Nature Search

Obesity rise plateaus in developed nations and accelerates in developing nations

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Bin Zhou
Nowell H. Phelps
Majid Ezzati
ResearchOpen Access13 May 2026
Nature

Volume: 653, P: 510-518
Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990–2023: a Global Burden of Disease study

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Sooji Lee
Hayeon Lee
Dong Keon Yon
Research30 Mar 2026
Nature Medicine

Volume: 32, P: 1454-1478
Investigating the analytical robustness of the social and behavioural sciences

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Balazs Aczel
Barnabas Szaszi
Brian A. Nosek
Research01 Apr 2026
Nature

Volume: 652, P: 135-142
Analysis of Endocrine Disruption in Southern California Coastal Fish using an Aquatic Multi-Species Microarray

Michael Baker
Barbara Ruggeri
Gary Hardiman
ResearchOpen Access02 Feb 2009
Nature Precedings

P: 1
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Inhibition of Interferon Action by p-Fluorophenylalanine

ROBERT M. FRIEDMAN
JOSEPH A. SONNABEND
Research25 Jul 1964
Nature

Volume: 203, P: 366-367
Mitochondrial and Cytoplasmic Enzymes for the Reduction of Fumarate to Succinate in Yeast

CRISTIANO ROSSI
JOSEPH HAUBER
THOMAS P. SINGER
Research10 Oct 1964
Nature

Volume: 204, P: 167-170
Inference on inner galaxy structure via gravitational waves from supermassive binaries

The lowest-frequency gravitational wave background may be shaped by supermassive black hole binaries that scatter nearby stars or dark matter. In this case, the NANOGrav 15-year dataset favours dense galactic centres with 10⁶ solar masses per cubic parsec.

Yifan Chen
Matthias Daniel
Olivia Young
Research05 Feb 2026
Nature Astronomy

Volume: 10, P: 554-563
Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein

Gunter Reuter
Marianna Giarre
Pierre Spierer
Research15 Mar 1990
Nature

Volume: 344, P: 219-223
Mapping of metabolites in whole animals by ³¹P NMR using surface coils

Joseph J. H. Ackerman
Thomas H. Grove
George K. Radda
Research10 Jan 1980
Nature

Volume: 283, P: 167-170
Impacts of nature-inclusive urban development on well-being and fairness perceptions

Urban development that supports nature and people is a challenge. This study finds that, despite gains in jobs, income and ecological health with ‘green development’, former villagers in Qunli New Town, Harbin, China, feel less content than newcomers given the rural attributes they lost.

Shuo Gao
Wenjing Zhang
E. J. Milner-Gulland
ResearchOpen Access07 Apr 2026
Nature Cities

Volume: 3, P: 416-427
Intrathecal delivery of CNTF using encapsulated genetically modifiedxenogeneic cells in amyotrophic lateral sclerosis patients

Patrick Aebischer
Myriam Schluep
E. Edward Baetge
Research01 Jun 1996
Nature Medicine

Volume: 2, P: 696-699
Inhibition of protein kinase C by alcohols and anaesthetics

Simon J. Slater
Kingsley J. A. Cox
Christopher D. Stubbs
Research01 Jul 1993
Nature

Volume: 364, P: 82-84
Recent Impressions of War-Time America

JOSEPH NEEDHAM
Research07 Dec 1940
Nature

Volume: 146, P: 737-739
Aetiology of Multiple Sclerosis

JOSEPH BERNSOHN
LEO M. STEPHANIDES
Research19 Aug 1967
Nature

Volume: 215, P: 821-823
Early Pleistocene ecosystem turnover in South Siberia linked to abrupt regional cooling

Proxy records from Lake Baikal show that rapid cooling coincided with Northern Hemisphere ice sheet expansion 2.7 million years ago, a change accompanied by a transition to open steppe ecosystems.

Joseph B. Novak
Alexander A. Prokopenko
Pratigya J. Polissar
Research02 Feb 2026
Nature Geoscience

Volume: 19, P: 331-338
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules

Alain Roussel
Bryan F. Anderson
Edward N. Baker
Research01 Aug 1997
Nature Structural Biology

Volume: 4, P: 635-643
Improved protein binder design using β-pairing targeted RFdiffusion

This study demonstrates the capability of deep learning protein design models in generating functionally validated β-strand pairing interfaces, expanding the structural diversity of de novo binding proteins and accessible target surfaces.

Isaac Sappington
Martin Toul
David Baker
ResearchOpen Access10 Jan 2026
Nature Communications

Volume: 17, P: 1-15
Accurate single-domain scaffolding of three nonoverlapping protein epitopes using deep learning

A deep-learning-based de novo design strategy was developed that enables simultaneous scaffolding of three distinct epitopes derived from respiratory syncytial virus within small single-domain immunogens. Crystallographic analyses confirmed precise presentation of the designed motifs. The multiepitope constructs elicited enhanced cross-reactive and neutralizing antibody responses, demonstrating the potential of generative models for complex multisite protein engineering.

Karla M. Castro
Joseph L. Watson
Bruno E. Correia
ResearchOpen Access05 Dec 2025
Nature Chemical Biology

Volume: 22, P: 604-611
Luminous Clouds

JOSEPH JOHN MURPHY
Research30 Jan 1890
Nature

Volume: 41, P: 298
Algae thrive under Pure CO₂

JOSEPH SECKBACH
FRANK A. BAKER
PETER M. SHUGARMAN
Research15 Aug 1970
Nature

Volume: 227, P: 744-745
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Clues from sea-surface records

Joseph O. Fletcher
News & Views23 Aug 1984
Nature

Volume: 310, P: 630
Structural Homology of Human, Bovine, and Porcine Milk Lactoferrins: Evidence for Shared Antigenic Determinants

Scott J Magnuson
Joseph F Henry
William T Hutchens
Research01 Aug 1990
Pediatric Research

Volume: 28, P: 176-181
Two New Plasma Instabilities in the Solar Wind

JOSEPH V. HOLLWEG
H. J. VÖLK
Research31 Jan 1970
Nature

Volume: 225, P: 441-443
Isolation of Δ⁷-Cholesten-3-one from Butterfat

OWEN W. PARKS
DANIEL P. SCHWARTZ
JOSEPH N. DAMICO
Research23 Apr 1966
Nature

Volume: 210, P: 416-417
Kinetochore mutations and histone phosphorylation pattern changes accompany holo- and macro-monocentromere evolution

Centromeres ensure chromosome segregation. Analyzed sister species with distinct centromere types show that kinetochore mutations, histone modifications, and centromeric DNA amplification underlie the process of mono- to holocentromere evolution.

Yi-Tzu Kuo
Pavel Neumann
Andreas Houben
ResearchOpen Access20 Dec 2025
Nature Communications

Volume: 16, P: 1-18
Use of a Juvenile Hormone Analogue as Insecticide for Pests of Stored Grain

P. JOSEPH THOMAS
PREM LATA BHATNAGAR-THOMAS
Research31 Aug 1968
Nature

Volume: 219, P: 949
Excretion of Indolyl Acids in Phenylketonuric Monkeys

DALLAS E. BOGGS
DAREN MCLAY
HARRY A. WAISMAN
Research05 Oct 1963
Nature

Volume: 200, P: 76
Atomically accurate de novo design of antibodies with RFdiffusion

The combination of computational design, laboratory-based screening and biophysical validation enables the de novo generation of variable heavy-chain antibody fragments and antibodies that precisely target chosen disease-related molecules.

Nathaniel R. Bennett
Joseph L. Watson
David Baker
ResearchOpen Access05 Nov 2025
Nature

Volume: 649, P: 183-193
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.

Krista Freimann
Anneke Brümmer
Kaur Alasoo
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Expression of a liver-specific function by mouse fibroblast nuclei transplanted into rat hepatoma cytoplasts

Leah Ann Lipsich
Joseph R. Kates
Joseph J. Lucas
Research01 Sept 1979
Nature

Volume: 281, P: 74-76
Macromolecular modeling and design in Rosetta: recent methods and frameworks

This Perspective reviews tools developed over the past five years in the macromolecular modeling, docking and design software Rosetta.

Julia Koehler Leman
Brian D. Weitzner
Richard Bonneau
Reviews01 Jun 2020
Nature Methods

Volume: 17, P: 665-680
Glutamate as transmitter of hippocampal perforant path

W. FROST WHITE
J. VICTOR NADLER
JOSEPH T. CUMMINS
Research24 Nov 1977
Nature

Volume: 270, P: 356-357
Regional Cerebral Blood Flow in the Newborn Beagle Pup: the Germinal Matrix is a “Low-Flow” Structure

Joseph F Pasternak
Dennis R Groothuis
Dolores P Fischer
Research01 Jun 1982
Pediatric Research

Volume: 16, P: 499-503
Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae

This study provides a nucleotide-level survey of genome variation in 63 Saccharomyces cerevisiae strains sampled from different ecological niches and geographical locations. The analysis of genome-wide patterns of the nucleotide polymorphism and deletion variants discovered lays the foundation for genome-wide association studies in yeast.

Joseph Schacherer
Joshua A. Shapiro
Leonid Kruglyak
Research11 Feb 2009
Nature

Volume: 458, P: 342-345
Bottom-up design of Ca²⁺ channels from defined selectivity filter geometry

De novo design of Ca²⁺ channels with ion selectivity that can assemble appropriately and mediate Ca²⁺ conductance when expressed in cells is described.

Yulai Liu
Connor Weidle
David Baker
Research22 Oct 2025
Nature

Volume: 648, P: 468-476
Activity of vitamin A analogues in cell cultures of mouse epidermis and organ cultures of hamster trachea

MICHAEL B. SPORN
GERALD H. CLAMON
UMBERTO SAFFIOTTI
Research03 Jan 1975
Nature

Volume: 253, P: 47-50
Fatty Acid and Glucose Metabolism in the Perfused Heart

JOSEPH C. SHIPP
LIONEL H. OPIE
DAVID CHALLONER
Research25 Mar 1961
Nature

Volume: 189, P: 1018-1019
Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease

Dysregulation of lipid metabolism is associated with coronary artery disease (CAD). Here, the authors perform GWAS of the serum lipidome to identify variants associated with lipid species that are putatively in the mechanistic pathway to CAD.

Gemma Cadby
Corey Giles
Eric K. Moses
ResearchOpen Access06 Jun 2022
Nature Communications

Volume: 13, P: 1-17
NGC3256: an emerging elliptical galaxy

J. R. Graham
G. S. Wright
M. F. Bode
Research19 Jul 1984
Nature

Volume: 310, P: 213-214
The Sea-Serpent Explained

JOSEPH DREW
Research05 Sept 1878
Nature

Volume: 18, P: 489
Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial

As presented at the ESMO Congress 2025: Results of the phase 2/3 AGITG DYNAMIC-III trial show that de-escalated chemotherapy based on ctDNA-negative status in patients with stage III colon cancer did not meet non-inferiority for 3-year recurrence-free survival when compared to standard of care, although it enables better informed treatment decisions.

Jeanne Tie
Yuxuan Wang
Petr Kavan
Research20 Oct 2025
Nature Medicine

Volume: 31, P: 4291-4300
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Possible role for poly(A) as an inhibitor of endonuclease activity in eukaryotic cells

CARL C. LEVY
MORTON SCHMUKLER
ROBERT G. DORR
Research24 Jul 1975
Nature

Volume: 256, P: 340-342
Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis

Inhibition of a cardiac stroma-enriched mechanosensor, SRC—in concert with suppression of the TGFβ pathway—potentiates the reversal of fibroblast activation and alleviates contractile dysfunction in fibrotic hearts.

Sangkyun Cho
Siyeon Rhee
Joseph C. Wu
Research30 Apr 2025
Nature

Volume: 642, P: 766-775
Interactions between the lipidome and genetic and environmental factors in autism

Detailed analyses pairing deep phenotyping and molecular profiles reveal mediating roles of plasma lipids in genetic and environmental factors associated with autism-related traits in children.

Chloe X. Yap
Anjali K. Henders
Jacob Gratten
ResearchOpen Access19 Apr 2023
Nature Medicine

Volume: 29, P: 936-949
α and β-Retinyl acetate reverse metaplasias of vitamin A deficiency in hamster trachea in organ culture

GERALD H. CLAMON
MICHAEL B. SPORN
UMBERTO SAFFIOTTI
Research01 Jul 1974
Nature

Volume: 250, P: 64-66
Metabolic phenotyping of BMI to characterize cardiometabolic risk: evidence from large population-based cohorts

A substantial proportion of patients with cardiometabolic conditions appear to have normal BMI. Conversely, not all obese individuals exhibit these disorders. Here, we show that a metabolic BMI score derived from lipidomic models, allows quantify metabolic dysregulation in obesity independently of BMI.

Habtamu B. Beyene
Corey Giles
Peter J. Meikle
ResearchOpen Access07 Oct 2023
Nature Communications

Volume: 14, P: 1-19

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