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piR48444 targets METTL7A to inhibit BMP2 mRNA m6A methylation and METTL7A/eIF4E complex-mediated BMP2 mRNA stability and translation, ultimately inhibiting osteogenic differentiation of MSCs and bone regeneration.

Laser plasma instabilities are the main factors contributing to degradation of hohlraum performance in inertial confinement fusion experiments. Here, the authors show asymmetric backscattering within the same laser cone at the SG-100kJ laser facility, unveiling the role of crossed-beam energy transfer and laser polarization.

This study provides a single-cell and spatial atlas of the prometastatic tumor microenvironment in esophageal squamous cell carcinoma and characterizes the immunosuppressive function of GPR116⁺ pericytes in cancer metastasis and immune evasion.

Orthopedic implant-associated biofilm infections (IABIs) are refractory to elimination due to the dense biofilm formation and local immunosuppressive microenvironment. Here, the authors report a biofilm microenvironment-responsive self-thermophoretic nanomotor that leverages amplified copper ion interference and macrophage reprogramming to combat refractory orthopedic IABIs.

Here, the authors show that a human gut fungus, Clavispora lusitaniae P4013B, alleviates colitis in mice through the activation of the aryl hydrocarbon receptor, in turn mediated by its metabolite indole-3ethanol, indicating its potential as a probiotic for inflammatory bowel disease.

A genome-wide CRISPR knockout screen reveals UHRF1 restricts HCoV-229E by epigenetically silencing its receptor, APN. As UHRF1 declines with age, APN expression rises, enhancing viral susceptibility in macrophages from elderly individuals.

High-entropy nanocarbides (HENCs) containing 5–22 metal elements are synthesized through a nanoconfined impulse synthetic strategy enabled by Joule heating-induced in situ reactions in carbon nanotube films. These HENCs exhibit multi-element effects and enhanced electrocatalytic activities due to their nanoscale size and modified catalytic sites.

Activation of C–C bonds is a powerful method for directly functionalizing organic molecules, but is still a challenging task. Here, the authors show that N-heterocyclic carbenes can activate the C–C bonds in cyclic ketones, allowing the enantioselective formation of lactams.

Alkali metal cations affect CO₂ electroreduction performance. Here, the authors provide a comprehensive molecular understanding of the alkali metal cation effects on both CO₂ activation and competing hydrogen evolution based on explicit solvation models.

The methanol oxidation reaction is crucial for direct methanol fuel cells but is hindered by CO poisoning of Pt-based catalysts. Here, the authors report high-entropy alloyed single-atom Pt catalysts that resist CO poisoning, achieving a mass activity of 35.3 A mg^-1 and maintaining high durability.

This work introduces GLORI 2.0 and 3.0, enabling sensitive m⁶A quantification from RNA inputs as low as a few hundred cells.

An endohedral metallofullerene–polymer layer, which features ultrafast electron extraction and in situ encapsulation, improves the efficiency and stability of perovskite solar cells.

Time resolved measurements provide insights to the intriguing process of ultrafast molecular fragmentation. Here the authors use CEP-locked laser pulses in pump–probe scheme to explore the H₂⁺dissociation and find out that the electron localization to one of the nuclei occurs in about 15 fs.

A synergistic approach for uranium extraction, a rechargeable microelectrode adsorbent system, integrates the functions of adsorption and electrochemical reduction, leading to an excellent extraction rate and high adsorption capacity.

Photocatalytic H₂O₂ generation represents a promising approach for artificial photosynthesis. Here, ZrS₃ nanobelts with controllable disulfide and sulfide anion vacancies exhibit an excellent photocatalytic H₂O₂ generation performance together with selective oxidation of benzylamine to benzonitrile.

Lai et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures and their potential functions and implications.

The authors systematically investigate the polarization switching kinetics of sliding ferroelectric WTe₂, demonstrating their ultrafast response (0.6 ns).

Triple-negative breast cancer immunotherapeutic efficacy is greatly affected by oxidative imbalance within the lymph nodes, driving dendritic cell dysfunction. Here, this group presents a chimeric exosome-derived immunomodulator involving ROS scavenger mesoporous silica and lipid modulator toyocamycin coated with dendritic cell-derived exosomes to restore the lymph node immuno-microenvironment in triple-negative breast cancer.

Controlling the doping depth in perovskites allows the creation of a depletion region that inhibits the migration of iodide ions under illumination. Solar cells exhibit a power conversion efficiency of 24.6% and maintain 88% of the initial efficiency after 1,900 h of continuous operation.

Two-dimensional conjugated coordination polymers can show large electrical conductivity. Here, the authors synthesize high-quality single crystals of Cu₃BHT to unveil the atomic structure and intrinsic superconducting properties.

This study identifies lineage-specific XEG1/XLP1 gene pair in the genus Phytophthora, revealing that selective pressure on these genes drives functional differentiation. This selection is closely linked to the host range and adaptability of Phytophthora species.

Long-term durability is crucial for heavy-duty usage of lithium ion batteries; however, electrode failure mechanisms are still unknown. Here, the authors reveal the fracture mechanisms of single crystal silicon electrodes over extended cycling, and show how electrolyte additives can heal electrode cracks.

The use of heteroatom-centered anions as super-electron-donors (SEDs) for direct single-electron-transfer reactions has rarely been studied. Here, the authors show that heteroatom anions can be applied as SEDs to initiate radical reactions for synthesis of 3-substituted benzofurans, which have applications in both organic synthesis and pesticide development.

Viruses are pivotal players in deep-sea hydrothermal vents, shaping microbiomes by preying on key hosts. Through a global-scale analysis of vent viruses and their interactions, this study reveals that endemism is a key driver of viral ecology and evolution in these extreme ecosystems.

Cepharanthine is a secondary metabolite isolated from Stephania with a variety of medicinal properties. Here, the authors assembled three Stephania genomes, propose cepharanthine biosynthetic pathway, and assess the antiviral potential of cepharanthine-related metabolites.

Native chemical ligation is pivotal in chemical protein synthesis but often requires excessive additives due to the low reactivity of peptide alkyl thioesters. Here, the authors introduce a thioacid-based additive-free peptide ligation using vinyl thianthrenium tetrafluoroborate, enhancing efficiency and simplicity in synthesizing complex proteins like hyalomin-3 and ubiquitin.

Interventional embolization is essential for cancer treatment, but it lacks submillimeter vessel selectivity. Here, the authors show an embolic particle steering in micro-vessel networks via shape-adaptive acoustic manipulation and achieve superselective embolization.

Wide-bandgap perovskite solar cells suffer from phase segregation. Zhang et al. show that thiocyanate ions overcome the issue by occupying iodide vacancies while regulating crystallization, enabling perovskite/organic tandem cells with 25.06% efficiency.

Analyses of genetic variation and population structure based on over 3,000 cultivated rice (Oryza sativa) genomes reveal subpopulations that correlate with geographic location and patterns of introgression consistent with multiple rice domestication events.

Neural Perturbational Inference is an approach for estimating effective connectivity, in which virtual perturbations to a surrogate brain allow gaining insights into human brain functions.

A single-cell transcriptomic study from the Human Cell Atlas integrating over 11 million brain cells from 70 studies uncovers differences across human brain regions and identifies rare progenitor and microglia subtypes.

Anomalous mechanical behaviors provide an opportunity to regulate the functions of materials. Here the authors show that materials with coexisting negative, zero and positive compressibilities can “squeeze” volume compressibility into one direction, and thus stabilize transmission processes under pressure.

Substantial open-circuit voltage loss and inherent non-radiative recombination hinder efficiency improvements in wide-bandgap perovskite solar cells. Here the authors augment two-dimensional perovskite phases on the surface to promote (100) facet growth on three-dimensional perovskite facets, improving the open-circuit voltage and efficiency of the resulting wide-bandgap perovskite solar cells.

Giant cell tumor of bone (GCTB) is a rare primary osteolytic bone tumor with high local recurrence rate after surgical resection. Here the authors conduct a phase Ib/II trial, evaluating the efficacy and safety of JMT103 (RANK-RANKL inhibitor) in patients with unresectable or surgically-challenging GCTB.

Neutrophils demonstrate highly dynamic functional and transcriptional changes depending on their tissue environment. Udalova and colleagues use an inflammation model to examine neutrophils and find that the transcription factors RUNX1 and KLF6 control maturation; RELB, IRF5 and JUNB drive effector responses; and RFX2 and RELB promote survival.

In this phase 3 trial, first-line treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma with anti-PD-1 finotonlimab plus cisplatin plus 5-fluorouracil (C5F) prolonged overall survival compared with placebo plus C5F.

Genetic bases of grain shape differentiation between the two subspecies of Asian cultivated rice have not been fully elucidated. Here, the authors report GSE9, a de novo gene evolved from a non-coding region of wild rice through acquisition of start codon, contributes to the grain shape difference between the two subspecies.

Zhang, Peng, and colleagues benchmark metabolic RNA labelling chemistries for time-resolved single-cell RNA sequencing, improving in vivo detection of newly synthesized RNA during zebrafish embryogenesis.

Identification of a broadly therapeutic antibody h1A6.2 against enteroviruses, which mimics the entry receptor SCARB2 and triggers monocyte/macrophage-dependent Fc effector functions in mice.