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ACKR4 is scavenger for chemokines. Here, authors identify a ternary signalling complex comprising receptor, βarrestin and the inactive G protein that facilitates GRK2/3 recruitment and chemokine internalization.

Newly crystallized arc magmas can remelt when H2O-rich fluids are added, producing voluminous granitic magmas, leaving behind relatively low volumes of residual rock, explaining the scarcity of arc rocks of intermediate composition and continent maturation.

There is a lack of energy system transformation pathways required to achieve a full phase-out of fossil fuels by 2050 in the literature. This paper finds it requires rapid electrification and 1.6–1.8-fold increases in power generation compared to cost-effective 1.5 °C pathways.

Using inbred medaka strains, the authors mapped 59 genetic loci linked to heart rate. Gene editing validated conserved genes affecting heart rate and morphology, highlighting the power of isogenic strains in uncovering mechanisms of cardiac traits and disease.

The study identifies novel genetic variants linked to core cerebrospinal fluid Alzheimer’s Disease biomarkers using a genome-wide analysis, showing how endophenotypes can identify genes and disease mechanisms not captured by case-control studies.

Myeloid cells show marked heterogeneity in Alzheimer’s disease. This study introduces CODEX-CNS, a single-cell spatial proteomics pipeline, and identifies a human microglial subpopulation enriched in Alzheimer’s disease brains that associates with dense amyloid-β plaques.

RNA velocity is a widely used method to predict the fate of single cells. Here the authors show that the concept can be adapted to predict the fate of individual human subjects, using RNA velocity of whole blood at a single point in time to predict future clinical outcomes and treatment responses.

Collagen based 3D tissue-like cultures have been shown to modulate HIV-1 infectivity and mode of spread. Here, the authors demonstrate that varying the density of type I collagen matrices impair HIV-1 particle fusion and sensitize virions for TLR-based innate immune recognition by macrophages implicating structural changes in Env, TLR2 interaction and TLR8 positive endosomes promoting innate immune detection of viral gRNA.

Nuclear deformation and mechano-signalling are regulated by the coupling of vimentin cytoskeleton to the extracellular matrix through fibrillar adhesions, modulating the timescale of mechanotransduction on force removal.

Deviations from the textbook current–phase relationship of a Josephson junction can arise from the intrinsic physics of the junction, but also from the inductance of metallic traces. Now a scheme has been developed to distinguish these cases.

\({\rm{Micro}}{\mathbb{S}}{\rm{plit}}\) is a computational unmixing method for multiplexed fluorescence imaging of up to four structures per imaging channel.

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and the seeding patterns that underpin it.

In this individual participant data meta-analysis, and across 321,345 smartphone-ratings of affective well-being and nearly 1 million hours of physical activity measurement, Rehder et al. clarify the nature and extent of activity–well-being relations and document their relevance in humans’ everyday life.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Systematic comparisons of different masking approaches for rare variant association tests across 54 traits in UK Biobank highlight strategies for gene-level burden analyses that increase study power and replicability.

A low-cost, modular self-driving laboratory platform (RoboChem-Flex) is designed to democratize autonomous chemical experimentation. This platform combines customizable hardware with Python-based control software to make advanced Bayesian optimization more accessible. Photochemical, biocatalytic and thermal processes are demonstrated, showcasing a broad range of potential applications in both fully closed-loop and human-in-the-loop approaches.

It is important to assess the gap between national climate ambitions and the goal of limiting global temperature increase. This multi-model analysis shows that if net-zero pledges are implemented, meeting the 2 °C target is feasible, while increasing ambition and international cooperation is crucial.

Tailoring relativistic laser–plasma interactions on femtosecond timescales unlocks a direct route to extreme field generation using a coherent harmonic focus.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming and local immunosuppression.

Dutta et al. demonstrate that the tumor suppressor complex BRCA1–BARD1 physically interacts with the RNA–DNA helicase Senataxin (SETX) and upregulates the activity of SETX to resolve harmful R-loops crucial for the avoidance of transcription–replication conflicts.

Allosteric biosensors are constructed by combining reporter proteins with machine-learning-designed receptor domains.

The authors simulate phytoplankton macromolecular composition—proteins, carbohydrates and lipids—under present and future scenarios. They show increased protein allocation in subtropical phytoplankton but declines in high-latitude populations under warming, with implications for marine food webs.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

A single-cell spatial atlas identifies a B cell-predominant microenvironment within the profibrotic tubular niche that marks a subset of patients with diabetic kidney disease with rapid progression.

The predicted increase in frequency of droughts and rising temperatures in Europe will lead core populations of a temperate plant to an evolutionary dead-end unless they acquire genetic alleles that are present only in extreme edge Mediterranean, Scandinavian, or Siberian populations.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Recently, the dose escalation stage of the GLORIA trial investigating NOX-A12 (L-RNA aptamer-based CXCL12 inhibitor) in combination with radiotherapy in patients with glioblastoma was reported. Here, the authors report the preclinical rationale and an expansion arm of the GLORIA trial combining NOX-A12, radiotherapy and bevacizumab (anti-VEGF) in patients with newly diagnosed glioblastoma.

Analysis of nuclear and mitochondrial genomes from archaeological canid remains found across Europe and Anatolia shows that a genetically homogeneous dog population was already widely distributed across the region by 15,000 years ago.

This study presents a framework for the automated generation of reaction networks in heterogeneous catalysis. Powered by state-of-the-art machine learning models, the framework enables the investigation of thermal and electrochemical processes not amenable to density functional theory. The capabilities of its kinetic module are demonstrated by simulating Fischer–Tropsch networks with 37,000 reactions.

A fully green printing strategy enables biodegradable and recyclable magnetoresistive sensors made from iron-based materials. By combining sustainability with high low-field sensitivity, the work opens a pathway toward environmentally responsible disposable magnetoelectronics.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Frozen particulate organic carbon released during sea-ice ridge formation in the Arctic Ocean are a potential food source for plankton during winter months, according to water sampling observations and particle dispersal simulations. A peer review file is available.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

The Amazon faces worsening droughts, yet little is known about large-scale variation in the physiological limits of Amazon trees. Here, the authors reveal family-level conservatism in embolism resistance and estimate that Brazilian and Guiana shield forests are more resistant than Western Amazonia forests.

Algal photosynthesis relies on a biomolecular condensate known as the pyrenoid, which sequesters the cell’s Rubisco. The pyrenoid constituent Rubisco activase partitions to the condensate via an element functionally involved in Rubisco activation.

Groundwater, enhanced through managed aquifer recharge, is crucial for alleviating water stress. This study demonstrates that isotopic tracers, including tritium from nuclear power plant effluents, can be used to map groundwater flow in Swiss alluvial systems, revealing insights into groundwater travel time distributions and informing sustainable groundwater management globally.

Extreme rainfall reshapes permafrost, cooling shallow soils but warming deeper layers. Impacts depend on climate and ecosystems, potentially accelerating thaw and increasing carbon-release risks.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Recent studies have shown that probing the heating and ionization dynamics of solid-density plasmas with x-ray free-electron laser (XFEL) beams is inherently challenging. Here, the authors demonstrate sub-picosecond time resolution of solid-density Cu plasmas driven by an optical laser pulse, by combining resonant x-ray emission spectroscopy and absorption imaging from an XFEL probe beam.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.