Nature Search

Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Intelligent decision-making systems for early detection of alzheimer’s disease using wearable technologies and deep learning

R. Sathish
R. Muthukumar
S. Palani Murugan
ResearchOpen Access22 Jan 2026
Scientific Reports

P: 1-18
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

P: 1-18
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Global, regional and national burden of dietary iron deficiency from 1990 to 2021: a Global Burden of Disease study

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Sooji Lee
Yejun Son
Nicholas. J. Kassebaum
Research22 Apr 2025
Nature Medicine

Volume: 31, P: 1809-1829
Cryo-EM structures of PP2A:B55 with p107 and Eya3 define substrate recruitment

Padi and Godek et al. solve cryo-electron microscopy structures of protein phosphatase 2A (PP2A):B55 bound to p107 and Eya3, which, together with nuclear magnetic resonance dephosphorylation experiments, show how PP2A:B55 recruits specific substrates and how it achieves efficient dephosphorylation of phosphosites with high cellular fidelity.

Sathish K. R. Padi
Rachel J. Godek
Rebecca Page
ResearchOpen Access17 Apr 2025
Nature Structural & Molecular Biology

Volume: 32, P: 1373-1382
Gaussian dual adjacency graph based spatial correlated and temporal time dependent traffic prediction in Bangalore City

Sathish Kumar Ravichandran
Chin-Shiuh Shieh
Archana Sasi
ResearchOpen Access21 Nov 2025
Scientific Reports

Volume: 15, P: 1-23
Integration of fast charging EV infrastructure with high gain Z-source converters and hybrid optimized MPPT algorithm

R. Sathish
V. Sekar
ResearchOpen Access16 Dec 2025
Scientific Reports

Volume: 16, P: 1-26
Vascularized human brain organoids as a model of the brain–peripheral axis in HIV-1 neuropathogenesis

Sathish Selvam
Roberta S. Dos Reis
Velpandi Ayyavoo
ResearchOpen Access05 Jan 2026
Scientific Reports

Volume: 16, P: 1-14
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network

Single-cell and spatial transcriptomics analysis of stricturing Crohn’s disease highlights cellular heterogeneity in fibrotic tissue and identifies neighborhoods of fibroblasts and immune cells contributing to this severe disease complication.

Lingjia Kong
Sathish Subramanian
Ramnik J. Xavier
Research25 Jun 2025
Nature Genetics

Volume: 57, P: 1742-1753
Midlife and the menopause transition in type 2 diabetes mellitus prevention

Physiological changes in female individuals during the menopause transition influence cardiometabolic health and type 2 diabetes mellitus (T2DM) incidence. T2DM prevention programmes during midlife among individuals who are at high risk are cost effective but, we suggest, could be enhanced by consideration of the menopause transition and other sex-specific differences in T2DM prevention strategies.

Maxine E. Whelan
Sathish Thirunavukkarasu
Robyn J. Tapp
Comments & Opinion01 Dec 2025
Nature Reviews Endocrinology

P: 1-2
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Damaris Kinyoki
Aaron E. Osgood-Zimmerman
Simon I. Hay
ResearchOpen Access12 Oct 2021
Nature Medicine

Volume: 27, P: 1761-1782
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
Genetically restricted suppressor T-cell clones derived from lepromatous leprosy lesions

Robert L. Modlin
Hideyuki Kato
Barry R. Bloom
Research31 Jul 1986
Nature

Volume: 322, P: 459-461
Internet of Things enabled open source assisted real-time blood glucose monitoring framework

Abubeker K. M
Ramani. R
Kamalraj Subramaniam
ResearchOpen Access14 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

Roy Burstein
Nathaniel J. Henry
Simon I. Hay
ResearchOpen Access16 Oct 2019
Nature

Volume: 574, P: 353-358
Characteristic variation of Mach number in subsonic co-flowing jets by varying lip thickness

K. Sathish Kumar
R. Naren Shankar
It Ee Lee
ResearchOpen Access26 Nov 2025
Scientific Reports

Volume: 15, P: 1-19
Cloned suppressor T cells from a lepromatous leprosy patient suppress Mycobacterium leprae reactive helper T cells

Tom H. M. Ottenhoff
Diënne G. Elferink
René R. P. de Vries
Research31 Jul 1986
Nature

Volume: 322, P: 462-464
Effect of cerium oxide nanocatalyst on performance emissions and noise of diesel biodiesel blends in a variable compression ratio engine

M. Anish
Mohd Majid
J. Jayaprabakar
ResearchOpen Access19 Nov 2025
Scientific Reports

Volume: 15, P: 1-20
Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain

Sathish Srinivasan
Jerome C Nwachukwu
Kendall W Nettles
Amendments and Corrections17 May 2017
Nature Chemical Biology

Volume: 13, P: 691
Full antagonism of the estrogen receptor without a prototypical ligand side chain

A sulfonamide series lacking the prototypical side chain behave as full antagonists or inverse agonists of estrogen receptor (ERα) signaling in a graded fashion dependent on coactivator recruitment and helix-11 positioning.

Sathish Srinivasan
Jerome C Nwachukwu
Kendall W Nettles
Research21 Nov 2016
Nature Chemical Biology

Volume: 13, P: 111-118
Cryo-EM structures of PP2A:B55–FAM122A and PP2A:B55–ARPP19

Cryo-electron microscopy structures of the PP2A:B55 holoenzyme bound to its inhibitors ARPP19 and FAM122A show distinct binding modes of the two inhibitors.

Sathish K. R. Padi
Margaret R. Vos
Wolfgang Peti
ResearchOpen Access20 Dec 2023
Nature

Volume: 625, P: 195-203
Comparative genetic architectures of schizophrenia in East Asian and European populations

Genome-wide meta-analysis with individuals of East Asian or European ancestry identifies 176 loci associated with schizophrenia. Despite consistent genetic effects across populations, polygenic risk models trained in one population have reduced performance in the other population.

Max Lam
Chia-Yen Chen
Hailiang Huang
Research18 Nov 2019
Nature Genetics

Volume: 51, P: 1670-1678
Correction: Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain

Sathish Srinivasan
Jerome C Nwachukwu
Kendall W Nettles
Amendments and Corrections17 May 2017
Nature Chemical Biology

Volume: 13, P: 691
Mapping routine measles vaccination in low- and middle-income countries

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Alyssa N. Sbarra
Sam Rolfe
Jonathan F. Mosser
ResearchOpen Access16 Dec 2020
Nature

Volume: 589, P: 415-419
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

Natasha L Harvey
R Sathish Srinivasan
Guillermo Oliver
Research18 Sept 2005
Nature Genetics

Volume: 37, P: 1072-1081
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

The 3CL protease of SARS-CoV-2 is inhibited by PF-00835231 in vitro. Here, the authors show that the prodrug PF-07304814 has broad spectrum activity, inhibiting SARS-CoV and SARS-CoV-2 in mice and its ADME and safety profile support clinical development.

Britton Boras
Rhys M. Jones
Charlotte Allerton
ResearchOpen Access18 Oct 2021
Nature Communications

Volume: 12, P: 1-17
The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer

Elevated expression of long noncoding RNA H19 is seen in clinical samples of neuroendocrine prostate cancer (PCa). Here the authors show H19 promotes plasticity from luminal to neuroendocrine by epigenetic reprogramming.

Neha Singh
Varune R. Ramnarine
Andrew S. Kraft
ResearchOpen Access21 Dec 2021
Nature Communications

Volume: 12, P: 1-20
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

Some nuclear receptors dimerize with retinoid X receptor to allow ligand-dependent signalling. Here, Kojetin et al.use structural and biophysical techniques to identify structural changes that guide these complex signalling networks.

Douglas J. Kojetin
Edna Matta-Camacho
Kendall W. Nettles
ResearchOpen Access20 Aug 2015
Nature Communications

Volume: 6, P: 1-14
CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production

Antibody responses are regulated by selective survival of B cells with proper antigen specificity. Here the authors show that CEACAM1 is critical for B-cell survival during homeostasis and antiviral responses.

Vishal Khairnar
Vikas Duhan
Karl S. Lang
ResearchOpen Access18 Feb 2015
Nature Communications

Volume: 6, P: 1-13
Experimental evaluation of soapberry seed oil biodiesel performance in CRDI diesel engine

Mohammed Owais Ahmed Sajjad
T. Sathish
T. R. Praveenkumar
ResearchOpen Access07 Apr 2023
Scientific Reports

Volume: 13, P: 1-9
Soil quality and microbial diversity across organic and conventional coffee in central Western Ghats India

V. M. Apoorva Angadi
R. Krishna Murthy
T. S. Hareesh
ResearchOpen Access01 Oct 2025
Scientific Reports

Volume: 15, P: 1-13
Real-time observation of trigger factor function on translating ribosomes

Fluorescently labelling trigger factor (TF) to monitor its real-time interaction with ribosome and polypeptide reveals that binding to the ribosome opens and activates TF. Rather than remaining bound to the ribosome, TF is carried away from it on the new polypeptide chain and remains associated with it for a time that depends on the propensity of the protein to aggregate.

Christian M. Kaiser
Hung-Chun Chang
José M. Barral
Research15 Oct 2006
Nature

Volume: 444, P: 455-460
Benefit of lifestyle-based T2DM prevention is influenced by prediabetes phenotype

Prediabetes phenotype can influence the effectiveness of lifestyle intervention-based diabetes prevention programmes. This Perspectives suggests that diabetes prevention programmes are not effective in individuals with isolated impaired fasting glucose and calls for further research to improve prevention of type 2 diabetes mellitus in this population.

Matthew D. Campbell
Thirunavukkarasu Sathish
Robyn J. Tapp
Reviews14 Feb 2020
Nature Reviews Endocrinology

Volume: 16, P: 395-400
Experimental study on mechanical performance and microstructural characterization of optimized sisal fiber reinforced polyester composites

G. Sathishkumar
A. Uma Devi
Ashish Kumar Srivastava
ResearchOpen Access17 Oct 2025
Scientific Reports

Volume: 15, P: 1-26
Facile synthesis of iron nanoparticles from Camellia Sinensis leaves catalysed for biodiesel synthesis from Azolla filiculoides

Sathish Sundararaman
M. Karthikeyan
Praveenkumar T R
ResearchOpen Access04 Jun 2024
Scientific Reports

Volume: 14, P: 1-15
Dynamic alterations in monocyte numbers, subset frequencies and activation markers in acute and convalescent COVID-19 individuals

Anuradha Rajamanickam
Nathella Pavan Kumar
Subash Babu
ResearchOpen Access12 Oct 2021
Scientific Reports

Volume: 11, P: 1-9
Peristaltic transport of Sutterby nanofluid flow in an inclined tapered channel with an artificial neural network model and biomedical engineering application

P. Chinnasamy
R. Sivajothi
K. Loganathan
ResearchOpen Access04 Jan 2024
Scientific Reports

Volume: 14, P: 1-23
SVM directed machine learning classifier for human action recognition network

Dharmanna Lamani
Pramod Kumar
Baseem Khan
ResearchOpen Access03 Jan 2025
Scientific Reports

Volume: 15, P: 1-18
TrkA expression directs the anti-neoplastic activity of MLK3 inhibitors in triple-negative breast cancer

Rakesh Sathish Nair
Sandeep Kumar
Ajay Rana
Research22 Feb 2023
Oncogene

Volume: 42, P: 1132-1143
Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy

Dwaipayan Sen
Balaji Balakrishnan
Giridhara R. Jayandharan
ResearchOpen Access13 May 2013
Scientific Reports

Volume: 3, P: 1-6
HPV16 genetic variation and the development of cervical cancer worldwide

I Cornet
T Gheit
G M Clifford
ResearchOpen Access20 Nov 2012
British Journal of Cancer

Volume: 108, P: 240-244
Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations

Targeted sequencing finds a higher burden of rare protein-truncating variants in constrained genes among schizophrenia cases of diverse ancestries. Meta-analyses with existing datasets show that this excess burden is consistent across five ancestral populations.

Dongjing Liu
Dara Meyer
Alexander W. Charney
ResearchOpen Access13 Mar 2023
Nature Genetics

Volume: 55, P: 369-376
An intelligent fuzzy-particle swarm optimization supervisory-based control of robot manipulator for industrial welding applications

A. Sathish Kumar
S. Naveen
Kumaran Palani
ResearchOpen Access22 May 2023
Scientific Reports

Volume: 13, P: 1-13
MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3

Sunil Kumar Singh
Sandeep Kumar
Ajay Rana
ResearchOpen Access13 Sept 2021
Oncogene

Volume: 40, P: 6153-6165
Palmitate induces integrated stress response and lipoapoptosis in trophoblasts

Prakash Kumar Sahoo
Chandan Krishnamoorthy
Sathish Kumar Natarajan
ResearchOpen Access11 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-12
Genetic variants associated with longevity in long-living Indians

Sandhya Kiran Pemmasani
Shakthiraju R G
Anuradha Acharya
ResearchOpen Access20 Nov 2024
npj Aging

Volume: 10, P: 1-8
Environmental remediation at vegetable marketplaces through production of biowaste catalysts for biofuel generation

T. Sathish
R. Saravanan
S. Rajkumar
ResearchOpen Access28 Mar 2023
Scientific Reports

Volume: 13, P: 1-16
Development and validation of resource-driven risk prediction models for incident chronic kidney disease in type 2 diabetes

Sarega Gurudas
Manjula Nugawela
Sobha Sivaprasad
ResearchOpen Access01 Jul 2021
Scientific Reports

Volume: 11, P: 1-11

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