Nature Search

The PIK3CA/AKT pathway drives therapy resistance in rhabdomyosarcoma

Resistance to combination therapies has been reported in rhabdomyosarcoma (RMS). Here, the authors discover that PIK3CA/AKT pathway regulation of multidrug-resistant ABC transporters is involved in the resistance to therapies in RMS, and use of the PI3Kα inhibitor alpelisib re-sensitizes RMS to therapy.

Qiqi Yang
Yueyang Wang
David M. Langenau
ResearchOpen Access10 Dec 2025
Nature Communications

Volume: 17, P: 1-17
Building material stock drives embodied carbon emissions and risks future climate goals in China

Reducing the embodied carbon emissions of building material stock is essential for mitigation. Using a high-resolution multiyear dataset in China, researchers show the historically massive contributions of these emissions during past decades of rapid urbanization and the potential risks for future climate goals.

Chaoqun Zhang
Lin Yang
Qiao Wang
Research02 Jan 2026
Nature Climate Change

P: 1-8
Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism

Skeletal muscle is central to whole-body energy balance. Here, Yang et al. show that MLL4-dependent enhancer activation is a key regulatory node for the governance of muscle metabolic efficiency and systemic metabolism via the control of muscle AMPK.

Likun Yang
Lin Liu
Zhenji Gan
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-22
Realizing the practical application of CO₂ electroreduction for urban wastewater denitrification

An approach that integrates electrochemical CO₂ reduction and biological denitrification provides a new solution for nitrogen removal, where the formate obtained from CO₂ is used directly as the carbon source in the denitrification process in wastewater treatment.

Qiqi Wu
Sijia Ji
Guangxu Chen
Research29 Sept 2025
Nature Water

Volume: 3, P: 1291-1302
Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength

Mitochondrial function is important for muscle maintenance and function, and mitochondrial proteolysis maintains mitochondrial integrity and function. Here the authors report that that loss of LONP1-dependent mitochondrial proteolysis in muscle causes reduced muscle mass and strength via activation of autophagy.

Zhisheng Xu
Tingting Fu
Zhenji Gan
ResearchOpen Access16 Feb 2022
Nature Communications

Volume: 13, P: 1-20
Retraction Note: Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish

Chuan Yan
Qiqi Yang
Zhiyuan Gong
Amendments and CorrectionsOpen Access29 Nov 2023
Scientific Reports

Volume: 13, P: 1
Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes

Fu, Sun, Xue, Zhou et al. show that the mitoprotease LONP1 selectively degrades a complex II component to control intracellular succinate levels, which is needed for white-to-beige adipocyte cell fate programming during adipocyte thermogenic remodelling.

Tingting Fu
Wanping Sun
Zhenji Gan
Research22 May 2023
Nature Cell Biology

Volume: 25, P: 848-864
Pangeneric genome analyses reveal the evolution and diversity of the orchid genus Dendrobium

This study explores the genome evolution and diversity of orchids by constructing and analysing chromosome-scale de novo assembled genomes of the representative accessions across 12 sections in Dendrobium, one of the largest orchid genera.

Yan Li
Bin Zhang
Hao Yu
Research10 Jan 2025
Nature Plants

Volume: 11, P: 421-437
Observational and genetic evidence disagree on the association between loneliness and risk of multiple diseases

Loneliness was found to be linked to increased risk for 30 out of 56 diseases in a UK Biobank study. However, genetic analyses show that loneliness likely causes only six diseases. These findings suggest that loneliness is more a potential surrogate marker than a direct cause for most diseases.

Yannis Yan Liang
Mingqing Zhou
Jihui Zhang
ResearchOpen Access16 Sept 2024
Nature Human Behaviour

Volume: 8, P: 2209-2221
Longitudinal association of metabolic dysfunction-associated fatty liver disease, serum metabolites, with cognitive function trajectories

Anxin Wang
Xue Tian
Qian Hua
ResearchOpen Access24 Mar 2025
npj Metabolic Health and Disease

Volume: 3, P: 1-7
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression

A synthetic ligand-responsive condensate approach enables inducible condensate recruitment to different cellular compartments for spatiotemporal control of gene expression and gene product release.

Yukai Wang
Jian Jiang
An-Ping Zeng
ResearchOpen Access14 Mar 2025
Nature Chemical Biology

Volume: 21, P: 1457-1466
FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment

Functional revascularization is vital to the recovery of blood flow. Here, Sun et al. show that myofiber FNIP1 is a negative regulator of muscle functional angiogenesis and revascularization after ischemia by controlling macrophage recruitment.

Zongchao Sun
Likun Yang
Zhenji Gan
ResearchOpen Access06 Nov 2023
Nature Communications

Volume: 14, P: 1-18
Reactivatable stimulated emission depletion microscopy using fluorescence-recoverable nanographene

Stimulated emission depletion (STED) microscopy is compromised by the trade-off between resolution and photobleaching. Here, the authors present ReSTED, a reactivatable STED microscopy using fluorescence-recoverable nanographene that enables hour-long, super-resolution 3D imaging without bleaching.

Qiqi Yang
Antonio Virgilio Failla
Xiaomin Liu
ResearchOpen Access04 Feb 2025
Nature Communications

Volume: 16, P: 1-13
Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity

Middle-aged obesity, marked by excessive fat accumulation, is closely linked to DNA damage. Here, the authors show that the DNA repair enzyme Eepd1, primarily expressed in adipose tissue, in its myristoylated form, promotes lipolysis and thermogenesis by activating PKA to combat obesity.

Suzhen Chen
Yanping Wang
Junli Liu
ResearchOpen Access14 Jan 2025
Nature Communications

Volume: 16, P: 1-21
Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs

This study identifies the evolutionarily conserved Exportin 4 as an essential regulator in the nuclear export of circRNAs. Defective circRNA export results in R-loop formation and DNA damage in cells, as well as testis and neurological defects in mice.

Liang Chen
Yucong Wang
Ge Shan
ResearchOpen Access01 Oct 2022
Nature Communications

Volume: 13, P: 1-18
RETRACTED ARTICLE: Chemical inhibition reveals differential requirements of signaling pathways in kras^V12- and Myc-induced liver tumors in transgenic zebrafish

Chuan Yan
Qiqi Yang
Zhiyuan Gong
ResearchOpen Access05 Apr 2017
Scientific Reports

Volume: 7, P: 1-11
Machine-learning-assisted single-vessel analysis of nanoparticle permeability in tumour vasculatures

Using genetically tailored protein-based nanoprobes and taking advantage of image-segmentation-based machine learning, a high-throughput assessment of vascular permeability of individual blood vessels in 32 different tumours is quantified. These insights are valuable in developing personalized anticancer nanomedicine therapeutics and strategies modulating vascular permeability to treat tumours.

Mingsheng Zhu
Jie Zhuang
Xinglu Huang
Research13 Feb 2023
Nature Nanotechnology

Volume: 18, P: 657-666
A seven-Earth-radius helium-burning star inside a 20.5-min detached binary

A very uncommon detached binary system with a 20.5-min orbital period has been discovered to harbour a carbon–oxygen white dwarf star and a low-mass subdwarf B star with a seven-Earth radius that traces the theoretical limit of binary evolution predicted 20 years ago.

Jie Lin
Chengyuan Wu
Wenxiong Li
Research09 Feb 2024
Nature Astronomy

Volume: 8, P: 491-503
Study on the scale dependence of the spatial distribution pattern of ecosystem service value - a case study of Gangu County, China

Yingying Wu
Xuelu Liu
Miaomiao Zhang
ResearchOpen Access28 May 2025
Scientific Reports

Volume: 15, P: 1-18
The B-type response regulator GmRR11d mediates systemic inhibition of symbiotic nodulation

Cytokinin is essential for regulation of nodulation. Here, the authors identified a B-type response regulator GmRR11d that governs a transcriptional program associated with nodulation and cytokinin activation essential for systemic regulation of nodulation.

Jiahuan Chen
Zhijuan Wang
Xia Li
ResearchOpen Access10 Dec 2022
Nature Communications

Volume: 13, P: 1-17
Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue

Slit3 is shown to be secreted from M2-like macrophages resident in adipose tissue, where it enables cold adaptation by stimulating norepinephrine release from sympathetic neurons.

Yi-Na Wang
Yan Tang
Qi-Qun Tang
Research15 Nov 2021
Nature Metabolism

Volume: 3, P: 1536-1551
Weight loss dietary knowledge, attitudes, and practices among different body weight groups in Northeast China

Yanchun Li
Yixin Ma
Shunyu Ning
ResearchOpen Access27 May 2025
Scientific Reports

Volume: 15, P: 1-15
Activation of liver stromal cells is associated with male-biased liver tumor initiation in xmrk and Myc transgenic zebrafish

Qiqi Yang
Chuan Yan
Zhiyuan Gong
ResearchOpen Access04 Sept 2017
Scientific Reports

Volume: 7, P: 1-9
Genetic analyses reveal association between rosacea and cardiovascular diseases

Yafang Gao
Chengan Xu
Qiqi Yan
ResearchOpen Access24 Feb 2025
Scientific Reports

Volume: 15, P: 1-9
Cognition of agriculture waste and payments for a circular agriculture model in Central China

Haimanot B. Atinkut
Tingwu Yan
Qiqi Liu
ResearchOpen Access02 Jul 2020
Scientific Reports

Volume: 10, P: 1-15
Single-cell imaging of human cancer xenografts using adult immunodeficient zebrafish

This protocol describes how to engraft human cancer cells in immunocompromised adult zebrafish. The fish are first adapted to 37 °C, followed by intraperitoneal or periocular muscle transplantation of xenograft cells and fluorescence imaging.

Chuan Yan
Daniel Do
David M. Langenau
Protocols21 Aug 2020
Nature Protocols

Volume: 15, P: 3105-3128
Environmental vertical management reform and firms’ ESG performance: evidence from China

Jing Yang
Qiqi Wang
Yueyuan Huang
ResearchOpen Access19 Nov 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-13
GmBEHL1, a BES1/BZR1 family protein, negatively regulates soybean nodulation

Qiqi Yan
Lixiang Wang
Xia Li
ResearchOpen Access16 May 2018
Scientific Reports

Volume: 8, P: 1-12
C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes

Caifeng Chen
Na Wu
Yan Zheng
ResearchOpen Access05 Jun 2018
Scientific Reports

Volume: 8, P: 1-11
Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish

Qiqi Yang
Chuan Yan
Zhiyuan Gong
ResearchOpen Access31 May 2018
Scientific Reports

Volume: 8, P: 1-12
Associations between maternal adversity and health and children’s telomere length

Xiao-Yan Chen
Camilla K. M. Lo
Ko Ling Chan
ResearchOpen Access28 Mar 2025
Translational Psychiatry

Volume: 15, P: 1-8
Relationship between glucose to lymphocyte ratio and the first peritonitis episode in patients treated with peritoneal dialysis

Qiqi Yan
Guiling Liu
Deguang Wang
ResearchOpen Access26 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates

Hui Zhao
Qiqi Wang
Yong Q. Zhang
ResearchOpen Access21 Oct 2019
Translational Psychiatry

Volume: 9, P: 1-13
Migratory Whooper Swans Cygnus cygnus Transmit H5N1 Virus between China and Mongolia: Combination Evidence from Satellite Tracking and Phylogenetics Analysis

Shuhong Li
Weiyue Meng
Yanbing Li
ResearchOpen Access04 May 2018
Scientific Reports

Volume: 8, P: 1-9
A single-cell sequence analysis of mouse subcutaneous white adipose tissue reveals dynamic changes during weaning

A single-cell sequence on mouse subcutaneous white adipose tissue analyses the dynamics of preadipocytes and immune cells populations in early life time and suggests potential changes involved in the beige-like remodeling during weaning.

Shuwen Qian
Chenyang Zhang
Qi-qun Tang
ResearchOpen Access29 Jun 2024
Communications Biology

Volume: 7, P: 1-14
Differential sedimentary evolution of typical aulacogens of Meso-Neoproterozoic in North China craton

Cong Tan
Qiqi Lyu
Xue Yan
ResearchOpen Access22 Feb 2024
Scientific Reports

Volume: 14, P: 1-17
Author Correction: Activation of liver stromal cells is associated with male-biased liver tumor initiation in xmrk and Myc transgenic zebrafish

Qiqi Yang
Chuan Yan
Zhiyuan Gong
Amendments and CorrectionsOpen Access31 May 2023
Scientific Reports

Volume: 13, P: 1-3
Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart disease

Yajun Liang
Zhongrui Yan
Chengxuan Qiu
ResearchOpen Access29 Jul 2022
Scientific Reports

Volume: 12, P: 1-9
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis

Fan Yu
Qianping Zhang
Quan Chen
ResearchOpen Access03 May 2022
Cell Discovery

Volume: 8, P: 1-17
Superhydrophobic hBN-Regulated Sponges with Excellent Absorbency Fabricated Using a Green and Facile Method

Ying Zhou
Yao Wang
Chao Yan
ResearchOpen Access23 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Decoupling of nutrient element cycles in soil and plants across an altitude gradient

Qiqi Tan
Guoan Wang
ResearchOpen Access11 Oct 2016
Scientific Reports

Volume: 6, P: 1-9
Genetic tracing uncovers the importance of epithelial-to-mesenchymal transition in small cell lung cancer chemotherapy resistance but not metastasis

Yuting Chen
Chenchen Guo
Hongbin Ji
CorrespondenceOpen Access04 Jun 2024
Cell Discovery

Volume: 10, P: 1-4

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