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Organophosphoryl compounds are important motifs, however regioselective phosphorylation of alkenes remains challenging. Here, the authors report a visible light driven triple catalytic strategy enabling radical Markovnikov hydrophosphorylation of unactivated alkenes via sequential reaction of (bis)homoallylic alcohols, Ph₂PCl, and water.

Reversible-deactivation radical polymerisations are highly sensitive to oxygen and inhibitors, hindering their industrial application. Here, the authors report a heterogeneous phenanthroline-based conjugated hypercrosslinked polymer photocatalyst for photoinduced copper-catalysed atom transfer radical polymerisations, achieving high oxygen and inhibitor tolerance.

CRISPR-Cas systems are prokaryotic immune defenses commonly targeted by phage-encoded anti-CRISPR (Acr) proteins. Here, authors report cryo-EM structures of Cas2/3 and its complex with AcrIF19 from Pectobacterium atrosepticum, and uncover its dual inhibitory mechanism against Cas2/3 function.

In this study, the authors find that the perirhinal cortex controls hippocampal seizures in male mice via multiple downstream circuits that arise from distinct neuronal subpopulations, including projections to the fasciola cinerea, highlighting it as a promising therapeutic target.

Nasopharyngeal carcinoma (NPC) screening in southern China uses EBV serology, but its positive predictive value is low. Here, the authors introduce a swab-based E-CpMQ method in high-risk individuals, achieving better specificity.

Here, the authors uncover a mechanism by which drug-target homologs mediate non-antibiotic drug effects on bacterial growth, and suggest a universal homology-based competition strategy to reverse MTX-induced microbiota dysbiosis.

In this work, authors show that HTLV-1 subverts the typical antiviral role of the innate immune effector protein IRF7; instead of triggering an IFN-I response, the virus uses IRF7 to promote the growth of infected cells by establishing an oncogenic IRF7-STAT5B axis via HBZ protein.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Li, Tao, and colleagues present epi-Patho-DBiT to spatially map chromatin accessibility and histone modifications in archived human lymphoma tissues, revealing epigenetic drivers of lymphoma development, progression and transformation.

Traditional edge audio recognition struggles with high overhead and latency owing to separate denoising and recognition modules. Wang et al. propose a memristor-based neuromorphic system integrating on-chip denoising and recognition, achieving full recognition accuracy with low energy consumption and strong noise robustness.

This study marks the spatial cell atlas of Toxocara canis neuroinvasion in mice, which reveals microenvironment of host-parasite interactions and offers insights into helminth-induced neurological dysfunction and chronic neurological disorders.

This study identifies Snora61, a snoRNA enriched in intestinal stem cells (ISCs). Snora61 knockout impairs ISC function. Snora61 binds to the Lgr5 promoter, recruiting RBMX and HMGB2 to activate Lgr5 transcription.

Functional group interconversion, a pivotal synthetic technique for precise editing of molecular building blocks, is rare when facilitated by energy transfer catalysis. Herein, the authors report two instances of photochemical rearrangement of isonitriles, facilitated by energy transfer catalysis under visible light.

The PD-1/PD-L1 pathway is central to immunotherapy, but PD-L1 recycling limits durable responses. This study identifies TM9SF2 as a key regulator of PD-L1 trafficking and shows that disrupting its PGK1-dependent complex depletes PD-L1 and enhances antitumor immunity.

Here, the authors show that the PLA2G6 protein is a component of the IP3R1–GRP75–VDAC1 complex at the mitochondria-associated endoplasmic reticulum (ER) membrane, maintaining the integrity and function of ER–mitochondria contacts.

FLT3-ITD mutations drive relapse in acute myeloid leukemia (AML) despite targeted therapies. This group studies therapeutic potential and resistance mechanisms of FLT3-ITD inhibition with QUIZartinib and Omacetaxine Mepesuccinate (QUIZOM) in preclinical and clinical AML specimens.

Combined Cdc42 loss and KRas activation trigger polarity-YAP-IL1/TNFα signaling to induce inflammation, stem cell loss, and necroptosis in mouse intestinal epithelia. Disrupting cell polarity in the context of an oncogenic insult causes a necrotizing enterocolitis-like disease.

What is it about the Hubble Space Telescope that so captivates its users and the public at large? I offer my personal views on this iconic telescope.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

Tang et al. identify cysteinyl leukotriene receptor 1 (CysLTR1) as a critical regulator of tumor-induced myelopoiesis, suggesting CysLTR1 targeting to sensitize tumors to immune checkpoint blockade.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Urbanization is reshaping microbial ecology within wastewater treatment systems. This study reveals that urbanization drives microbial homogenization and that reduced diversity is linked to poorer wastewater treatment performance and stability.

Here, the authors report an exome-wide association study for multi-organ imaging traits by leveraging recent bioinformatic tools such as AlphaMissense. The identified signals elucidate the genetic effects from rare variants on human organs and their connections to complex diseases

Wu et al. investigated the efficacy and safety of fruquintinib plus sintilimab in 34 Chinese patients with advanced cervical cancer. The study finds that 32% of patients responded to the combination treatment and disease was controlled in 97%; side effects were manageable.

This study reveals that rice roots secrete heptadecanoic acid to recruit beneficial Bacillus for defence against blast fungus, a process regulated by a MAPK pathway.

Although ultra-high-resolution mass spectrometry (UHRMS) coupled with high-performance liquid chromatography (LC-UHRMS) can identify the isomeric diversity of molecular formulas in organic matter, its application is limited by high operational costs, the requirement for expert handling, and complex data interpretation. Here, the authors report a graph neural network model for inferring isomeric diversity from direct infusion UHRMS (DI-UHRMS) data and demonstrate its high accuracy in predicting the chromatographic isomeric diversity of natural dissolved organic matter, with comparable results achieved across various DI-UHRMS techniques.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

This study from Wei-Guang Li, Tian-Le Xu and colleagues shows that neuropeptide Y released by specific hippocampal inhibitory neurons can switch fear memories into extinction memories by acting on two distinct receptor-defined neuron populations.

Exhausted CD8⁺ T cells increase proteasome activity due to the accumulation of depolarized mitochondria, which drives the selective degradation of mitochondrial proteins and releases of regulatory haem through haemoprotein breakdown.

Emerging multidrug-resistant Neisseria gonorrhoeae is a global health threat in the treatment of gonorrhoea. This study reports the discovery and characterization of a promising antigonorrhoea agent that addresses antibiotic resistance.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Nanofiltration membranes are promising for chemical and environmental science, though it is challenging to design membrane balancing selectivity and fouling resistance. Here the authors design a membrane by modifying the interfacial polymerization using lyotropic liquid crystals to optimize performance.

A plasma-cascade strategy enables cyclohexanone cyanohydrin (Cy(OH)CN) synthesis via direct co-conversion of N₂ and CH₄ with cyclohexanone under mild and catalyst-free conditions. A 0.60 mmol h⁻¹ formation rate and 95.8% selectivity for Cy(OH)CN is achieved without using expensive NH₃ or toxic HCN.

A new study shows that reduced fat metabolism in renal tubule cells contributes to kidney fibrosis.

Authors present a whisker sensor enabling robots to sense surroundings via vision-tracked, magnetically actuated whiskers. It detects contact and flow, identifies objects and fluids, and gently grasps fragile items.

Long‑range chromosome encounters in cells are hard to quantify. Here, the authors induce artificial contacts in yeast and show that intra‑chromosomal interactions form faster than inter‑chromosomal ones in G1 yeast, driven by condensin‑mediated loop extrusion.