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Mechanistic insight into how SARS-CoV-2 nsp14 methyltransferase activity installs m⁷G on host RNAs to drive stress-granule assembly.

This study reveals that ion displacement–induced antiferroelectricity in CuBiP₂Se₆ enables polymorphic functionalization, allowing a single device to achieve multilevel conductance and synaptic behavior for energy-efficient neuromorphic computing.

Mitochondrial DNA heteroplasmy associates with context-specific nuclear CpG methylation, supported by a cell model. Heteroplasmy–CpG scores relate to mortality and cardiovascular risk, though direction and mechanisms remain unclear.

The authors report magnetotransport evidence for the coexistence of a two-dimensional (2D) superconducting state and a 2D ferromagnetic state at the interface between amorphous CaZrO₃ film and KTaO₃ single crystal. Moreover, the magnetoresistance hysteresis reaches a maximum near the superconducting transition temperature.

SFTS is an emerging tick-borne disease with high mortality rates caused by the SFTS virus. Here, the authors identify LRP1 as an entry factor for SFTSV, show that SFTSV glycoprotein Gn interacts with LRP1 and that blocking LRP1 reduces viral infection and improves survival in lethal mouse models.

Microbial iron cycling can enhance the accumulation of rare earth elements and yttrium in host minerals by facilitating their release from iron oxides back into the pore water, according to an integrated geochemical, magnetic, and microscopic analysis.

Results of a multicentre phase 1 clinical trial evaluating treatment with the engineered herpes simplex virus VG161 in advanced liver cancer indicate a good safety profile and promising efficacy.

Here, the authors report that introducing βcyclodextrins (CD) as anion-receptors into Zn(OTf)2 aqueous electrolyte could significantly optimize the Zn anode SEI structure for achieving stable ZIB.

Biotic-abiotic hybrid systems are promising for solar-to-chemical conversion, but it remains challenging to achieve atomically precise interface contact. Here, the authors report a general strategy of facilitating direct electron uptake via building single-atom bridges across biotic-abiotic interfaces to enhance solar-driven hydrogen production.

Here, authors report femtosecond laser direct lithography of perovskites system (PEA)₂PbI₄, achieving nanoscale feature size and pixel-level control over temporal dynamics for the creation of temporally programmable holograms. These holograms can multiplex multiple independent images with low crosstalk, showing great application potential in tunable photonic devices and holography displays.

Helicobacter pylori FabX, a dehydrogenase/isomerase flavoprotein, is required for unsaturated fatty acid synthesis. Here, the authors characterize FabX substrate recognition and catalytic mechanism, and reveal that it contains an atypical [4Fe-4S] cluster, which is essential and participates in the catalytic cycle.

The cellular organization of retinal development is biologically complex. Here, the authors use spatial transcriptomics to analyse developing human retina providing insights into spatiotemporal expression signatures and cellular communication during retinogenesis

The fabrication of ohmic electrical contacts for 2D semiconductor devices remains an important challenge towards their industrialization. Here, the authors report the low-temperature van der Waals epitaxial growth of ultrathin Cd electrodes for 2D MoS₂ transistors, showing improved contact resistance and mobility.

Miniature gene editing tools are highly desired for efficient in vivo delivery and disease treatment. Here, the authors reported engineering hypercompact TnpB-ωRNA for robust gene editing with minimal off-target effect in cultured cells and use it to rescue fatal genetic liver disease in a tyrosinaemia mouse model.

Duplication of the MECP2 gene (encoding methyl-CpG-binding protein 2) causes MECP2 duplication syndrome. Here the authors develop a Cas13Y system capable of targeting the MECP2 mRNA for degradation and reducing protein levels in the brain of humanized MECP2-transgenic mice and nonhuman primates.

Considerable genetic variation exists in maize ear size and kernel number. Here the authors show that variation in a gene encoding an ethylene biosynthetic enzyme impacts ear length, flower fertility and kernel yield suggesting an important role for ethylene signaling during inflorescence development.

Idiopathic pulmonary fibrosis is a fatal lung disease with limited treatment options. Here the authors show that tartrate-resistant acid phosphatase 5 (Acp5) promotes lung fibrosis by enhancing beta-catenin signaling and that inhibition of Acp5 can reverse stablished pulmonary fibrosis.

An insertion of an Alu element into an intron of the TBXT gene is identified as a genetic mechanism of tail-loss evolution in humans and apes, with implications for human health today.

Biomolecular cyptography that exploits specific interactions could be used for data encryption. Here the authors use the folding of M13 DNA to encrypt information for secure communication.

Improved glycemic control after transplantation of human pluripotent stem-cell-derived islets for diabetes treatment in non-human primates.

Silica-supported, single site, main group Zn(II) and Ga(III) ions catalyze ethylene and propylene oligomerization. Here, experimental and theoretical evidence suggests a Cossee-Arlman reaction mechanism similar to that for transition metal catalysts.

Pigs can be genetically modified to inactivate endogenous retroviruses and to display enhanced compatibility with the human immune system using a combination of CRISPR–Cas9 and transposon technologies.

Multi-omics profiling of the blood and heart of two human decedents receiving pig heart xenografts, including single-cell studies, reveals early immune responses and perioperative cardiac xenograft dysfunction in one of the two decedents, which may be due to mismatched heart size and/or insufficient immunosuppression.

Dirac magnetoexcitons with non-trivial nanoscale electrodynamics are formed from the excitation of Landau levels in charge-neutral graphene. Here, the Dirac magnetoexciton dispersion is directly imaged up to 7 T via a magneto cryogenic near-field microscope.

Diamond nanowires can produce single photons ten times more efficiently than bulk diamond, while consuming ten times less power.

Conventional deoxygenation methods typically result in inevitable trace oxygen residue in organic semiconductors. Here, Huang et al. reports a non-destructive soft-plasma treatment for deoxygenation and that removal of trace oxygen can be used to modulate p-type characteristics.

This study describes a method to insert large stretches of exogenous DNA into mammalian genomes, which is used to insert human ACE2 loci into mouse to produce a model of human SARS-CoV-2 infection.

Selection of kernel number per ear has improved maize yield, but the genetic base is unclear. Here, the authors reveal that a serine/threonine protein kinase KNR6 is a positive regulator of the trait and show in vitro evidences that KNR6 may function through phosphorylating an Arf GTPase-activating protein.

The genetic basis of gastric cancer, the fourth most common cancer worldwide, remains poorly understood. Here, the authors sequence and analyse the exomes and transcriptomes of primary gastric tumours and cell lines, and identify a ZAK kinase isoform that may have an oncogenic role in gastric cancer.

Nanoscale optomechanical systems offer a route to using optical forces for a range of devices based on photonic structures. Deotareet al. present a reconfigurable optical filter based on coupled silicon photonic crystal nanobeam cavities that can overcome thermo-optic effects at high frequencies.

Aragonite-dominated seep carbonates are a promising archive for understanding past seawater chemistry changes, according to an isotopic analysis of a core from the South China Sea.