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In this work, the authors present their Chloroalkane Azide Membrane Permeability (CHAMP) assay that measures cytosolic accumulation of small molecules in Escherichia coli, enabling rapid profiling of compounds, with the goal to simplify and accelerate antimicrobial drug discovery.

Despite high efficiencies, all-perovskite tandem solar cells are hindered by thermal instability. Guo et al. address this issue by introducing a multi-Lewis-base modulator, which suppresses the formation of dense Cs-rich films in Pb-Sn perovskites to concurrently deliver high performance and stability.

The efficiency of palladium catalyzed CO₂ electroreduction is severely hindered by catalyst deactivation. Here, the authors report that engineering a palladium-fullerene interface enhances resistance to deactivation, enabling energy-efficient CO₂-to-formate conversion over a broad potential window.

The mismatched bilateral bond strength between NiO_x and perovskite hinders the development of inverted perovskite solar cells. Here, authors adsorb 1-(benzothiaxole-2-ylthio)succinic acid on NiO_x surface for passivating bilateral defects and achieve maximum efficiency close to 27% in stable devices.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

This work constructs a ‘mitochondrial autonomous drive’ (MAD) system, which utilizes the downregulation of mitophagy to accelerate mitochondrial intercellular transport through tunneling nanotubes (TNTs), enabling the delivery of exogenous substances for deep penetration and treatment of tumors.

Species mixing is known to influence leaf litter decomposition, but its effects on root decomposition remain poorly understood. This study reveals strong non-additive mixing effects in absorptive root decomposition, especially in combinations including ectomycorrhizal species, with implications for soil carbon and nutrient dynamics.

The perovskite/electron transport layer interface in inverted solar cells suffers from severe nonradiative recombination losses. Here, authors employ amino acid salts to passivate the film surface, achieving a power conversion efficiency of 26.28% using vacuum flash processing technology.

Asymmetric catalysis plays a crucial role in the synthesis of optically active organic molecules, but its application to stereogenic-at-metal complexes is more challenging. Here, the authors report the asymmetric synthesis of stereogenic-at-iridium complexes through kinetic resolution via a Pd-catalyzed Suzuki-Miyaura cross-coupling reaction.

CBASS systems trigger bacterial suicide via membrane disruption. Here, authors show that effector CapV relocates to the cell pole upon sensing 3’3’-cGAMP, where it cleaves phospholipids and ruptures membranes, revealing a filament-dependent activation mechanism for antiviral defense

CD36 drives lymph node metastasis in breast cancer by activating YAP signaling-mediated anoikis resistance via inducing the PPARα-CYP7A1 bile acid biosynthesis pathway.

Octahedral chiral-at-metal complexes have chirality based on the metal centre, but reactivity occurs at the organic ligands. Here, the authors report such a complex as a highly active Brønsted base catalyst, with loadings down to 0.02 mol% for asymmetric Michael additions and 0.25 mol% for aza-Henry reactions.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Trace amounts of strong acid can suppress Zn corrosion and promote uniform Zn deposition. Here, the authors use HTFSI to create a hydrophobic micro-environment at the Zn-electrolyte interface, enabling high efficiency and cycling stability.

The accrual of soil carbon from absorptive fine roots exceeds that of leaf litter in forests despite lower productivity, according to an analysis of field observations from Northern Hemisphere forest sites.

Communication of chirality at a molecular level is the fundamental for transmitting chirality information but one-step communication modes in many artificial systems limits further processing the chirality information. Here, the authors report chirality communication of aromatic oligoamide sequences within interpenetrated helicate architecture in a hierarchical manner.

In the dose-expansion cohort of this phase 1b trial, the EGFR×HER3 bispecific antibody–drug conjugate BL-B01D1 given to patients with metastatic esophageal squamous cell carcinoma led to encouraging clinical response rates, which need to be confirmed in larger efficacy trials.

Perovskite solar cells degrade quickly under natural day/night cycling, compared with continuous illumination, owing to periodic lattice strain during cycling; the lattice strain can be regulated by adding phenylselenenyl chloride.

The authors make an ionic thermoelectric cell with a eutectic solvent of formamide that can operate at temperatures as low as −35 °C by applying hydrophilic and gold coated treatments to the electrode and introducing a thermal separator.

This study shows how auditory cortex activation and cognitive function develop during a six-month follow-up after gene therapy in children with congenital deafness.

Diabetic cardiomyopathy involves dysregulated protein deubiquitination. Here the authors show that deubiquitinating enzymes OTUD1 knockout prevents cardiac hypertrophy by deubiquitinating AMPKα2 at K60/K379, disrupting CAMKK2-mediated phosphorylation.

The scalable fabrication of wide-bandgap perovskites in air remains challenging due to moisture-induced degradation of perovskites. Here, authors utilize low polarity and moderately volatile n-butanol to enhance film uniformity, achieving efficiency of 29.4% for double-sided textured tandem cells.

Mucosal melanoma (MM) is a cancer with poor prognosis derived from mucosal melanocytes. Here, the authors implement a combination of genetic changes that occur in MM patients in a zebrafish model, revealing the potential MM cell of origin and showing that patient and zebrafish MMs share a gene signature that is more metastatic and immune-evasive.

Soil ecosystems are not only reservoirs of food-borne pathogens, but also transmitters through contaminated water and agricultural products. This study examines the survival of food-borne pathogen Escherichia coli O157:H7 across 81 natural soils from eastern China, mapping geographic survival patterns and identifying key abiotic and biotic drivers.

Conjugates of small-molecule anticancer drugs with a polyzwitterion that has negligible interaction with proteins and a weak interaction with phospholipids eradicate large tumours and patient-derived tumour xenografts in mice.

Advanced electrolyte is essential for high-energy-density lithium metal batteries. Here, the authors design a molecular anchoring dilute electrolyte via intermolecular hydrogen bonding with free solvents to improve the battery electrochemical and thermal stabilities.

Duchenne muscular dystrophy (DMD) results from mutations in the DMD. Here the authors report using adenine base editing of exon splice sites to restore dystrophin expression and muscle function in a humanized mouse model of DMD with exon 50 and 51 of mouse DMD gene replaced with human exon 50.

Modules of foldable crystalline silicon solar cells retain their power-conversion efficiency after being subjected to bending stress or exposure to air-flow simulations of a violent storm.

Suo et al. show that sulfonium-based molecules afford formamidinium lead iodide perovskites protection against environmental stress factors, improved phase stability and solar cells retaining efficiency over 4,500-h operational stability tests.

To emulate the ordered arrangement of radically and cationically polymerizable monomers using single-unit monomer insertion (SUMI) remians challenging. Here the authors demonstrate sequence-defined vinyl polymers via SUMI by manipulating thiocarbonylthio end-groups.

Tailored to provide diabetes management recommendations from large training and validation datasets, an artificial intelligence system integrating language and computer vision capabilities is shown to improve self-management of patients in a prospective implementation study.

A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

Magnetic resonance imaging and spectroscopy provide quantitative insights into the growth of sodium microstructures in batteries.

A fibre lithium-ion battery that can potentially be woven into textiles shows enhanced battery performance and safety compared with liquid electrolytes.

While water-splitting provides a renewable means to generate fuel, the water-oxidation half-reaction is considered a bottleneck process. Here, authors tune lattice oxygen reactivity and scaling relations via alkali metal ion mediation in NaMn₃O₇ for oxygen evolution electrocatalysis.

An interim analysis of a single-arm trial in 5 children with hereditary deafness shows that binaural AAV gene therapy is safe and leads to hearing improvement up to 13–26 weeks of follow-up.

RAB17 and LMO4 modulate ferroptosis by regulating GPX4 expression through the Nrf2-Keap1 signaling pathway.

Two newly designed co-adsorbed dye-sensitized solar cells that harvest light quantitatively across the entire visible domain are described, which offer promising applications as power supplies and battery replacements for low-power electronic devices.

Reliably controlling the morphology in organic solar cells is desired for up-scaling. Here Weng et al. combine the advantages of the fibril network donor and the state of the art Y6 acceptor in a two-step approach to deliver a high efficiency of 16% without batch-to-batch variation.

Ribose-5-phosphate (R5P) is a precursor for nucleic acid biogenesis. Here, Guo and Ji et al. show that multiple routes can flexibly supply R5P to enable Toxoplasma gondii growth.

The authors demonstrate enhanced energy storage performance and thermal stability in lead-free Bi_0.5Na_0.5TiO₃-based multilayer capacitors by employing a hierarchical design strategy across composition, microstructure, and device architecture.

Integrated single-cell atlases of human fetal cerebella and MBs show potential cell populations predisposed to transformation and regulatory circuitries underlying tumour cell states and oncogenesis, highlighting hitherto unrecognized transitional progenitor intermediates predictive of disease prognosis.

Designing efficient redox mediators for solar-to-fuel conversion is a challenge, requiring multi-electron transfer, suitable redox potential, and stable pH buffering. Here, the authors report polyoxometalate-based mediators with defect engineering, enabling reliable solar-to-fuel conversion.

STAG2 is a core subunit of the cohesin complex involved in DNA looping, but its transcriptional targets are largely unknown. Here the authors show STAG2 controls the 3D chromatin structure at the IRF9 locus to restrict IRF9 expression. Loss of STAG2 results in IRF9 activation, which in turn upregulates PD-L1 expression in cancer cells, suggesting a tumor suppressor function in immune evasion.