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An empirical correlation between the fragility of glass forming liquids and the broadness of their relaxation spectrum is believed to be universal. Van Lange et al. report an inverted correlation in a class of polymeric materials, implying a special role of long-ranged ionic interactions in vitrification.

Newly emerging SARS-CoV-2 variants underscore the need for broad-spectrum antiviral solutions. This study shows a macrocyclic peptide inhibitor that locks the SARS-CoV-2 spike trimer into a “closed” conformation by engaging a conserved region, and demonstrates that intranasal administration of the peptide inhibitor protects against Omicron variants.

Oceans provide essential ecosystem services to human society, yet the climate impacts on blue capital have long been ignored. Incorporating the latest works on ocean science and economics, researchers show that accounting for the potential damage would almost double the social cost of carbon estimation.

Plant community responses to climate change tend to be lagged in forests, but could be faster in grasslands. Here, the authors integrate long-term experimental data with >1 million occurrence records for >300 species, finding grassland community shifts towards species associated with warmer and drier conditions at a pace that aligns with that of climate change.

The Authors assess systemic risks in global trade by modelling disruptions at maritime chokepoints. They estimate USD192 billion of exposed trade and USD10.7 billion in economic losses, emphasizing the urgent need to safeguard strategic passages.

Vaulet et al. developed and validated four continuous indices from histological lesion scores to assess kidney transplant rejection, offering an alternative to the Banff categories that reflect the continuous nature of rejection.

High-pressure-temperature experiments that explore the impact of carbon and silicon on the plastic deformation of hexagonal close-packed iron suggest depth-dependent elastic anisotropy in Earth’s inner core may originate from chemical stratification

The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape genes upon Xist RNA overexpression in neural progenitors.

The authors show that babies conceived during the COVID-19 pandemic have a different parental socioeconomic composition than expected had the pandemic not occurred.

Reverse-biased bipolar membranes can enable CO₂ electrolysis with iridium-free anodes for extended durations, but only if 100% of the ionic charge is carried by water dissociation. Here, the authors show that practical systems fall far below unity water dissociation efficiencies, highlighting a performance gap for sustained alkaline operation using nickel-based anodes.

In a phase 1b trial in three patients with Fanconi anemia, an irradiation- and busulfan-free conditioning regimen containing an anti-CD117 antibody, combined with T cell- and B cell-depleted haploidentical hematopoietic stem cell transplantation, was safe and led to high levels of donor engraftment.

While multiband superconductivity is the subject of extensive studies, the possibility of multiband charge density waves (CDW) remains elusive. Here, the authors report evidence of gap opening on both inner and outer bands by a CDW state in 2H-NbSe₂, suggesting a possible multiband CDW.

It is not well understood why in resource-poor settings some children fail to gain weight and stunting increases following hospital discharge. Here, the authors show inflammation driven by illness, enteropathy and social factors redirects recovery away from linear growth and limits weight gain.

Mars’ bow shock, where the solar wind meets the planet’s plasma environment, responds dynamically to solar wind conditions. Here, the authors show that even under relatively calm solar wind, it globally oscillates within minutes and shifts by hundreds of kilometers.

Disorder has been a prime challenge to study the topological properties in a hybrid system. Here, Zhanget al. report ballistic superconductivity in InSb nanowires interfacing with a NbTiN superconductor, paving the way for disorder-free Majorana devices.

Insights to elucidate the composition–behaviour relationship in organic photovoltaic materials are required. Here the phase behaviour of disordered polymer:small-molecule acceptor blends is studied and an extended model is invoked to understand the temperature–composition diagrams.

The role of interspecific interactions in biodiversity–ecosystem stability relationships is unclear. Here the authors develop a theoretical approach and show that empirical diversity–stability relationships in grasslands are best explained by species-specific dynamics rather than by interspecific interactions.

Ring-expanding carbon-atom insertion reactions are currently limited to the installation of few functional groups. Now researchers show the use of a radical carbyne precursor for the insertion of carbon atoms bearing varied functional groups to access 2-substituted naphthalenes from indene.

A spectroscopic technique that enables momentum-resolved probing of excitations of atomic gases in optical lattices allows the full band structure of such systems to be measured for the first time. The method should facilitate the comparison of quantum-gas phases with their condensed-matter counterparts.

This Resource provides a detailed atlas of morphogen-induced responses in human neural organoids.

A graph neural network framework enables individualized genetic risk prediction at the single-cell level.

Protein homeostasis maintenance (proteostasis) is critical for cell function, but declines during aging. Here the authors detail a proteostatic checkpoint in Drosophila intestinal stem cells coordinating cell cycle arrest with protein aggregate clearance, along with its role in aging related intestinal dysfunction.

LDAK-KVIK is a mixed-model association method for genome-wide studies that optimizes computational performance and power. LDAK-KVIK can also perform gene-based tests and produces state-of-the-art polygenic scores.

Two-dimensional charge ordering cannot be fully described by Peierls-like weak coupling mechanisms appropriate for one-dimensional materials. Here, the authors show how strong orbital-dependent electron–phonon coupling drives two-dimensional charge ordering in archetypal niobium diselenide.

The asymmetric hydrogenation of alkenes is a common route to optically active compounds, but alkene synthesis is often atom-inefficient, and the formation of isomers further complicates the procedure. Now the Ir-catalysed deoxygenation of racemic alcohols is shown to be a simple route to enantioenriched products.

A study reports on the antigenic characterization of SARS-CoV-2 BA.1, BA.1.1 and BA.2 and the neutralizing activity of different monoclonal antibodies and sera against them.

Magnetic reconnection dynamics in Venus’ magnetosphere are not well-known due to limited observations. Here, the authors show direct evidence for closed magnetic topology in Venus’ magnetotail and a link between the cold ion flow in the magnetotail and its direct magnetic connectivity to the ionosphere.

Previously, ion escape was expected to be steady under constant external conditions. Here, the authors show that ion escape at Mars exhibits anomalous spatial-temporal variability.

A technique that combines retrograde axon tracing with single-cell transcriptomics is used to characterize neurons innervating pancreatic ductal adenocarcinoma and healthy pancreas, providing insight into the role of neural connections in cancer progression.

Quantum gases are useful toy models for the study of quantum magnetism. Exquisite control of a spinor gas of fermionic atoms in an optical lattice has now been demonstrated, opening up the exploration of quantum magnetism with high spins.

Authors present a bispecific antiviral design targeting the virus and the host that simultaneously offers broad-spectrum protection against multiple existing transmissible human-pathogenic coronaviruses, including the Paxlovid-resistant SARS-CoV-2 mutants.

Experiments under upper-tropospheric conditions map the chemical formation of isoprene oxygenated organic molecules (important molecules for new particle formation) and reveal that relative radical ratios control their composition

Formation and metasomatism of the Moon’s primary crust constrained by experimentally determined partition coefficients for chlorine coupled with models of the evolution of the lunar interior.

High-throughput screening and hit optimization have led to the development of a small molecule, CIM-834, that targets the SARS-CoV-2 membrane protein and blocks assembly of the virus.

Here the authors characterize a single-domain antibody that broadly neutralizes SARS-CoV-2 variants with high potency by targeting the heptad repeat 2 (HR2) coiled coil, conserved in sarbecoviruses. Binding to its quaternary epitope blocks membrane fusion, by locking HR2 in its prefusion conformation.

Single-layer organic light-emitting diodes based on thermally activated delayed fluorescence are demonstrated, exhibiting pure-blue emission, high quantum and power efficiencies, and operational stability.

Earth-abundant Ni-X (X= Zn, Ga, In) bimetallic nanocrystals are achieved via colloidal synthesis and studied as alkyne semihydrogenation catalysts, for which the Ni₃Zn composition is found to offer an optimal balance between selectivity and activity.

Here, the authors present multi-ancestry genome-wide meta-analyses of uterine fibroids, identifying 11 new gene associations, and demonstrating that heritability is higher in African ancestries.

The association between triglyceride (TG) and mortality remains controversial in individuals with heart failure (HF). Here the authors show a U-shaped association where high TG levels are associated with ASCVD-related admission or death and lower TG levels are associated with HF-related readmission or death.

The authors reveal that, in fruit fly ovaries, the protein Rhino is guided to specific regions of the genome by a combination of two histone modifications, enhancing understanding of how cells protect their DNA from harmful virus-like elements.

Degree of polymerisation, fraction and pattern of acetylation change the material and biological properties of chitosan. Here, the authors show that enzymes can N-acetylate fully deacetylated chitosan to replicate the natural control over acetylation pattern not found in chemically produced chitosan allowing more control over properties.

Moreno-Justicia and colleagues report transcriptomic and proteomic pipelines to explore heterogeneity within human skeletal muscle fibers, identifying sources of fiber heterogeneity in healthy individuals and children with nemaline myopathy.

Heart failure is a leading cause of morbidity and mortality, and ERBB4 signaling has been proposed as a potential therapeutic target. Here they identify small molecule ERBB4 agonists capable of decreasing cardiomyocyte damage and fibrosis in models of cardiovascular disease.