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The high demand of soft strain sensors requires solutions to reduce resource waste. Here, the authors propose a machine learning framework that corrects unstable signals in soft strain sensors, making them more accurate, reliable and longer-lasting, and extending their usable lifetime by more than 3,000 times.

Alkene 1,1- difunctionalization holds significant importance in organic synthesis due to its ability to effectively enhance the complexity and functionality of molecular frameworks. Here, the authors report an electrochemical strategy for 1,1-difunctionalization of halogenated aromatics with unactivated alkenes, using synergistic Fe/Ni catalysis.

Changhua County, Taiwan launched a hepatitis C elimination initiative which integrates population-based screening and targeted strategies for high-risk groups. Here, the authors evaluate its impacts on hepatitis C virus cascade care and treatment outcomes and compare to a counterfactual scenario without the program.

AgBiS₂ nanocrystals show promise for thin, low-cost solar cells but are hindered by poor charge transport and limited infrared absorption. Yang et al. grow a molecular lead halide perovskite layer on the nanocrystals to passivate defects, improve transport, and enable highpower conversion efficiency.

Idiopathic pulmonary fibrosis is a fatal lung disease driven by aberrant fibroblast activation, but the underlying metabolic changes remain unclear. Here, the authors show that dysregulated branched chain amino acid metabolism promotes lung fibrosis and can be therapeutically targeted.

The authors report an asymmetric de Mayo reaction catalyzed by a chiral hafnium phosphate complex, enabling visible-light-promoted dearomatization and exoaromatic C–C bond insertion of salicylaldehyde derivatives with alkenes.

Self-assembled monolayers struggle to uniformly coat textured surfaces, limiting high-efficiency perovskite and silicon tandem solar cells. Du et al. increase surface hydroxyl groups by incorporating carbon into polysilicon, enabling stable monolayer attachment and record device efficiency.

Tang et al. demonstrate that disease progression in Duchenne muscular dystrophy is driven not only by dystrophin deficiency but also by ANXA11-mediated failure of regenerative myofiber maturation. Targeting ANXA11 improves muscle regeneration and function in mdx mice.

The authors revealed that defective sulfation of a cholesterol-derived metabolite drives harmful lipid buildup in cartilage cells, while the sulfated form protects against osteoarthritis.

Precise transcription-repair coordination is required for efficient DSB repair. Here, the authors show that DNA-PK-mediated CRTC2 Ser433 phosphorylation, relocates DNA-PK from transcription to repair complexes and promote NHEJ. Inhibition of CRTC2 sensitizes liver cancer to radioimmunotherapy.

The malto-oligosaccharides (MOS) serve as essential primers for starch synthesis in higher plants. Authors demonstrate that two enzymes, PHS1 and DPE1, form a binary complex and coordinately promote MOS synthesis as a key initial step in starch biosynthesis.

Fibroblast heterogeneity is a hallmark of fibrosis including in the kidney, but their precise roles in driving renal fibrosis are incompletely understood. Here the authors report that a switch to a CD248⁺ extra cellular matrix -producing fibroblast subset contributes to kidney fibrosis, and blocking CD248 with a monoclonal antibody mitigates the phenotype in male mice.

This study identifies a mitochondrial protection pathway that safeguards mitochondrial DNA integrity and limits liver damage. Disrupting this pathway triggers inflammation and fibrosis, while restoring protection or inhibiting DNA sensing markedly ameliorates fatty liver disease.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

The study shows that proactive collaboration, driven by team initiatives, enables robot teams to anticipate needs and reorganize themselves by recruiting or releasing teammates, improving performance in real-world and simulated tasks.

The authors introduce HyperRAG, a hypergraph-based retrieval method that captures higher-order relationships in domain knowledge to reduce hallucinations in large language models, improving accuracy and robustness across multiple datasets and medical tasks.

High yield and wide adaptation rice are crucial for grain supply and food security. Here the authors report OsPI4Kγ7 which contributes to different “adaptability-yield” trade-offs in japonica and indica, and provides an alternative breeding strategy for raising grain yield in different latitudes.

Preeclampsia is a serious pregnancy complication, but early identification of women at risk remains difficult due to limited biomarkers. Here, the authors show that cell-free DNA fragmentomics from maternal blood can predict preeclampsia risk early in pregnancy.

Skin lesions are common manifestations of systemic lupus erythematosus (SLE). Here, the authors present a spatial transcriptomic atlas of lesional skin from patients with lupus and identify an acute inflammatory signature in SLE, contrasting with chronic damage in tertiary lymphoid structures in discoid lupus.

Ru-catalyzed asymmetric ring-closing metathesis (ARCM) reactions are less reported and restricted to the synthesis of tertiary stereocenters. Herein, the authors report ARCM to produce chiral heterocyclic compounds with quaternary stereocenters, by synthesizing stereogenic-at-Ru catalysts via controllable C–H activation.

This study shows that the UMOD p.H36Y mutation promotes kidney inflammation by enabling mutant tubular cells to trigger macrophage pyroptosis through the App–Cd74 pathway.

Wang et al. report dual cationic imidazole ligands to control perovskite dimensionality, from 0D to parallel 1D, and bridged 1D structures. Bridged 1D/3D perovskite heterostructure enables solar cells with certified efficiency of 27.02% and 30×30 cm² solar modules with efficiency of 21.41%.

This work develops a 3D-printed aluminium alloy with an Al₃Er nanoscale skeleton that deforms rather than breaks, achieving 700 MPa strength and 7% elongation, the mechanisms of which enable stronger lightweight structural metals.

Immunosuppressive tumor-associated macrophages (TAM) contribute to resistance to immune checkpoint blockade. Here, the authors propose BCAT1 to inhibit crotonate-mediated epigenetic reprogramming of tumor-associated macrophages, with BCAT1 loss promoting immune escape in hepatocellular carcinoma mouse models.

The authors report an artificial plateau neuron with bistable, spike-malleable dynamics that generates programmable rhythmic bursts, enabling a quadruped robot to walk adaptively and energy-efficiently via distributed hardware control without centralized computation.

Peptide asparaginyl ligases (PALs) are powerful protein engineering tools but remain rare. Here, authors mine natural diversity in Viola to discover 29 new PALs, reveal pH-dependent mechanism, and define transferable expression-increasing principles.

A multifunctional titanium-based surface integrating water repellency, solar heating, and corrosion resistance was developed. It demonstrates strong anti-/de-icing performance and outstanding durability, as validated by outdoor testing

All-inorganic perovskite solar cells promise strong stability but still suffer from moisture-driven surface damage and limited efficiency. Zhang et al. form a one-dimensional/three-dimensional interface using a tailored salt to stabilize the material and boost performance.

RNA-binding proteins (RBPs) regulate gene expression, but predicting RBP–RNA interactions across species is challenging. Here, the authors introduce MuSIC, a deep learning framework leveraging label smoothing and evolutionary conservation across 11 species to predict cross-species RBP–RNA interactions.

Despite the global prevalence of SARS-CoV-2 infection, its maternal–fetal interface during the first trimester remains underexplored. Here, the authors combined a cohort of 700+ samples and determine that maternal SARS-CoV-2 infection in the first trimester rarely infects placental tissue but alters immune responses and cellular communication, which may influence pregnancy outcomes.

Aerogels are promising for thermal insulation materials, though often have unfavorable mechanical properties. Here the authors design an aramid nanofiber aerogel to optimize mechanical and insulative properties.

In NIID, toxic polyG from NOTCH2NLC GGC repeats disrupts nucleoli and chromatin, causing DNA damage and senescence. Here, the authors show that ASOs targeting the repeats reduce polyG buildup and reverse damage, suggesting a new treatment.

Due to interacting metabolic, renal and cardiovascular dysfunction, cardiovascular-kidney-metabolic syndrome is difficult to treat. Here, the authors show a urea-responsive, kidney-targeted nanocarrier enables site-specific SGLT2 inhibition, restores cardiorenal metabolism and improves efficacy.

Not all deer are equally susceptible to SARS-CoV-2. Authors show that spike mutations reshape ACE2 compatibility across cervids, providing a structural basis for variant-dependent differences in spillover potential.

Enhancer RNAs and other noncoding RNAs are difficult to monitor in living cells. Here, the authors develop REDDIT, a sensitive reporter for tracking transcription of coding and noncoding RNAs, and use it to identify pathways regulating a lncRNA and an enhancer RNA in stem cells.

Direct catalytic decomposition offers a green approach for N₂O abatement, however, catalytic performance is severely limited by slow oxygen desorption kinetics and the intrinsic electronic structure of active sites. Here, the authors introduce iron species into a Co/β zeolite catalyst to precisely tailor the microstructure of cobalt active sites and optimize oxygen desorption pathways, significantly promoting NO-assisted oxygen desorption during N₂O decomposition and improving the catalytic active site.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Wide-bandgap perovskites offer promise for tandems but suffer from formation-pathway instabilities. Huang et al. use in-situ analysis to guide CsPbX₃ intermediate evolution, enabling uniform α-phase formation and high-efficiency, stable devices.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

Organic electrode materials are attractive for sustainable batteries but are often limited by poor charge transport. Here, authors demonstrate that a universal thiourea coupling strategy enhances both electron and proton transport in quinone electrodes, enabling stable operation of aqueous zinc batteries under practical conditions.

A dated phylogeny of 16,585 vascular plant species native to China reveals three major centres of endemism, including a potential new global biodiversity hotspot.

Understanding the subcellular distribution of RNA-binding proteins can shed light on their structural and functional features. Here, the authors map RNA-binding proteins across cellular compartments, revealing hierarchies and atypical functions.

The authors develop a polyvinylidene fluoride and mica bimorph to enhance pyroelectric response. The secondary pyroelectric contribution employs interfacial thermal stress to improve the pyroelectric performance for flexible electronics.

Conversion-type batteries face performance decay under high loading due to shuttle effects and sluggish kinetics. Here, authors introduce an f-d orbital tag-team catalysis mechanism using cerium single-atom catalysts, achieving a competitive iodine loading of 44.7 mg cm⁻² and an areal capacity of 10.2 mAh cm⁻² in zinc–iodine batteries.

Growth-coupled biosynthesis in microbes can stabilise production yields, yet their population-level effects are unclear. Here the authors use ScRNA-seq to reveal that an evolved glycyrrhetinic acid-producing growth-coupled yeast strain population achieves division of labour.