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A symmetry-broken Mn(II) dimer enables the dual-stimuli-responsive luminescence through spin-canted Mn‒Mn coupling, providing a new mechanism for modulating d-d transitions and serving an optical manometer for sensing.

Conotoxins are disulfide-rich therapeutic peptides with high affinity and selectivity for ion channels, yet their optimization is hindered by limited sequence diversity and laborious engineering. Here, the authors introduce CreoPep, a deep learning-based generative framework that integrates a progressive masking strategy and an augmentation pipeline that combines physics-based energy screening with temperature-controlled multinomial sampling, rationally designing and generating diverse and potent conotoxin variants.

The quantum fusion of two independent 10-user networks is demonstrated based on multi-user entanglement swapping. Active temporal and wavelength multiplexing schemes are developed to merge the two networks into a larger network with 18 users in the quantum correlation layer.

The electrooxidation of ethylene to ethylene glycol (EG) offers a sustainable pathway for chemical manufacturing, but demands selective non-precious-metal electrocatalysts. Here, the authors report a class of (111)-rich Mn₂O₃ nanoarray electrode, which achieves a high selectivity of 52.6% for for ethylene-to-EG conversion in aqueous electrolytes.

The study shows that high-coordination-shell defects in Fe-N₅ single-atom catalysts enhance peroxymonosulfate activation, enabling rapid and selective degradation of pollutants and revealing how remote site modulation controls catalytic efficiency.

Genetic variation present in wild rice is a reservoir of useful genes for rice breeding. Here, the authors report the haplotype-resolved gapless genome assembly of wild rice, the development of two sets of chromosome segment substitution lines, and the cloning of a blast resistance gene originated from wild rice.

The de novo design and synthesis of the Sc 2.0 chromosome XIII enable in-depth investigations into biology. Here the authors construct the 884 Kb synXIII of Saccharomyces cerevisiae to investigate replicative aging.

Robust Cu single-atom catalysts show promise for CO₂ electroreduction but face stability challenges. Here, the authors report a self-healing Cu single-atom catalyst that maintains high performance and stability for CO₂-to-CH₄ conversion at industrial current densities.

An antibody–polysialic acid conjugate induces calcification on the surface of methicillin-resistant Staphylococcus aureus and boosts immunogenicity in mice.

Integrating human mobility and activity data with ground-level measurements and air quality models, Shen et al. find that despite a reduction in outdoor PM_2.5 during the COVID-19 quarantine in China, overall population exposure to PM_2.5 increased.

Heating-resistive flexible electronics is promising, yet challenging. Here, the authors report a direct printing and writing strategy for refractory entropy-alloy-based flexible sensors with sensitivity over a broad temperature range, enabling real-time monitoring of morphing aircrafts in harsh environments.

Citrullus super-pangenome constructed using 27 telomere-to-telomere assemblies encompassing all seven Citrullus species highlights genomic diversity across wild and cultivated watermelons and the potential for crop improvement.

RNF214 ubiquitin ligase is understudied. Here the authors show RNF214 promotes hepatocellular carcinoma progression by inducing non-proteolytic ubiquitylation of TEADs and activating YAP signaling pathway.

Water dissociation has proven power in tuning the behaviors of electrochemical CO₂ reduction. Here, the authors report the spontaneous water dissociation capability of the intermetallic electride LaCu_0.67Si_1.33 material that enables high rate electrosynthesis of methane from CO₂.

This study demonstrates that the adaptor protein AP-3β recruits the 19S regulatory particle (RP) of the proteasome to stress granules (SGs) after heat stress and promotes SG disassembly through RP-associated deubiquitylation process.

Diffuse-type gastric cancer (DGC) accounts for 30% of gastric cancers and has few treatment options. Here the authors present a mutation and proteome dataset for 84 patients, identifying three major classes of DGC and indicating potential targets for therapy.

The authors investigate the electronic structure of kagome CsCr₃Sb₅ using high-resolution angle-resolved photoemission spectroscopy and ab-initio calculations. The results identify CsCr₃Sb₅ as a strongly correlated Hund’s metal with incipient flat bands near the Fermi level.

Superionic fluoride dielectrics with a low ion migration barrier are capable of excellent capacitive coupling and are highly compatible with scalable device manufacturing processes for integrated electronics.

The regulation of genetic diversity resulting from polyploidization and its impact on environmental adaptability remain unclear. Here, the authors show that LHP1-mediated epigenetic buffering of subgenome diversity and defense responses confers genome plasticity and adaptability in allopolyploid wheat.

The PI3K/AKT signalling pathway regulates cancer metabolism. Here, the authors show a reciprocal positive feedback crosstalk between the PI3K/AKT and pentose phosphate pathway which promotes tumourigenesis.

Here, authors report an inter-site structural heterogeneity induced effect of hierarchical single atom Fe catalysts for robust oxygen reduction. Dynamic evolutions and insights into structure-activity relationship are presented.

Predictive methods for gastric cancer to try and differentiate between potential treatment response are required. Here the authors use a multiplexed immunohistochemistry method to propose the proximity of tumour infiltrating immune cells as an indicator of likely therapeutic response.

How subgenome-divergent and -convergent transcription is mediated and harmonized in hexaploid common wheat genome remains unclear. Here, via characterizing the cistrome maps, the authors reveal that transposon elements with transcription factor binding ability have the potential to make the contribution.

Selective RNA processing and stabilization (SRPS) can regulate bacterial operons, but the process is not well understood. Here, the authors show that the stoichiometry of cellulosome, a 12-subunit protein complex expressed from an operon in Gram-positive Clostridium cellullolyticum, is regulated by SRPS.

A power generator exhibits enhanced output due to a dual-charge-carrier design. The voltage produced is constant yet competitive even under low relative humidity.

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