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Scientific Reports (11)
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Showing 1–50 of 59 results

Advanced filters: Author: Xiaoling Yao Clear advanced filters

Chromatin-intrinsic mechanisms determine orientation-specific class switch recombination

How chromatin architecture enforces productive class switching is not fully understood. Here, the authors demonstrate that transcriptional orientation, genomic distance, and Igh domain organization bias AID‑initiated breaks toward deletional joining required for productive CSR.

Sha Luo
Ruolin Qiao
Xuefei Zhang
ResearchOpen Access28 Feb 2026
Nature Communications

Volume: 17, P: 1-14
Author Correction: NIPBL-mediated RAD21 facilitates tumorigenicity by the PI3K pathway in non-small-cell lung cancer

Xiaoling Xu
Ding Wang
Weimin Mao
Amendments and CorrectionsOpen Access01 Apr 2024
Communications Biology

Volume: 7, P: 1
Identification of T cell stress response state (T_STR) and key genes related to T cells in discoid lupus erythematosus

Xingfeng Zhuo
Xue Xing
Lei Zhang
ResearchOpen Access10 Nov 2025
Scientific Reports

Volume: 15, P: 1-15
Prodrug nanoplatform for triggering ferroptosis to eliminate senescent cells in age-associated pathologies

Accumulation of senescent cells is associated with age-related diseases. Here, the authors present a prodrug nanoplatform to trigger ferroptosis specifically and exclusively in senescent cells.

Chengkang Jin
Xiaoling Xu
Liyun Shi
ResearchOpen Access13 Dec 2025
Nature Communications

Volume: 17, P: 1-21
Atezolizumab plus bevacizumab and chemotherapy in metastatic nonsquamous NSCLC: the randomized double-blind phase 3 IMpower151 trial

In the IMpower151 trial, the drug combination previously shown to be effective in the IMpower150 trial was not significantly effective in a Chinese population.

Caicun Zhou
Xiaorong Dong
Minu K. Srivastava
ResearchOpen Access16 May 2025
Nature Medicine

Volume: 31, P: 2375-2384
Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

Reactive oxygen species induced by endoplasmic reitculum stress can be exploited for cancer therapy. Here, nanoparticles are targetted to the endoplasmic reticulum and, when accompanied by PDT, produce stress resulting in calreticulin exposure on the cell surface, which activates dendritic cells.

Wei Li
Jie Yang
Jian You
ResearchOpen Access26 Jul 2019
Nature Communications

Volume: 10, P: 1-16
NGS-based spinal muscular atrophy carrier screening of 10,585 diverse couples in China: a pan-ethnic study

Sumin Zhao
Wanyang Wang
Zhiyu Peng
Research03 Sept 2020
European Journal of Human Genetics

Volume: 29, P: 194-204
Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant

The SARS-CoV-2 Delta variant has spread rapidly worldwide. Here, the authors characterise a single chain of transmission of Delta in China, and find evidence that it is more infectious and replicates faster during early infection compared to early pandemic lineages.

Baisheng Li
Aiping Deng
Jing Lu
ResearchOpen Access24 Jan 2022
Nature Communications

Volume: 13, P: 1-9
Dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis

The domestic chicken Gallus gallus domesticus is a classic model for the study of folliculogenesis. Here the authors integrate multi-omics analyses characterizing the dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis.

Diyan Li
Chunyou Ning
Mingzhou Li
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-14
Identification of a seven-long non-coding RNA signature associated with Jab1/CSN5 in predicting hepatocellular carcinoma

Weijie Ma
Ye Yao
Francois X. Claret
ResearchOpen Access10 Jul 2021
Cell Death Discovery

Volume: 7, P: 1-10
Pilot study of expanded carrier screening for 11 recessive diseases in China: results from 10,476 ethnically diverse couples

Sumin Zhao
Jiale Xiang
Zhiyu Peng
ResearchOpen Access01 Oct 2018
European Journal of Human Genetics

Volume: 27, P: 254-262
Trend and risk factors of low birth weight and macrosomia in south China, 2005–2017: a retrospective observational study

Jiaming Rao
Dazhi Fan
Zhengping Liu
ResearchOpen Access21 Feb 2018
Scientific Reports

Volume: 8, P: 1-8
Genome-wide identification of microRNA expression quantitative trait loci

As important post-transcriptional regulators of gene expression, microRNAs play a key role in the generation of complex phenotypes. Here, Huan et al.identify miR-eQTLs in whole blood samples to create a roadmap linking regulation of microRNA expression to complex diseases.

Tianxiao Huan
Jian Rong
Jane E. Freedman
Research20 Mar 2015
Nature Communications

Volume: 6, P: 1-9
Metabolomic and transcriptomic profiling of HNSCC identifies AMIGO2 as a therapeutic target modulating tumor microenvironment

Gan Liu
Xinfeng Yao
Zongcheng Yang
ResearchOpen Access18 Nov 2025
npj Precision Oncology

Volume: 9, P: 1-18
Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4

Yinghao Sun and colleagues report a genome-wide association study for prostate cancer in Han Chinese men. They identify two new risk-associated loci at chromosomes 9q31 and 19q13.

Jianfeng Xu
Zengnan Mo
Yinghao Sun
Research30 Sept 2012
Nature Genetics

Volume: 44, P: 1231-1235
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma

Long Yu and colleagues report a genome-wide association study for hepatitis B virus–related hepatocellular carcinoma (HBV-HCC). They report that genetic variants in STAT4 and HLA-DQ genes confer risk of HBV-HCC.

De-Ke Jiang
Jielin Sun
Long Yu
Research16 Dec 2012
Nature Genetics

Volume: 45, P: 72-75
GDNF signaling modulation by Akkermansia muciniphila ameliorates constipation–depression comorbidity in Parkinson’s disease

Chunyan Mu
Zairen Zhou
Xiaoling Qin
ResearchOpen Access28 Nov 2025
npj Parkinson's Disease

Volume: 11, P: 1-19
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Cristian Pattaro
Alexander Teumer
Caroline S. Fox
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-19
Suppressing protein damage response to overcome multidrug resistance in cancer therapy

Fangyuan Shao
Zongjie Li
Chu-Xia Deng
ResearchOpen Access30 Sept 2025
Cell Discovery

Volume: 11, P: 1-18
Mendelian randomization study of serum uric acid levels and urate-lowering drugs on pulmonary arterial hypertension outcomes

Xiaoling Yao
Xin Cai
Zong Jiang
ResearchOpen Access06 Feb 2025
Scientific Reports

Volume: 15, P: 1-10
Effect of magnetization on antibacterial, lipid-lowering and antioxidant activities of isoquinoline alkaloids

Xueting Feng
Weijie Li
Shun Yao
ResearchOpen Access27 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
Paradoxical psoriasis in pediatric tumor necrosis factor-α inhibitor therapy database

Yurong Piao
Xiaolin Xu
Huawei Mao
Research23 Jul 2025
Pediatric Research

Volume: 99, P: 958-963
Toripalimab plus chemotherapy for first line treatment of advanced non-small cell lung cancer (CHOICE-01): final OS and biomarker exploration of a randomized, double-blind, phase 3 trial

Jia Zhong
Kailun Fei
Jie Wang
ResearchOpen Access24 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-9
In vivo mechanisms of resveratrol liposomes in targeting the TLR4/NLRP3 pathway in lung cancer

Chunxia Chen
Huan Huang
Luying Huang
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
DATS, the data tag suite to enable discoverability of datasets

Susanna-Assunta Sansone
Alejandra Gonzalez-Beltran
Lucila Ohno-Machado
ResearchOpen Access06 Jun 2017
Scientific Data

Volume: 4, P: 1-8
Enhancing urban resilience through machine learning-supported flood risk assessment: integrating flood susceptibility with building function vulnerability

Xiaoling Qin
Shifu Wang
Haochen Shi
ResearchOpen Access03 May 2025
npj Urban Sustainability

Volume: 5, P: 1-19
Analysis of the status and influencing factors of dignity impairment symptoms in critically ill patients after ICU treatment

Jinlei Du
Gutao Peng
Chencong Nie
ResearchOpen Access21 Oct 2024
Scientific Reports

Volume: 14, P: 1-8
Reconstructing the local structures of Chinese ancient architecture using unsupervised depth estimation

Xiaoling Yao
Lihua Hu
Jifu Zhang
ResearchOpen Access30 Aug 2024
Heritage Science

Volume: 12, P: 1-13
Butin regulates the NLRP3/CASP-1/GSDMD pyroptosis axis to inhibit proliferation and pyroptosis in human fibroblast-like synoviocytes of rheumatoid arthritis

Hao Li
Yuzheng Yang
Wukai Ma
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-14
The chromosome-level genome assembly and genes involved in biosynthesis of nervonic acid of Malania oleifera

Tianquan Yang
Rengang Zhang
Yongpeng Ma
ResearchOpen Access19 May 2023
Scientific Data

Volume: 10, P: 1-8
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype

Genome-wide analyses identify variants near HDAC9 associated with abdominal aortic calcification and other cardiovascular phenotypes. Functional work shows that HDAC9 promotes an osteogenic vascular smooth muscle cell phenotype, enhancing calcification and reducing contractility.

Rajeev Malhotra
Andreas C. Mauer
Christopher J. O’Donnell
Research28 Oct 2019
Nature Genetics

Volume: 51, P: 1580-1587
Enhancing the selectivity and conditional sensitivity of an antimicrobial peptide through cleavage simulations and homoarginine incorporation to combat drug-resistant bacteria

Keyi Yao
Jiachen Liu
Lei Wang
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-18
Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination

Huang, Li, An, Yang, Cui et al. perform a single-cell multi-omics analysis of human spermatogenesis and identify a DNA demethylation event upon meiosis initiation, which is associated with meiotic recombination.

Yaping Huang
Lin Li
Xiao-Yang Zhao
Research18 Sept 2023
Nature Cell Biology

Volume: 25, P: 1520-1534
Targeting miR-337 mitigates disuse-induced bone loss

Jiao Li
Ding Ma
Xiaoling Zhang
ResearchOpen Access26 Aug 2025
Cell Discovery

Volume: 11, P: 1-16
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

The next step after sequencing a genome is to figure out how the cell actually uses it as an instruction manual. A large international consortium has examined 1% of the genome for what part is transcribed, where proteins are bound, what the chromatin structure looks like, and how the sequence compares to that of other organisms.

Ewan Birney
John A. Stamatoyannopoulos
Pieter J. de Jong
Research14 Jun 2007
Nature

Volume: 447, P: 799-816
Author Correction: N⁶-methyladenine is incorporated into mammalian genome by DNA polymerase

Xiaoling Liu
Weiyi Lai
Hailin Wang
Amendments and Corrections25 May 2020
Cell Research

Volume: 31, P: 241
Prevalence, practice pattern, and mortality of hyperkalemia in Chinese patients undergoing hemodialysis in the visualize HD study

Zhao Xinju
Xing Changying
Zuo Li
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Correction: USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c

Ye Yao
Weijie Ma
Yufeng Yuan
Amendments and CorrectionsOpen Access15 May 2023
Oncogenesis

Volume: 12, P: 1-2
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Georg B. Ehret
Patricia B. Munroe
Toby Johnson
Research11 Sept 2011
Nature

Volume: 478, P: 103-109
Author Correction: Targeted inhibition of RBPJ transcription complex alleviates the exhaustion of CD8⁺ T cells in hepatocellular carcinoma

Banglun Pan
Zengbin Wang
Nanhong Tang
Amendments and CorrectionsOpen Access26 Oct 2023
Communications Biology

Volume: 6, P: 1
Integrated transcriptome and targeted metabolome analyses provide insights into flavonoid biosynthesis in kiwifruit (Actinidia chinensis)

Jipeng Mao
Zhu Gao
Lu Chen
ResearchOpen Access21 Aug 2024
Scientific Reports

Volume: 14, P: 1-12
CTBP1 links metabolic syndrome to polycystic ovary syndrome through interruption of aromatase and SREBP1

CTBP1 in granulosa cells of PCOS patients represses transcription of aromatase CYP19A1 and regulates stability of SREBP1a, which both contributes to dysregulation of hormone synthesis and lipid metabolism.

Yue Kong
Guang Yang
Gong Yang
ResearchOpen Access18 Sept 2024
Communications Biology

Volume: 7, P: 1-16
Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways

Xi Chen
Weijie Ma
Yufeng Yuan
ResearchOpen Access30 Apr 2021
Cell Death & Disease

Volume: 12, P: 1-14
USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c

Ye Yao
Weijie Ma
Yufeng Yuan
ResearchOpen Access02 Jun 2022
Oncogenesis

Volume: 11, P: 1-12
SIRT1 regulates hepatocyte programmed cell death via GSDME - IL18 axis in human and mouse liver transplantation

Kentaro Kadono
Hidenobu Kojima
Jerzy W. Kupiec-Weglinski
ResearchOpen Access23 Nov 2023
Cell Death & Disease

Volume: 14, P: 1-12
NIPBL-mediated RAD21 facilitates tumorigenicity by the PI3K pathway in non-small-cell lung cancer

The oncogenic role of RAD21 in NSCLC is mediated by NIPBL via H3K27 demethylation and suggest its use as a potential novel diagnostic marker and therapeutic target for NSCLC.

Xiaoling Xu
Ding Wang
Weimin Mao
ResearchOpen Access20 Feb 2024
Communications Biology

Volume: 7, P: 1-15
Targeting DGAT1 inhibits prostate cancer cells growth by inducing autophagy flux blockage via oxidative stress

Haiying Cui
Yao Wang
Xiaokun Gang
Research16 Nov 2023
Oncogene

Volume: 43, P: 136-150
A novel recombinant lineage’s contribution to the outbreak of coxsackievirus A6-associated hand, foot and mouth disease in Shanghai, China, 2012-2013

Xiaobo Feng
Wencai Guan
Zhirong Yao
ResearchOpen Access30 Jun 2015
Scientific Reports

Volume: 5, P: 1-12
Retraction Note: BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer

Weihong Niu
Yanwei Luo
Ming Zhou
Amendments and CorrectionsOpen Access03 Sept 2019
Cell Death & Disease

Volume: 10, P: 1
Targeted inhibition of RBPJ transcription complex alleviates the exhaustion of CD8⁺ T cells in hepatocellular carcinoma

In vitro and in vivo validation of Cancer Genome Atlas screening results demonstrate that RBPJ is an important factor regulating the function of T cells in hepatocellular carcinoma.

Banglun Pan
Zengbin Wang
Nanhong Tang
ResearchOpen Access30 Jan 2023
Communications Biology

Volume: 6, P: 1-15

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