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Quasi-three-dimensional plasmonic crystals have potential uses in miniaturized photonics. In this study, a method is described to enhance plasmonic resonance in the crystals by coupling them to optical modes of Fabry–Perot type cavities, with possible applications in photonic and sensor components.

Integrating an electronic device with a cavity can cause the electrons to couple to photons strongly enough to form hybrid modes. Now, the cavity effects induced by intrinsic graphite gates are shown to modify the low-energy properties of graphene.

A completely solid-state, single-chip, microwave-frequency surface acoustic wave phonon laser can generate coherent phonons from thermal noise or resonantly amplify injected phonons using only a direct current bias field.

Quantum simulations of the phase diagram of quantum chromodynamics faces hard challenges, such as having to prepare mixed states and enforcing the non-Abelian gauge symmetry constraints. Here, the authors show how to solve the two above problems in a trapped-ion device using motional ancillae and charge-singlet measurements.

The authors present an integrated acousto-optic modulator fabricated in a wafer-scale process that realizes efficient, high-speed modulation of visible light with high optical power handling.

Eigenmodes of photonic crystal defects have now been topologically protected in an experimental demonstration that also shows how to minimize the mode volume.

The North American southwest was dustier during interglacial climates, in contrast with global trends. Long-term regional dust emissions depend on the erosion of hillslope and tributary sediments into alluvial, river, and playa dust sources downstream.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Proxy reconstructions show a decreasing trend from the Middle to Late Holocene, which conflicts with model results showing an increasing trend. Statistical analysis of model output shows that these conflicting results originate from two distinct modes of variability, which dominate at different regions and times.

Under extreme conditions, nonlinear lattice dynamics in a material can manifest and reveal unexpected properties. Here, using inelastic neutron scattering and first-principles calculations the authors find the presence of nonlinear travelling waves in a fluorite structured system, which exhibit characteristics different from regular phonons.

How the cortex generates movement to achieve different tasks remains poorly understood. Here the authors show that the cortex serializes motor control by first performing task-specific computations in dorsal premotor cortex in order to then generate task-independent commands in primary motor cortex.

Active galactic nuclei are surrounded by a dusty and molecular disk that fuels supermassive black holes and connects them to their host galaxies. Here, the authors show with JWST interferometric observations that most of the dust in the Circinus galaxies lies in a compact disk, while only a tiny fraction traces hot outflowing material.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Here, the authors show that brain dynamics mature from childhood to adulthood with increased hierarchical propagation and reduced visual-somatomotor dynamics. Top-down hierarchical flow strengthens throughout this developmental period.

The [1,2]-Wittig rearrangement of allylic ethers is traditionally considered to proceed via formation and recombination of radical pairs. Now it has been shown that an alternative reaction cascade, involving initial enantioselective [2,3]-rearrangement followed by base-promoted anionic fragmentation–recombination that proceeds with high enantiospecificity, allows a catalytic enantioselective [1,2]-Wittig process.

Brillouin interactions between sound and light can excite mechanical resonances in photonic microsystems, with potential for sensing and frequency reference applications. The authors demonstrate experimental excitation of mechanical resonances ranging from 49 to 1,400 MHz using forward Brillouin scattering.

Expanded alkali fullerides are molecular superconductors with a Mott parent insulating state. Kluppet al.use infrared spectroscopy to detect the molecular Jahn–Teller distortion of fulleride ions and establish its relevance to strongly correlated superconductivity.

Most active particles studied to date lack the ability to undergo controlled shape transformations and control over their propulsion in response to environmental stimuli. Here, the authors present a class of active particles made from stimuli-responsive materials that exhibit fully reversible shape-dependent propulsion.

Samples returned from asteroid Bennu by NASA’s OSIRIS-REx mission contain N-rich organics with prebiotic implications. This material probably formed in the earliest stages of the asteroid’s history possibly even before its water ice melted.

Femtosecond photoexcitation drives a coherent twist–untwist motion of the moiré superlattice in 2° and 57° twisted WSe₂/MoSe₂ heterobilayers.

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

Here, the authors show that post-translational molecular signatures of human skeletal muscle in response to acute or chronic aerobic and resistance exercise are distinct, potentially dictating the differential physiologic adaptations to different exercise modes.

Covalent KRAS inhibitors show initial responses but resistance limits durability. Here drug-induced hapten peptides are identified and characterized, enabling production of high affinity, cross-HLA T cell engagers that stabilize low density hapten peptide MHCs to drive tumor-specific killing.

This study presents a BRET biosensor that measures how anticancer drugs cooperatively engage PRMT5 complexes in cells, revealing how cellular metabolites such as SAM and MTA enhance drug action and enable precision therapies for MTAP-deleted tumors.

Bosonic qubits can be engineered to feature intrinsic protection against certain kinds of errors, which makes quantum error correction across many bosonic qubits possible with less overhead.

Behavioural and psychosocial interventions can effectively reduce the risk of cardiovascular disease. In this Perspective, Burg et al. identify the elements and actions needed for a broad implementation of these interventions in standard cardiovascular care.

A method of nanometre-level patterning of high-density extended 1D and 2D defects in thin films of perovskite oxides is developed.

The authors present a scalable mass spectral search tool that identifies both known molecules and structural variants by estimating match significance. The method revealed biosynthetic pathways in Streptomyces, expanding the scope of metabolite discovery.

Understanding and manipulating the photonic band structure formed in stacked Fabry-Pérot microcavity organic light-emitting diodes (OLEDs) is key to optimizing their performance. Here, through intelligent device design, the authors tune the photonic band gap in vertically-stacked OLED microcavities.

Motor cortical neurons enable performance of a wide range of movements. Here, the authors report that dominant population activity patterns, the neural modes, are largely preserved across various tasks, with many displaying consistent temporal dynamics and reliably mapping onto muscle activity.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Researchers demonstrated integrated non-magnetic isolators with 24.5-dB contrast, –2.16-dB insertion loss and 2-THz (16-nm) optical bandwidth.

Here, a combination of forward genetics and genome-wide association analyses has been used to show that variation at a single genetic locus in Arabidopsis thaliana underlies phenotypic variation in vegetative growth as well as resistance to infection. The strong enhancement of resistance mediated by one of the alleles at this locus explains the allele's persistence in natural populations throughout the world, even though it drastically reduces the production of new leaves.

Optical control of atomic quantum systems poses stringent requirements on modulators. Here, the authors present a piezoelectrically actuated silicon-nitride-based high-speed spatial light modulator technology meeting those needs.

Origami is widely practiced in the design of foldable structures for smart applications and usually consists of stiff sheets that only deform along prescribed creases. Pinsonet al. take a statistical physics approach to design and characterize arbitrary patterns as a function of folding energy.

An epsilon-near-zero medium is used to demonstrate ultrastrong coupling between phonons and gap plasmons. The approach may pave the path to exploitation of vibrational transitions.

Gene regulation varies across cell types and states. Here, the authors present airqtl, a scalable method for single-cell eQTL mapping that enables efficient causal gene regulatory network inference, revealing the genetic drivers of cell state-specific regulation.

Gaussian boson sampling is performed on 216 squeezed modes entangled with three-dimensional connectivity⁵, using Borealis, registering events with up to 219 photons and a mean photon number of 125.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Gutnick et al. design a light-sensitive small molecule, zapalog, which reversibly dimerizes any two proteins. Tethering mitochondria to active kinesin motors uncovers distinct modes of mitochondrial motility in axons.

Petawatt laser-matter interactions could open the way to fusion energy or compact particular accelerators, but predicting the amount of light absorbed in these interactions is challenging. New analysis by Levy et al.reveals the theoretical upper and lower limits of this absorption.