex evolutionary relationship of Wbl transcription factors between actinobacteria and their associated phages.
- Daisy Guiza Beltran
- Tao Wan
- LiMei Zhang
