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Using volatile vanadium oxide and non-volatile tantalum oxide/hafnium oxide memristor arrays, a first-principles Fourier transform system can be created that can outperform conventional Fourier transform hardware in terms of throughput and reduce memory cost.

This study shows how the anti-cancer drug Actinomycin D blocks RNA polymerase II transcription and reveals why it preferentially targets CTG and CAG repeats, thereby providing a basis for modifying ACTD to target DNA repeat-associated disorders.

Technology advancement is essential for climate action, yet the uneven distribution of technological progress across the world can slow mitigation. Through empirical and scenario analysis, researchers find that participating in trade agreements could enhance technological transfers and lead to emission reductions.

Programming ultrafast, reversible motions at the micron scale in subcellular soft materials and active matter requires precise spatiotemporal control over molecular processes. Here, the authors investigate elastic cortical protein networks that assemble rapidly and demonstrate repeatable force generation that actuates using light-sensitive Ca2+ release.

The study of highly active electrodes in organic electrosynthesis remains an under-investigated component of the subfield. This work introduces a bottom-up route to prepare chitin-derived composite carbon aerogel electrodes (CCAEs), which can be directly used as electrodes in organic electrosynthesis systems.

Maintaining proper reactive oxygen species (ROS) balance is critical for cellular and individual health, yet its dynamic nature encumbers monitoring and assessment. Here the authors propose a platform using mass cytometry-based detection, termed SN-ROP, to identify distinct ROS profiles associated with specific immune cell functions and disease states.

China’s crowded coasts must balance seafood demand with conserving migratory shorebirds that rely on tidal flats along the East Asian–Australasian Flyway. This study suggests that well-managed mariculture feeds shorebirds and limits overharvest, benefiting seafood production and biodiversity.

Blue QD-LEDs suffer from poor operational stability due to the carrier accumulation at transport layers. Here, the authors propose a strategy to mitigate the hole accumulation driven oxidation in hole transport layer, effectively elongating the operational lifetime of blue QD-LEDs.

Hole–electron resonance in WTe2 unlocks Coulomb-unconstrained spin transfer across WTe2/Fe3GaTe2, producing a giant 289% unusual anisotropic magnetoresistance and chiral transverse transport beyond conventional spin-transport models.

Antibody-conjugated Mesenchymal stromal cells (Ac-MSC) carrying internalized therapeutic agents represent a promising therapeutic approach for the treatment of autoimmune disease. Here, an ac-MSC-based drug delivery system, consisting of anti-CD4 antibody-conjugated MSCs loaded with a RORγt inverse agonist, is engineered to achieve selective targeting of pathogenic CD4 T cells and to deliver therapeutic benefits in mouse models of psoriasis and arthritis.

Wei, Bai, Wang, and colleagues present HypnoS, a genetically-encoded fluorescent sensor for the real-time monitoring of intracellular adenosine (iAdo) in a cell type-specific manner. They monitor iAdo dynamics during seizures or sleep-wake cycles with high spatiotemporal resolution in the brain of living animals.

Epithelial malfunction is an unmet critical challenge in trachea repair. Here, Chen et al. developed a multiplexed hydrogel to promote tracheal repair with native-like epithelium in pre-clinical models, exhibiting clinical translation potential.

A lab-scale proof-of-principle demonstration of a quantum network comprising one server chip and 20 client photonic chips implementing twin-field quantum key distribution shows excellent scalability and reliability and yields a pathway towards future large-scale networks.

Stimulated Brillouin scattering is a non-linear interaction that allows light to be stored as coherent acoustic waves. Here, the authors report on Brillouin scattering-induced transparency in an optical microresonator whose high quality allows for long-lifetime non-reciprocal light storage.

Although Bernal stacked trilayer graphene is believed to be the stable packing type, at temperatures below 1,000 °C the transformation from rhombohedral packing does not occur. Zhang et al.show that rhombohedral stacking can be converted to Bernal type by evaporating triazine onto graphene at 150 °C.

The coupling of ferroelectricity and magnetic order enables the tunability of material properties. Here, authors realize magnetic-field-enhanced ferroelectricity and electrical-field-controlled magneto-transport in non-magnetic moiré superlattices.

Using ancient DNA, isotopes and proteomics, this work reveals social inequality and mobility in Eastern Zhou China, showing female sacrifices, dietary disparities across classes, kinship networks among elites, and rare evidence of social mobility.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

This study shows that the El Niño/Southern Oscillation (ENSO) drives sea surface salinity (SSS) variability in the China Seas through coupled freshwater and oceanic processes, influencing regional fisheries. Under a warming climate, projected intensification of ENSO will amplify SSS heterogeneity.

Charge density waves usually cause electrons to become heavier and slow down. Here, the authors find the opposite is true in CuTe and study the phenomenon using advanced q-EELS.

Glucocorticoids, potent anti-inflammatory drugs, can cause or exacerbate obesity, yet the underlying molecular mechanisms remain largely unknown. Here, the authors show KLF9 in macrophages integrates the beneficial anti-inflammatory and adverse metabolic effects of glucocorticoids.

Exotic chiral fermions beyond Weyl fermions have recently been discovered in a series of chiral crystals such as CoSi. Here, the authors report the evidences of chiral fermions in RhSn with opposite handedness compared to those observed in CoSi, where the structural chirality is also opposite.

Here, the authors synthesize a variety of ultra-thin III–V single crystals, ranging from ultra-narrow to wide bandgap semiconductors, through enhancing the interfacial interaction between the III–V crystals and the growth substrates.

Asymmetric hydrogenation (AH) and direct reductive amination (DRA) are both frequently utilized in chemical industry. Here, the authors combine these two transformations to efficiently convert in one step prochiral olefins into chiral amino compounds.

Single-atomic impurities may induce novel quantum state, but they are unexplored in topological magnets. Here, the authors report spin-down polarized bound states which further interact with neighboring states to form spin-orbit split quantized orbitals in a topological magnet Co₃Sn₂S₂.

The ultrathin oxide nanosheets obtained through previous approaches usually exhibit amorphism or polycrystallinity, which limit their properties towards electronic devices. Here, the authors synthesize ultrathin antimony oxide single crystals with high dielectric constant (~100) and large breakdown voltage (~5.7 GV m⁻¹).

Multifunctional underwater sensors with integrated self-powered signal transmission, effective thermal-moisture regulation, and multi-signal decoupling are desirable of underwater tasks. Here, the authors report a three-dimensional thermoelectric device composed of porous polyurethane foam coated with a waterproof conductive layer for human-machine interaction in aquatic settings.

A matrix-confined molecular layer of compact surface coverage and good conductivity is developed as charge transport substrate to fabricate perovskite solar-cell devices with high efficiencies, which shows application potential for scalable production.

Upconversion nanoparticles, which convert lower-energy light into higher-energy light, have many potential applications including sensing and imaging. Here, Wen et al. review recent advances that have addressed concentration quenching and enabled increasingly bright nanoparticles, opening up their full potential.

A light-induced spin voltage is demonstrated that arises from a spin-dependent excitation and diffusion of photo-excited electrons near heavy-metal/magnetic-insulator interfaces.

Ocean salinity could change as the climate warms. Here the authors show that the South Indian Ocean has freshened most of the Southern Hemisphere oceans and highlight the mechanisms behind this freshening, as well as the implications for Indian Ocean stratification and structure.

Telomere shortening marks cellular aging and links to heart disease. Here, the authors show shared genetic loci between leukocyte telomere length and coronary artery disease, highlighting genes such as SH2B3 and pathways involved in DNA biosynthesis and telomere maintenance.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Domestication of crops has boosted food production but increased dependence on fertilizers and pesticides. This study shows that wild rice harbors a higher abundance of nitrogen-fixing genes in the rhizosphere, while domesticated rice has more genes associated with nitrous oxide production.

Some materials host multiple charge density wave states, however, their dynamics and the nature of phase transitions are often unclear. Here, using temperature and orientation resolved ultrafast spectroscopy, the authors reveal charge density waves of different dimensionality in CuTe and elucidate their mechanism.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Hillside urbanization rises as cities exhaust flat land, threatening sensitive ecosystems. Mapping of 11.65 Mha added since 2000 reveals that 35% of them are in critical areas, fragmenting habitats and endangering 70% of globally threatened species.

Diabetic retinopathy is a major cause of blindness, yet ways to predict who will be affected remain limited. Here, the authors show that patterns of blood proteins can reveal disease mechanisms and enable powerful early prediction across diverse populations.

Existing 3D Spatial Transcriptomics reconstruction approaches often overlook spatial information or experiment-induced distortions. Here, authors propose ST-GEARS to bridge the gap between in vivo cell locations and in vitro analysis, accurately recovering spatial profiles.

The authors achieve configurable ferroelectric switching kinetics in CuInP₂S₆ through precisely tuning the Cu ions interlayer hopping, paving the way for development of advanced multifunctional ferroelectric devices.

Pt/CeO₂ ensemble catalysts show great potential for hydrocarbon oxidation, but the nature of active sites and interfacial evolution during reaction has been debated. Here, the authors demonstrate metallic Pt ensembles serve as the true active sites for C₃H₆ oxidation, and confirm dynamic nature of oxygen activation with the threshold temperature around 170 °C.

Folate plays an essential role in dividing cells and is regulated by methionine adenosyltransferase (MAT), where a switch from MAT Iα to MAT IIα expression seems to promote liver cancer progression. Here the authors demonstrate that MAT IIα stability is regulated by acetylation and this regulation is important for tumour growth.

Through multimodal analyses of human cardiac tissues across different ages, Fan, Zheng, Zhan, Xu, Liu and colleagues reveal that RNA-binding protein ARID5A drives inflammaging by stabilizing the MAVS mRNA and activating the NF-κB–TBK1 pathway, and show that inactivating myocardial ARID5A attenuates cardiac senescence and functional decline.

Chen et al. report that the immune modulatory metabolite itaconic acid selectively inhibits the activity of TET DNA dioxygenases to repress the inflammatory responses.

The COVID-19 pandemic has raised concerns about increased neuropsychiatric conditions in children and youths, with potential links to SARS-CoV-2 infection. Here, the authors analyze EHR data from 25 institutions, showing that COVID-19 positive children and youths have a modestly increased risk of developing neuropsychiatric conditions, such as anxiety, depression, and ADHD, compared to those who tested negative.

While yeast Rap1 regulates telomere length and protects telomeres from non-homologous end joining, its role in higher eukaryotes is controversial. Here the authors present evidence that in mammals, RAP1 cooperates with TRF2 to prevent homologous recombination-mediated repair of telomeres.

High-density dynamic random access memory is crucial for addressing the memory wall issue, yet its three-dimensional integration faces significant challenges. Liao et al. utilize a single-step self-aligned integration scheme, achieving 4 F² density and demonstrating 4-bit operation.