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The authors introduce a non-invasive, ultrafast imaging method that combines femtosecond transient absorption microscopy with a WSe₂ exciton sensor to visualize multilevel exciton transport driven by correlated electronic states in twisted WS₂ moiré superlattices.

Tobacco is not only an important industrial crop but also severs as a model for plant science research and chassis for plant metabolic engineering. Here, the authors report genome-scale metabolic regulatory network and reveal key transcriptional hubs for different metabolite biosynthesis.

Less is known about the entire microbial pathogen profile of small mammals. Here, the authors analyse 2,408 tissue-resolved metatranscriptomes to map the infectome in small mammals, uncovering high viral, bacterial, fungal and parasitic diversity and showing how geography, hosts, and seasons shape zoonotic risk.

Timber is a sustainable construction material, yet its large-scale application remains limited. Here, the authors introduce a reciprocal frame configuration that improves curvature adaptability and structural performance, facilitating efficient, low-cost, and flexible construction of large-span timber structures.

Radical methylation ranks among the most important yet challenging transformations in chemistry and biology, which often involves small and unstable radical intermediates, and results in low reactivity and poor selectivity. Herein, the authors report a bioinspired transfer methylation protocol for the direct and selective C(sp²)-H methylation of heteroarenes.

The fast skin-permeable polyzwitterion poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] may enable non-invasive transdermal delivery of insulin, and potentially facilitate the use of other protein- and peptide-based therapeutics through transdermal delivery.

The 64-plex fluorescence imaging of RNA in tissues is achieved in one imaging cycle

Electronic friction energy dissipation in semiconductor devices significantly impacts performance

limits, yet the dynamic mechanisms remain unclear. Here, we demonstrate that defects accelerate electronic energy dissipation, enhancing friction.

Lithium-metal batteries require the controlled growth of lithium for reliable operation, but it has been challenging to understand which factors impact and determine lithium nucleation and growth. Now, the interfaces between lithium and both the substrate and the electrolyte have been shown to play critical roles in governing lithium nucleation processes.

Synthesis of biaryls by coupling strategies is unavoidably accompanied by stoichiometric metal waste. Here, the authors report the homo- and cross-electrophile coupling by using hydrazine as metal surrogate, only liberating N₂ and H₂ as side products.

Laser-capture microdissection and mini-bulk exome sequencing are combined to analyse somatic mutations in morphologically normal tissues from nine organs from five donors, revealing variation in mutation burdens, mutational signatures and clonal expansions.

Single-beam optical pulling is counterintuitive and attractive, but to date its pulling range has been less than 0.2 mm. Here the authors demonstrate a 40-cm-long optical pulling of a droplet along a nanofibre by momentum engineering of its guided mode.

Chen, Hu, Zhao, Fang and colleagues show that the ribosomal large subunit protein Rpl12 functions as a conserved ribophagy receptor in multiple organisms.

High-entropy alloy nanoparticles (HEA-NPs) are promising catalysts, but their synthesis remains challenging. Here, the authors report a continuous-flow method and a hydrothermal mechanism for the general synthesis of carbon-supported sub-2 nm high-loading HEA-NPs as electrocatalysts.

The performance of devices based on fully non-fused ring electron acceptors has been limited due to the low acceptor crystallinity. Here, authors report these acceptors with peripheral substituents that guarantee the planarity of the skeleton, achieving efficiency of 18.04% in organic solar cells.

Monomethylation of histone H4 lysine 20 (H4K20me1) contributes to DNA replication but the mechanism is not well understood. Here, the authors identify a conserved tandem Tudor domain of BAHCC1 as a H4K20me1-specific reader, which promotes the recruitment of MCM complex to chromatin for efficient DNA replication.

A fuzzy sequencer can exceed the current limit of information efficiency of DNA sequencers for resequencing applications.

Jujube is a perennial fruit crop with significant economic and medicinal values. Here, the author report genome assemblies of four jujube accessions, construct pan-genome together with four previously published genomes, and generate resequencing data to reveal genetic basis of domestication traits.

A conductive, low-melting-point and healable sulfur iodide material aids the practical realization of solid-state Li–S batteries, which have high theoretical energy densities and show potential in next-generation battery chemistry.

The hypersensitivity of sulfide solid-state electrolytes to moisture are not compatible with today’s manufacturing infrastructure. Here, authors present a reversible surface modification strategy using 1-undecanethiol, that enables the processability of sulfide SSEs under humid ambient air.

Friction and wear cause widespread energy loss and damage. Here, the authors propose a strategy to reduce friction and wear through inducing dynamic electronic density redistribution via alternating electric current.

Catfish represent 6.3% of all vertebrate species, and occupy a phylogenetic position close to the common ancestor of bony fish. Liu et al. present a reference genome of the channel catfish, and reveal a genomic basis for the evolutionary loss of scales in these species.

This study highlights the role Polar regions as a limiting factor in global sustainability due to teleconnection effects, and then propose a SDG target, key indicators, and emphasize Indigenous inclusion and global action.

A new donkey reference genome and comparisons with wild asses yields insights into the evolutionary history of donkey domestication and identifies a genetic variant that results in the non-Dun coat colours of domestic donkeys.

Electronic structure modulation of active sites is important for Fenton-like catalysis. A non-metallic iodine single-atom catalyst with C-I coordination is reported here, which can effectively activate peroxymonosulfate into ¹O₂ for water treatment.

CCL22 promotes positive selection in germinal centres by highlighting affinity-enhanced B cells for helper T cells to sense and seek remotely.

Structural characterization of protein complexes is challenging for low-input samples. Here, authors develop a SNAP-MS mass spectrometry workflow based on dissolvable hydrogel beads to enable efficient purification and native-MS-based analysis from biological samples.

Disulfiram is an FDA-approved drug for treating alcoholism. Wu and colleagues show that disulfiram can be repurposed to efficiently inhibit pyroptosis by specifically blocking gasdermin-mediated pore formation.

In this study, Chen and colleagues present genomic sequences of 102 SARS-CoV-2 isolates collected in Beijing. They look closely at genomic variation between isolates that arose as a result of domestic and global transmission. Their data suggest that SARS-CoV-2 genomes have a high mutational tolerance, which may have potential implications for the development of vaccines.

A high-quality draft genome assembly of Musa balbisiana (the banana B-genome) is reported. Comparative genomic and gene functional analyses provide insights into the subgenome evolution and functional divergence between the A- and B-subgenomes.

Spatial-frequency tracking adaptive beacon light-field encoded endoscopy enables imaging through a single multimode fibre under bending and twisting. In vivo imaging with subcellular resolution is demonstrated in mice models.

Existing methods use bifunctional chimaeras for extracellular protein degradation but rely on specific lysosome-targeting receptors, raising resistance issues. Here, the authors develop MONOTAB, a monofunctional platform that degrades extracellular proteins and vesicles without receptor dependency.

High-performance mechanical metamaterials have been designed through a multilayer strategy and topology optimization, showing capability in approaching the theoretical stiffness limit, as well as prospects in treating multiphysics problems

Superlubricity can be unstable in graphene systems, especially under high applied loads. Here the authors use microspheres uniformly coated by graphene to measure friction between 2D materials and show that superlow friction is preserved for long periods of time under high loads and various atmospheres.

Psoriasis is a chronic inflammatory disease affecting up to 3% of the population. Here, Zuo et al.perform exome array analysis, identify single-nucleotide polymorphisms at 15 new loci, implicating several biological pathways in psoriasis risk and disease heritability.

Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing Granzyme K, a complement-activating tryptase, which is a potential therapeutic target.

The avalanche or carrier-multiplication effect has the potential to improve the performance of photodetectors and solar cells, but usually requires high threshold energies. Here, the authors report stepwise WSe₂ homojunctions exhibiting threshold energies approaching the semiconductor bandgap at room temperature.