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Electrochemical carbon capture provides a sustainable method for effective carbon management. Here, the authors develop a modular porous solid electrolyte reactor system, achieving continuous carbon capture from air and flue gases through a recirculation mode with high efficiency and stability.

Intravenous delivery of an adenine base editor and a single-guide RNA for the Fah gene can correct an A>G splice-site mutation in an adult mouse model of tyrosinaemia.

PKM2 is involved in the aging process but the mechanism remains elusive. Here, the authors show that PKM2 forms aggregates during aging and identify two small molecules which can dissolve the PKM2 aggregates and delay aging.

In this work, the authors demonstrate that LLPS of the quaternary USH2 protein complex initiates the formation of stereociliary ankle link condensates, providing insights into the pathogenesis of deafness.

Translocation renal cell carcinoma (tRCC) is driven by MiT family gene fusions. Here, the authors demonstrate that RNA-binding features of TFE3 fusions facilitate condensate formation, promoting transcriptional hub assembly and oncogenic gene activation.

Si et al. demonstrated that wheat TaNHLP1 interacts with ABA regulators and RACK1A to increase tiller number, and that promoter variants that elevate TaNHLP1 expression enhance yield. This regulatory module is conserved across plants.

Bullous pemphigoid (BP) is a type 2 immunity associated skin inflammatory disease. Here the authors characterize the underlying immune-stromal crosstalk in this disease using scRNA sequencing to show that IL13-IL13RA1 signals are involved with fibroblast and DC mediated enhancement of Th2 responses.

This study presents iKraph, a large-scale biomedical knowledge graph built using an award-winning natural language processing pipeline with expert-level accuracy. Using probabilistic semantic reasoning, iKraph enables automated knowledge discovery with excellent performance.

Natural antimicrobial metabolites produced by soil microorganisms can be used as green pesticides. Here, the authors isolated a Pseudomonas mosselii strain 923 from rice rhizosphere soils and identify the compound pyrazolotriazine pseudoiodinine inhibits the growth of plant bacterial and fungal pathogens.

Candida albicans infection exacerbates intestinal inflammation through IL-1β dependent mechanisms. Here the authors characterise the function of a hyphae protein Als3 and show that Als3 promotes ASC oligomerization so that innate cells sense infection and promote IL-1β mediated effector mechanisms.

Li and colleagues show that G3BP1, a protein known to regulate the RNA stress response, is critical for DNA sensing and efficient activation of the cytoplasmic DNA sensor cGAS.

The photoluminescence of metal nanoclusters can be modulated through traps. Here, the authors show how H₂O molecules passivate oxygen vacancies allowing sensitive color tuning and boosting the emission efficiency.

Hybrid necrosis in wheat is caused by the complementary genes Ne1 and Ne2. The underlying mechanism remains enigmatic. Here, Si et al. demonstrated that a genetic interaction between the α/β hydrolase (Ne1) and the NLR immune receptor (Ne2) triggers autoimmune responses, inducing hybrid necrosis.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

Quantum speed limits are fundamental constraints on the speed of quantum state evolution. Here, the authors observe the known maximal quantum speed limits for few and many-body states on a superconducting quantum processor and identify the minimal quantum speed limits, which are less common than maximal ones.

Hybrids can be self-pollinated to produce true-breeding progeny through seeds by simultaneous genome editing of four endogenous genes in a rice F₁ hybrid variety.

Gene expression is highly variable between tissues, and changes during development and with age. Here, the authors provide a comprehensive RNA-Seq analysis of the rat transcriptome, spanning eleven organs, four developmental stages and both sexes.

Integrin CR3 (CD11b/CD18) is a receptor responsible for recognizing fungal β-glucan. Here, Zhou et al show that the Candida albicans Als family proteins are ligands for the CD11b I domain; an interaction which synergizes with β-glucan to activate CR3.

Pityriasis rubra pilaris (PRP) is a chronic immune‐mediated papulosquamous dermatosis and is caused by dysregulation of keratinocytes. Here the authors identify keratin 32 (KRT32) mutations associated with PRP which results in the inhibitory function of KRT32 towards NF-kB signalling and IKK complex formation being reduced.

The management of charge carrier recombination and transport in heterojunction back contact solar cells poses significant challenges in achieving a high efficiency. Here, authors analyze various loss mechanisms of devices fabricated by laser patterning, and achieve a certified efficiency of 27.09%.

Chromosome conformation capture techniques enable the study of genome organization in cancer cells. Here, the authors use Hi-C, WGS, and RNA-seq to study the 3D genome of multiple myeloma and find that genome disorganization is associated with copy number variations and changes in gene expression.

Here the authors developed a nucleolus Hi-C technique (nHi-C) for enriching nucleolus-associated interactions, and revealed specific heterochromatin interaction patterns within and around nucleoli in human cells at high resolution.

Here the authors show that the Koolen-de Vries syndrome associated gene KANSL1 modulates autophagosome-lysosome fusion via transcriptional regulation of autophagosomal gene Syntaxin17, and that 13-cis retinoic acid can reverses mitophagic defects and neurobehavioural abnormalities of mice lacking Kansl1.

Coronavirus nucleocapsid (N) protein is important for viral genome packaging and virion assembly. Here the authors show that natural chemical (-)-gallocatechin gallate (GCG) disrupts the liquid–liquid phase separation of N and inhibits SARS-CoV-2 replication.

Polymetalated aromatic compounds are challenging synthetic goals. Here, the authors describe the synthesis of tetra-aurated indole and octa-aurated benzodipyrrole complexes, in which incorporation of the aurated substituents at the nitrogen atoms leads to hyperconjugative aromaticity in the five-membered rings.

How ROS levels are regulated in cancer stem cells and their contribution to cancer resistance is currently not clear. Here, the authors show that prohibitin regulates mitochondrial ROS production stabilizing the peroxidase PRDX3 and this accounts for radiotherapy resistance in glioma stem-like cells.

Plant cryptochromes are regulated by blue-light dependent phosphorylation. Here the authors map thein vivo phosphorylation sites of Arabidopsiscryptochrome 2 and identify four closely related kinases that act to both activate and destabilize the receptor in response to blue light.

NAD⁺ is shown to be a ligand of the armadillo/heat repeat motifs (ARM) domain of SARM1, and it is suggested that this binding of NAD⁺ mediates self-inhibition of SARM1.

Shen et al. report that prolonged obesity is associated with cerebrovascular dysfunction and Tak1 activation in brainstem microglia. Pharmacological inhibition or genetic depletion of Tak1 restores cerebrovascular function in obese mice.

Organ regeneration by transplantation of ESC/iPSC-derived tissues is a promising but still challenging approach. Here Lin et al. show that liver damage caused by a chemical insult induces not only fibrosis but also Lgr5⁺ cell expansion that can be further promoted by treatment with HGF/R-spondin1.