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The authors identify Npr1 as a nucleophagy receptor in fission yeast that acts redundantly with Epr1 to degrade nuclear components. Tethering chromatin to the inner nuclear membrane blocks nucleophagy, suggesting a genome protection mechanism.

Here the authors show that marine diatoms produce tryptophanol, a molecule that at extremely low concentrations rapidly activates nitrogen assimilation genes and enzymes. This facilitates acquisition of nitrogen, a vital ocean nutrient.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

This study uses two large fundus cohorts to show that retinal foundation models generalize well across populations but exhibit age-related fairness gaps. It highlights how pre-training data composition shapes model generalisability and fairness.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

A self-powered symbiotic transcatheter pacemaker that regenerates energy via electromagnetic induction from the cardiac motion demonstrates a month-long operation in a porcine model of arrhythmia and surpasses the critical energy condition for lifelong service.

FUNDC1 in endothelial cell (ECs) via endothelin (ET) 1 release regulates insulin sensitivity and adiposity and that high fat diet feeding promotes obesity, insulin resistance and diabetes by increasing FUNDC1 and consequent ET1 release from ECs.

By resonant excitation of an InAs quantum dot embedded in a microcavity, a deterministic single-photon source is demonstrated. Single-photon purity of 0.9795(6), photon indistinguishability of 0.9856(13), and an overall end-to-end efficiency of 0.712(18) are simultaneously obtained.

It is essential to test the neutralization of approved vaccines against SARSCoV-2 Omicron sublineages. Kurhade et al. find that sera from people with three doses of BNT162b2 neutralize Omicron BA.1, BA.2, and BA.3 to a lesser extent than the original strain USAWA1/2020.

This study shows that acidification increases substrate affinity in ammonia-oxidizing microbes, partly offsetting reduced ammonia availability. Stronger responses in archaea than bacteria explain contrasting ecosystem reactions.

Interleukin-2 (IL-2) and checkpoint inhibitors such as anti-TIGIT have been used individually as tumour therapies. Here the authors fuse IL-2 and anti-TIGIT in a combined therapeutic and show that this promotes Treg cell fragility in the tumour environment which in turn promotes neutrophil function to enhance CD8 T cell anti-tumour function in mouse models.

SleepGPT is a time-frequency foundation model for sleep decoding, built on a generative pretrained transformer, achieving superior performance in various downstream tasks across datasets.

Consuming fish oil is linked to reduced risk of cardiovascular disease in some populations, but the effects are not consistent across studies. Here the authors report that smooth muscle cell AMPKα2 is required for the protective effects of fish oil on atherosclerosis in mice, and acts via post-translational regulation of the fatty acid receptor GPR120.

Here, the authors find that the brain recovers during sleep in a hierarchical pattern: higher association areas quiet down while primary sensory regions ramp up during early sleep, with these differences diminishing as slow waves decline.

This study reports a universally cryogenic stripping strategy for transferring laser-induced graphene onto diverse surfaces without modulus limitations. The thickness of typical receiver elastomers can be reduced to 6.7 μm for large-scale electronic skins.

IBI318 is a recombinant bispecific IgG1 antibody that targets PD-1 and PD-L1. Here the authors report the results of a phase II trial of IBI318 combined with the receptor tyrosine kinase inhibitor lenvatinib in patients with advanced non-small cell lung cancer with acquired resistance to first-line immune checkpoint inhibitors.

Samples of serum from individuals immunized with the BNT162b2 vaccine show neutralization activity against engineered SARS-CoV-2s bearing the spike mutations from B.1.617 and other variants.

Quantum information cannot be copied, posing challenges for long-distance communication due to signal losses. Here the quantum relay architecture using a single-photon source enhances the signal-to-noise ratio of quantum information transmission.

OTX2 binds to and activates genes involved in embryonic genome activation, including TPRX1 and TPRX2. OTX2 knockdown impairs embryonic genome activation and early development, which can be partially rescued by overexpression of TPRX1 and TPRX2.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

Here, the authors report a linear antimicrobial peptide (AMP) that exhibits antimicrobial activity in vitro and in a murine model of bacterial pneumonia and is able to alleviate bacterial resistance and restore antibiotic sensitivity.

An avian influenza H7N9 virus causes severe human disease, including acute and often lethal respiratory failure. Here, the authors report that plasma levels of angiotensin II, a regulatory peptide of the renin–angiotensin system, are associated with disease severity and fatal outcome in infected patients.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Conventional iridium catalysts suffer from instability due to surface amorphization into hydrous IrOx phase during reaction. Here, the authors report how a TiOx@Ti support transforms iridium nanoparticles into stable crystalline IrO2, enabling both high activity and durability in water electrolyzers.

The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.

Proton exchange membrane water electrolyzers suffer from high catalyst loading and sluggish oxygen evolution. Here, the authors report that tunnel-type iridium oxide concentrates activity at tunnel mouths, enabling high performance at low catalyst loading.

Target identification of natural products plays a critical role in the development of innovative drugs. Here, this group integrates molecular docking and molecular dynamics simulations on Bufalin and reports the potential targets as well as its role in reversing endocrine resistance.

Zinc deficiency is a global health issue, particularly in populations consuming wheat with low Zn concentration. This meta-analysis finds that foliar and combined soil+foliar Zn applications significantly increase wheat grain Zn levels, proposing optimized fertilization methods to meet nutritional targets.

Mitochondria-associated ER membranes (MAMs) are involved in the regulation of many cellular functions. Here, the authors report that FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes play an essential role in the process of angiogenesis and neoangiogenesis.

C10, a potent non-nucleoside inhibitor targeting NSP14’s SAM-binding pocket, suppresses viral translation, exhibits immunostimulatory effects, and reverses NSP14-induced transcriptome alterations, offering promise for broader coronavirus treatment.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

A universal AI-powered pipeline for fast, precise and plug-and-play image analysis of diverse 3D cellular structures across multiple imaging resolutions.

By using scanning tunnelling microscopy and spectroscopy, researchers observe layer-dependent electronic correlations in rhombohedral graphene multilayers at 77 K, revealing the layer-enhanced low-energy flat bands and interlayer interactions.

Shi, Zhou, Xuan, Jiang et al. identify a population of CD8⁺ T cells that migrate from bone marrow to the small intestine during leukaemogenesis and then traffic back to contribute to anti-leukaemia immune responses during chemotherapy treatment.

Ultrafast electron diffraction can probe structural dynamics of photochemical reactions in real space and real time. Here the authors study the ring-opening of cyclohexadiene with sub-100 fs temporal resolution and sub-angstrom spatial resolution.