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Showing 101–150 of 214 results

Advanced filters: Author: Xinyu Pi Clear advanced filters

Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer

KRAS^G12D mutations frequently co-occur with mutated TP53 tumour suppressor in patients with pancreatic ductal adenocarcinoma (PDAC). Here the authors report the design of dual targeted therapeutic extracellular vesicles containing high copy numbers of TP53 mRNA and siKRAS^G12D, showing anti-tumor activity in PDAC preclinical models.

Chi-Ling Chiang
Yifan Ma
L. James Lee
ResearchOpen Access23 Oct 2023
Nature Communications

Volume: 14, P: 1-18
Prediction of high-risk pregnancy based on machine learning algorithms

Xinyu Pi
Junzhi Wang
Wenli Zhang
ResearchOpen Access04 May 2025
Scientific Reports

Volume: 15, P: 1-8
Control of lysogeny and antiphage defense by a prophage-encoded kinase-phosphatase module

The ‘Pf’ bacteriophages of Pseudomonas aeruginosa play roles in biofilm formation and virulence. Here, the authors identify a prophage regulatory module, KKP (kinase-kinase-phosphatase), that controls virion production of co-resident Pf prophages and mediates host defense against diverse lytic phages.

Yunxue Guo
Kaihao Tang
Xiaoxue Wang
ResearchOpen Access23 Aug 2024
Nature Communications

Volume: 15, P: 1-17
Garvicin Q-producing Lactococcus garvieae LG3092: its role in mitigating dysbiosis and H. pylori-associated gastritis

Yanyan Shang
Yuwei Wu
Qingping Wu
ResearchOpen Access28 Nov 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-17
BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage with an aggressive subtype caused by translocations involving PAX3- /PAX7-FOXO1 chimeric transcription factors. Here the authors show that the BRG1-containing BAF complex is overexpressed and acts largely independently of the PAX3-FOXO1 chimera on chromatin to result in a myogenic differentiation blockade in this malignancy.

Dominik Laubscher
Berkley E. Gryder
Javed Khan
ResearchOpen Access26 Nov 2021
Nature Communications

Volume: 12, P: 1-16
Terrestrial plastisphere as unique niches for fungal communities

Fungal communities on microplastics in the terrestrial biosphere are enriched in the genera Penicillium and pathogenic Alternaria compared to communities in soil samples, suggest analyses of 125 experimental microcosms.

Yuanze Sun
Siyuan Xie
Jie Wang
ResearchOpen Access03 Sept 2024
Communications Earth & Environment

Volume: 5, P: 1-11
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of glucose homeostasis and a drug target for type 2 diabetes but available GLP-1R agonists are suboptimal due to several side-effects. Here authors report the cryo-EM structure of GLP-1R bound to an ago-allosteric modulator in complex with heterotrimeric G_s which offers insights into the molecular details of ago-allosterism.

Zhaotong Cong
Li-Nan Chen
Ming-Wei Wang
ResearchOpen Access18 Jun 2021
Nature Communications

Volume: 12, P: 1-11
Clarifying the clinical role of biparametric MRI: reflections on diagnostic equivalence and patient-level stratification

Xinyu Wang
Changhong Yan
Correspondence01 Oct 2025
Prostate Cancer and Prostatic Diseases

Volume: 28, P: 1026-1027
Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma

High levels of histone acetylation at rhabdomyosarcoma SEs, including SOX8, are detrimental to transcription via exclusion of RNA Pol II, but not BRD4, from phase condensates.

Berkley E. Gryder
Silvia Pomella
Javed Khan
Research29 Nov 2019
Nature Genetics

Volume: 51, P: 1714-1722
The effects of the combined application of organic and inorganic fertilizers on the annual balance of nitrogen and phosphorus in farmlands

Kexin Zhang
Xinyu Wan
Hongxiang Hu
ResearchOpen Access13 Oct 2025
Scientific Reports

Volume: 15, P: 1-14
Cooperation between bHLH transcription factors and histones for DNA access

Cryo-EM structures and analysis provide insight into the mechanisms by which basic helix–loop–helix transcription factors access E-box DNA sequences that are embedded within nucleosomes, and cooperate with other transcription factors.

Alicia K. Michael
Lisa Stoos
Nicolas H. Thomä
ResearchOpen Access05 Jul 2023
Nature

Volume: 619, P: 385-393
The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells

Liang et al. report mechanisms of migrasome biogenesis in migrating cells. They propose that sphingomyelin synthase 2 (SMS2) is required for migrasomes, first by localizing in stable puncta where they eventually form migrasome structures.

Haisha Liang
Xinyu Ma
Li Yu
Research24 Jul 2023
Nature Cell Biology

Volume: 25, P: 1173-1184
A novel SWIPT channel model and jointly age optimization in SWIPT-enabled access networks based on age of energy harvesting

Zhe Wang
Jiekai He
Lina Ge
ResearchOpen Access26 Mar 2025
Scientific Reports

Volume: 15, P: 1-25
Macromolecular protein crystallisation with biotemplate of live cells

Mubai Sun
Huaiyu Yang
Jinghui Wang
ResearchOpen Access22 Feb 2022
Scientific Reports

Volume: 12, P: 1-10
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity

Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

Anais Elewaut
Guillem Estivill
Anna C. Obenauf
ResearchOpen Access27 Nov 2024
Nature

Volume: 637, P: 716-725
A novel peptide RR-171 derived from human umbilical cord serum induces apoptosis and pyroptosis in pancreatic cancer cells

Weigang Chen
Kai Yang
Yong Chen
ResearchOpen Access14 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma

The MYC oncogene is activated in the majority of human cancers and has proven challenging to target therapeutically. In this study, the authors identify genome-wide MYC synthetic-lethal interactions that could serve as potential alternative targets for the treatment of MYC-driven cancers.

Anja Deutzmann
Delaney K. Sullivan
Dean W. Felsher
ResearchOpen Access01 Feb 2024
Nature Communications

Volume: 15, P: 1-13
An in-memory computing architecture based on two-dimensional semiconductors for multiply-accumulate operations

In standard computing architectures, memory and logic circuits are separated, a feature that slows matrix operations vital to deep learning algorithms. Here, the authors present an alternate in-memory architecture and demonstrate a feasible approach for analog matrix multiplication.

Yin Wang
Hongwei Tang
Wenzhong Bao
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-8
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness

Activated Notch signalling promotes cancer metastasis and stemness. Here the authors show that Notch1 activates transcription of DNA replication factor RCF4 and that RCF4 binds and stabilises Notch1 intracellular domain (NICD1) to promote cancer metastasis.

Lei Liu
Tianyu Tao
Han Tian
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-16
Low expression of SGCA promotes lung squamous cell carcinoma malignant progression

Guojie Chen
Guangyao Mao
Mei Lin
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease

Qi Pang
Peiwen Wang
Aihua Zhang
ResearchOpen Access30 Mar 2022
Cell Death & Disease

Volume: 13, P: 1-15
Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression

Posterior scleral birefringence, measured by triple-input polarization-sensitive optical coherence, predicts the onset of myopia in guinea pigs and is associated with myopia status in patients.

Xinyu Liu
Liqin Jiang
Leopold Schmetterer
ResearchOpen Access26 Jun 2023
Nature Biomedical Engineering

Volume: 7, P: 986-1000
A high-sensitivity flexible bionic tentacle sensor for multidimensional force sensing and autonomous obstacle avoidance applications

Xinyu Liu
Kunru Li
Xiujian Chou
ResearchOpen Access21 Oct 2024
Microsystems & Nanoengineering

Volume: 10, P: 1-12
HDAC2 negatively regulates memory formation and synaptic plasticity

Histone acetylation has been implicated in learning and memory. Neuron-specific overexpression of histone deacetylase 2 (HDAC2), but not HDAC1, is shown to decrease memory formation in a rodent model. This encourages development and testing of HDAC2-selective inhibitors for human diseases associated with memory impairment.

Ji-Song Guan
Stephen J. Haggarty
Li-Huei Tsai
Research07 May 2009
Nature

Volume: 459, P: 55-60
Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host

Only one of the three Taenia species causing taeniasis in humans was previously sequenced. Here the authors provide draft genomes of Taenia saginata and Taenia asiatica, analyse genome evolution of all three species, and identify potential targets for developing diagnostic markers or intervention tools.

Shuai Wang
Sen Wang
Xuepeng Cai
ResearchOpen Access22 Sept 2016
Nature Communications

Volume: 7, P: 1-12
Biocompatible autonomous self-healing PVA-CS/TA hydrogels based on hydrogen bonding and electrostatic interaction

Xiaogang Yu
Jinxin Huang
Wei Zhang
ResearchOpen Access13 Jan 2025
Scientific Reports

Volume: 15, P: 1-16
Delving into quasi-periodic type optical solitons in fully nonlinear complex structured perturbed Gerdjikov–Ivanov equation

Zhimin Yan
Jinbo Li
Nabil Mlaiki
ResearchOpen Access14 Mar 2025
Scientific Reports

Volume: 15, P: 1-19
Dihydrolipoamide dehydrogenase (DLD) is a novel molecular target of bortezomib

Yu Feng
Hongmei Luo
Yuhuan Zheng
ResearchOpen Access13 Aug 2024
Cell Death & Disease

Volume: 15, P: 1-11
LincRNA-p21/AIF-1/CMPK2/NLRP3 pathway promoted inflammation, autophagy and apoptosis of human tubular epithelial cell induced by urate via exosomes

Jianbing Hao
Xinyu Guo
Lirong Hao
ResearchOpen Access05 Aug 2024
Scientific Reports

Volume: 14, P: 1-15
A self-powered hydration-monitoring and drug-delivery skin patch for closed-loop treatment of atopic dermatitis

Shan Liang
Shiwei Liu
Meihua Chen
ResearchOpen Access18 Aug 2025
Microsystems & Nanoengineering

Volume: 11, P: 1-14
Probing electron localization during molecular dissociation by femtosecond strong-field ion momentum spectroscopy

Ultrafast spectroscopy allows for the real-time observation of molecular processes and enables a better understanding of the electron dynamics and nuclear evolution that occur during a chemical reaction. Here, the authors study, experimentally and theoretically, the electron localization that occurs on a femtosecond timescale during the dissociation of N₂O.

Xinning Zhao
Ting Xu
Dajun Ding
ResearchOpen Access30 May 2023
Communications Physics

Volume: 6, P: 1-7
Research on durability of underground lining structures using damage theory

Hongke Pan
Xiaosan Yin
ResearchOpen Access29 May 2025
Scientific Reports

Volume: 15, P: 1-10
MFSD12, transcriptionally regulated by PLAGL2, promotes bladder cancer progression

MFSD12 exerts a tumor-promoting effect on bladder cancer progression, and it was modulated by the transcription factor PLAGL2.

Jiani He
Changming Dong
Xiaojun Man
ResearchOpen Access30 Sept 2025
Communications Biology

Volume: 8, P: 1-15
Evolutionary analysis of the DHHCs in Saccharinae

Hao Wen
Xinyu Liu
Jishan Lin
ResearchOpen Access17 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Doped, conductive SiO₂ nanoparticles for large microwave absorption

Michael Green
Zhanqiang Liu
Xiaobo Chen
ResearchOpen Access14 Nov 2018
Light: Science & Applications

Volume: 7, P: 1-9
A high-efficiency primary-side regulation control strategy for half-bridge LLC resonant converter with wide input voltage range

Mian Dai
Daying Sun
Chong Wang
ResearchOpen Access19 Oct 2023
Scientific Reports

Volume: 13, P: 1-16
Different Inhibitory Effect and Mechanism of Hydroxyapatite Nanoparticles on Normal Cells and Cancer Cells In Vitro and In Vivo

Yingchao Han
Shipu Li
Xinyu Wang
ResearchOpen Access20 Nov 2014
Scientific Reports

Volume: 4, P: 1-8
Room temperature 90° phase-matching in zirconium and magnesium co-doped lithium niobate crystals

Tengfei Kong
Hongde Liu
Jingjun Xu
ResearchOpen Access01 Mar 2018
Scientific Reports

Volume: 8, P: 1-7
Numerical simulation method for double shield TBMs crossing weak zones

Zhiwen Wang
Meng Wei
Xin Tong
ResearchOpen Access21 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis

Yuhua Shi
Yang Yang
Fushan Shi
ResearchOpen Access03 Feb 2022
Cell Death & Disease

Volume: 13, P: 1-14
A combined improved dung beetle optimization and extreme learning machine framework for precise SOC estimation

Kaihua Yao
Xinyu Yan
Yuxiang Han
ResearchOpen Access20 May 2025
Scientific Reports

Volume: 15, P: 1-15
Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cells

Jun Ma
Xinyu Li
Yubin Ge
ResearchOpen Access08 Feb 2017
Scientific Reports

Volume: 7, P: 1-14
Single-cell transcriptional dissection illuminates an evolution of immunosuppressive microenvironment during pancreatic ductal adenocarcinoma metastasis

Xiaowei Liu
Jinen Song
Hubing Shi
ResearchOpen Access09 Jun 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-18
Study on the influence of near-fault vertical ground motion on the dynamic response of separation and collision of bridge

Xuerong Liu
Leilei Li
Wenjun An
ResearchOpen Access17 Oct 2025
Scientific Reports

Volume: 15, P: 1-16
Effect of solar proton events on test mass for gravitational wave detection in the 24th solar cycle

Ruilong Han
Minghui Cai
Jianwei Han
ResearchOpen Access19 Jun 2023
Scientific Reports

Volume: 13, P: 1-14
0.01% atropine combined with carteolol hydrochloride can inhibit the scleral remodeling in guinea pigs with form-deprivation myopia

Qin Xiang
Jing Yang
Zhou Fu
ResearchOpen Access11 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Toward high-fidelity coherent electron spin transport in a GaAs double quantum dot

Xinyu Zhao
Xuedong Hu
ResearchOpen Access18 Sept 2018
Scientific Reports

Volume: 8, P: 1-15
Crystal orientation and crystal structure of paramagnetic α-Al under a pulsed electromagnetic field

Qingwei Bai
Jun Wang
Xinyu Bao
ResearchOpen Access30 Jun 2020
Scientific Reports

Volume: 10, P: 1-13
Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia

Daniel A. Luedtke
Yongwei Su
Yubin Ge
ResearchOpen Access26 Feb 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-11
Exposure to arsenic and other potentially toxic elements: health risk assessment and source analysis in the Wuming Basin, Guangxi Province, China

Bo Hu
Jie Li
Lei Wang
ResearchOpen Access03 Feb 2024
Scientific Reports

Volume: 14, P: 1-12

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