Nature Search

cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Eric Van Buren
Yi Zhang
Xihong Lin
Research31 Dec 2025
Nature Methods

P: 1-12
Take it past the limit

Mo Qiao
News & Views18 Dec 2025
Nature Chemical Engineering

Volume: 2, P: 732
Casting pathways for net zero

Mo Qiao
Research Highlights18 Dec 2025
Nature Chemical Engineering

Volume: 2, P: 727
Projecting the products of hydrogen projects

Mo Qiao
Research Highlights12 Dec 2025
Nature Chemical Engineering

Volume: 3, P: 7
Wastewater is a double threat

Mo Qiao
Research Highlights19 Nov 2025
Nature Chemical Engineering

Volume: 2, P: 669
Assessing the potential of deep learning for protein–ligand docking

Morehead et al. introduce the benchmark PoseBench and evaluate the strengths and limitations of current AI-based protein–ligand docking and structure prediction methods.

Alex Morehead
Nabin Giri
Jianlin Cheng
ResearchOpen Access31 Dec 2025
Nature Machine Intelligence

Volume: 8, P: 32-41
In charge of selectivity

Mo Qiao
Research Highlights21 Oct 2025
Nature Chemical Engineering

Volume: 2, P: 620
Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation

CARD9 and CARD11 propagate signaling by nucleating Bcl10 polymerization in immune cells and are both held in an autoinhibited state prior to activation. Here, the authors combine structural, biochemical, and cell-based approaches to reveal the structural basis for CARD9/11 autoinhibition and show that the two proteins are activated through similar but distinct mechanisms.

Michael J. Holliday
Axel Witt
Wayne J. Fairbrother
ResearchOpen Access11 Jul 2019
Nature Communications

Volume: 10, P: 1-17
FX-Cell: a method for single-cell RNA sequencing on difficult-to-digest and cryopreserved plant samples

This work describes FX-Cell and its derivatives to achieve single-cell RNA sequencing from challenging and cryopreserved plant tissues, expanding the scope of single-cell genomics across field-grown samples.

Xin Ming
Mu-Chun Wan
Jia-Wei Wang
Research27 Nov 2025
Nature Methods

Volume: 22, P: 2551-2562
Snail modulates the assembly of fibronectin via α5 integrin for myocardial migration in zebrafish embryos

Liangjun Qiao
Hongwei Gao
Xianming Mo
ResearchOpen Access26 Mar 2014
Scientific Reports

Volume: 4, P: 1-6
Fuel cells as lifelong learners

Mo Qiao
Research Highlights20 Aug 2025
Nature Chemical Engineering

Volume: 2, P: 464
Tapping into electrolysis

Mo Qiao
Research Highlights22 Jul 2025
Nature Chemical Engineering

Volume: 2, P: 403
Battery safety goes wireless

Mo Qiao
Research Highlights23 Jun 2025
Nature Chemical Engineering

Volume: 2, P: 346
A nanoclustered solution to biphasic transport

Mo Qiao
Research Highlights23 May 2025
Nature Chemical Engineering

Volume: 2, P: 286
Selective separation of similar-sized solutes

Mo Qiao
Research Highlights23 Apr 2025
Nature Chemical Engineering

Volume: 2, P: 235
From laboratory research to industrial engineering

Kai Qiao, a senior engineer at SINOPEC Dalian Research Institute of Petroleum and Petrochemicals Co., Ltd, and a visiting professor in the Department of Chemical Engineering at Dalian University of Technology, talks to Nature Chemical Engineering about his career as a chemical engineer working on biomass-derived chemical production.

Mo Qiao
Comments & Opinion08 Feb 2024
Nature Chemical Engineering

Volume: 1, P: 124-126
Solar-powered flow reactor

Mo Qiao
Research Highlights24 Mar 2025
Nature Chemical Engineering

Volume: 2, P: 162
The green hydrogen implementation gap

Mo Qiao
Research Highlights24 Feb 2025
Nature Chemical Engineering

Volume: 2, P: 94
Increased DNA damage in full-grown oocytes is correlated with diminished autophagy activation

DNA damage repair machinery is not robust in full-grown mammalian oocytes. Here, the authors demonstrate that mammalian oocytes fail to activate autophagy in response to DNA DSBs, correlating with an altered chromatin structure, improper localization of DNA damage repair proteins and increased DNA damage.

Fei Sun
Nourhan Nashat Ali
Ahmed Z. Balboula
ResearchOpen Access01 Nov 2024
Nature Communications

Volume: 15, P: 1-20
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Joshua S. Weinstock
Jayakrishnan Gopakumar
Siddhartha Jaiswal
Research12 Apr 2023
Nature

Volume: 616, P: 755-763
A framework for direct CO₂ capture from air

Mo Qiao
Research Highlights31 Dec 2024
Nature Chemical Engineering

Volume: 2, P: 27
Nonlinear microbial thermal response and its implications for abrupt soil organic carbon responses to warming

This study leverages the empirical datasets and microbial-explicit SOC model to show a thermal threshold of microbial CUE and heterotrophic respiration at 15 °C, implying a potential abrupt transition to more vulnerable SOC under climate warming.

Kailiang Yu
Lei He
Thomas W. Crowther
ResearchOpen Access20 Mar 2025
Nature Communications

Volume: 16, P: 1-10
Electrochemical ion pumping

Mo Qiao
Research Highlights29 Nov 2024
Nature Chemical Engineering

Volume: 1, P: 673
Humidity-driven CO₂ pumping

Mo Qiao
Research Highlights23 Sept 2024
Nature Chemical Engineering

Volume: 1, P: 555
Proline-based tripodal cages with guest-adaptive features for capturing hydrophilic and amphiphilic fluoride substances

Proteins dynamically adjust their conformations to interact with their ligands through binding sites that accommodate either amphiphilic or hydrophilic substrates, but most synthetic receptors are designed to bind desolvated substances. Here, the authors design proline-based receptors capable of binding hydrated and amphiphilic substances.

Bo Huang
Sihao Li
Jianfeng Cai
ResearchOpen Access04 Apr 2025
Nature Communications

Volume: 16, P: 1-12
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Xihao Li
Han Chen
Xihong Lin
Research07 Feb 2025
Nature Computational Science

Volume: 5, P: 125-143
Multimodal spatial transcriptomic characterization of mouse kidney injury and repair

Kidney injury progression involves complex changes in cellular composition and spatial organization. Here, the authors use multimodal spatial transcriptomics to reveal fibro-inflammatory niche with Runx2 and integrin beta-2 driving fibrotic remodeling.

Qiao Xuanyuan
Haojia Wu
Benjamin D. Humphreys
ResearchOpen Access14 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Timing the electricity market

Mo Qiao
Research Highlights14 Aug 2024
Nature Chemical Engineering

Volume: 1, P: 498
Switchable thermal pathways in batteries

Mo Qiao
Research Highlights22 Jul 2024
Nature Chemical Engineering

Volume: 1, P: 446
Reducing desalination energy consumption

Mo Qiao
Research Highlights17 Oct 2024
Nature Chemical Engineering

Volume: 1, P: 612
MYADM binds human parechovirus 1 and is essential for viral entry

Host factors required for parechovirus entry are not well understood. Here, the authors identify MYADM as an essential host entry factor that directly binds human parechovirus 1 and that is required for PeV-A infection in cell lines and human gastrointestinal epithelial organoids.

Wenjie Qiao
Christopher M. Richards
Jan E. Carette
ResearchOpen Access24 Apr 2024
Nature Communications

Volume: 15, P: 1-14
Closing the thermoset recycling loop

Mo Qiao
Research Highlights10 May 2024
Nature Chemical Engineering

Volume: 1, P: 333
TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression

Aberrant EGFR expression is associated with triple-negative breast cancer (TNBC). Here the authors identify that TMEM25 interacts with EGFR and the loss of TMEM25 allows monomeric EGFR-mediated hyperactivation of STAT3 to promote TNBC progression.

Jing Bi
Zhihui Wu
Hong-Rui Wang
ResearchOpen Access24 Apr 2023
Nature Communications

Volume: 14, P: 1-15
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
The X-Age Project to construct a Chinese aging clock

In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

Jiaming Li
Mengmeng Jiang
Guang-Hui Liu
Reviews09 Sept 2025
Nature Aging

Volume: 5, P: 1669-1685
Systems pharmacology approaches decipher the anti-cancer efficacy of ethnopharmacological agents in hepatocellular carcinoma

Tingting Hao
Xiaonan Yang
Yang Dong
ResearchOpen Access17 Dec 2025
Scientific Reports

Volume: 15, P: 1-17
Reticulate allopolyploidy and subsequent dysploidy drive evolution and diversification in the cotton family

Polyploidy and subsequent post-polyploid diploidization (PPD) contribute to evolutionary success of plant species. Here, using 11 genomes from all nine subfamilies of Malvaceae as an example, the authors provide evidence to support the “polyploidy for survival and PPD for success” hypothesis.

Ren-Gang Zhang
Hang Zhao
Yong-Peng Ma
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
Syndecan-4 modulates the proliferation of neural cells and the formation of CaP axons during zebrafish embryonic neurogenesis

Ning Luo
Hongda Li
Xianming Mo
ResearchOpen Access04 May 2016
Scientific Reports

Volume: 6, P: 1-12
Understanding the global subnational migration patterns driven by hydrological intrusion exposure

Hydrological risks drive migration more than socioeconomic factors. Vulnerable groups often stay in high-risk areas or migrate nearby. The study reveals an S-shaped migration pattern influenced by settlement resilience and adaptability.

Renlu Qiao
Shuo Gao
Zhiqiang Wu
ResearchOpen Access26 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis

Noninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients, but its radiobiologic mechanisms of action are unclear. Here, the authors show that photon radiation durably and favourably reprograms cardiac conduction in the absence of transmural fibrosis suggesting this could be the mechanism through which cardiac radiotherapy to modulates arrhythmia susceptibility.

David M. Zhang
Rachita Navara
Stacey L. Rentschler
ResearchOpen Access24 Sept 2021
Nature Communications

Volume: 12, P: 1-14
Whole genome sequence analysis of blood lipid levels in >66,000 individuals

Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.

Margaret Sunitha Selvaraj
Xihao Li
Pradeep Natarajan
ResearchOpen Access11 Oct 2022
Nature Communications

Volume: 13, P: 1-18
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Pierrick Wainschtein
Deepti Jain
Peter M. Visscher
Research07 Mar 2022
Nature Genetics

Volume: 54, P: 263-273
High resolution spatial profiling of kidney injury and repair using RNA hybridization-based in situ sequencing

Advancements in spatial transcriptomics technologies have enabled the analysis of gene expression at cellular resolution in situ. The authors applied direct RNA hybridization-based in situ sequencing (dRNA HybISS) and developed a computational tool, CellScopes, to study gene expression in mouse kidneys, identifying cellular changes and interactions during injury and repair.

Haojia Wu
Eryn E. Dixon
Benjamin D. Humphreys
ResearchOpen Access15 Feb 2024
Nature Communications

Volume: 15, P: 1-16
Author Correction: Designing a synthetic moss genome using GenoDesigner

Wenfei Yu
Shuo Zhang
Junbiao Dai
Amendments and Corrections07 Jun 2024
Nature Plants

Volume: 10, P: 1053
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

The goals, resources and design of the NHLBI Trans-Omics for Precision Medicine (TOPMed) programme are described, and analyses of rare variants detected in the first 53,831 samples provide insights into mutational processes and recent human evolutionary history.

Daniel Taliun
Daniel N. Harris
Gonçalo R. Abecasis
ResearchOpen Access10 Feb 2021
Nature

Volume: 590, P: 290-299
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.

Pradeep Natarajan
Akhil Pampana
Gina M. Peloso
ResearchOpen Access12 Apr 2021
Nature Communications

Volume: 12, P: 1-14
Prognostic analysis of appendectomy versus right hemicolectomy for T1 appendiceal adenocarcinoma: a multicenter retrospective analysis

Qiao Zhang
Guobing Xia
Fei Pei
ResearchOpen Access14 Sept 2024
Scientific Reports

Volume: 14, P: 1-6
Strain-driven Kovacs-like memory effect in glasses

An abnormal stress memory effect is discovered in different types of glassy materials when they are subjected to a low strain after a high strain. This strategy can be used to depress the stress relaxation and increase the stability under loading.

Yu Tong
Lijian Song
Jun-Qiang Wang
ResearchOpen Access18 Dec 2023
Nature Communications

Volume: 14, P: 1-8

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