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Imperatorin stimulates cardiomyocyte DNA repair and proliferation by enhancing the phosphorylation of TDP1 at serine 81 through facilitating the proximity-mediated interaction between TDP1 and DNA-PKcs.

The authors present Lock-in-SIM, an open-access method for high-fidelity background-suppressed SIM reconstruction, which enables live-cell investigation of intraorganellar ultrastructures, including ER– lysosome interactions and mitochondria-mediated mitochondrial fission.

Controlling relative and absolute stereochemical configurations in reactions creating multiple stereocentres at remote positions is a highly challenging task. Here, the authors report such control using complimentary, non-enantiomeric organocatalysts for addition to α,β-unsaturated ketones.

Bi, Mo, Liu et al. carry out high-throughput screening and analysis to profile genome-wide pro-tumour enhancers and uncover enhancer connectomes in glioma. In particular, they identify specific single-nucleotide polymorphisms associated with glioma risk and progression.

Open-shell organic radicals possess narrow energy gaps making them efficient solar absorbers. Here the authors synthesize robust triarylamine radicals enabling near unity absorption of the full solar spectrum for efficient photothermal applications.

Bellman equation is widely applied in solving dynamic optimization problems. Here, the authors present a memristive Bellman solver reducing the computational complexity and improving energy efficiency for advanced decision-making process.

Lei et al. develop a 4-1BB co-stimulated anti-CD19 CAR-NK cell product, show efficacy in pre-clinical models, and test safety and feasibility in a phase 1 trial in patients with refractory/relapsed large B cell lymphoma.

Immune checkpoint inhibitors and antiangiogenic agents have shown some activity in patients with late-stage gastric cancer. Here the authors report the results of a phase II trial of neoadjuvant anti-PD1 (camrelizumab), antiangiogenic agent (apatinib), and chemotherapy (S-1 ± Oxaliplatin) in stage T4a/bN + M0 gastric cancer patients.

Sodium-sulfur batteries performance is hindered by the shuttling and sluggish redox of S species. Herein, authors propose geometric and electronic descriptors concomitantly correlated with coordinative unsaturation of Fe single atoms to engineer highly active and robust positive electrode for Na-S batteries.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Van Hove singularities (VHS) are believed to exist in one and two dimensions, but rarely found in three dimensions (3D). Here the authors report the discovery of 3D VHS in a topological magnet EuCd₂As₂ by magneto-infrared spectroscopy.

Yao and Gong et al. identify WD40 repeat-containing protein 6 (WDR6) to be upregulated in the liver of insulin-resistant mice. WDR6 contributes to promoting hepatic de novo lipogenesis during insulin resistance by upregulation of fatty acid synthase, and the authors identify a small molecule to inhibit this effect of WDR6 and reduce hepatic steatosis.

Kim and colleagues perform a phase 2 clinical trial (ELM-2) of odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma and report on the primary analyses of the efficacy and safety profile.

Organic materials hold great potential of for spintronic applications. Here the authors show electronic phase dependent magnetoresistance (MR) effect in LPCMO/Alq₃/Co junctions with large MR up to 440% at 10 K as well as electrical Hanle effect as the Hallmark of the spin injection.

The diamondback moth, Plutella xylostella is a cosmopolitan agricultural pest. By analyzing 532 genomes from 114 populations around the world, the authors find evidence supporting a South American origin of this moth, and look for signatures of positive selection.

In strongly correlated materials multiple electronic phases can form simultaneously in real space, offering the potential of devices with multiple electronic properties, if such phase separation can be controlled. Here, Li et al study this electronic phase separation in LaMnO3/CaMnO3/PrMnO3 superlattice, and find a nano-network electronic phase separation resulting from local strain relaxation that persists through thermal cycling.

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Jianquan Liu and colleagues report the draft genome sequence of the domestic yak, Bos grunniens. Their comparative analyses with low-altitude cattle provide insights into high-altitude adaptation in the yak.

“Conventional chemotherapy-photothermal therapy combination has limited efficacy in drug resistant cancers. Here they develop Copper-palladium tetrapod nanoparticles to overcome these challenges and show them to work in synergy with autophagy inhibitors to treat drug resistant cancers”

STRaM is an advanced bioinformatic pipeline for handling complex engineered-cell and cell-line provenance. Our automated system evaluates similarity index, purity index, editing/mutation index for cell products identification and traceability.

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Yanqing Su, Wanmin Lin colleagues report the construction of an instance-based learning classifier by non-specific hybridization of DNA sequences both in simulation and in a small-scale experiment. The approach is simple, robust and scalable to larger classification applications.

The solar wind affects the magnetosphere, but whether this holds true for solar flares was unclear. By combining geospace modelling with observations, solar flares are shown to influence the dynamics of the magnetosphere and its ionosphere coupling.

Phase transformations in 2D materials have distinct kinetic and thermodynamic features, resulting from their reduced dimensionality and unique interactions. This Review discusses the properties of phase transitions and defects in 2D materials, and examines technological applications and challenges in the study of 2D phase transitions.