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Showing 1–50 of 70 results

Advanced filters: Author: Rakesh Paul Clear advanced filters

Detection of Metabolites by Proton Ex Vivo NMR, in Vivo MR Spectroscopy Peaks and Tissue Content Analysis: Biochemical-Magnetic Resonance Correlation: Preliminary Results

Rakesh Sharma
Madan Rehani
Arun Agrawala
ResearchOpen Access15 Jan 2010
Nature Precedings

P: 1
Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial

In a multicenter, randomized trial of patients with atrial fibrillation and a low risk of thromboembolic events, treatment with the anticoagulant rivaroxaban showed no benefit in reducing cognitive decline, stroke or transient ischemic attack when compared to placebo.

Léna Rivard
Paul Khairy
William Liang
ResearchOpen Access07 Jan 2026
Nature Medicine

Volume: 32, P: 297-305
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

P: 1-18
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
GATA simple sequence repeats function as enhancer blocker boundaries

GATA simple sequence repeats (SSRs) are located throughout vertebrate genomes in a non-random fashion. The authors show that these act as enhancer blocker elements in both human cells and Drosophila, indicating a conserved function of GATA SSRs.

Ram P. Kumar
Jaya Krishnan
Rakesh K. Mishra
Research14 May 2013
Nature Communications

Volume: 4, P: 1-7
Comparison of dual therapies for hypertension treatment in India: a randomized clinical trial

To address an evidence gap for the efficacy of hypertension therapy using dual drug combinations in patients of South Asian origin, a randomized clinical trial conducted in India found that three types of dual drug combinations, each administered in a single pill, had similarly large effects on reducing blood pressure.

Dorairaj Prabhakaran
Ambuj Roy
Neil R. Poulter
ResearchOpen Access25 Jul 2025
Nature Medicine

Volume: 31, P: 3169-3175
A single NLR gene confers resistance to leaf and stripe rust in wheat

Leaf rust and stripe rust of wheat are two important fungal diseases of cultivated wheat and they are caused by infection of different pathogens. Here, the authors report the nucleotide-binding leucine-rich repeat (NLR) protein encoding gene Yr87/Lr85 confers resistance to both diseases.

Davinder Sharma
Raz Avni
Amir Sharon
ResearchOpen Access15 Nov 2024
Nature Communications

Volume: 15, P: 1-16
Can we deliver randomized trials of focal therapy in prostate cancer?

Tissue-preserving focal therapies that target individual cancer lesions rather than the whole prostate have emerged as potential interventions for localized prostate cancer. In this article, the Prostate Cancer RCT Consensus Group recommends the development of a cohort-embedded randomized controlled trial methodology to evaluate focal therapy use in men with clinically significant localized disease. The importance for a randomized controlled trial design to provide cost-efficient practice-changing data is highlighted.

Hashim U. Ahmed
Viktor Berge
Mark Emberton
Reviews22 Apr 2014
Nature Reviews Clinical Oncology

Volume: 11, P: 482-491
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
Mapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000–2018

Bhattacharjee and Schaeffer et al. map exclusive breastfeeding (EBF) in 94 low- and middle-income countries (LMICs), finding increased EBF practice and reduced subnational variation across the majority of LMICs from 2000 to 2018. However, only six LMICs will meet WHO’s target of ≥70% EBF by 2030 nationally, and only three will achieve this in all districts.

Natalia V. Bhattacharjee
Lauren E. Schaeffer
Simon I. Hay
ResearchOpen Access03 Jun 2021
Nature Human Behaviour

Volume: 5, P: 1027-1045
Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy

Targeted IKZF2 degradation represents a potential therapeutic strategy for cancer immunotherapy. Here, the authors described the discovery of PVTX-405 as a potent, highly selective, and orally efficacious IKZF2 molecular glue degrader and their preclinical data support the clinical development of PVTX-405.

Zhixiang Chen
Harshil Dhruv
Shaomeng Wang
ResearchOpen Access01 May 2025
Nature Communications

Volume: 16, P: 1-16
N-acyl homoserine lactone signaling modulates bacterial community associated with human dental plaque

Rakesh Sikdar
Mai V. Beauclaire
Mikael H. Elias
ResearchOpen Access17 Nov 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-16
Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing

Imaging and transcriptomic approaches to investigate mouse enteric nervous system diversity and development reveal a new classification of intestinal myenteric neurons and a novel principle of neuronal diversification by postmitotic transitions.

Khomgrit Morarach
Anastassia Mikhailova
Ulrika Marklund
Research07 Dec 2020
Nature Neuroscience

Volume: 24, P: 34-46
MRI and MRSI Application in Neurodegeneration

Rakesh Sharma
ResearchOpen Access30 Mar 2010
Nature Precedings

P: 1
Correction: Corrigendum: Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

Christopher G Willett
Yves Boucher
Rakesh K Jain
Amendments and Corrections01 Jun 2004
Nature Medicine

Volume: 10, P: 649
A homing system targets therapeutic T cells to brain cancer

Therapeutic T cells bearing ligands engineered to optimize adhesion and transmigration through the blood–brain barrier can be targeted to brain tumours.

Heba Samaha
Antonella Pignata
Nabil Ahmed
Research05 Sept 2018
Nature

Volume: 561, P: 331-337
Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial

In the phase 2 HUDSON study, patients with advanced non-small-cell lung cancer received anti-PD-L1 combined with biomarker-guided therapy targeting ATR kinase, PARP, STAT3 or CD73, leading to encouraging clinical benefit in response to combination of the ATR kinase inhibitor ceralasertib with durvalumab.

Benjamin Besse
Elvire Pons-Tostivint
John V. Heymach
ResearchOpen Access13 Feb 2024
Nature Medicine

Volume: 30, P: 716-729
Sharing of proximal fibers by the anterolateral and lateral collateral ligaments in the human knee: a cadaveric study

Ashutosh Kumar
Khursheed Raza
Prabhat Agrawal
ResearchOpen Access29 Jul 2023
Scientific Reports

Volume: 13, P: 1-8
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

Christopher G Willett
Yves Boucher
Rakesh K Jain
Research25 Jan 2004
Nature Medicine

Volume: 10, P: 145-147
Inter-center variations in length of hospitalization for infants with congenital jejunal or ileal atresia

Katie A. Huff
Isabella Zaniletti
Cherrie Welch
Research27 Nov 2025
Journal of Perinatology

P: 1-8
Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

A human SARS-CoV-2 challenge study in individuals without previous exposure to the virus or vaccines provides detailed profiles of local and systemic epithelial and immune cell response dynamics over time and infection status.

Rik G. H. Lindeboom
Kaylee B. Worlock
Sarah A. Teichmann
ResearchOpen Access19 Jun 2024
Nature

Volume: 631, P: 189-198
Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction

Allosteric small-molecule inhibitors of the p53-induced oncogenic phosphatase Wip1 bind at a ‘flap’ subdomain near the catalytic site. Inhibitor GSK2830371 inhibits the phosphatase and oncogenic activities in cell lines and a xenograft tumor model.

Aidan G Gilmartin
Thomas H Faitg
Rakesh Kumar
Research05 Jan 2014
Nature Chemical Biology

Volume: 10, P: 181-187
Mapping child growth failure across low- and middle-income countries

High-resolution subnational mapping of child growth failure indicators for 105 low- and middle-income countries between 2000 and 2017 shows that, despite considerable progress, substantial geographical inequalities still exist in some countries.

Damaris K. Kinyoki
Aaron E. Osgood-Zimmerman
Simon I. Hay
ResearchOpen Access08 Jan 2020
Nature

Volume: 577, P: 231-234
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

Postmortem studies indicate reduced synaptic density in schizophrenia. Sellgren et al. show increased synaptic pruning in patient-derived cell models and provide evidence that C4 risk variants increase engulfment, while minocycline decreases it.

Carl M. Sellgren
Jessica Gracias
Roy H. Perlis
Research04 Feb 2019
Nature Neuroscience

Volume: 22, P: 374-385
Somatic mutational landscape across Indian breast cancer cases by whole exome sequencing

Rahul Kumar
Supriya Awasthi
Pranay Tanwar
ResearchOpen Access12 Aug 2024
Scientific Reports

Volume: 14, P: 1-11
Utilizing a publicly accessible automated machine learning platform to enable diagnosis before tumor surgery

Hosseinzadeh et al. demonstrate use of a publicly accessible automated machine learning platform to differentiate between a common benign tumor and malignant transformation of it within the paranasal sinuses. This AI algorithm beat prior human prediction, and showed that physicians with no coding background can effectively utilize this tool.

Farideh Hosseinzadeh
George Liu
Zara M. Patel
ResearchOpen Access08 Oct 2025
Communications Medicine

Volume: 5, P: 1-7
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Remarkable preservation of terpenoids and record of volatile signalling in plant-animal interactions from Miocene amber

Suryendu Dutta
Rakesh C. Mehrotra
C. Zoramthara
ResearchOpen Access08 Sept 2017
Scientific Reports

Volume: 7, P: 1-6
Dissociation of Inflammatory and Epithelial Responses in a Murine Model of Chronic Asthma

Paul S Foster
Yang Ming
Rakesh K Kumar
Research01 May 2000
Laboratory Investigation

Volume: 80, P: 655-662
CD4⁺ T-Lymphocytes Regulate Airway Remodeling and Hyper-Reactivity in a Mouse Model of Chronic Asthma

Paul S Foster
Ming Yang
Rakesh K Kumar
Research01 Apr 2002
Laboratory Investigation

Volume: 82, P: 455-462
Assembling the brain trust: the multidisciplinary imperative in neuro-oncology

Ethan B. Ludmir
Anita Mahajan
Mary Frances McAleer
Correspondence31 May 2019
Nature Reviews Clinical Oncology

Volume: 16, P: 521-522
Neuropsychologic Deficits in Schizophrenia

Herbert Y Meltzer
Paul A Thompson
Rakesh Ranjan
Research01 Mar 1996
Neuropsychopharmacology

Volume: 14, P: 27-33
Engineering and physical sciences in oncology: challenges and opportunities

This Review by Mitchellet al. summarizes how engineering and the physical sciences have advanced oncology by highlighting four important areas: the physical microenvironment of the tumour, drug delivery, cellular and molecular imaging, and microfluidics and microfabrication.

Michael J. Mitchell
Rakesh K. Jain
Robert Langer
Reviews13 Oct 2017
Nature Reviews Cancer

Volume: 17, P: 659-675
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
Management of the patent ductus arteriosus among infants born at 23 to 32 weeks’ gestation between 2011 to 2022: a report from in the Children’s Hospitals Neonatal Consortium

Mark F. Weems
Molly K. Ball
Sharada H. Gowda
ResearchOpen Access15 Mar 2025
Journal of Perinatology

Volume: 45, P: 1540-1547
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Venovenous versus venoarterial extracorporeal membrane oxygenation among infants with hypoxic-ischemic encephalopathy: is there a difference in outcome?

Prashant Agarwal
Girija Natarajan
Irfan Ahmad
Research19 May 2021
Journal of Perinatology

Volume: 41, P: 1916-1923
Results from Arm A of Phase 1/2 DREAMM-6 trial: belantamab mafodotin with lenalidomide plus dexamethasone in patients with relapsed/refractory multiple myeloma

Rakesh Popat
Bradley Augustson
Hang Quach
CorrespondenceOpen Access21 Oct 2024
Blood Cancer Journal

Volume: 14, P: 1-4
Practice variation in therapeutic hypothermia for hypoxic ischemic encephalopathy among neonates with congenital heart disease in the United States

Vonita Chawla
Allison M. Peluso
Cherrie Welch
Research22 Nov 2024
Journal of Perinatology

Volume: 45, P: 265-267
Stimulatory Effects of L-5-Hydroxytryptophan on Postdexamethasone β-Endorphin Levels in Major Depression

Michael Maes
Ann Van Gastel
Roger Desnyder
Research01 Oct 1996
Neuropsychopharmacology

Volume: 15, P: 340-348
Impact of congenital heart disease and prematurity on brain injury from a national registry

Giulia P. Lima
Sarah U. Morton
Cherrie Welch
Research02 Apr 2025
Journal of Perinatology

Volume: 45, P: 1005-1008
MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3

Sunil Kumar Singh
Sandeep Kumar
Ajay Rana
ResearchOpen Access13 Sept 2021
Oncogene

Volume: 40, P: 6153-6165
Correction: Epidemiology and risk factors for cerebral venous sinus thrombosis: insights from leading centres in the i-RegVeD registry, India

Sumit Aggarwal
Arun Kumar
Heena Tabassum
Amendments and CorrectionsOpen Access06 Nov 2025
Scientific Reports

Volume: 15, P: 1
Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFos

Andrew Hartley
Laura C. A. Galbraith
Imran Ahmad
ResearchOpen Access30 Jan 2025
British Journal of Cancer

Volume: 132, P: 502-512
Epidemiology and risk factors for cerebral venous sinus thrombosis: insights from leading centres in the i-RegVeD registry, India

Sumit Aggarwal
Arun Kumar
Heena Tabassum
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images

Donghuan Lu
Karteek Popuri
Kristin Fargher
ResearchOpen Access09 Apr 2018
Scientific Reports

Volume: 8, P: 1-13
Effects of disulfide bridges and backbone connectivity on water sorption by protein matrices

Sang Beom Kim
Rakesh S. Singh
Pablo G. Debenedetti
ResearchOpen Access11 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
Hepatitis E virus infection

Hepatitis E virus (HEV) infection is often asymptomatic but can lead to acute and chronic hepatitis as well as to extrahepatic manifestations such as neurological or renal disease and pregnancy complications. In this Primer, Kamar et al. describe the epidemiology, pathophysiology, diagnosis and management of HEV infection.

Nassim Kamar
Jacques Izopet
Harry R. Dalton
Reviews16 Nov 2017
Nature Reviews Disease Primers

Volume: 3, P: 1-16
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16

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