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Replicating the human brain’s imaginative ability has long been a core AI goal, yet current systems remain limited in speed and efficiency. Yang et al. present a hardware platform based on resistive memory, enabling high-speed, low-power AI content generation while fully preserving output quality.

The scarcity of effective doping strategies has so far limited the development of scalable complementary electronic circuits based on 2D semiconductors. Here, the authors report the fabrication of wafer-scale homogeneous top-gated complementary inverter arrays and logic circuits based on p-type and n-type doped 2D WSe₂ semiconducting channels.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Scaling interpretable tree-based AI on analog content addressable memory is hindered by its inherent soft decision boundary and device variations. Wen et al. harness these probabilistic boundaries in a robust MoS₂ array, achieving 96% recognition accuracy on the Wisconsin Diagnostic Breast Cancer dataset.

Neural mechanisms underlying social behavior are not fully understood. Here authors show two lateral septum neuron types in male mice that bidirectionally regulate social memory via distinct hippocampal-hypothalamic circuits.

Reversing unitary operations is crucial in quantum computing and control, yet remains a challenging task. The authors introduce shadow unitary inversion, achieving efficient inversion at the expectation value level with reduced query complexity, offering a promising approach for quantum error correction and information recovery.

Controlling the hydrothermal reaction kinetics during the fabrication of Sb₂(S,Se)₃ solar cells is challenging. Chen Qian et al. show that sodium sulfide buffers the pH and allows a controlled release of Se, enabling a certified efficiency of 10.7%.

An in situ multistep edge-contact process is developed for MoS₂ transistors, achieving quasi-non-volatile capacitorless two-transistor dynamic random-access memory with 5-bit accuracy and nanosecond write speeds.

This study introduces a meta-lens-based hyperspectral radiation thermometry that accurately measures temperatures up to 2973 K with error lower than 0.32%. The method is six times more precise than current methods and holds protentional for developing miniaturized, two-dimensional temperature sensors.

KIM1 is dramatically upregulated in acute kidney injury (AKI) and but how KIM1 affects AKI remains unknown. Here, the authors report that renal specific Kim1 knockout relieves AKI, unveil a YY1-KIM1-DR5 axis in the progression of AKI, and suggest potential therapeutic strategies against AKI.

A RISC-V microprocessor capable of executing standard 32-bit instructions has been designed with 5,900 MoS₂ transistors and a complete standard cell library based on 2D semiconductor technology.

The cross-population Sum of Single Effects (SuSiEx) model is a robust and computationally efficient method for conducting multi-ancestry fine-mapping of genome-wide association signals, producing smaller credible sets and capturing population-specific causal variants.

Xu et al. identify the MondoA–TXNIP signalling axis as a regulator of antitumour immune surveillance in response to lactic acid in the tumour microenvironment.

Using a large multisite dataset of people with major depressive disorder and healthy controls, the authors show global brain connectivity alterations in the sensorimotor, visual, and default mode networks.

Cytoplasmic stress granules (SG) regulate cell fate and are involved in several physiological and pathological processes. Here, using mouse models of allergic rhinitis (AR), the authors reveal the formation of SGs within macrophages of the nasal mucosa and implicate SGs in the regulation of Lrp1-mediated efferocytosis and Type 2 cytokine production, aggravating AR symptoms.

Despite initial treatment with surgical resection, glioblastoma multiforme (GBM) frequently recurs. Here the authors report the design of an immunostimulatory autolysing Salmonella based-nanocapsule delivery system, promoting anti-tumor immune responses and preventing postoperative relapse in preclinical GBM models.

Maan et al., Meier et al. and Song et al. report that microtubule plus-tip end binding proteins can undergo liquid–liquid phase separation and regulate microtubule dynamics.

How the Asian monsoon, earth surface processes and human development interact is not well known. Here, a new record of dust storm intensity shows a relationship between the stability of dynasties and dust storm activity for the last ~2200 years, which argues for a strong human control of dust storms in East Asia over this time.

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Therapeutic options for small cell lung cancer (SCLC) are limited. Here the authors show that a telomere-targeting drug, 6-Thio-2’-deoxyguanosine, inhibits growth of SCLC tumors by inducing telomere dysfunction preferentially in cancer initiating cells and promoting anti-tumor immune responses.

Chen et al. report on a renal UTX-phosphoglycerate dehydrogenase axis that regulates serine secretion to affect lipid metabolism in the kidney and liver upon over-nutrition, suggesting potential treatment targets for obesity-related diseases.

Synthesizing Se-based nanocrystals with large diameters remains challenging. Here, a reactivity-controlled epitaxial growth strategy was demonstrated to synthesize nanocrystals of ZnSe, CdSe and PbSe with average diameters of 35 nm, 76 nm and 87 nm, respectively. The large ZnSe nanocrystals emitted pure blue light, which is important for display technology.

Cortical morphology shows maturation during childhood and adolescence. Here the authors show this is structurally constrained by a diffusion network model and that this constraint is linked to gene expression profiles of microstructural development.

mRNA with engineered poly(A) tails produces prolonged higher levels of protein.

The emerging kesterite Cu₂ZnSnS₄ solar cell offers a potential low-cost, non-toxic, materially abundant platform for next-generation photovoltaics, yet its efficiency has been mired below 10%. Yan et al. now use post-heat treatment of the heterojunction to show device efficiencies that surpass 10%.

Red phosphorus is a promising anode for Na-ion batteries but suffers from large volume change upon cycling. Here the authors show a red-phosphorus-impregnated carbon nanofiber design in which the sodiated red phosphorus is featured by a “liquid-like” behavior and ultra-stable electrochemical performance is realized.

This Review examines switching mechanisms in memristive devices based on van der Waals materials, and explores the advantages such devices offer and the challenges that must be faced for them to be of use in next-generation electronic and computing applications.

Incorporating MnBr₂ into (BA)₂CsPb₂Br₇ films enhanced ferroelectric properties, alongside a high PLQE of 88.7%, achieving a nonvolatile, reversible in situ photoluminescence modulation of Mn²⁺.

An evaluation of polygenic score prediction models for BMI, height, and type-2 diabetes in Native Hawaiians revealed that these models tend to underperform for Native Hawaiians, particularly among those most enriched with Polynesian ancestries.