The authors show that intraperitoneal injection of tubeimoside I (TBM) alleviates the endothelial dysfunction caused by sepsis. Their results suggest that TBM functions by reducing oxidative stress and apoptosis via SIRT3, an NAD-dependent deacetylase. TBM is therefore a promising new therapeutic agent against sepsis-induced endothelial dysfunction.
- Xiyang Yang
- Xingbing Li
- Jianghong Yan
