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The contribution of ether lipid species in cancer cell fate has not been fully understood yet. Here the authors show that malignant cancer cells employ ether lipids to modulate membrane biophysical properties, enhancing iron endocytosis and ferroptosis susceptibility.

Fracto-mechanoluminescence is the emission of light from fracturing solids. Here, the authors show that this emission in Mn halides arises from elastic stiffness, electromechanical coupling, and trap states that activate Mn²⁺ d−d transitions.

Molecular information encoded within supramolecular frameworks offers a powerful paradigm for directing emergent function beyond the genetic code, but systematic investigations into alternative spatial configurations and their consequences remain scarce. Here the authors use metalla-[2]catenanes to probe sequence–function relationships in layered architectures.

Genetic variants of TREX1, a negative regulator of type I interferon responses, have been linked previously to non-monogenic systemic lupus erythematosus (SLE). Here the authors analyze UK Biobank multi-omics data to show that, while a derived oligoprotein interferon signature associates with increased SLE risk, TREX1 variants do not.

Virtual nature exposure reduces self-reported pain and is associated with decreased brain responses linked to somatosensory and nociceptive processing, providing new insights into the underlying mechanisms of nature-induced analgesia.

N-acetyltransferase 10 (NAT10) is an N⁴‐acetylcytidine (ac⁴C) writer, which catalyzes RNA acetylation at cytidine N⁴ position on RNAs. Here, the authors show that NAT10 catalyzes ac⁴C addition to a long non-coding RNA encoded by the oncogenic DNA virus Kaposi’s sarcoma-associated herpesvirus (KSHV), triggering viral lytic reactivation from latency, which promotes NAT10 recruitment of IFI16 mRNA, resulting in inflammasome activation.

Engineered mucus-tethering bispecific nanobodies neutralize and entrap viruses to enhance mucosal immunity, preventing influenza infection and limiting SARS-CoV-2 transmission.

Data provided by Amazonian peoples are used to estimate the value of wild animals as a source of food, including its spatial distribution and nutritional value, providing information that will be key for improved management of forest ecosystems in the region.

This study surveyed key informants across 26 countries on burning plastic for waste management and energy needs. It finds high awareness of this practice, with potential drivers including inadequate waste collection and a lack of affordable fuels.

Many transport networks exhibit a core–periphery structure, where few nodes are highly interconnected and the rest form a tree-shaped structure. Here, the authors demonstrate how to generate such a structure through a pruning process based on removal of underutilized links and redistribution of loads.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

The function and regulatory mechanism of mRNA acetylation modification in cancer progression remains largely unknown. Here the authors identify that targeting tumor N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 improves anti-tumor response via MYC/CDK2/DNMT1/dsRNA/type I IFN pathway, and show the synergic anti-tumor effect of NAT10 inhibition with aPD-1.

Complex infectious conditions, such as sepsis, requires rapid assessment of both pathogens and host responses. Here, the authors develop MIDAS, an assay platform that profiles bacterial RNA and inflammatory proteins simultaneously in under 4 hours.

A catalogue of nucleotide-binding leucine-rich repeat (NLR) genes in wild and cultivated potato genomes enables the identification of genes that confer protection against late blight, and provides a transgene-free strategy for engineering disease resistance in potato.

Control magnetic order with electric fields is of critical importance for spintronic devices, however, for certain material classes, such as van der Waals magnets, it is challenging. Here, Huang et al propose a spin-electric potential arising from polar spin interactions between differing constituent van der Waals magnets, which enables the electric field switching of spin orders.

Authors provide real-world evidence demonstrating that rifaximin use in patients with cirrhosis and hepatic encephalopathy was associated with increased antimicrobial resistance, increasing the risk of infection-related complications and mortality.

The authors find that TDP-43 loss of function—the pathology defining the neurodegenerative conditions ALS and FTD—induces novel mRNA polyadenylation events, which have different effects, including an increase in RNA stability, leading to higher protein levels.

Lo and colleagues report that double-positive thymocytes from neonates express less Zap70 and show reduced Ca^2⁺/NFAT signaling compared to double-positive thymocytes from older thymi. This diminished Ca^2⁺ signaling alters negative selection for self-reactive TCRs, resulting in a cell-intrinsic temporal window for regulatory T versus conventional T cell development in the thymus.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

The authors identify a Cys→Ser transformation (C19S) in insulin leading to neoepitope presentation and CD4⁺ T cell autoreactivity in type 1 diabetes. Inflammation and oxidative stress enhanced C19S transformation in β cells and antigen-presenting cells, resulting in C19S-specific CD4⁺ T cells with an activated memory phenotype linked to disease progression.

Viruses such as EBV use various mechanisms to avoid antiviral responses. Here the authors propose that the EBV protein BRRF2 is secreted via extracellular vesicles from NPC cells, disrupts the cGAS-STING pathway, reduces cGAS-DNA phase separation and the subsequent antiviral response.

Distinguishing glioblastoma and primary central nervous system lymphoma (PCNSL) remains challenging due to their overlapping pathology features. Here, the authors develop a computational tool, PICTURE, for differentiating similar pathological features enabling improved diagnosis of CNS tumours.

The authors use a computational model of word recognition to show that adults’ interpretation of young children’s speech depends heavily on beliefs about what children are likely to say.

Superconductivity has been induced in 2D electron gases, but high-field interplay between it and quantum Hall edge states remains elusive. Here the authors reach this regime by growing transparent superconducting contacts in GaAs, reporting modification of resistance in the quantum Hall regime.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

The current mountain pine beetle infestation in forests in British Columbia ranks among the largest ecological disturbances recorded to date. An analysis of remote sensing data suggests that the resultant forest loss has led to a 1 °C rise in summertime surface temperatures.

Primary angle-closure glaucoma is a leading cause of blindness. Here, the authors identify rare deleterious variants in UBOX5 as risk factors and implicate BIP ubiquitination as a potential disease mechanism.

Phenolic compounds have long captivated the interest of organic synthesis, particularly in their quest for selective hydroxylation of arenes using H₂O as a hydroxyl source but the inherent high reactivity and low redox potential of phenols often lead to undesirable overoxidation byproducts. Here the authors develop an electrophotochemical approach, finetuning substrate oxidative potential and enabling para-selective hydroxylation of anilides.

The joint analysis of datasets from NOvA and T2K, the two currently operating long-baseline neutrino oscillation experiments, provides new constraints related to neutrino masses and fundamental symmetries.

Previous work has shown that helical domain walls can form between states of different spin-polarization during a ferromagnetic spin transition in the fractional quantum Hall regime. Here, the authors study the transport through a single helical domain wall and find strong deviations from a simplified theory of weakly interacting edge channels.

Superconductivity mediated by phonons is usually conventional due to isotropic electron-phonon coupling. Here, Wang et al. report highly anisotropic phonons only along [001] direction in Sr_0.1Bi₂Se₃, indicating a singular electron-phonon coupling which favors a p-wave nematic superconductivity scenario.

Nickelate superconductors attract enormous attention in the field of high-temperature superconductivity. Here the authors report observation of perfect diamagnetism and interfacial effect on the electronic structures in infinite layer Nd_0.8Sr_0.2NiO₂ superconductors.

Here the authors uncover how a floppy tail in a protein acts as a remote switch, flipping activity on or off by tweaking internal motion, which reveals a powerful new way proteins regulate themselves without direct contact.

Glioblastoma therapy is challenging, and new approaches are needed. Here, the authors report on a mitochondrial targeting nanomotor with self-feedback mechanisms to trigger the mineralisation of mitochondria which together with curcumin, inhibits glioblastoma progression.

This work shows a diagnosis technique that works for multiple cancers and features cost advantage, environmental compliance and user-friendly protocol.