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Traditional edge audio recognition struggles with high overhead and latency owing to separate denoising and recognition modules. Wang et al. propose a memristor-based neuromorphic system integrating on-chip denoising and recognition, achieving full recognition accuracy with low energy consumption and strong noise robustness.

Immune-related adverse effects often hinder targeted therapies, such as severe diarrhoea caused by EGFR tyrosine kinase inhibitor treatment. Here authors show that EGFR inhibition induces diarrhoea via changes in the jejunal chemokine milieu, facilitating migration of T and B lymphocytes from Peyer’s patches to the jejunum, which results in inhibited intestinal stem cell proliferation via IFN-γ-induced JAK/STAT signalling.

Stabilizing metal oxides is a prerequisite for efficient electrochemical CO2 reduction. Here, the authors report a La2O3-socketed δ-Bi2O3 heterojunction that impedes Bi2O3 reduction to metallic Bi, achieving high-efficiency formate production in industrial-level electrolyzers.

This study introduces a pseudo-dynamic framework that maps static deformations in architected solids to particle trajectories in engineered landscapes, enabling programmable phase transitions and reconfigurable domain-wall lattices under uniform loading.

Enhanced future methane emissions from global wetlands under warming could substantially offset the emissions reduction goals of the Global Methane Pledge, according to ensemble simulations from terrestrial biosphere models.

Mitochondrial cristae structure is essential for energy production and immune regulation, but therapeutic strategies targeting cristae remodeling are lacking. Here, the authors show that targeting triose phosphate isomerase 1 restores cristae architecture, rewires microglial metabolism, and protects against ischemic stroke.

Conventional Si-based physical unclonable functions (PUFs) are normally limited by limited entropy and lack of reconfigurability, exposing them to machine learning attacks. Here, the authors report optically reconfigurable PUFs based on 2D MoS₂ ring-oscillator arrays, demonstrating machine-learning-attack-resistant image encryption.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Conventional oxide catalysts for water splitting often undergo overoxidation and dissolution at high potentials. Here, the authors report a metallic AgRuIr catalyst that resists oxidation and dissolution, providing a robust alternative to oxide-based systems for stable water electrolysis.

Tang, Dai, Qing, Zhang and colleagues describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K9me3 heterochromatin and genome stability.

Global grassland fragmentation has left only ~24% of grasslands intact by 2020, with contrasting biodiversity effects and conservation outperforming restoration in 61% of ecoregions, based on global fragmentation mapping, vertebrate richness analyses, and land-use scenario projections.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Converting basic chemicals into high-value products via electrosynthesis combines sustainability with economic benefits. Here, the authors report a redox-mediated domino electrosynthesis of N,N-dimethylformamide with industrial-relevant productivity and modularized cathodic integration.

Pathological mechanisms underlying the onset and progression of PTSD (post-traumatic stress disorder) are not fully understood. Here authors show that stress-induced Sgk1 upregulation in basolateral amygdala neurons projecting to the hippocampus as a key mechanism underlying the delayed PTSD-like avoidance behavior in mice.

Tyrosine kinase inhibitors (TKIs) combined with immunotherapy have improved outcomes in advanced renal cell carcinoma (aRCC), yet resistance persists. This group presents single-cell transcriptomic profiling of aRCC patients treated with TKIs and immune checkpoint inhibitors, uncovering an immunosuppressive microenvironment linked to therapeutic resistance.

Microcavity exciton polaritons are a promising platform for optical parametric processes. Here, authors achieve efficient parametric emission with strong phase coherence in quantum confined microcavities, demonstrating a polariton supersolid phase at room temperature.

Here the authors reveal a large-scale multi-ancestry genome-wide association study (GWAS) that identifies 11 new risk loci for kidney cancer, including one specific to Chinese populations.

This randomized open-label trial shows that hemoadsorption combined with hemodialysis reduces all-cause and cardiovascular mortality, and cardiovascular events in patients with end-stage kidney disease compared to hemodialysis (mainly low-flux hemodialysis plus intermittent hemodiafiltration) alone.

Current strategies for regulating enzyme activity are often enzyme-specific. Here, the authors report a spintronic approach that uses chiral gold nanohelices as electron spin polarizers to enantiospecifically modulate cyclooxygenase-2 activity for rheumatoid arthritis intervention, and explore electron spin polarization as an orthogonal mechanism for enzymatic regulation.

Neural mechanisms underlying social behavior are not fully understood. Here authors show two lateral septum neuron types in male mice that bidirectionally regulate social memory via distinct hippocampal-hypothalamic circuits.

Plasmons in carbon nanotubes (CNTs) benefit from high quality factors but the modulation of their dispersion relation remains challenging. Here the authors report the observation of hybrid plasmon-phonon polaritons in CNT arrays coupled with 2D hexagonal boron nitride, showing frequency-dependent topological transitions and whispering-gallery modes.

A MoSe₂ piezocatalyst with lattice strain upcycles wastewater pollutants into value-added chemicals, offering an environmental and energy solution by accelerating carbon reduction and lowering reaction energy barriers.

Glaucoma is a common cause of vision loss. Here the authors show that elevated intraocular pressure disrupts the blood retinal barrier (BRB) and contributes to retinal ganglion cell death in mouse glaucoma models, and detect similar BRB disruption in human glaucoma donor eyes.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

Human coronavirus infections broadly require host kinase MELK, which stabilizes the actin cytoskeleton by phosphorylating cofilin-1. Consequently, MELK inhibition by OTSSP167 exhibits broad-spectrum antiviral activity against diverse strains.

Sunlight triggers ammonium chloride in aerosols to produce Cl₂ gas, explaining 12-55% of daytime levels. This chlorine source, boosted by black carbon, impacts atmospheric oxidation.

Elevated exposure to 4-hydroxyphenanthrene (4-OHPhe) is positively associated with obesity risk. Here, the authors show that exposure to 4-OHPhe downregulates expression of hydroxylamine reductase genes in Bacteroides uniformis, leading to altered gut microbiota-bile acid-FXR axis and suppression of adipose thermogenesis.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

VSIG4 is a co-inhibitory receptor expressed by Kupffer cells. Here, the authors identify a direct binding interaction between VSIG4 and T cell CD5 that can calibrate CD8⁺ T cell responses to liver metastasis. They also design an anti-VSIG4 nanobody to enhance immune checkpoint blockade treatment of mice.

Prime editing using non-canonical prime editing guide RNAs, where the reverse transcription template and primer binding site is integrated within the single guide RNA loops rather than attached to the 3′ ends of CRISPR–Cas guide RNAs, increases editing efficiency.

Inflammatory signaling profoundly influences cellular metabolism and stress responses. Here, the authors show that the IKK complex directly controls TFEB stability through β-TrCP2–dependent proteasomal degradation, mechanistically linking inflammation to lysosomal regulation.

Conventional analyses of resting-state fMRI data often fail to capture nonlinear features that are important for the early detection of Alzheimer’s disease. Here, the authors develop a surrogate model using reservoir computing and compressed sensing to enhance fMRI data interpretation, achieving classification accuracies up to 87% and identifying altered dynamics in cortical regions involved in executive control, working memory, emotional regulation, spatial cognition, and self-referential processing.

Inborn errors of cell death (IECD) with autoinflammatory manifestations could be induced by excessive T cell death. Here the authors characterize IECD patients with autoinflammatory manifestations who possess overactive RIPK1 variants which promote T cell death, secretion of TNF and IFN-γ along with activation of monocytes and macrophages which promotes further autoinflammation.

Photoinduced radical doping strategy enables blue luminescence and elastic bending (>180°) in organic crystals. Confined oxygen radicals and dynamic π-π/Br···O interactions enable flexibility with low optical loss, advancing flexible optoelectronics.

You, Hu et al. discover a population of COTL1^high NK cells regulated by GITRL⁺ macrophages and demonstrate their functional importance in mediating anti-tumour immunity in cancer with impaired tumour-specific MHC-I expression.

Tunnel oxide passivating contact solar cells face unresolved questions about the atomic scale nature of pinholes that limit performance. The authors use aberration corrected transmission electron microscopy to reveal two pinhole types and showing that oxygen-based passivation rather than pinholes geometry drives efficiency.

Labdane derived hapmnioide-type diterpenoids, which have been identified as chemical markers for Haplomitrium liverwort, show potent anti-inflammatory and allelopathic activities. Here, the authors report the total synthesis of seven typical Haplomitrium diterpenoids through late-stage biomimetic skeletal reorganization.

Electrical feed-forward used for noise compensation in microwave signal generation provides low phase noise and timing jitter while easing the requirements of the optical frequency comb divider.