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Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Climate warming is projected to expand plant phosphorus limitation from 47% to 59% of global silicate rock areas. However, phosphorus release from accelerated chemical weathering of these rocks offsets about 15.5% of this increase.

Spermine is a polyamine dysregulated in different cancers. This group shows that Serpinb9 prevents spermine synthase degradation, raising spermine levels and impairing the tumor immune microenvironment, and identifying Serpinb9 as a potential therapeutic target for pancreatic cancer immunotherapy.

GRASP is a protein complex structure prediction model that integrates diverse forms of simulated and real-world experimental restraints, including those from crosslinking, covalent labeling, chemical shift perturbation and deep mutational scanning.

A scalable approach is provided for preparing and verifying intermediate-scale genuine entanglement on a 66-qubit superconducting quantum processor.

Targeted degradation has the potential to treat diseases associated with pathological protein build up. Here, the authors report on an oligo-PROTAC which degrades FUS, a protein associated with frontotemporal dementia, demonstrating delivery on DNA nanoflowers for increase blood-brain barrier crossing and retention.

A variant of the OAS1 gene, which encodes an enzyme that is critical for the innate immune response to viral infections, is associated with decreased risk of death in patients with COVID-19.

Two-step Mendelian randomization, combined with multiple layers of omics evidence, implicates COL6A3-derived endotrophin as a mediator of coronary artery disease risk in the context of obesity.

Despite rapid developments in predicting the complex structures of proteins, there are still inconsistencies between predictions and experiments. Feng et al. developed ColabDock, a general framework for deep learning models that integrates various experimental restraints and improves complex interface prediction, including antibody–antigen interactions.

Genome-wide association studies comprising 1,091 metabolites and 309 metabolite ratios in 8,299 individuals from the Canadian Longitudinal Study on Aging provide insights into the genetic architecture of metabolites and their role in human diseases.

The application of quantum computing to computational chemistry faces various experimental and theoretical challenges. Now, a quantum simulation on a noisy quantum device has achieved chemical accuracy for small H₂ and LiH molecules.

Complex-valued neural networks can recognize phase-sensitive data in wave-related phenomena. Here, authors report a complex-valued optical convolution accelerator operating at over 2 TOPS for recognition of radar images, represents advances towards real-time analysis of complex satellite data.

A computational approach to generate reference-free protein families from the sequence space in metagenomes reveals an enormously diverse functional space.

How obesity contributes to COVID-19 severity is not fully understood. In this study, Yoshiji et al. found that the plasma protein nephronectin partially mediates the effect of obesity on the risk of COVID-19 severity using a two-step Mendelian randomization approach and omics analyses.

Through the monolithic integration of enhancement-mode n-type and p-type gallium nitride field-effect transistors, complementary integrated circuits including latch circuits and ring oscillators can be created for use in high-power and high-frequency applications.

Immune cell changes are associated with Kawasaki disease (KD) pathogenesis. Here, using single cell RNA sequencing of PBMC, the authors show monocyte inflammatory genes are over-expressed in KD and TCR and BCR clonotype sequences show oligoclonal expansions after intravenous immunoglobulin therapy.

Cross-ancestry genome-wide association analyses in individuals of European and East Asian ancestry identify 11 new risk loci for intracranial aneurysms and highlight a polygenic architecture explaining a substantial fraction of disease heritability.

Holographic duality, which relates systems with and without gravity, suggests that quantum entanglement is essential for understanding gravitational phenomena on a fundamental level. The authors conjecture an infinite set of necessary conditions for a quantum state, which can holographically describe a semiclassical gravitational spacetime, and relate those conditions to properties of evaporating black holes.

The technological development requires the future advanced combustion engines be designed to operate at low temperature. Here, the authors show that partially oxide Pt-[O]_x-Bi interface catalyzes CO oxidation at ~ 50 °C via providing moderate CO adsorption and activating CO molecules with electron transformation.

Photoreduction of permanent gas faces challenges in reactant diffusion and activation at the three-phase interface. Here the authors showed porous metal-organic framework membranes decorated by metal single atoms can boost the photoreduction of CO₂ and O₂ at the high-throughput gas-solid interface.

The electrochemical reduction of nitrogen to ammonia represents a challenge of major interest that would substantially decrease the burden of the energy-consuming Haber–Bosch process. Now, Yin, Yan, Zhang, Si and colleagues achieve high ammonia yield and Faradaic efficiency over 66% using bismuth nanocatalysts promoted by alkali cations.

Controlling the reaction path is instrumental for developing efficient catalysts for CO₂ hydrogenation. Here, the authors report that the ensemble of Pt single atoms coordinated with oxygen atoms in MIL-101 induces distinct reaction path to improve selective hydrogenation of CO₂ into methanol relative to nanocrystal counterparts.

AI-driven RASP model and FAAST pipeline utilize experimental information to aid multi-domain or few-MSA protein structure prediction and accelerate accurate NMR NOESY assignments, advancing integrative structural biology.

Periploca sepium can produce latex and contains the rubber component cis-polyisoprene. Its structure, accumulation and relations with rubber particle-associated proteins were characterized, indicating its promise as an alternative source for natural rubber.

Use of UK Biobank whole-exome sequencing data to directly call HLA alleles is more accurate than imputing HLA alleles and reveals 360 associations for 11 auto-immune phenotypes, allow for better characterization of the role of the HLA region in human disease.

Paranjpe, Jayaraman et al. profile the plasma proteome to identify markers of acute and long-term COVID-19-associated kidney dysfunction. They find that while both acute and long-term kidney dysfunction are associated with tubular dysfunction markers, the acute phase is also associated with markers of myocardial damage and hemodynamic disturbance.