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Researchers study the transition from bound states in the continuum (BICs) to quasi-BIC caused by out-of-plane asymmetry and illustrate how quality factors of BIC resonances are valuable tools for precise chip patterning accuracy.

Deep brain stimulation tuned to cue-reactivity within the nucleus accumbens region reduced drug cravings, heralding an evocation-based programming strategy for opioid use disorder.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Here, the authors present genome-wide aDNA from 138 Early Bronze Age individuals from Lower Austria. Their findings point to a patrilocal society with non-strict female exogamic practices and long-distance genetic connections across Central Europe.

Vinyard et al. present a generative method to model cell dynamics using neural stochastic differential equations that learn state-dependent drift and diffusion, outperforming existing approaches and enabling perturbation studies of development and disease.

The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.

Biexcitons play an important role in determining the optical properties of transition metal dichalcogenide monolayers, but their precise structure is poorly understood. Using a combination of ultrafast spectroscopy and theory, the origin of their fine structure is revealed.

The low-density lipoprotein receptor family members LRP1, LRP4 and VLDLR are entry receptors for yellow fever virus.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

TARPs are tetraspanins that are claudin-like but regulate glutamate receptors. Here, the moieties that define TARP function and distinguish them from claudins are uncovered through cryo-EM, structure prediction, and electrophysiology.

The study of lattice vibrations coupled to electronic excitations may provide an avenue for exploring exotic physical phenomena. Here, Xuet al. observe a Fano resonance in the Weyl semimetal TaAs, revealing evidence for a strong coupling between phonons and Weyl fermions.

GATA2 deficiency is one of the major causes of hereditary pediatric myelodysplastic neoplasms (MDS). Using iPSC-based models, this work recapitulates stepwise mutational trajectories in GATA2-related MDS and reveals their impact on myeloid differentiation.

Thermal lepton pairs are ideal probes for the temperature of quark-gluon plasma. Here, the STAR Collaboration uses thermal electron-positron pair production to measure quark-gluon plasma average temperature at different stages of the evolution.

Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance in multiple worm disease models, extending healthspan.

Microporous hydrogels have potential in 3D tissue culture, but precise control over pore formation is challenging. Here, the authors report the use of photopolymerization-induced phase separation to prepare hydrogels suitable for 3D cell culture and bioprinting.

MRI data from more than 100 studies have been aggregated to yield new insights about brain development and ageing, and create an interactive open resource for comparison of brain structures throughout the human lifespan, including those associated with neurological and psychiatric disorders.

Going from model development to a pilot implementation study, a deep learning model shows that acute aortic syndrome can be diagnosed directly from noncontrast CT, increasing accuracy and decreasing time to diagnosis.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

A new method to quantify three masting components from individual tree-years has revealed that globally, masting is uncommon in tree species that depend on mutualist dispersers, with its distribution further mediated by climate and nutrient availability.

Achieved high thermoelectric figure of merit (ZT) in organic thermoelectric materials remains a challenge due to their low packing order and poor host/dopant miscibility. Here, the authors report side chain-engineered n-doped fullerene derivatives with record ZT >0.3 for organic thermoelectrics.

Here, the authors demonstrate a multi-momentum transformation metasurface. The orbital angular momentum meta-transformer reconstructs different vortex beams into on-axis distinct patterns, and the linear momentum meta-transformer converts red, green and blue beams to vivid color images.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

The origin of superconductivity enhancement in FeSe monolayer grown on SrTiO₃ compared to bulk FeSe is still a debated issue. Here, Shi et al. report a further 15 K jump of T_c accompanying a second Lifshitz transition triggered by electron doping in FeSe/SrTiO₃monolayer films.

Coherent radio emission with a long (nearly 6.5 h) period has been detected from both magnetic poles of a rotating compact object, offering insights into the evolution and emission mechanism of compact radio transients.

The dynamic behavior of supramolecular polymers in aqueous environments remains poorly understood due to the assembly pathway complexity. Here, the authors present a combinatorial titration methodology to probe in situ a binary assembly mechanism between spheroidal micelles and β-sheet polymers of peptide amphiphiles, which collectively govern supramolecular dynamics.

The behavior of quantum magnets depends strongly on the effective dimensionality of the inter-spin interactions. Here the authors tune the influence of two- and three-dimensional couplings in Yb₂Pt₂Pb with a magnetic field and hence control the behavior of emergent one-dimensional excitations.

In this type of thermal cloak, when a fluid circulates around the object of interest, the temperature perturbation is minimized as the effective thermal conductivity of the fluid becomes very high due to convective effects.

This study provides the first evidence in humans that tirzepatide modulates brain electrophysiology, with changes in low-frequency accumbens power linked to food preoccupation.

KDM4C regulates cathepsin L-mediated histone H3 N-terminal tail clipping through grainyhead-like 2 (GRHL2) methylation in breast cancer. This link between the cellular redox state and chromatin remodeling might represent a therapeutic target in KDM4C-amplified tumors.

Neuroanatomical shape measurements are multidimensional geometric descriptions of brain structure. This study develops multivariate heritability analysis methods and examines structural brain MRI scans and genetic data to estimate the heritability of neuroanatomical shape.

ScNT-seq leverages metabolic labeling of nascent RNA and droplet-based sequencing for parallel analysis of newly transcribed and pre-existing mRNAs, which enables time-resolved analysis of dynamic biological processes in single cells.

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Skyrmions—vortex-like spin textures—are conventionally only seen in materials that exhibit the right magnetic properties. Li et al.now create so-called artificial skyrmions using a cobalt disk embedded in a magnetized nickel film, thus presenting a platform for controlling skyrmions.

Bedload can dominate river sediment flux after a major earthquake for a prolonged time period.

An integrated data and sample repository for clinical, cellular and multi-omics research from diverse spaceflight missions known as Space Omics and Medical Atlas (SOMA) is presented.

Liu et al., report extensive maps of chromatin interactions, single-cell expression, and other molecular features in human arterioles and uncover mechanisms linking noncoding genetic variants to gene expression and the development of hypertension.

Stabilizing non-trivial magnetic spin textures at room temperature remains challenging. Here, the authors propose introducing magnetic atoms into the van der Waals gap of 2D magnets Fe₃GaTe₂ to stabilize the magnetic spin textures beyond skyrmion.

Small molecule antagonists of CCR6 are potential drugs for autoimmune disorders. Here the authors present inactive structures of CCR6 bound by different allosteric antagonists from two series simultaneously, offering multiple approaches to inhibit CCR6.

A long-period radio transient with coincident radio and X-ray emission and observational properties unlike any known Galactic object has been observed by the Australian Square Kilometre Array Pathfinder.

The authors perform a genome-wide association study of adolescent idiopathic scoliosis patients of Han Chinese descent, and identify 3 new loci for disease susceptibility.

Nitrogen application rates for wheat production in China are ~2.5 times greater than those in the USA. Nitrogen benchmarks can guide smallholder farmers and policymakers towards improved nitrogen use efficiency.

Optical elements fabricated with a 3D printing technique generate beams carrying orbital angular momentum under incoherent white light illumination.

In general, heating increases disorder and leads to the loss of magnetism in condensed matter. Here, the authors demonstrate that a normal metal can be magnetized by applying a temperature gradient during non-uniform heating when attached to a magnetic insulator.

Despite of the charge disorder, the three-dimensional antiferromagnet NaCaNi₂F₇ is an almost ideal realization of the spin-1 antiferromagnetic Heisenberg model on a pyrochlore lattice, showing key features of quantum spin liquid.