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Inorganic cesium lead iodide perovskites promise stable solar cells but are limited by slow conversion from a templating phase. Li et al. tuned crystal orientation using surface-bound lead-complexing groups to speed conversion and achieve efficient, durable devices.

Why hollow porous crystals speed reactions has remained unclear. Real-time imaging in a model metal organic framework shows that hollow particles separate products from reactants, and shell thickness controls this transport and catalytic gain.

Here authors present a method combining DFT calculations with experimental synthesis to address the challenges of slow recovery and limited recyclability in chemiresistive sensing MOFs.

The authors demonstrate efficient trion modulation in MoS₂ enabled by plasmonic HfN gates. A photoluminescence modulation depth of ~24% was achieved over large tunable surface areas.

How co-invading species facilitate one another remains largely unknown. This study shows that facilitation is often asymmetric and increases when co-invading plants differ in competitiveness and their ability to shape microbial communities.

MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems ranging from cell culture to mice.

Here, the authors develop a repertoire of multivalent nanobodies that target key toxins in Staphylococcus aureus infection that show protective activity in murine models of sepsis and pneumonia.

Selective C–F functionalization of polyfluoroarenes remains a considerable challenge, particularly for controlled and sequential substitution. Now it has been shown that reactivity-tunable pyridine-boryl radicals enable sequential and versatile C–F transformations through a link-and-lose pathway, allowing hydro- and deuterodefluorination, defluorinative arylation and alkylation with spectroscopic observation of key radical intermediates.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

The study introduces manifold topological deep learning (MTDL) that extends topological deep learning to data on differentiable manifolds through de Rham-Hodge theory. MTDL outperforms competing methods on various biomedical imaging benchmarks.

This study proposes a self-supervised pre-trained model for experimental data from fusion devices. Experiments conducted on HL-3 demonstrate that this model can serve as a virtual backup diagnostic, reconstructing missing diagnostic data with 97.2% accuracy, and comprehensively enhance the performance of other downstream AI4Fusion algorithms as a device-specific foundation model.

Social rewards hold therapeutic potential for alleviating drug relapse, yet the neural substrates remain unclear. Here, authors show that social reward and drug relapse activate distinct dopaminergic populations within the VTA, which dynamically compete to regulate behavioral outcomes.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

Chen et al. uncover the mechanism of transferring chirality from chiral perovskite host to a molecular guest mediated by the electronic coupling at the interface. A photoactive charge transfer state is identified, which inherits the chiroptical properties of the host matrix, resulting in selectivity to circularly polarized photons.

Xu, Li, Deng and colleagues identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and autophagy. They show this modulates pyroptosis, antitumour immunity and chemotherapy response in mouse models.

Immune checkpoint inhibitors have shown some activity in patients with adrenocortical carcinoma (ACC), a rare aggressive malignancy with limited treatment options. Here the authors report the results of a phase 2 trial of camrelizumab (anti-PD1) plus apatinib (VEGFR inhibitor) for previously treated ACC.

The growth of the smallest aerosol particles is critical to their impacts on climate and air quality. Here, the concentration gradient of nanoparticles is shown to be an important microphysical mechanism for their rapid initial growth.

The fluorescence-based protein assembly platform GEMINI is able to record the history of individual cells by leveraging a computationally designed protein assembly as an intracellular memory device.

A mechano-intelligent transmission mechanism based on the slipknot delivers precise force signals for clinical practice and robotic operations such as minimally invasive surgery and tendon-driven robotics.

Graphene film-based metamaterials are applied for polarization manipulation of electromagnetic shielding effectiveness, achieving high performance in polarization sensitivity, full polarization shielding, and switching efficiency.

The authors report diode-like resistance in a non-magnetic topological insulator in the quantum Hall regime.

Hepatocyte-specific GPR110 mediates metabolic dysfunction-associated steatohepatitis progression by regulating hepatic oestrogen sensitivity in a sex-specific manner, specifically in female mice.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Structural colour offers an alternative to pigment-based colouration, but patterning often requires multiple steps. Here, the authors report a one-step, mask-free strategy for the formation of structural colour patterns based on manipulation of a nanoparticle enriched disordered layer.

Electrical doping and charge transfer in 2D antiferromagnet CrSBr reversibly switch its magnetic state, enabling gate-tunable spin valves and ultralow-power spin control without ferromagnetic contacts, advancing fully electrical 2D spintronics.

Entanglement entropy is a crucial quantity in several research fields, yet its calculation in higher-dimensional systems remains challenging. Here the authors develop a quantum Monte Carlo-based algorithm to efficiently extract large-scale entanglement entropy data and apply it to quantum critical systems.

CrPS₄, a 2D van der Waals A-type antiferromagnet, is shown to exhibit ideal characteristics of Stoner–Wohlfarth antiferromagnets, such as ferromagnet-like binary switching rather than layer-by-layer flipping as in other 2D A-type antiferromagnets.

The pilot phase of PigGTEx, re-analyzing 5,457 published RNA-seq samples, presents a pan-tissue catalog of molecular quantitative trait loci. Cross-species comparisons identify traits with shared genetic regulation in humans.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

A fibre-structured bandage converts the temperature gradient between the wound and dressing into an electric stimulus to generate an electric field that accelerates wound healing.

Limited improvement of systemic therapy has been achieved in first line treatment for advanced Biliary tract cancer (BTC). In this randomized phase 2 trial on BTC, the combination of sintilimab, anlotinib, and gemcitabine/cisplatin demonstrated an improvement in progression - free survival (PFS) and objective response rate (ORR) while reducing the risk of disease progression compared to chemotherapy monotherapy.

EuCo₂Al₉ is identified as a metallic spin supersolid with high thermal conductivity, exhibiting coexisting spin orders, strong quantum fluctuations and a giant magnetocaloric effect enabling efficient sub-Kelvin refrigeration.

Tungsten ditelluride has been recently discovered to possess very large and unsaturated magnetoresistance, which opens interesting perspectives for potential applications. Here the authors show suppression of the magnetoresistance and emergence of superconductivity at high pressure.

Fast reendothelialisation of vascular grafts is important for maintain patency. Here, the authors report on a vascular graft that regenerates the neo-adventitia with lymphatic endothelial cells, which increases the recruitment of circulatory progenitor cells, achieving 90% patency in small-diameter arterial grafts.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Wang, He, Gong and colleagues identify an age-related decline in the palmitoyltransferase ZDHHC11 in chondrocytes that leads to senescence and the pathogenesis of osteoarthritis, highlighting the potential of targeted ZDHHC11 delivery as a therapeutic strategy for osteoarthritis.

Organic co-crystals are useful in the fabrication of functional materials, but it is challenging to achieve structural diversity of co-crystals. Here, the authors report nine sets of macrocycle cocrystals with diverse structures and stoichiometric ratios giving different luminescence properties.

A mechanical design is developed for the fabrication of ultralong, fracture-free and perturbation-free semiconductor fibres to address the increasing demand for flexible and wearable optoelectronics.