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The unfolded protein response is activated at the ER due to protein misfolding. Here the authors show that in Magnaporthe oryzae, the plasma membrane localized MoPh1 protein perceives stress through ER-PM contact sites and stimulates autophagy to support stress relief.

Endocsymbiosis is known to fuel deep-sea life, while ectosymbiosis remains poorly understood. Analysing the genome of a cold-seep scallop, this study uncovers key adaptations to the deep sea and metabolic complementarity with chemosynthetic bacteria on its gill surface.

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

Nociceptive hypersensitivity and prolonged wound healing due to the interaction of peripheral neuropathy and local immune disorders hinder the regenerative repair of diabetic foot ulcer. Here, the authors report a low-intensity focused ultrasound-activated piezoelectric gel bandage with immune homeostasis modulation and neuropathic pain relief functions for comprehensive repair of diabetic wounds.

Zinc isotopes in basalts along a 1,100-km transect of the Gakkel Ridge record widespread mantle recycling of surface carbonates via ancient oceanic subduction, explaining the unusually carbon-rich nature of the Arctic asthenosphere.

In conventional s-wave superconductors, ferromagnetism is strongly suppressed, due to the singlet pairing of the electrons. Here, Xiang, He, Lin, and coauthors find a long-range ferromagnetic order among impurity sites in the spin-orbit coupled Fe(Se,Te) using scanning superconducting quantum interference device microscopy.

Non-Hermitian and nonreciprocal valley dynamics are usually enabled by gain control. Here, authors demonstrate three non-Hermitian nonreciprocal effects in a honeycomb phononic metamaterial including unidirectional transport of bulk states, valley-dependent skin effects and anomalous beam routing, by controlling coupling loss.

Here, the authors show that the PLA2G6 protein is a component of the IP3R1–GRP75–VDAC1 complex at the mitochondria-associated endoplasmic reticulum (ER) membrane, maintaining the integrity and function of ER–mitochondria contacts.

The Kibble-Zurek mechanism describes universal scaling laws in the dynamics across a continuous or quantum phase transition driven in finite time, but it is limited to slow quenches. Here, by focusing on a holographic superfluid disk model, the authors advance beyond this framework and uncover universal statistics of topological defects that holds for both slow and fast quenches.

Random access memory has multiple data registers and uses addresses to specify which register should be read or modified. Now a quantum random access memory has been demonstrated that uses quantum addresses to return data in superposition.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Cells can form a rotating doublet. This rotation is driven by the symmetry breaking of myosin polarization in the cortices of the two cells.

Yu, Yin, Zhu, Lu and colleagues show that Acr inhibits Cas activity through a scaffold RNA interaction and further develop an RNA truncation optimization strategy to enhance editing performance.

New findings from articulated head and trunk material of Megamastax amblyodus yield previously unseen morphological details of a Silurian stem osteichthyan.

Vestibular schwannomas that are caused by genetic mutations in the NF2 gene are hard to treat and lead to hearing loss. Here authors show in a mouse model that faithfully represents the human condition that combination therapy with anti-PD-1 and anti-VEGF inhibits tumor growth via normalizing the tumor vasculature and enhances T and NK cell antitumor cytotoxicity via upregulation of NKG2D.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

A nonlinear Hall rectenna based on the type-II Weyl semimetal niobium iridium tetratelluride (NbIrTe₄) can offer 27th-order nonlinear frequency comb generation and high-bandwidth mixing exceeding 100 GHz.

Mitochondrial damage is a central pathological mechanism of cerebral ischemia-reperfusion injury. This study develops a bioengineered nanolamellar system to sequentially restore neuronal cell mitochondrial function and modulate microglial polarization to mitigate ischemia-reperfusion injury.

A wearable human–machine interface combines inertial and electromyography sensors with deep learning to robustly extract gesture signals and enable real-time robotic control under diverse motion artefacts in dynamic environments.

B7H3 is an immune checkpoint overexpressed in many cancers and associated with tumor immune evasion. Here, the authors discover that in colorectal cancer, particularly microsatellite-stable tumors, palmitic acid promotes ZDHHC24- mediated B7H3 palmitoylation, regulating CD8⁺ T cell antitumor activity.

The commercialization of organic solar cells has been hindered by the limited device stability. Here, authors show that the connectivity of electron transport network is a key factor determining electron transport and device stability, with polymeric acceptors likely to establish such a network.

Despite high efficiencies, all-perovskite tandem solar cells are hindered by thermal instability. Guo et al. address this issue by introducing a multi-Lewis-base modulator, which suppresses the formation of dense Cs-rich films in Pb-Sn perovskites to concurrently deliver high performance and stability.

Zero-field mobility has been an unreliable indicator to predict thick-film organic solar cell performance. Here, authors reveal that critical length is a decisive factor governing thick-film device performance and achieve maximum efficiency of 19.0% in 300-nm thick-film D18:L8-BO:BTP-eC9 devices.

Tao et al. show that SCRN1 acts as a scaffold to facilitate GPX4 phosphorylation by STK38, thereby preventing chaperone-mediated autophagy of GPX4 and subsequent ferroptosis in patient-derived organoids and mouse models for hepatocellular carcinoma.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

A DNA matrix material potentiates humoral response through multiple administration routes, generating neutralizing antibodies and conferring robust protection against infection.

NIID is a neurodegenerative disease caused by GGC repeat expansions within NOTCH2NLC gene. Here, authors develop a precise gene-editing therapy that effectively treats the disease in multiple models.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

An asymmetric self-assembled monolayer improves the efficiency of perovskite/silicon tandem solar cells compared with symmetric self-assembled monolayers, resulting in a certified power conversion efficiency of up to 34.58%.

Topologically protected edge states can be observed when combining two Si-based phononic crystals of opposite phases, as well as on-chip elastic wave splitting via partition of edges states at the intersection of topological channels.

Plants and pathogens secrete proteases to aid defense or counter immunity. Here the authors show that Xanthomonas oryzae secretes a cysteine protease to degrade the rice defense protein OsXIP2 whereas rice counter-attacks by secreting a cysteine protease inhibitor.

Endothelial RAB5IF is a critical proangiogenic regulator of both normal and pathological retinal angiogenesis. Here the authors show that RAB5IF-SUMO2-Gαi1/3 signaling axis drives this process, presenting new therapeutic targets for neovascular eye diseases.

Elucidating the genetic basis of aneuploid phenotypes has posed a challenge. Here, the authors use loss-of-function screening in synthetic aneuploid yeast and gain-of-function testing in euploid yeast to identify various dosage-dependent nonlinear polygenic interactions driving aneuploid traits.

Frequency transfer, which allows researchers to go beyond in-range analyses of spectrum properties towards out-of-the range predictions, is a key challenge in machine learning. Here, the authors propose a multi-physics deep learning framework without the knowledge of the multi-physics response to inverse design metasurface.

Wang et al. propose a 3D meta-holographic zoom micro-projector, integrating a high-resolution metasurface with a tailored liquid lens, resulting in a 3D zoom micro-projector of only 0.18 cm³, small enough to fit on a fingertip.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.