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Contaminants such as CO₂ and H₂S present in natural gas and biogas streams must be removed before use; existing strategies to do so can be rather complex. Here, the authors use a fluorinated porous metal–organic framework to remove CO₂ and H₂S from CH₄-rich feeds in a single step, potentially simplifying the process.

NASA’s Perseverance rover detected high nickel abundances in an ancient Martian river channel. Their chemistry resembles nickel enrichments in ancient Earth rocks and may hint at complex redox–organic processes in Mars’ past.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

The electronic behaviour of complex oxides such as LaNiO₃ depends on many intrinsic and extrinsic factors, making it challenging to identify microscopic mechanisms. Here the authors demonstrate the influence of oxygen vacancies on the thickness-dependent metal-insulator transition of LaNiO₃ films.

The acetyl-CoA pathway is the most ancient CO₂ fixation pathway in nature. Here, the authors show that metals selectively reduce CO₂ to the intermediates and end-products of the acetyl-CoA pathway, which is consistent with a prebiotic origin of this pathway.

Dutta et al. demonstrate that the tumor suppressor complex BRCA1–BARD1 physically interacts with the RNA–DNA helicase Senataxin (SETX) and upregulates the activity of SETX to resolve harmful R-loops crucial for the avoidance of transcription–replication conflicts.

Scenario modelling of nickel supply to meet demand to 2050 identifies extensive overlap between land and coastal mines and high-priority areas for terrestrial and marine conservation, and shows how this tension would increase under a moratorium on deep-sea mining.

Anaerobic methane-oxidizing archaea mitigate methane emissions in anoxic environments. Here, Egas et al. show that these microbes can also oxidize carbon monoxide, prompting re-evaluation of their classification as obligate methanotrophs and their role in methane mitigation.

PI3K has emerged as a potential therapeutic target for serious endometrial cancer but efficacy and duration of response is limited. Here, the authors develop a serous endometrial cancer murine model driven by PIK3CA mutation, TP53 loss and MYC overexpression, identifying FGFR pathway activation as a driver of PI3K-targeted therapeutic resistance and immune suppression.

This work achieves a generalizable strategy for the robust deposition of conductive metal-organic framework on individual threads to create a wearable MOF@thread array patch that can efficiently detect and differentiate toxic gases.

Nickel-catalysed cross-coupling reactions generally use Ni(II) or Ni(0) precatalysts. Here the authors report thermally stable dinuclear Ni(I) complexes with commercial isocyanide ligands for the efficient catalysis in Kumada, Suzuki–Miyaura and Buchwald–Hartwig cross-coupling reactions.

The phenotypic and functional heterogeneity of Natural Killer (NK) cells between immunologically distinct tumor types has not been extensively investigated. Here, the authors combine multi-omic approaches, analysis of patient cohorts, and preclinical mouse models, comparing HGSOC to NSCLC as putative checkpoint-resistant and sensitive tumours. They observe an enrichment in NKG2A⁺ NK cells in HGSOC and propose that its inhibition boosts NK cell-CD8⁺ T cell interactions for improved cancer immunotherapy.

Structural complexity often hinders the efficient conversion of lignin into sustainable high-value products. This bifunctional core–shell catalyst enables a relay reaction that transforms lignin into jet-fuel range cycloalkanes with high yields.

Bio-inspired Ni-based molecular catalysts are efficient for H₂ oxidation, but are suffering from the poor stability in the presence of O₂. Here, the authors develop a strategy to boost greatly their stability by dispersing them in a hydrophobic and redox-silent polymer matrix.

Nickel(II) dihalide precatalysts with bidentate nitrogen ligands are widely used in cross-coupling reactions, notably in combination with photosensitizers, forming catalytic systems that currently drive major conceptual and synthetic thrusts within organic chemistry. Here the authors show a general mechanism by which these precatalysts are converted to the reduced, catalytically active species, using a range of characterization and spectroscopic techniques.

MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

The authors provide experimental evidence that Eu substitution in the spacer layer of Nd_1-xEu_xNiO₂ thin films enhances the superconducting gap, driving the system toward a strong-coupling regime. The Eu substitution also introduces exchange coupling between Eu 4f magnetic moments and Ni 3d_x²−y² electrons, leading to magnetic-field-enhanced “re-entrant” superconductivity.

Exsolution enables the formation of active catalytic nanoparticles, but their thermal stability remains limited. Here, the authors use secondary-electron imaging at atomic resolution to directly visualize the coarsening of exsolved nanoparticles.

There is ongoing research into new electrocatalysts for hydrogen production from water splitting. Here, the authors report the electrocatalytic performance of nickel/nickel oxide heterostructures on carbon nanotubes, and are able to assemble a water electrolyzer operated by a single-cell 1.5 V battery.

Histone modifications, such as N^ε-lysine acetylation and methylation, play critical roles in regulating eukaryotic transcription. Now, the oxidation of acetyl-lysine to hydroxyacetyl-lysine of a select histone has been identified as a distinct modification catalysed by the human JmjC histone demethylase KDM3A, which plays a role in the cellular hypoxic response.

Dry reforming of methane (DRM) offers a promising route to convert greenhouse gases into valuable syngas, yet its industrial application is limited by catalyst deactivation and carbon deposition under severe conditions. Here, the authors introduce a Ce-modified, Ni-exsolved perovskite catalyst that exhibits synergistic effects, enabling highly efficient and durable DRM performance.

Methyl groups play a vital role in pharmaceuticals, where their installation onto aryl and heteroaryl moieties of drug candidates can often enhance drug-target interactions. Here, the authors report the methylation of phenols (as tosylates) and aryl halides via a hydrazone-mediated Ni catalyzed cross-coupling reaction, employing formaldehyde hydrazone as the methyl reagent.

Gut microbiota-targeted therapeutics for lupus are lacking. Here, the authors show that a human isolate of Faecalibacterium prausnitzii ameliorates gut microbial dysbiosis and alleviates autoimmune activation, autoantibody production and kidney damage in a lupus-prone mouse model.

Bacteria adjust their metabolism to the cellular energy state. Here, authors identify a layer of regulation of AMP-forming acetyl-CoA synthetase AcsA activity by AcuB acting as energy sensor inhibiting the AcsA deacetylase AcuC in presence of AMP.

Proving sustainable chemical plastic recycling must rely on realistic feedstocks and sustainability-driven catalyst design. Here, the authors report titania-supported Ru–Ni alloy nanoparticles achieving up to 55% liquid (C6 to C45) products for low-carbon and profitable polyethylene hydrogenolysis and determine a metric for sustainable product distributions.

NiFe-based hydroxides are well-known for alkaline water oxidation but face efficiency issues due to unclear Fe dynamics. Here, the authors report that surface Fe dynamics are affected by Fe diffusion on the counter electrode and have developed a zinc-templated precursor to stabilize active Fe sites.

Controlled dislocation self-assembly is demonstrated in discontinuous-columnar Bi(Fe,Mn)O₃ thin film. Guiding dislocations along grain boundaries tailors polarization homogeneity, revealing a microstructure-driven design principle for ferroelectrics.

Reduced nickel-rich metal and oxidized nickel carbonate inclusions within diamonds provide evidence of metasomatic redox reactions and support the role of carbonatitic melts in oxidizing small volumes of the deep upper mantle and transition zone.

Previous models explain solid-solution strengthening by differences in atomic volume and electronegativity of the constituent atoms. Here, the authors consider both factors simultaneously and identify atomic volume as the dominant factor for FCC alloys.

This protocol describes the use of OaAEP1, an ultrafast transpeptidase that naturally forms backbone cyclic peptides in plants, for an expanded range of reactions that can be used to modify proteins and peptides at a specific terminus or side chain.

Catalysts are required to increase the rate of H₂ evolution over silicon photocathodes, but their presence can lead to parasitic light absorption. Here, the authors explore the contributions of catalysts and light absorption to the overall performance of Si microwires, depositing Ni–Mo catalysts spatioselectively to optimize efficiency.

Skyrmions—vortex-like spin textures—are conventionally only seen in materials that exhibit the right magnetic properties. Li et al.now create so-called artificial skyrmions using a cobalt disk embedded in a magnetized nickel film, thus presenting a platform for controlling skyrmions.

The Akt-mTOR axis influences cell activation, differentiation and metabolism. Jordan and colleagues show that thymic and inducible T_H17 cells exhibit different requirements for mTORC1 and mTORC2 as well as Akt isoforms.

XRISM spectroscopy of the nucleus of the Circinus galaxy indicates elemental abundances suggestive of a dominant enrichment from core-collapse supernovae with progenitors below 20 solar masses; more massive stars may directly collapse into black holes.

Sulfate-reducing bacteria deploy large adhesins during biofilm formation. Here, the authors reveal how an adhesin-associated regulatory system controls proteolytic processing of these adhesins and incorporates c-di-GMP signaling with parallels and distinct features compared to adhesin control in Gammaproteobacteria.

Structural studies demonstrate that myosin generates forces that cause structural changes in actin, modulating cooperative binding by α-catenin and thus signal transduction and intercellular communication via adhesion complexes.

A dynamic interconversion of three nickel states in lithium nickel oxide is demonstrated using evidence from x-ray spectroscopic data and first-principles calculations, which explains many physical properties of this and similar materials.

Water interactions with 2D materials shape sensing and fluid control. Here, the authors show that water diffuses on hexagonal boron nitride with distinct rotational dynamics and lower friction than on graphene, revealing substrate effects on interfacial water.

Cells regulate metabolic enzymes via ubiquitin-mediated degradation, yet responsible E3 ligases remain poorly defined. Here, the authors identify LRRC58 as a cysteine-responsive E3 ligase substrate receptor that selectively ubiquitylates CDO1 distinctive from degrader-induced protein degradation.

The anti-CRISPR protein AcrVA2 specifically interrupts Cas12a biogenesis by triggering co-translational mRNA degradation.

Gram-negative bacteria use diverse virulence factors to infect eukaryotic cells. Here, the authors perform structure-function analyses on the S. negevensis deSUMOylase SnCE1 and provide mechanistic insights how lysine acetylation reprograms virulence adjusting it to the host cells’ metabolic state.

Single-atom and nanocluster catalysts have been widely studied in heterogeneous catalysis, yet their coexistence and potential synergistic effects remain unclear. Here, the authors investigate atomic-scale Ni-based catalysts for bioethanol reforming and reveal a synergistic interaction between single atoms and nanoclusters.

Here the authors report NiGa₂O_4–x(OH)_y for light-driven CO₂ hydrogenation to methanol. The surface Lewis acid–base pairs and -OH groups act as conduits for H^- /H⁺ transport to active sites, enhancing photocatalytic methanol production.

Anion-exchange membrane water electrolysers have the potential to rival more costly acidic proton-exchange membrane electrolysers, but their performance and efficiency commonly still fall short. Now an anion-exchange membrane water electrolyser is prepared with a NiFe layered double hydroxide catalyst-coated membrane that achieves high current densities above 2 A cm⁻² at 1.8 V and operando X-ray absorption spectroscopy is used to track the formation of the catalytically active γ-LDH phase.