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Here, the authors show that transient, mosaic induction of Yamanaka factors in the epidermis can promote skin repair beyond reprogramming cells. They also influence neighboring epithelial cells and immune–mesenchymal niches by reshaping injury response programs.

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.

Absorption in one-port passive systems is known to be bound by causality constraints. Here, authors study reflection and transmission of a two-port system to introduce a generalized causality constraint based on duality symmetry. Experimentally, the broadened bandwidth of their meta-absorbers shows the untapped absorption potential of broadband acoustic metamaterials.

A multi-modal analysis of pre-metastatic liver biopsies from patients with localized pancreatic cancer with a minimum of 3 years of follow-up shows that immunological, proliferative and metabolomic features distinguish patients who develop metastases from disease-free survivors and can be used to predict outcomes.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Active fluids, such as bacterial suspensions, exhibit chaotic flows at low Reynolds number - a phenomenon known as active turbulence. Here, the authors show a discontinuous transition from laminar to chaotic flows in unconfined active nematics.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

Vassy, Dornisch and colleagues developed a genomics-based prostate cancer risk model to support a randomized clinical trial of precision screening in a national healthcare system.

Respiration enhances cerebrospinal fluid flow through mechanical and autonomic pathways. Inhale length and diaphragm motion influence its displacement and net flow, identifying a modifiable, noninvasive mechanism relevant to brain homeostasis.

Bosonic systems live in an infinite-dimensional space, and in order to be able to describe them one usually reduces it to an effective finite dimension or constrain the dynamics in some way, but it is not fully understood whether this captures all the physics at play. Here, the authors fill this gap showing that such representations can successfully and rigorously approximate bosonic physics.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the variation in clonal architecture within and between individuals.

Hole spin qubits in germanium have seen significant advancements, though improving control and noise resilience remains a key challenge. Here, the authors realize a dressed singlet-triplet qubit in germanium, achieving frequency-modulated high-fidelity control and a tenfold increase in coherence time.

Turbulent flows are observed in atmosphere, ocean, and technology, with turbulent mixing due to stretching and folding of material elements. The authors analyze a geometric perspective of this process and uncover statistical properties of an ensemble of material loops in a turbulent environment.

Pre-exposure prophylaxis (PrEP) is an effective HIV prevention measure but identifying those most at risk to target for treatment is challenging. Here, the authors demonstrate that non-selective PrEP distribution outperforms targeted strategies when use is not consistent, and/or prevalence of untreated HIV is high.

Variants in the PSMC5 gene impair proteasome function and cellular homeostasis, altering brain development in children. This study reveals underlying molecular mechanisms contributing to this neurodevelopmental phenotype, and suggests therapeutic leads for neurodevelopmental proteasomopathies.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

There are a number of non-trivial integrable models in one-dimension, making them an attractive starting point for studying quantum dynamics. Biella et al. study transport between two semi-infinite solvable models and show that a slowly-relaxing region forms around the integrability-breaking junction.

In this large hVISA clinical study, authors find that heteroresistance is not only common but links to clinical failure. The team proposes a new outcome-based test threshold (PAP–AUC 0.65) to guide safer therapy.

Heat transport is well described by the Green–Kubo formalism. Now, the formalism is combined with density-functional theory, enabling simulations of thermal conduction in systems that cannot be adequately modelled by classical interatomic potentials.

Traditional network diffusion models primarily focus on direct connections, often overlooking the role of indirect pathways. Using the d-path Laplacian framework, this study quantifies indirect influence and reveals a structural phase transition associated with altered diffusion dynamics, providing new insights into network behavior and applications in information spreading, disease propagation, or transport dynamics across physical and biological systems.

Tavoni et al. show that complex inference strategies are worth the cognitive effort only in environments of moderate statistical complexity.

Many recent advances in reservoir computing utilize inherently stochastic dynamics and can be designed so that the number of readouts scales exponentially with device size. Here, authors prove the universality of stochastic echo state networks and test the performance of two practical examples.

Regulation of the actin cytoskeleton is essential for blood-brain barrier integrity and immune cell transmigration. Here, the authors show that the ion channel K2P2.1 regulates this process by shielding key signaling lipids and modulating actin dynamics.

An Fe^III/V redox mechanism in Li₄FeSbO₆ on delithiation without Fe^IV or oxygen formation with resistance to aging, high operating potential and low voltage hysteresis is demonstrated, with implications for Fe-based high-voltage applications.

Previous numerical work has predicted a new spin liquid phase in the antiferromagnetic Kitaev model at intermediate magnetic fields; however, its nature is not easily discernible by numerical approaches. Here, by using a variational approach, the authors show that this phase is a gapped Abelian spin liquid

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Entanglement of polymers underlies a variety of phenomena across multiple scales that are driven by different active processes. Here, the authors study the viscoelastic properties of highly entangled, flexible, self-propelled polymers using Brownian dynamics simulations and show that the active motion of the polymers increase the elasticity of the solution by orders of magnitude due to the emergence of grip forces at entanglement points and increases with polymer length and activity.

Simple interactions among coexisting biological species on a network can be harnessed to solve computationally hard problems. Solution quality improves under gradual increases in competitive pressure due to a cascade of bifurcations that implements Katz centrality-based node removal, yielding near-optimal maximum independent set.

Defective viral genomes (DVGs) can interfere with virus replication and provide a potential approach to control infection. Here, Rezelj et al. use a combined experimental evolution and computational approach to identify DVG sequences that optimally interfere with Zika virus infection and show antiviral activity in mice and mosquitoes.

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

The still-developing understanding of topologically non-trivial phases of matter has led to new mechanisms for unconventional many-body behaviour. Here the authors present a model where the symmetry needed for a symmetry-protected topological phase only emerges after the formation of long-range order.

In order to predict the behaviours of self-propelled particles it is important to understand the fluid disturbances they generate. Here the authors measure the flow-fields around active particles and show that they are in agreement with theoretical predictions which take into account electrokinetic effects.

Increasing the critical current of superconductors has been a central scientific effort, but the fundamental understanding of critical currents near 0 K is lacking. Here, Doron et al. report that in disordered superconductors the critical current near 0 K is well explained by a thermal bi-stability where electrons thermally decouple from phonons in a discontinuous manner.

Relativistic electron-positron (pair) plasmas play a fundamental role in the magnetospheres, jets, and winds of black holes and neutron stars, but existing studies have been purely theoretical. Here, the authors open up the exciting possibility to probe relativistic pair-plasmas in the laboratory.

Modelling diverse ecological phenomena across scales with a single mathematical framework is challenging. Here, the authors draw on density functional theory to develop a framework that bridges between mechanistic theories at fine scales and statistical models at large scales.

Evidence for quantum criticality in Fe-based superconductors is still being accumulated. Here, the authors observe power-law behavior of the elastoresistivity as a function of composition in Ba(Fe_1−xCo_x)₂As₂ near a putative nematic quantum critical point, consistent with expectations for quantum criticality, while the temperature dependence near the critical doping deviates from a power law.

An algorithm is developed to design a shape, a trajectoid, that can trace any given infinite periodic trajectory when rolling down a slope, finding unexpected implications for quantum and classical optics.

Previous observational studies of the diabetes drugs metformin vs. sulfonylureas have yielded mixed results about whether metformin reduces the risk of dementia, relative to the sulfonylureas. Here, the authors apply a novel competing risks approach to emulate dementia-related target trials in electronic health records of diabetic patients and a complementary systems pharmacology evaluation on human neural cells.

The authors demonstrate an optical trap where particles are trapped inside of a laser cavity. This is possible due to intracavity nonlinear feedback forces that produce stronger confinement on all 3 axes than standard optical tweezers, which greatly reduces the laser intensity needed to trap the same particle.