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Addressing how the nitrogen-induced changes in plant diversity differ from those in soil organisms is critical. This global meta-analysis suggests that nitrogen enrichment has stronger negative effects on plant diversity but modest to negligible effects on soil bacterial and fungal diversity.

Optical switching of a moiré Chern ferromagnet is demonstrated in twisted molybdenum ditelluride bilayers using continuous-wave circularly polarized light, paving the way for dissipationless spintronics and quantized Chern junction devices.

Organocatalytic allylic substitution of Morita-Baylis-Hillman (MBH) adducts constitute powerful transformations within organic synthesis. Here the authors present an asymmetric direct α-C–H allylic alkylation of NH₂-unprotected benzylamines with MBH adducts, using a bifunctional chiral pyridoxal catalyst, producing biologically important chiral γ-amino acid derivatives.

Long mesocotyl is a critical trait for the application of rice deep direct seeding or mechanized dry seeding cultivation method. Here, Sun et al. find OsGSK2 is selected for mesocotyl length variation during domestication and it coordinates strigolactone and brassinosteroid signaling to determine mesocotyl elongation.

Scalable fabrication of quantum emitters with precise spatial positioning remains challenging. Here the authors present a scalable method for the deterministic fabrication of high-quality single-photon emitter arrays in hexagonal boron nitride, using nano-indentation to enable site-specific impurity insertion.

Hydroxy fatty acids (HFA) accumulated in the seed of Physaira species are useful in various industrial applications. Here, the authors report three chromosome-level genomes of Physaria species and reveal variation of FAH12 causing the disparity in hydroxylation activity among the three species.

The authors implement on-chip Rydberg exciton-polaritons by coupling WS₂ monolayers to a photonic crystal. Rydberg polaritons exhibit a nonlinearity of 8.0 ± 2.3 times larger than that of the ground polaritonic states due mostly to their extended exciton radii and photonic crystal-induced spatially localized electric field distribution.

CABLE harnesses cytoarchitectural information such as cell or nuclear shape to infer fiber tracts in the brain of, for example, marmosets, macaques or humans.

This study presents ECloudGen, which uses latent diffusion to generate electron clouds from protein pockets and decodes them into molecules. The adopted two-stage training expands the chemical space accessible to generative drug design.

The nature of localized interlayer excitons (LIXs) in moiré superlattices is still elusive Here, the authors propose a donor-acceptor pair mechanism for LIXs in MoSe₂/WSe₂ heterobilayers.

A room-temperature double-layer WS₂ microcavity is used to explore spin anisotropy and tune it with interlayer spacing.

Here, the authors investigate the Raman spectra of few-layered WS₂ when the excitation energy is in resonance with the dark exciton, and observe a Fano resonance between dark excitonsand zone-edge acoustic phonons.

Electronically mismatched Diels−Alder reaction between two electron-deficient components is synthetically useful and yet underdeveloped. Herein, a photoinduced formal [4 + 2] cycloaddition of enone with a variety of electron-deficient dienes is described.

Giant THG anisotropy in 2D VOCl emerges from a synergistic coupling of charge-transfer Mott insulator behavior with intrinsic C₃ symmetry breaking.

Room-temperature solid-state single photon emitters in the telecom range are suitable for quantum communication. Here, the authors observe defects in high-purity 3C-SiC epitaxy layers grown on a silicon substrate, with good characteristics in terms of brightness, emission’s polarization and photostability.

One strategy to address multidrug resistance in cancer is the development of modular methods to access bioactive scaffolds. Here, the authors report a Rh(III)-catalyzed carboxylic acid-directed C(sp²)−H allylation and apply it to the modular synthesis of (Z)-allylic macrolides which enhance antitumoral drug activity.

The upscaling of kesterite photovoltaics is challenging and results in low performance. Xiang et al. tune the thiourea/metal precursor ratio to improve the morphology of the kesterite film, achieving 10.1% certified power conversion efficiency in 10.48-cm² modules.

Reconstruction of metal-organic frameworks occurs under reaction conditions, hindering mechanism understanding. Here, the authors identify the alkaline reconstructed β-Ni(OH)₂ with residual ligand that can catalyze the deprotonated anion of hydrogen peroxide at high current densities.

Furanocembranoid-like natural products with the alkene-substituted furan scaffold display a range of biological activities, but are difficult to access. Here, the authors report a modular biomimetic strategy to synthesise diverse alkene-substituted furan-containing macrolactams via palladium-catalysed unactivated Csp³-H olefination.

Recently, the quantum anomalous Hall effect has been successfully achieved in the intrinsic magnetic topological insulator MnBi₂Te₄, but zero-field quantization has proved difficult to achieve due to poor sample quality. Here, the authors report zero-field quantization and chiral edge states in five-septuple-layer MnBi₂Te₄.

While HER2-targeted therapies such as trastuzumab can be effective in patients with breast cancer, resistance often develops. Here, the authors demonstrate that the histone reader ZYMND8 promotes glycerophospholipid metabolic reprogramming via c-Myc and cPLA2α to increase secretion of IL-27, mediating resistance to HER2-targeted antibodies in preclinical models of breast cancer.

A three-dimensional metal stamp can be used to selectively exfoliate two-dimensional materials, allowing the remaining material to be patterned into two-dimensional arrays without leaving chemical or polymer residues.

The authors present a comprehensive regulome atlas for rice by mapping chromatin accessibility across 23 tissues from three rice varieties. By integrating matched RNA-seq data, they accurately predict numerous associations between non-coding regulatory elements and target genes. This study provides a foundational resource for gene editing and breeding strategies targeting non-coding regions in rice, potentially advancing crop improvement efforts.

Viruses exploit host cell machinery for replication, but their spatial cues remain elusive. Using nanochip-enabled membrane shaping, the authors discover saddle curvature association of viral proteins, revealing a new spatial regulation mechanism.

The authors demonstrate on-chip circularly polarized light detection using the chiral properties of transition metal dichalcogenide valleytronic transistors on centrosymmetric plasmonic metamaterials.

Panicle architecture significantly determines rice grain yield. Here, the authors investigate the transcriptome of young panicles from 275 rice varieties and propose a method to identify causal genes for panicle traits and construct regulatory networks.

The efficiency of nonlinear optical processes in 2D materials is often reduced by weak light-matter interactions and crystal symmetry constraints. Here, the authors report the enhancement of classical second-harmonic generation in hexagonal boron nitride and quantum spontaneous parametric down-conversion in NbOCl₂ flakes by combining them with Au or SiO₂/Au substrates.

The high-voltage oxygen redox activity of Li-rich layered oxides enables additional capacity beyond conventional transition metal redox contributions. Here, authors investigate the correlation between oxygen redox activity and superstructure units. They prove that an excess of LiNiMn5 hinders the extraction/insertion of lithium ions.

In vivo gene editing hinges on identifying an ideal delivery vehicle from numerous candidates. Here, authors establish the GFP-on mouse model capable of translating successful adenine base editing to a fluorescent readout thus enabling the rapid evaluation of genome editing delivery vehicles.

The small size (≤15-nt) of micorexons poses difficulties for genome annotation and identification using standard RNA sequence mapping approaches. Here, the authors develop computational pipelines to discover and predict microexons in plants and reveal diverse evolutionary trajectories via genomewide microexon modeling.

The influence of Li occupancy on electro-chemomechanical stability in Co-free Ni-rich layered oxides for Li-ion batteries has been overlooked. Here, authors investigate different Li structural units in the oxide lattice and show that tuning the Li occupancy improves battery cycling stability.

AIF3 variants are identified in children with mitochondrial disorder with yet unclear impact/mechanism. Here, the authors show that AIF3 splicing disrupts mitochondrial respiration, glutathione-redox homeostasis and brain development via dysregulating AIF’s NAD(P)H dehydrogenase and glutathione reductase activities.

Using a framework based on optoelectronic polarization eigenvectors and optoelectronic conversion matrixes, an on-chip full-Stokes polarimeter can be created that offers a root mean square error of less than 1% for each Stokes parameter over the entire range of polarization states at arbitrary light intensities.

The detection of light intensity, polarization, and spectral information with a single device is desired for efficient optical sensing and computing applications. Here, the authors report the realization of metasurface-assisted graphene photodetectors able to simultaneously detect polarization states and wavelengths of broadband infrared light.

Intravenous delivery of an adenine base editor and a single-guide RNA for the Fah gene can correct an A>G splice-site mutation in an adult mouse model of tyrosinaemia.

Compact sources of entangled photons are desired for quantum communication, computing, and cryptography. Here, the authors report high entangled photon pair generation rates in rhombohedral boron nitride, showing its potential as a tunable platform for Bell state generation.

Authors realize a tunable hybrid improper ferroelectricity in [La₂NiMnO₆/La₂CoMnO₆]n double perovskite superlattices at room temperature by a strain-driven oxygen octahedral distortion strategy.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Non-radiative decay in two-dimensional WSe₂ quantum emitters is electrically suppressed through charge depletion using dual gate configurations. The single-photon emitter transition quantum efficiency after gating is increased to 76.4 ± 14.6% on average.

Quantum-metric-induced nonlinear transport, including the nonlinear anomalous Hall effect and a diode-like response, is observed in thin films of a topological antiferromagnet, providing a means to design magnetic nonlinear devices.

Allergic asthma is characterized by goblet cell metaplasia. Here, the authors show protein SUMOylation contributes to goblet cell metaplasia and SUMOylation-mediated ROCK2 activation is an integral component of Rho/ROCK signalling pathway in controlling the airway goblet cell metaplasia.

Information security remains a vital concern for communications technology, and quantum key distribution may offer the highest security theoretically possible. This Review discusses the performance limitations, high costs and practical security concerns for quantum key distribution to scale to a global level.

The authors demonstrate electrical on/off switching of interlayer interactions in tungsten diselenide/molybdenum disulfide heterobilayers, the phase diagram of which contains layer-dependent correlated regions that reveal the role of strong correlations in interlayer exciton dynamics.