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Gravitationally induced stratification during self-assembly often leads to density driven vertical segregation limiting the synthesis of metastable nanofilms. Here, the authors address this limitation with an antigravity confined interfacial self-assembly synthesis where capillary forces dominate and enable precise molecular organization resulting in ordered and stable nanofilms.

Emulating Schrodinger-equation-governed temporal dynamics in metamaterials is of strong interest. Here, the authors demonstrate that temporal scattering processes exhibit eigenstate topological braiding and dynamical topological phase transitions in circuit metamaterials.

IBI318 is a recombinant bispecific IgG1 antibody that targets PD-1 and PD-L1. Here the authors report the results of a phase II trial of IBI318 combined with the receptor tyrosine kinase inhibitor lenvatinib in patients with advanced non-small cell lung cancer with acquired resistance to first-line immune checkpoint inhibitors.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Natural variation of the F-box protein ZmFBL41 in maize confers resistance to Rhizoctonia solani, the causal fungus for banded leaf and sheath blight in maize, through decreased interaction of ZmFBL41 with the cinnamyl alcohol dehydrogenase ZmCAD.

Charging and discharging Li-metal batteries (LMBs) at low temperatures is problematic due to the sluggish charge-transfer process. Here the authors discuss the roles of solvation structures of Li-ions in the charge-transfer kinetics and design an electrolyte to enable low-temperature operations of LMBs.

Rechargeable magnesium batteries suffer from slow solid-state Mg²⁺diffusion in the intercalation cathode. Here the authors show magnesium/iodine chemistry in which the liquid–solid two-phase reaction leads to increased rate capabilities by overcoming the sluggish kinetics.

Controlling the nucleation and growth is essential for enabling long-life Li-metal batteries. Here the authors report the growth of faceted single-crystalline Li seeds on a lithiophobic Fe/LiF composite substrate that enables dense Li deposition under fast-charging conditions.

Shell-isolated nanoparticle enhanced Raman spectroscopy (SHINERS) has enhanced the sensitivity of Raman spectroscopy for applications in materials and life sciences. Here, the authors develop its femtosecond stimulated version (SHINE-FSRS) for in-situ monitoring of molecular dynamics on ultrafast scales.

Zhuang et al. define climate-resilient zones with global conservation consensus as marine climate refuges. They find that only 14% of marine protected areas and other effective area-based conservation measures are within these refuges, highlighting the need to expand marine conservation coverage.

Human embryonic stem cells are simultaneously capable of self-renewal and poised for differentiation. Here, the authors show a role for the ZNF263 transcription factor promotes primed pluripotency and facilitates differentiation into primary germ layer lineages.

The authors report the observation of tunneling spectra with extremely asymmetric coherence peaks in the underdoped cuprate superconductor Bi₂Sr_2-xLa_xCuO₆. They argue that the extremely asymmetric peaks arise from ‘half-Bogoliubons’, corresponding to three-hole and one-hole excitations of the local pairing state of two holes per 4a₀ × 4a₀ plaquette.

Dispersion engineering is pivotal in nonlinear photonics but traditionally fixed by post-fabrication immutability. Here, the authors demonstrate integrated chalcogenide microresonators with arbitrarily reconfigurable dispersion, providing a scalable and reprogrammable architecture for multifunctional photonic circuits.

In-phase/quadrature (IQ) electro-optic modulators are underpinning devices for coherent transmission technology. Here the authors present IQ modulators in the lithium-niobate-on-insulator platform, which provide improved overall performance and advanced modulation formats for future coherent transmission systems.

This study proposes approaches to quantify battery carbon intensity and achieve zero-carbon batteries through multi-directional V2X(Vehicle-to-Everything) and battery circular economy in a community with energy paradigm shifting towards renewable and sustainability.

Zero thermal expansion materials—often composites of negative and positive coefficient materials—are needed for applications that see large temperature changes. Here, the authors demonstrate that polarization around pores in single-phase mesoporous lead titanate can be used to tune thermal expansion to near zero.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Poor electrochemical reversibility of the conversion-type cathode materials remains an important challenge for their practical applications. Here, the authors report a highly reversible fluoride cathode material with low hysteresis through concerted doping of cobalt and oxygen into iron fluoride.

Stem cell therapies face immune rejection risks with allogeneic ESCs. Here, the authors establish genetically matched autologous ESCs in monkeys via embryo splitting, showing potentially superior genomic stability over iPSCs and ntESCs.

Multi-omic analysis of 100 clear cell renal cell carcinomas identifies four transcriptomic subgroups (IM1–IM4). IM4 is a high-risk subtype characterized by specific metabolic changes and a loss of lipid droplets.

The night-time seeing (the extent to which a star’s light is blurred by the atmosphere) at Dome A, the highest part on the Antarctic plateau, can be as good as 0.13 arcseconds above a height of only 8 metres.

Array-based epigenome-wide association studies only test about 2% of the CpG sites in the genome. Here, the authors describe EWASplus, a supervised machine learning strategy that extends EWAS coverage to the entire genome, and use it to identify novel brain CpGs associated with Alzheimer’s disease.

Although COVID-19 vaccines are proving to be generally effective, new therapeutics to neutralize SARS-CoV-2 are required. Here, the authors engineer bispecific antibodies from ACE2-blocking B38 and H4 SARS-CoV-2 neutralizing antibodies and demonstrate their superiority in mice and nonhuman primates.

In the field of plant genome engineering, new nucleases with improved editing efficiency and alterative PAM requirements are needed. Here, the authors report a probiotic sourced CRISPR-LrCas9 system with similar PAM requirement to Cas12a and show its high efficiencies in various genome editing applications.

How cortical interneurons establish precise connections among intermingled populations of excitatory neurons remains unclear. Here, the authors reveal that Cadherins instruct cell type and input-specific synaptic targeting of interneurons onto different pyramidal cell populations.

Increased precipitation enhanced bacterial diversity but reduced fungal diversity, while drought intensification increased stress-tolerant species but decreased moisture-sensitive species, according to a two-year field experiment with different precipitation treatments in Xiaohongshan, China.

Skp2 forms part of the SCF complex—an E3 ubiquitin ligase. Here the authors identify macroH2A1 as a novel target of Skp2 and propose an axis of regulation involving Skp2-macroH2A1-CDK8-p27 in cancer.

Missense mutant p53 (mutp53) proteins often accumulate in cancers. Here the authors show that the lipogenic enzyme FASN enhances mutp53 protein stability to drive tumor growth by promoting mutp53 palmitoylation.

Mechanistic insights into Cryptosporidium parvum invasion identify a non-canonical role for Protein Disulfide Isomerase through interaction with host keratin 18.

Spatial analysis of microbiomes at single cell resolution is challenging. Here the authors report a highly multiplexed method for spatial profiling, sequential error-robust fluorescence in situ hybridisation (SEER-FISH), and show that this allows mapping of microbial communities at micron-scale.

A high-quality genome assembly of Weining rye sheds new light on gene duplications and their effects on starch biosynthesis genes, gene expression features underlying early heading trait and putative domestication-associated chromosomal regions.

A large range of inert and non-defective sites in catalysts is a primary factor impeding catalyst activity in acidic CO₂ electroreduction. Here, the authors achieve high HCOOH selectivity and activity in acidic electrolyte by introducing tensile strain to activate inert sites.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.