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This study elucidates a mechanism in amyloid aggregates mediated by scarce β-strands that bridge adjacent β-sheets. This cross-β-strand linker shapes molecular packing and structural diversity, enabling aggregates to balance order and disorder.

Here, Chen et al. develop an injectable hydrogel that induces innate immune memory against reinfection and promotes bone repair in osteomyelitis, offering a biomaterial-based immunomodulatory strategy for refractory bone infections.

Simultaneous profiling of spatial transcriptomics (ST) and metabolomics (SM) offers a novel way to decode tissue microenvironment heterogeneity. Here, the authors present SpatialMETA, a conditional variational autoencoder-based framework designed for the integration of ST and SM data.

Artificial photosynthesis to produce CH₃OH holds promise but faces selectivity challenges. Here, the authors report a defect-phase synergetic NiTi-TiO₂ system that achieves almost 100% CH₃OH selectivity in pure H₂O by successfully controlling the evolution of key reaction intermediates.

Natural antimicrobial peptides and enzymes are good candidates for application but suffer from low stability. Here, the authors report on biomimetic self-assembling peptides which mimic both antimicrobial peptide and enzyme functionality, demonstrating application against fungal infection.

A layered hybrid lead halide intercalated with Ru(bpy)₃²⁺ is assembled through Pb²⁺-carboxylate coordination. The material has broad visible light absorption and drives photocatalytic CO₂ reduction to CO with a quantum yield of ~3.0% at 500 nm.

Arboviruses and symbiotic viruses can be paternally transmitted by male insects to their offspring, but the mechanism remains largely unknown. Here, the authors identify the sperm-specific serpin protein HongrES1 of the leafhopper Recilia dorsalis as a mediator of paternal transmission of the reovirus rice gall dwarf virus and of a previously undescribed symbiotic virus of the Virgaviridae family, Recilia dorsalis filamentous virus, via direct binding of virions to leafhopper sperm surfaces and subsequent paternal transmission via interaction with both viral capsid proteins.

A data interface that is based on complementary metal–oxide–semiconductor technology can provide wireless data transfer between cryogenic and room temperature, and minimize the heat-to-information transfer ratio.

In urethral damage, exogenous implants designed for urethral repair are hindered by the open and harsh urethral microenvironments and the isotropic compression and swelling properties of the material. Here, Yang et al. develop a tri-layer hydrogel with anti-fouling and low-swelling properties for scarless urethral repair.

Enveloped viruses encased within a lipid bilayer membrane are highly contagious and cause diseases like influenza and COVID-19, so strategies for their prevention and inactivation are needed. Here, the authors develop a diatomic iron nanozyme with lipoxidase-like activity for the inactivation of enveloped viruses, where the diatomic iron sites destroy the viral envelope via lipid peroxidation.

Single-atom catalyst design for methanol steam reforming faces stability and activity hurdles. Here, Cd atoms anchored at anatase-rutile phase interfaces achieve exceptional catalytic efficiency, low CO production, and scalable hydrogen generation.

Forecast models of bacterial antimicrobial resistance (AMR) surveillance records from 101 countries reveal that the global burden of AMR is associated with the impact of climate change intertwined with the failure to achieve sustainable development goals.

The sub-terahertz rotational transitions of polar molecules can be used as frequency bases to create low-cost, low-power miniaturized clocks.

The DAWN study is a phase 3 clinical trial that demonstrates effective glycemic control of dorzagliatin as an add-on therapy to metfomin in patients with type 2 diabetes.

It is challenging to grow atomically thin non-van der Waals perovskites due to strong electronic coupling between adjacent layers. Here authors present the growth of perovskite single crystal nanosheets using a low supersaturation crystallisation strategy.

The authors propose a polymorphic heterogeneous shell strategy to design core-shell dual-phase dielectrics through synergistically controlling micro and local scale heterostructures, resulting in excellent overall energy storage performance.

An integrative network map of maize (Zea mays L.) that contains genomic, transcriptomic, translatomic and proteomic networks illustrates the landscape of molecular interactions of different functional elements and potential pathway modules in maize.

PD-L1 on tumor cells exerts an important dampening effect on T cells via their expression of PD-1. Miller and colleagues find that PD-L1 ‘back-signaling’ into T cells and macrophages can also dampen immune responses within the tumor microenvironment.

Fusarium graminearum is a major fungal pathogen of cereals. Here the authors show that F. graminearum secretes an effector, Osp24, that induces degradation of the wheat TaSnRK1α kinase to promote disease while an orphan wheat protein, TaFROG1, can compete with Osp24 for binding to TaSnRK1α and protect it from degradation

The interfacial stability of lithium metal is a crucial aspect for all-solid-state battery development. Here, authors report argyrodite solid electrolytes containing LiCl framework, where the Cl ions construct a LiCl-rich interphase capable of improving battery performances.

Adipose tissue (AT) inflammation is strongly associated with obesity and constitutes an obesogenic memory upon weight loss. Here, the authors show that intermittent fasting leads to an adipocyte p53-signaling dependent emergence of lipid-associated macrophages in visceral AT of obese mice which limits the systemic fasting response.

Size and charge can significantly affect delivery of therapeutic agents to tumours. Here, the authors report on nanoparticles optimised for delivery to the tumour which release smaller particles and change charge in the tumour microenvironment to optimise tumour penetration and cellular uptake.

Simple, fast, and accurate detection of food freshness has great significance to food safety and business. Here, the authors develop cellulose-based ratiometric fluorescent materials with superior amine-response, which can be used for visual monitoring the freshness of shrimp and crab.

A modular quantum system-on-chip architecture integrates thousands of individually addressable spin qubits in two-dimensional quantum microchiplet arrays into an integrated circuit designed for cryogenic control, supporting full connectivity for quantum memory arrays across spin–photon channels.

scAtlasVAE is a deep learning-based model for cross-atlas integration. Here it enables the development of a large-scale human CD8⁺ T cell atlas with integrated T cell receptor data.

Endocannabinoid signaling regulates food intake and is a potential therapeutic target for obesity. Here the authors show that adipocyte O-GlcNAc transferase (OGT) is required for high fat diet-induced hyperphagia via transcriptional activation of de novo lipid desaturation and accumulation of an endogenous appetite-inducing cannabinoid.

In humans and mouse models, the mycobiome of pancreatic ductal adenocarcinoma tumours is markedly enriched in Malassezia species compared to that of normal pancreas, which implicates these pathogenic fungi in oncogenesis.

Uncontrolled bleeding is a major cause of death, incentivizing the development of biomaterials that aid haemostasis and wound healing. This Review highlights the active components and forms of haemostatic materials, with a focus on their chemical design, and considers future trends in their development.