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Quantum error correction codes protect quantum information, but running algorithms also requires the ability to perform gates on logical qubits. A lattice surgery scheme for fault-tolerant gates has now been demonstrated in a quantum repetition code.

Ensuring high-fidelity quantum gates while increasing the number of qubits poses a great challenge. Here the authors present a scalable strategy for optimizing frequency trajectories as a form of error mitigation on a 68-qubit superconducting quantum processor, demonstrating high single- and two-qubit gate fidelities.

Spin qubits are a platform for quantum computing. There are many advantages for quantum information processing if the spin qubit can move. Here, Helgers et al. use a surface acoustic wave to define a moving quantum dot and demonstrate the magneticfield-free control of the spin precession, bringing “flying” spin qubits a step closer.

Store-operated calcium entry involves two proteins: Stim1 and Orai1, but are they sufficient for gating CRAC channels or are other factors required? Mammal systems have failed to provide a conclusive answer but yeast-based assay does: Stim1 and Orai1 are the only essential components of CRAC channel activity.

Dopamine is known to contribute to the amygdala-mediated aversive response, where increased dopamine release can augment amygdala function. Combining fMRI and PET imaging techniques, Kienast et al. present findings that suggest a functional link between anxiety temperament, dopamine storage capacity and emotional processing in the amygdala.

Tanycytic insulin receptors allow insulin access to the hypothalamic arcuate nucleus and are relevant for driving AgRP neuronal activity in response to feeding.

Schmidpeter and colleagues showed that anionic lipids bind to pacemaker ion channels and increase their activity by acting like keys that unlock salt bridges at the channel gates.

Although ABC-F proteins represent a ubiquitously distributed type of ATP-binding cassette (ABC) family member across phyla, their biological functions remain poorly characterized. A new study now shows that the bacterial ABC-F protein YjjK (EttA) gates ribosome entry into the translational cycle in an energy-dependent manner.

Typical quantum error correcting codes assign fixed roles to the underlying physical qubits. Now the performance benefits of alternative, dynamic error correction schemes have been demonstrated on a superconducting quantum processor.

Magic state distillation is achieved with logical qubits on a neutral-atom quantum computer using a dynamically reconfigurable architecture for parallel quantum operations.

Two-qubit operations exceeding 99% fidelity have been demonstrated by silicon devices made with standard semiconductor tooling in a 300-mm foundry environment.

The authors detail human antibodies that neutralize all three serotypes of poliovirus and mimic poliovirus receptor binding, accelerating antiviral development to further efforts to eradicate poliovirus.

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

Demonstrations of quantum advantage relying on sampling hard-to-compute probability distributions are plagued by difficulties in efficiently confirming the correctness of their output, which is known as the verification problem. Here, the authors use a trapped-ion platform to demonstrate efficient verification of quantum random sampling in measurement-based quantum computing.

A pathogenic subset of NK cells is identified that promotes type 1 diabetes and is generated via T cell-derived IL-21.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Deterministic generation of photonic multi-partite entangled states has previously been achieved for specific states using ad-hoc devices. Here, the authors present a single superconducting circuit device to deterministically generate a variety of states, namely W, GHZ, and cluster states.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Rathmell and colleagues show that metabolic reprograming of regulatory T cells is associated with severity of critical illness in patients with and without sepsis.

Chiral coupling between neighbouring magnetic domains is used in domain-wall racetracks to realize various all-electric logic operations by cascading the gates.

Quantum supremacy is demonstrated using a programmable superconducting processor known as Sycamore, taking approximately 200 seconds to sample one instance of a quantum circuit a million times, which would take a state-of-the-art supercomputer around ten thousand years to compute.

Treatment-seeking for fever is widely used to estimate treatment of childhood infections, but cross-country comparisons are problematic. Here, the authors estimate the probability of seeking treatment for fever at public facilities across 29 countries by quantifying person-level latent variables.

Silicon-based spin qubits are promising candidates for a scalable quantum computer. Here the authors demonstrate the violation of Bell’s inequality in gate-defined quantum dots in silicon, marking a significant advancement that showcases the maturity of this platform.

Chemical controllers made from DNA can be programmed to implement any dynamic behaviour compatible with chemical kinetics.

A hybrid analogue–digital quantum simulator is used to demonstrate beyond-classical performance in benchmarking experiments and to study thermalization phenomena in an XY quantum magnet, including the breakdown of Kibble–Zurek scaling predictions and signatures of the Kosterlitz–Thouless phase transition.

A study demonstrating increasing error suppression with larger surface code logical qubits, implemented on a superconducting quantum processor.

In this Resource, the authors present an open-source extensible benchmark tool, Benchpress, for evaluating the performance of mainstream quantum computing software. Benchpress was demonstrated to perform over 1,000 tests with up to 930 qubits to compare the performance of quantum software, providing insight into how to best use current programming stacks.

Two programmable riboregulator systems, based on toehold and three-way junction RNA motifs, were designed and validated as robust translational repressors in cells and applied for the construction of logic gates.

The authors reveal that the C-terminal tail anchors of BCL-2 family proteins control BH3 binding and cell survival by allosteric regulation at the mitochondrial membrane, involving BAX recruitment and complex disruption upon BH3 mimetic antagonism.

Without key cell cycle control genes, SAR11 cells experience aneuploidy and growth inhibition when exposed to changes in nutrients, carbon sources or temperature stress, a vulnerability that may represent an evolutionary trade-off for adaptation to oligotrophic environments.

Bohlen and colleagues report that the E3 ubiquitin ligase CBL is necessary for the development, tolerance and activation of B cells in humans, unlike in mice where CBL deficiency results in loss of T cells.

Highly sensitive, low-power, and chip-scale gas sensors are of great interest to both academia and industry. The authors developed a nanotransistor-based gas sensor with high sensitivity enabled by electron trapping effect in nanoparticles.

X-ray computed tomography is combined with burst ptychography and filtered back-propagation to achieve high-speed, three-dimensional imaging of features as small as 4 nm.

Physical realizations of qubits are often vulnerable to leakage errors, where the system ends up outside the basis used to store quantum information. A leakage removal protocol can suppress the impact of leakage on quantum error-correcting codes.

The authors introduce a hybrid quantum-classical algorithm for photonic quantum computing that focuses on tackling continuous-variable optimization problems using fewer quantum operations than existing methods. The approach shows better performance and practical implementation potential, demonstrated on Xanadu’s quantum chip.

Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.

A modular multicellular system has been created by mixing and matching discrete engineered bacterial cells in an artificial neural network-type architecture. The system is capable of solving multiple computational decision problems like identifying a number as prime and a letter as a vowel.

It is hoped that quantum computers may be faster than classical ones at solving optimization problems. Here the authors implement a quantum optimization algorithm over 23 qubits but find more limited performance when an optimization problem structure does not match the underlying hardware.

Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

Ethanol-induced fructose metabolism, mediated by KHK-A/C, drives excessive alcohol consumption and pathogenesis of alcoholic liver disease.

Leveraging in-memory computing with emerging gain-cell devices, the authors accelerate attention—a core mechanism in large language models. They train a 1.5-billion-parameter model, achieving up to a 70,000-fold reduction in energy consumption and a 100-fold speed-up compared with GPUs.

Investigating dynamics of polyatomic molecules is difficult as their potential energy surfaces are multidimensional due to coupled degrees of freedom. Here the authors demonstrate a spatial selective gating technique to probe the different vibrational modes of water upon core-level excitation with X-rays.

Huang et al. demonstrate an electrically controlled Fe–FePc molecular spin switch that reversibly changes its magnetic state and shifts a nearby spin’s resonance, showing potential of scalable, electrically tunable molecular quantum devices.

Delayed treatment for malaria increases the risk of severe disease. Here, the authors estimate the rates of treatment delay for children under five in malaria-endemic regions of Africa.

There are many opportunities to combine mobile technologies and social media with Artificial Intelligence to improve health in Africa. Here, the authors conduct a scoping review on such tools and make recommendations to enhance their contribution in advancing health in Africa.

RFdiffusion2, an extension of the RFdiffusion framework, builds de novo enzyme active sites using atom-level functional group constraints.

Recent theoretical work suggested that magic-angle graphene can simultaneously host localized and itinerant electrons. Now thermoelectric measurements provide evidence of this.